ES302369A1 - Metodo de preparacion de compuestos triciclicos. - Google Patents
Metodo de preparacion de compuestos triciclicos.Info
- Publication number
- ES302369A1 ES302369A1 ES0302369A ES302369A ES302369A1 ES 302369 A1 ES302369 A1 ES 302369A1 ES 0302369 A ES0302369 A ES 0302369A ES 302369 A ES302369 A ES 302369A ES 302369 A1 ES302369 A1 ES 302369A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- reaction
- alkyl
- see formula
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 150000001412 amines Chemical class 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 alkyl ketone oximes Chemical class 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 1
- 238000006434 Ritter amidation reaction Methods 0.000 abstract 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000003944 halohydrins Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/29—Saturated compounds containing keto groups bound to rings
- C07C49/313—Saturated compounds containing keto groups bound to rings polycyclic
- C07C49/323—Saturated compounds containing keto groups bound to rings polycyclic having keto groups bound to condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29723363A | 1963-07-24 | 1963-07-24 | |
| US376259A US3352912A (en) | 1963-07-24 | 1964-06-18 | Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES302369A1 true ES302369A1 (es) | 1965-03-16 |
Family
ID=26970055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0302369A Expired ES302369A1 (es) | 1963-07-24 | 1964-07-23 | Metodo de preparacion de compuestos triciclicos. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3352912A (da) |
| AT (1) | AT279581B (da) |
| BE (1) | BE650919A (da) |
| BR (1) | BR6460975D0 (da) |
| CH (2) | CH476673A (da) |
| DE (3) | DE1793207A1 (da) |
| DK (3) | DK112027B (da) |
| ES (1) | ES302369A1 (da) |
| FI (3) | FI42322B (da) |
| FR (1) | FR1572956A (da) |
| GB (1) | GB1069563A (da) |
| IL (1) | IL21753A (da) |
| NL (2) | NL6408505A (da) |
| SE (3) | SE320363B (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449422A (en) * | 1966-02-09 | 1969-06-10 | Smithkline Corp | Pentacycloundecane amines |
| DE1294371B (de) * | 1966-12-21 | 1969-05-08 | Penicillin Ges Dauelsberg & Co | Verfahren zur Herstellung von 1-Aminoadamantan und dessen N-Alkyl- bzw. N-Cyclohexylderivaten |
| US3489802A (en) * | 1967-01-23 | 1970-01-13 | Du Pont | Preparation of alpha-methyl-1-adamantane-methylamine and alpha,4 - dimethyl - 1 - bicyclo(2,2,2)octane methylamine |
| NL6900004A (da) * | 1969-01-02 | 1970-07-06 | ||
| US3682922A (en) * | 1969-01-16 | 1972-08-08 | Searle & Co | N-acyl-n-{8 (n{40 ,n{40 -disubstituted amino)-alkyl{9 -1-adamantylmethylamines |
| JPS4828903B1 (da) * | 1969-07-19 | 1973-09-05 | ||
| US3624086A (en) * | 1969-11-10 | 1971-11-30 | Searle & Co | Adamantanecarboxamidoalkanoic acid amides |
| US3852339A (en) * | 1970-06-15 | 1974-12-03 | Squibb & Sons Inc | Aminoalkoxyphenylurea derivatives |
| US3879400A (en) * | 1973-11-16 | 1975-04-22 | Upjohn Co | 1-Lower alkyl-(1-adamantylmethyl)piperidines and process for their preparation |
| JPS5346950A (en) * | 1976-10-12 | 1978-04-27 | Kao Corp | (54)1-acetylaminotricyclo(4,3,1,12,5)undecane and its preparation |
| US4351847A (en) * | 1981-06-26 | 1982-09-28 | Pennwalt Corporation | Antiviral alpha, alpha-dialkyl adamantylethylamines |
| US4551552A (en) * | 1984-05-23 | 1985-11-05 | E. I. Du Pont De Nemours And Company | Process for preparing rimantadine |
| US4751245A (en) * | 1986-06-25 | 1988-06-14 | E. R. Squibb & Sons, Inc. | Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine and method of using same |
| US5576355A (en) * | 1993-06-04 | 1996-11-19 | Mobil Oil Corp. | Diamondoid derivatives for pharmaceutical use |
| US5684024A (en) * | 1996-01-25 | 1997-11-04 | Viropharma Incorporated | Pyrazole dimers compositions and methods for treating influenza |
