ES2970828T3 - Nuevos anticuerpos anti-lam - Google Patents
Nuevos anticuerpos anti-lam Download PDFInfo
- Publication number
- ES2970828T3 ES2970828T3 ES17750586T ES17750586T ES2970828T3 ES 2970828 T3 ES2970828 T3 ES 2970828T3 ES 17750586 T ES17750586 T ES 17750586T ES 17750586 T ES17750586 T ES 17750586T ES 2970828 T3 ES2970828 T3 ES 2970828T3
- Authority
- ES
- Spain
- Prior art keywords
- lam
- antibody
- seq
- antibodies
- cases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1289—Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56933—Mycoplasma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/44—Multiple drug resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662293406P | 2016-02-10 | 2016-02-10 | |
| PCT/US2017/016058 WO2017139153A1 (en) | 2016-02-10 | 2017-02-01 | Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2970828T3 true ES2970828T3 (es) | 2024-05-30 |
Family
ID=59563993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17750586T Active ES2970828T3 (es) | 2016-02-10 | 2017-02-01 | Nuevos anticuerpos anti-lam |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10729771B2 (https=) |
| EP (2) | EP3414573B1 (https=) |
| JP (4) | JP2019506412A (https=) |
| CN (2) | CN110092830B (https=) |
| AU (2) | AU2017218415B2 (https=) |
| CA (1) | CA3013904C (https=) |
| ES (1) | ES2970828T3 (https=) |
| RU (1) | RU2732502C2 (https=) |
| WO (1) | WO2017139153A1 (https=) |
| ZA (3) | ZA201805990B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2970828T3 (es) | 2016-02-10 | 2024-05-30 | Univ Rutgers | Nuevos anticuerpos anti-lam |
| US10830760B2 (en) * | 2017-12-20 | 2020-11-10 | General Electric Company | Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity |
| JP2021521462A (ja) * | 2018-03-29 | 2021-08-26 | ファウンデーション オブ イノベーティブ ニュー ダイアグノスティクス | 抗体または抗体の組み合わせおよび対象の尿試料中のマイコバクテリウム関連抗原の検出のためのその使用 |
| WO2020018806A1 (en) | 2018-07-19 | 2020-01-23 | Rutgers, The State University Of New Jersey | Methods for dual detection and differentiation of infection by mycobactierum tuberculosis complex and nontuberculous mycobacteria |
| JP7130045B2 (ja) * | 2018-08-31 | 2022-09-02 | 富士フイルム株式会社 | イムノクロマトグラフキットおよび結核菌の検出方法 |
| CN114341639A (zh) | 2019-09-30 | 2022-04-12 | 富士胶片株式会社 | 免疫检查方法及浓缩用夹具 |
| JP7274595B2 (ja) | 2019-09-30 | 2023-05-16 | 富士フイルム株式会社 | イムノクロマトグラフィー |
| CN111337665A (zh) * | 2020-01-16 | 2020-06-26 | 卢氏实验室公司 | 一种用于检测肺结核感染的免疫层析试纸条及其制备方法 |
| WO2021152966A1 (ja) | 2020-01-31 | 2021-08-05 | 富士フイルム株式会社 | イムノクロマトグラフィー |
| JP7350100B2 (ja) | 2020-01-31 | 2023-09-25 | 富士フイルム株式会社 | イムノクロマトグラフィー |
| WO2021153127A1 (ja) | 2020-01-31 | 2021-08-05 | 富士フイルム株式会社 | 免疫検査方法 |
| CN111153992A (zh) * | 2020-02-21 | 2020-05-15 | 首都医科大学附属北京胸科医院 | 结核分枝杆菌lam的单克隆抗体及其用途 |
| EP4178610A4 (en) * | 2020-07-07 | 2024-08-28 | The Regents Of The University Of California | METHODS FOR DETECTION OF ANTIGENS FROM DIRECT CLINICAL SAMPLES |
| EP4192429A4 (en) * | 2020-08-05 | 2024-10-09 | The Administrators of The Tulane Educational Fund | METHOD FOR DETECTING TB IN BODY FLUID SAMPLES |
