ES2991090T3 - Inhibidores de KDM4 - Google Patents
Inhibidores de KDM4 Download PDFInfo
- Publication number
- ES2991090T3 ES2991090T3 ES18774276T ES18774276T ES2991090T3 ES 2991090 T3 ES2991090 T3 ES 2991090T3 ES 18774276 T ES18774276 T ES 18774276T ES 18774276 T ES18774276 T ES 18774276T ES 2991090 T3 ES2991090 T3 ES 2991090T3
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- Prior art keywords
- kdm4
- cancer
- cells
- compound
- tumor
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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| US20250134874A1 (en) * | 2021-12-23 | 2025-05-01 | Tachyon Therapeutics, Inc. | Pharmaceutical formulations comprising 3-({[(4r)-7-{methyl[4-(propan-2-yl)phenyl]amino}-3,4-dihydro-2h-1-benzopyran-4-yl]methyl}amino)pyridine-4-carboxylic acid |
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| AR099890A1 (es) * | 2014-03-31 | 2016-08-24 | Epitherapeutics Aps | Inhibidores de histona demetilasas |
| SG11201609033TA (en) | 2014-05-01 | 2016-11-29 | Celgene Quanticel Res Inc | Inhibitors of lysine specific demethylase-1 |
| SG11201610813TA (en) * | 2014-06-25 | 2017-01-27 | Quanticel Pharmaceuticals Inc | Histone demethylase inhibitors |
| US10059687B2 (en) * | 2015-12-28 | 2018-08-28 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
-
2018
- 2018-03-27 US US16/498,714 patent/US20200039938A1/en not_active Abandoned
- 2018-03-27 ES ES18774276T patent/ES2991090T3/es active Active
- 2018-03-27 WO PCT/US2018/024624 patent/WO2018183370A2/en not_active Ceased
- 2018-03-27 US US15/936,811 patent/US20180290977A1/en not_active Abandoned
- 2018-03-27 EP EP18774276.2A patent/EP3600301B1/en active Active
- 2018-03-27 JP JP2020503253A patent/JP7442439B2/ja active Active
- 2018-03-29 TW TW107110863A patent/TWI814723B/zh active
-
2022
- 2022-05-20 US US17/749,233 patent/US20240076271A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW201840537A (zh) | 2018-11-16 |
| US20200039938A1 (en) | 2020-02-06 |
| TWI814723B (zh) | 2023-09-11 |
| WO2018183370A3 (en) | 2018-12-20 |
| US20240076271A1 (en) | 2024-03-07 |
| JP2020515645A (ja) | 2020-05-28 |
| WO2018183370A2 (en) | 2018-10-04 |
| EP3600301A4 (en) | 2020-08-12 |
| US20180290977A1 (en) | 2018-10-11 |
| JP7442439B2 (ja) | 2024-03-04 |
| EP3600301B1 (en) | 2024-07-03 |
| EP3600301A2 (en) | 2020-02-05 |
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