ES2971466T3 - Combinación de un inhibidor de Mcl-1 y un tratamiento estándar de atención para cánceres hematológicos, usos y composiciones farmacéuticas de la misma - Google Patents
Combinación de un inhibidor de Mcl-1 y un tratamiento estándar de atención para cánceres hematológicos, usos y composiciones farmacéuticas de la misma Download PDFInfo
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- ES2971466T3 ES2971466T3 ES18731845T ES18731845T ES2971466T3 ES 2971466 T3 ES2971466 T3 ES 2971466T3 ES 18731845 T ES18731845 T ES 18731845T ES 18731845 T ES18731845 T ES 18731845T ES 2971466 T3 ES2971466 T3 ES 2971466T3
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- mcl
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- inhibitor
- cancer
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Classifications
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762523389P | 2017-06-22 | 2017-06-22 | |
| EP17189550 | 2017-09-06 | ||
| PCT/EP2018/066551 WO2018234433A1 (fr) | 2017-06-22 | 2018-06-21 | Combinaison d'un inhibiteur de mcl-1 et d'un standard de traitement de soin pour cancers hématologiques, utilisations et compositions pharmaceutiques associées |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2971466T3 true ES2971466T3 (es) | 2024-06-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18731845T Active ES2971466T3 (es) | 2017-06-22 | 2018-06-21 | Combinación de un inhibidor de Mcl-1 y un tratamiento estándar de atención para cánceres hematológicos, usos y composiciones farmacéuticas de la misma |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11466023B2 (fr) |
| EP (1) | EP3641775B1 (fr) |
| JP (1) | JP7186731B2 (fr) |
| KR (1) | KR20200018681A (fr) |
| CN (2) | CN117959451A (fr) |
| AR (1) | AR112202A1 (fr) |
| AU (1) | AU2018288520B2 (fr) |
| BR (1) | BR112019026959A2 (fr) |
| CA (1) | CA3068096C (fr) |
| CL (1) | CL2019003763A1 (fr) |
| CO (1) | CO2019014479A2 (fr) |
| CU (1) | CU20190105A7 (fr) |
| EA (1) | EA202090082A1 (fr) |
| ES (1) | ES2971466T3 (fr) |
| GE (1) | GEP20227357B (fr) |
| IL (1) | IL271475B2 (fr) |
| JO (1) | JOP20190287A1 (fr) |
| MA (1) | MA49444A (fr) |
| NI (1) | NI201900128A (fr) |
| PH (1) | PH12019502789A1 (fr) |
| SG (1) | SG11201911891WA (fr) |
| TW (1) | TWI753178B (fr) |
| UA (1) | UA126920C2 (fr) |
| UY (1) | UY37777A (fr) |
| WO (1) | WO2018234433A1 (fr) |
| ZA (1) | ZA201908446B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022290855A1 (en) | 2021-06-11 | 2023-12-07 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
| CA3222269A1 (fr) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Inhibiteurs de mcl-1 en combinaison avec des agents anticancereux |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1575582A4 (fr) * | 2002-11-06 | 2009-03-11 | Wyeth Corp | Therapie combinee de traitement de la leucemie aigue et du syndrome myelodysplasique |
| EP2358748B1 (fr) * | 2008-12-09 | 2016-07-06 | Dana-Farber Cancer Institute, Inc. | Procédés et compositions pour la modulation spécifique de mcl-1 |
| EP2558866B1 (fr) * | 2010-04-15 | 2016-08-17 | Tracon Pharmaceuticals, Inc. | Potentialisation de l'activité anticancéreuse par polythérapie avec des inhibiteurs de la voie ber |
| CA2712747A1 (fr) * | 2010-08-11 | 2012-02-11 | Universite De Montreal | Traitement d'association contre le cancer |
| FR3015483B1 (fr) | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP6798890B2 (ja) * | 2014-06-13 | 2020-12-09 | キャリセラ バイオサイエンシーズ， インコーポレイテッド | グルタミナーゼ阻害剤との併用療法 |
| FR3037958B1 (fr) | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037959B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037957B1 (fr) | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037956B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3046792B1 (fr) | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2018236904A1 (fr) * | 2017-06-19 | 2018-12-27 | Surface Oncology, Inc. | Combinaison d'anticorps anti-cd47 et d'agents induisant la mort cellulaire, et leurs utilisations |
-
2018
- 2018-06-21 GE GEAP201815242A patent/GEP20227357B/en unknown
- 2018-06-21 EP EP18731845.6A patent/EP3641775B1/fr active Active
- 2018-06-21 AU AU2018288520A patent/AU2018288520B2/en active Active
- 2018-06-21 UY UY0001037777A patent/UY37777A/es unknown
- 2018-06-21 EA EA202090082A patent/EA202090082A1/ru unknown
- 2018-06-21 CU CU2019000105A patent/CU20190105A7/es unknown
- 2018-06-21 ES ES18731845T patent/ES2971466T3/es active Active
- 2018-06-21 CA CA3068096A patent/CA3068096C/fr active Active
- 2018-06-21 AR ARP180101729 patent/AR112202A1/es unknown
- 2018-06-21 CN CN202410099418.6A patent/CN117959451A/zh active Pending
- 2018-06-21 JP JP2019570386A patent/JP7186731B2/ja active Active
- 2018-06-21 WO PCT/EP2018/066551 patent/WO2018234433A1/fr unknown
- 2018-06-21 US US16/622,967 patent/US11466023B2/en active Active
- 2018-06-21 SG SG11201911891WA patent/SG11201911891WA/en unknown
- 2018-06-21 TW TW107121294A patent/TWI753178B/zh active
- 2018-06-21 CN CN201880053619.5A patent/CN111032050B/zh active Active
- 2018-06-21 IL IL271475A patent/IL271475B2/en unknown
- 2018-06-21 MA MA049444A patent/MA49444A/fr unknown
- 2018-06-21 UA UAA202000317A patent/UA126920C2/uk unknown
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- 2018-06-21 KR KR1020207001915A patent/KR20200018681A/ko not_active Application Discontinuation
- 2018-12-22 JO JOP/2019/0287A patent/JOP20190287A1/ar unknown
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2019
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- 2019-12-18 ZA ZA2019/08446A patent/ZA201908446B/en unknown
- 2019-12-19 CL CL2019003763A patent/CL2019003763A1/es unknown
- 2019-12-19 NI NI201900128A patent/NI201900128A/es unknown
- 2019-12-20 CO CONC2019/0014479A patent/CO2019014479A2/es unknown
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