| JP7554275B2 (ja) | 2020-09-11 | 2024-09-19 | 富士フイルム株式会社 | 検体液の濃縮方法、及び、検体液の検査方法 |
| JP7590441B2 (ja) | 2020-09-11 | 2024-11-26 | 富士フイルム株式会社 | 濃縮デバイス、検体液の濃縮方法、検体液の検査方法、及び、検査キット |
| CN116113826B (zh) | 2020-09-11 | 2026-02-27 | 富士胶片株式会社 | 浓缩器件、被检体液的浓缩方法、被检体液的检查方法、及检查试剂盒 |
| WO2022081716A1 (en) * | 2020-10-13 | 2022-04-21 | Accubit LLC - Biotechnology | Methods of treating iga nephropathy with thiol-containing molecules |
| EP4263598A4 (en) * | 2020-12-15 | 2025-04-09 | Albert Einstein College of Medicine | High-affinity mycobacterium tuberculosis capsule-specific human monoclonal antibodies |
| CN113480659B (zh) * | 2021-06-30 | 2022-10-21 | 迪比康(上海)生物科技有限公司 | 人源抗结核分枝杆菌复合群lam单克隆抗体及其制备和应用 |
| CN114984870A (zh) * | 2022-03-15 | 2022-09-02 | 齐欣 | 一种重组蛋白质微球及其制备方法和应用 |
| CN117247450B (zh) * | 2023-10-10 | 2025-02-25 | 广州市雷德生物科技有限公司 | 一种lam抗体及其应用 |
| CN118178640B (zh) * | 2024-03-08 | 2025-11-21 | 中国农业大学 | 含有牛分枝杆菌表面多糖的佐剂及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| CA2474701C (en) | 1993-11-19 | 2009-01-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradeable microparticles containing a biologically active agent |
| US6656508B2 (en) | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
| US20010007660A1 (en) | 1997-06-04 | 2001-07-12 | Aharona Glatman-Freedman | Methods of treating and protecting against tuberculosis using a monoclonal antibody selective for mycobacterium tuberculosis |
| AU1384199A (en) | 1997-11-07 | 1999-05-31 | Chiron Corporation | Method for producing igf-1 sustained-release formulations |
| US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
| US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| US6953593B2 (en) | 2000-02-01 | 2005-10-11 | Lipoprotein Technologies, Inc. | Sustained-release microencapsulated delivery system |
| EP1385486A4 (en) | 2001-04-18 | 2006-05-17 | Nostrum Pharmaceuticals Inc | NEW COATING OF SLOW RELEASE PHARMACEUTICAL COMPOSITION |
| US7063725B2 (en) | 2002-10-21 | 2006-06-20 | Sdgi Holdings, Inc. | Systems and techniques for restoring and maintaining intervertebral anatomy |
| CA2437639C (en) | 2003-08-11 | 2016-07-05 | Valera Pharmaceuticals, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US20050187631A1 (en) | 2004-01-27 | 2005-08-25 | Sdgi Holdings, Inc. | Prosthetic device |
| BRPI0513596B8 (pt) * | 2004-07-20 | 2021-07-27 | Chemogen Inc | método e kit para detectar uma infecção micobacteriana em uma amostra de um indivíduo de interesse por meio da detecção de antígeno micobacteriano |
| CN101216491B (zh) * | 2008-01-08 | 2012-06-06 | 广州益善生物技术有限公司 | 结核分枝杆菌检测液相芯片及其制备方法 |
| EP2242836B1 (en) * | 2008-01-28 | 2015-05-20 | Thomas Jefferson University | Method of making hybrid cells that express useful antibodies |
| CA2737667A1 (en) | 2008-09-19 | 2010-03-25 | Medimmune, Llc | Targeted binding agents directed to cd105 and uses thereof |
| US8673845B2 (en) * | 2009-07-29 | 2014-03-18 | Toagosei Co., Ltd. | Carrier peptide fragment and use thereof |
| SG192047A1 (en) * | 2011-01-24 | 2013-08-30 | Univ Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