| US5821243A (en) * | 1996-07-22 | 1998-10-13 | Viropharma Incorporated | Compounds compositions and methods for treating influenza |
| PT870757E (pt) * | 1997-04-10 | 2002-09-30 | Pfizer | Derivados de adamantano substituidos por fluoro |
| GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
| WO2003004461A1 (en) * | 2001-07-02 | 2003-01-16 | Schering Corporation | Drugs for treating viral infections |
| SE0103836D0 (sv) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
| CN1649614A (zh) | 2002-02-22 | 2005-08-03 | 新河药品股份有限公司 | 活性剂传递系统和保护及施用活性剂的方法 |
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| JP5368789B2 (ja) * | 2005-06-17 | 2013-12-18 | アポジー・バイオテクノロジー・コーポレイション | スフィンゴシンキナーゼ阻害剤 |
| AR057623A1 (es) | 2005-11-28 | 2007-12-05 | Omega Bio Pharma H K Ltd | Materiales y metodos para el tratamiento de las infecciones virales |
| PE20091225A1 (es) | 2007-03-22 | 2009-09-16 | Astrazeneca Ab | Derivados de quinolina como antagonistas del receptor p2x7 |
| PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
| WO2014068265A1 (en) | 2012-10-29 | 2014-05-08 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
| EA031458B1 (ru) * | 2013-12-09 | 2019-01-31 | Юнилевер Н.В. | Способ получения адамантанамидов |
| WO2017093354A1 (en) | 2015-11-30 | 2017-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nmdar antagonists for the treatment of diseases associated with angiogenesis |
| US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
-
1964
- 1964-06-18 US US376259A patent/US3352912A/en not_active Expired - Lifetime
- 1964-07-18 DE DE19641793207 patent/DE1793207A1/de active Pending
- 1964-07-18 DE DE19641792295 patent/DE1792295B1/de not_active Withdrawn
- 1964-07-18 DE DE19641793208 patent/DE1793208A1/de active Pending
- 1964-07-20 BR BR160975/64A patent/BR6460975D0/pt unknown
- 1964-07-20 CH CH946964A patent/CH476673A/de not_active IP Right Cessation
- 1964-07-20 CH CH1457468A patent/CH479535A/de not_active IP Right Cessation
- 1964-07-23 DK DK367964AA patent/DK112027B/da unknown
- 1964-07-23 SE SE9752/67A patent/SE320363B/xx unknown
- 1964-07-23 IL IL21753A patent/IL21753A/xx unknown
- 1964-07-23 SE SE09751/67A patent/SE330693B/xx unknown
- 1964-07-23 BE BE650919D patent/BE650919A/xx unknown
- 1964-07-23 ES ES0302369A patent/ES302369A1/es not_active Expired
- 1964-07-23 SE SE8987/64A patent/SE321924B/xx unknown
- 1964-07-23 FI FI1584/64A patent/FI42322B/fi active
- 1964-07-24 NL NL6408505A patent/NL6408505A/xx unknown
- 1964-07-24 FR FR1572956D patent/FR1572956A/fr not_active Expired
- 1964-08-04 GB GB30940/64A patent/GB1069563A/en not_active Expired
- 1964-08-07 AT AT06819/68A patent/AT279581B/de not_active IP Right Cessation
-
1965
- 1965-07-09 DK DK353365AA patent/DK114199B/da unknown
- 1965-07-09 DK DK353265AA patent/DK114769B/da unknown
-
1969
- 1969-01-22 FI FI0198/69A patent/FI42211B/fi active
- 1969-01-22 FI FI0197/69A patent/FI42548B/fi active
-
1971
- 1971-02-17 NL NL7102097A patent/NL7102097A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK114769B (da) | 1969-08-04 |
| BR6460975D0 (pt) | 1973-08-09 |
| FI42211B (da) | 1970-03-02 |
| DK114199B (da) | 1969-06-09 |
| SE321924B (da) | 1970-03-23 |
| DK112027B (da) | 1968-11-04 |
| IL21753A (en) | 1968-01-25 |
| BE650919A (da) | 1964-11-16 |
| SE330693B (da) | 1970-11-30 |
| AT279581B (de) | 1970-03-10 |
| DE1793208A1 (de) | 1972-04-06 |
| FR1572956A (da) | 1969-07-04 |
| DE1468769B1 (de) | 1972-06-29 |
| CH479535A (de) | 1969-10-15 |
| FI42322B (da) | 1970-03-31 |
| NL6408505A (da) | 1965-01-25 |
| DE1792295B1 (de) | 1971-05-27 |
| SE320363B (da) | 1970-02-09 |
| DE1793207A1 (de) | 1972-03-30 |
| US3352912A (en) | 1967-11-14 |
| FI42548B (da) | 1970-06-01 |
| GB1069563A (en) | 1967-05-17 |
| NL7102097A (da) | 1971-05-25 |
| CH476673A (de) | 1969-08-15 |
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