ES3028099T3 - Polymorphic carbazole derivatives and uses thereof - Google Patents

Polymorphic carbazole derivatives and uses thereof Download PDF

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Publication number
ES3028099T3
ES3028099T3 ES20828454T ES20828454T ES3028099T3 ES 3028099 T3 ES3028099 T3 ES 3028099T3 ES 20828454 T ES20828454 T ES 20828454T ES 20828454 T ES20828454 T ES 20828454T ES 3028099 T3 ES3028099 T3 ES 3028099T3
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ES
Spain
Prior art keywords
compound
degrees
cancer
peaks
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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ES20828454T
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English (en)
Spanish (es)
Inventor
Alfredo C Castro
Nolan, Iii
Sarah Jean Bethune
Corinne Marie Folberth
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ImageneBio Inc
Original Assignee
Ikena Oncology Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES20828454T 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof Active ES3028099T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962940481P 2019-11-26 2019-11-26
PCT/US2020/062197 WO2021108528A1 (en) 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof

Publications (1)

Publication Number Publication Date
ES3028099T3 true ES3028099T3 (en) 2025-06-18

Family

ID=73856339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20828454T Active ES3028099T3 (en) 2019-11-26 2020-11-25 Polymorphic carbazole derivatives and uses thereof

Country Status (13)

Country Link
US (3) US11591339B2 (enExample)
EP (2) EP4529955A3 (enExample)
JP (2) JP2023502531A (enExample)
CN (2) CN122404338A (enExample)
AU (1) AU2020394424A1 (enExample)
CA (1) CA3159317A1 (enExample)
ES (1) ES3028099T3 (enExample)
FI (1) FI4065582T3 (enExample)
IL (1) IL293326A (enExample)
MX (2) MX2022006308A (enExample)
PL (1) PL4065582T3 (enExample)
PT (1) PT4065582T (enExample)
WO (1) WO2021108528A1 (enExample)

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* Cited by examiner, † Cited by third party
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AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
WO2021236717A1 (en) 2020-05-20 2021-11-25 Senda Biosciences, Inc. Fused imidazole derivatives as ahr antagonists

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Also Published As

Publication number Publication date
US20210253579A1 (en) 2021-08-19
US20230286990A1 (en) 2023-09-14
JP2023502531A (ja) 2023-01-24
EP4529955A2 (en) 2025-04-02
PL4065582T3 (pl) 2025-08-18
PT4065582T (pt) 2025-05-22
AU2020394424A1 (en) 2022-06-16
US12162884B2 (en) 2024-12-10
EP4065582B1 (en) 2025-02-19
EP4065582A1 (en) 2022-10-05
CA3159317A1 (en) 2021-06-03
MX2026004523A (es) 2026-05-04
WO2021108528A1 (en) 2021-06-03
US11591339B2 (en) 2023-02-28
MX2022006308A (es) 2022-06-22
JP2025113368A (ja) 2025-08-01
CN115279764B (zh) 2026-04-07
IL293326A (en) 2022-07-01
CN122404338A (zh) 2026-07-17
KR20220125231A (ko) 2022-09-14
US20250276975A1 (en) 2025-09-04
CN115279764A (zh) 2022-11-01
EP4529955A3 (en) 2025-07-16
FI4065582T3 (fi) 2025-05-25

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