| KR101707291B1 (ko) | 2012-02-29 | 2017-02-15 | 오쓰까 세이야꾸 가부시키가이샤 | 항리포아라비노만난 항체 및 당해 항체를 사용한 항산균증의 이뮤노어세이 |
| JO3462B1 (ar) * | 2012-08-22 | 2020-07-05 | Regeneron Pharma | أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها |
| ES2970828T3 (es) | 2016-02-10 | 2024-05-30 | Univ Rutgers | Nuevos anticuerpos anti-lam |
-
2017
- 2017-02-01 ES ES17750586T patent/ES2970828T3/es active Active
- 2017-02-01 CN CN201910291444.8A patent/CN110092830B/zh active Active
- 2017-02-01 AU AU2017218415A patent/AU2017218415B2/en active Active
- 2017-02-01 RU RU2018131622A patent/RU2732502C2/ru active
- 2017-02-01 JP JP2018541386A patent/JP2019506412A/ja active Pending
- 2017-02-01 EP EP17750586.4A patent/EP3414573B1/en active Active
- 2017-02-01 EP EP23208073.9A patent/EP4299072A3/en active Pending
- 2017-02-01 US US16/076,971 patent/US10729771B2/en active Active
- 2017-02-01 WO PCT/US2017/016058 patent/WO2017139153A1/en not_active Ceased
- 2017-02-01 CN CN201780017369.5A patent/CN109073649A/zh active Pending
- 2017-02-01 CA CA3013904A patent/CA3013904C/en active Active
-
2018
- 2018-09-06 ZA ZA2018/05990A patent/ZA201805990B/en unknown
-
2020
- 2020-06-24 US US16/910,621 patent/US11273220B2/en active Active
-
2021
- 2021-04-02 JP JP2021063301A patent/JP7316685B2/ja active Active
-
2022
- 2022-02-17 US US17/651,523 patent/US11707525B2/en active Active
- 2022-08-12 ZA ZA2022/09045A patent/ZA202209045B/en unknown
-
2023
- 2023-03-01 JP JP2023031004A patent/JP2023075196A/ja active Pending
- 2023-06-15 US US18/335,489 patent/US12303562B2/en active Active
- 2023-08-15 ZA ZA2023/07912A patent/ZA202307912B/en unknown
-
2024
- 2024-08-01 AU AU2024205286A patent/AU2024205286A1/en active Pending
- 2024-08-19 JP JP2024137825A patent/JP7813481B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2970828T3 (es) | Nuevos anticuerpos anti-lam | |
| JP7460091B2 (ja) | 広域中和抗ｈｉｖ－１抗体およびその使用方法 | |
| TW201623337A (zh) | 抗－因子ｄ抗體變異體及其用途 | |
| JP6560195B2 (ja) | 黄色ブドウ球菌のＬｕｋＧＨ（ＬｕｋＡＢ）毒素を中和する、非常に強力な抗体の生成 | |
| CA3093740A1 (en) | Anti-il-27 antibodies and uses thereof | |
| JP2017505758A (ja) | 黄色ブドウ球菌のｌｕｋｇｈ（ｌｕｋａｂ）毒素に対する抗体及び抗体配列 | |
| CN112969711B (zh) | 使用克拉扎珠单抗脱敏和改善hla致敏患者中的肾脏移植 | |
| CN113194996B (zh) | 克拉扎珠单抗用于治疗慢性抗体介导的器官移植物排斥反应 | |
| TW202124432A (zh) | 使用pd-1軸抑制劑及抗骨膜蛋白抗體治療癌症之方法 | |
| CN118126181B (zh) | 人和猴交叉种属抗ccr8膜蛋白抗体 | |
| WO2022188829A1 (zh) | 新型冠状病毒抗体及其用途 | |
| BR112018016226B1 (pt) | Anticorpo antilipoarabinomanana (anti-lam) monoclonal, kit para detectar um epítopo de lam, método in vitro para diagnosticar uma infecção de tuberculose ativa em um indivíduo e método in vitro de pré-concentração de lam a partir de uma amostra biológica | |
| WO2024148208A1 (en) | Antibodies specifically recognizing tnfr2 and compositions and uses thereof | |
| HK40103004A (zh) | 广谱中和抗hiv-1抗体及其使用方法 | |
| HK40019070A (en) | Broadly neutralizing anti-hiv-1 antibodies and methods of use thereof | |
| EA042959B1 (ru) | Нейтрализирующие анти-вич-1 антитела широкого спектра действия и способы их применения |