ES2999149T3 - Sample injector with sample loop and buffer loop - Google Patents

Sample injector with sample loop and buffer loop Download PDF

Info

Publication number
ES2999149T3
ES2999149T3 ES18190878T ES18190878T ES2999149T3 ES 2999149 T3 ES2999149 T3 ES 2999149T3 ES 18190878 T ES18190878 T ES 18190878T ES 18190878 T ES18190878 T ES 18190878T ES 2999149 T3 ES2999149 T3 ES 2999149T3
Authority
ES
Spain
Prior art keywords
sample
port
pump
sample loop
analytical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18190878T
Other languages
English (en)
Spanish (es)
Inventor
Adrian Sievers-Engler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2999149T3 publication Critical patent/ES2999149T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/18—Injection using a septum or microsyringe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
ES18190878T 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop Active ES2999149T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18190878.1A EP3617701B1 (en) 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop

Publications (1)

Publication Number Publication Date
ES2999149T3 true ES2999149T3 (en) 2025-02-24

Family

ID=63407076

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18190878T Active ES2999149T3 (en) 2018-08-27 2018-08-27 Sample injector with sample loop and buffer loop

Country Status (5)

Country Link
US (1) US11408865B2 (enExample)
EP (1) EP3617701B1 (enExample)
JP (1) JP6843932B2 (enExample)
CN (1) CN110865132A (enExample)
ES (1) ES2999149T3 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2999149T3 (en) * 2018-08-27 2025-02-24 Hoffmann La Roche Sample injector with sample loop and buffer loop
WO2020051073A1 (en) 2018-09-05 2020-03-12 Waters Technologies Corporation Interface module for two-dimensional liquid chromatography
ES2915839T3 (es) * 2019-06-04 2022-06-27 Hoffmann La Roche Intercambio de líquidos rápido en cromatografía de líquidos
CN115667713A (zh) 2020-03-26 2023-01-31 沃特世科技公司 用于液相色谱的计量泵
EP3961208B1 (en) * 2020-08-28 2025-08-06 F. Hoffmann-La Roche AG Sample injector
EP3991820A1 (en) * 2020-11-03 2022-05-04 Sartorius Stedim Biotech GmbH System for membrane chromatography
WO2025032940A1 (ja) * 2023-08-09 2025-02-13 株式会社島津製作所 オンラインサンプラ

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6250659A (ja) 1985-08-29 1987-03-05 Shimadzu Corp 液体クロマトグラフへの試料導入方法
JPH055728A (ja) * 1991-06-27 1993-01-14 Yokogawa Electric Corp 試料注入器
US6382035B1 (en) * 2001-04-02 2002-05-07 Rheodyne, Lp Multi-valving sample injection apparatus
DE10393201B4 (de) * 2002-09-11 2023-11-16 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Hochdruckfluidprobeninjektionsvorrichtung und Verfahren
EP1536228A1 (en) * 2003-11-27 2005-06-01 Agilent Technologies, Inc. Dual loop autosampling
JP2009543068A (ja) * 2006-06-30 2009-12-03 ウオーターズ・テクノロジーズ・コーポレイシヨン 高圧液体クロマトグラフィにおける試料導入時減圧作用の軽減
US8410426B2 (en) * 2007-11-02 2013-04-02 Agilent Technologies, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
DE102007059651B4 (de) * 2007-12-10 2017-05-24 Dionex Softron Gmbh Probengeber für die Hochleistungsflüssigkeitschromatographie
WO2009111228A2 (en) * 2008-02-29 2009-09-11 Waters Technologies Corporation Chromatography-based monitoring and control of multiple process streams
US8939018B2 (en) 2008-10-03 2015-01-27 Arkray, Inc. Analyzing device and method for controlling same
JP5111476B2 (ja) * 2009-10-26 2013-01-09 株式会社日立ハイテクノロジーズ 液体試料分析装置及び液体試料導入装置
US20130146479A1 (en) * 2010-05-21 2013-06-13 Antec Leyden B.V. Analytical apparatus comprising an electrochemical flow cell and a structure elucidation spectrometer
JP5505249B2 (ja) 2010-10-19 2014-05-28 株式会社島津製作所 オンライン試料導入装置
HUE055674T2 (hu) * 2010-10-29 2021-12-28 Thermo Fisher Scientific Oy Rendszerelrendezés automatizált mintaelõkészítõ és -elemzõ rendszerhez
CN104813164B (zh) * 2012-11-30 2018-05-22 安捷伦科技有限公司 用于液相色谱的混合器旁路样品注射
JP2016070695A (ja) * 2014-09-26 2016-05-09 株式会社島津製作所 オートサンプラ及びそのオートサンプラを備えた液体クロマトグラフ
DE202016100451U1 (de) * 2015-06-25 2016-02-16 Dionex Softron Gmbh Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie
CN107709985B (zh) * 2015-07-06 2020-03-31 株式会社岛津制作所 自动进样器以及液相色谱仪
CN108291896B (zh) 2015-12-18 2020-11-20 豪夫迈·罗氏有限公司 自动化临床诊断系统和方法
DE102016121512A1 (de) * 2016-11-10 2018-05-17 Dionex Softron Gmbh System, Verfahren und Verwendung der Flüssigkeitschromatografie
ES2999149T3 (en) * 2018-08-27 2025-02-24 Hoffmann La Roche Sample injector with sample loop and buffer loop

Also Published As

Publication number Publication date
EP3617701A1 (en) 2020-03-04
JP6843932B2 (ja) 2021-03-17
CN110865132A (zh) 2020-03-06
JP2020038205A (ja) 2020-03-12
EP3617701B1 (en) 2024-10-23
US11408865B2 (en) 2022-08-09
US20200064314A1 (en) 2020-02-27

Similar Documents

Publication Publication Date Title
ES2999149T3 (en) Sample injector with sample loop and buffer loop
JP2020038205A5 (enExample)
EP2633327B1 (en) System layout for an automated system for sample preparation and analysis
CN104903721B (zh) I相和ii相代谢物以及母体化合物的分析
KR20180093944A (ko) 자동화된 임상 진단 시스템 및 방법
JP2020521958A5 (enExample)
CN110988228A (zh) 多样品进行自动进样分析装置
US11913917B2 (en) Chromatograph and sample injection apparatus
CN108780064B (zh) 分析装置
JP7071443B2 (ja) 液体クロマトグラフィーシステム
JP7046070B2 (ja) 分析系におけるプロセス中に試薬を同定するための方法
CN112034082B (zh) 液相色谱中的快速液体交换
ES3043035T3 (en) Sample injector
US12422413B2 (en) Automated sample handling system for liquid chromatography-mass spectrometry
JP7051871B2 (ja) 分析系におけるプロセス中に試薬を同定するための方法
EP4160220A1 (en) Control method for automatic analysis device
US20200348326A1 (en) Fluidic Sample Pretreatment Device
WO2024013650A1 (en) A sample delivery system for an analytical instrument
JPWO2005036122A1 (ja) 相互作用分析方法及び相互作用分析装置