ES2981584T3 - Proceso para la fabricación de 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo - Google Patents

Proceso para la fabricación de 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo Download PDF

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Publication number
ES2981584T3
ES2981584T3 ES17152400T ES17152400T ES2981584T3 ES 2981584 T3 ES2981584 T3 ES 2981584T3 ES 17152400 T ES17152400 T ES 17152400T ES 17152400 T ES17152400 T ES 17152400T ES 2981584 T3 ES2981584 T3 ES 2981584T3
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Prior art keywords
compound
cancer
inhibitor
chk1
compounds
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ES17152400T
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English (en)
Spanish (es)
Inventor
Ian Collins
Thomas Peter Matthews
Da Fonseca Mchardy Tatiana Faria
James Osborne
Michael Lainchbury
Michael Ian Walton
Michelle Dawn Garrett
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES17152400T 2012-05-15 2013-05-14 Proceso para la fabricación de 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo Active ES2981584T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261647200P 2012-05-15 2012-05-15

Publications (1)

Publication Number Publication Date
ES2981584T3 true ES2981584T3 (es) 2024-10-09

Family

ID=48468659

Family Applications (2)

Application Number Title Priority Date Filing Date
ES17152400T Active ES2981584T3 (es) 2012-05-15 2013-05-14 Proceso para la fabricación de 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo
ES13723910.9T Active ES2624307T3 (es) 2012-05-15 2013-05-14 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo y usos terapéuticos del mismo

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13723910.9T Active ES2624307T3 (es) 2012-05-15 2013-05-14 5-[[4-[[Morfolin-2-il]metilamino]-5-(trifluorometil)-2-piridil]amino]pirazin-2-carbonitrilo y usos terapéuticos del mismo

Country Status (19)

Country Link
US (3) US9663503B2 (cg-RX-API-DMAC7.html)
EP (2) EP3210980B1 (cg-RX-API-DMAC7.html)
JP (2) JP6027230B2 (cg-RX-API-DMAC7.html)
KR (6) KR20210156333A (cg-RX-API-DMAC7.html)
CN (2) CN106279142B (cg-RX-API-DMAC7.html)
AU (2) AU2013261605B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014026801B1 (cg-RX-API-DMAC7.html)
CA (1) CA2870837C (cg-RX-API-DMAC7.html)
DK (1) DK2855448T3 (cg-RX-API-DMAC7.html)
ES (2) ES2981584T3 (cg-RX-API-DMAC7.html)
IL (1) IL235133A (cg-RX-API-DMAC7.html)
IN (1) IN2014DN09221A (cg-RX-API-DMAC7.html)
MX (1) MX358819B (cg-RX-API-DMAC7.html)
NZ (1) NZ702050A (cg-RX-API-DMAC7.html)
PL (1) PL2855448T3 (cg-RX-API-DMAC7.html)
RU (1) RU2659786C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201407238VA (cg-RX-API-DMAC7.html)
WO (1) WO2013171470A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201408452B (cg-RX-API-DMAC7.html)

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CN110872277B (zh) * 2019-11-14 2021-06-04 浙江大学 N-取代芳环-2-氨基嘧啶类化合物及用途
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US9663503B2 (en) 2017-05-30
IL235133A (en) 2017-03-30
RU2659786C2 (ru) 2018-07-04
KR102090792B1 (ko) 2020-03-18
SG11201407238VA (en) 2014-12-30
CN104302635A (zh) 2015-01-21
HK1203529A1 (en) 2015-10-30
ZA201408452B (en) 2016-08-31
IN2014DN09221A (cg-RX-API-DMAC7.html) 2015-07-10
AU2017268508A1 (en) 2017-12-14
CN106279142A (zh) 2017-01-04
WO2013171470A1 (en) 2013-11-21
EP2855448A1 (en) 2015-04-08
CA2870837A1 (en) 2013-11-21
CN104302635B (zh) 2016-07-06
BR112014026801A2 (pt) 2017-06-27
US20180022739A1 (en) 2018-01-25
JP2015520753A (ja) 2015-07-23
US20150126471A1 (en) 2015-05-07
KR20220151007A (ko) 2022-11-11
RU2014147105A (ru) 2016-07-10
AU2017268508B2 (en) 2019-07-04
AU2017268508C1 (en) 2019-10-17
EP3210980A1 (en) 2017-08-30
CN106279142B (zh) 2019-05-03
KR102341637B1 (ko) 2021-12-21
DK2855448T3 (en) 2017-05-01
PL2855448T3 (pl) 2017-09-29
NZ702050A (en) 2016-08-26
US10259806B2 (en) 2019-04-16
KR20210047981A (ko) 2021-04-30
EP2855448B1 (en) 2017-02-08
KR20200038990A (ko) 2020-04-14
ES2624307T3 (es) 2017-07-13
KR20210156333A (ko) 2021-12-24
KR20150023252A (ko) 2015-03-05
AU2013261605B2 (en) 2017-08-31
US11787792B2 (en) 2023-10-17
EP3210980B1 (en) 2024-04-03
KR102635954B1 (ko) 2024-02-13
JP2017036314A (ja) 2017-02-16
MX358819B (es) 2018-09-05
AU2013261605A1 (en) 2014-11-13
KR20240023685A (ko) 2024-02-22
HK1243408A1 (en) 2018-07-13
JP6362652B2 (ja) 2018-07-25
CA2870837C (en) 2022-05-10
US20210276990A1 (en) 2021-09-09
BR112014026801B1 (pt) 2022-03-03
MX2014012881A (es) 2015-04-08
KR102246265B1 (ko) 2021-04-29
JP6027230B2 (ja) 2016-11-16

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