RU2732502C2 - Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis - Google Patents

Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis Download PDF

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RU2732502C2
RU2732502C2 RU2018131622A RU2018131622A RU2732502C2 RU 2732502 C2 RU2732502 C2 RU 2732502C2 RU 2018131622 A RU2018131622 A RU 2018131622A RU 2018131622 A RU2018131622 A RU 2018131622A RU 2732502 C2 RU2732502 C2 RU 2732502C2
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lam
antibody
seq
variable region
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Абрахам ПИНТЕР
Диндаял ПАТЕЛ
Алок ЧОДАРИ
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Ратгерс, Де Стейт Юниверсити Оф Нью Джерси
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1289—Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56933—Mycoplasma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/44—Multiple drug resistance

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RU2018131622A 2016-02-10 2017-02-01 Новые моноклональные антитела к LAM и PIM6/LAM для диагностики и лечения инфекций, вызванных Mycobacterium tuberculosis RU2732502C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662293406P 2016-02-10 2016-02-10
US62/293,406 2016-02-10
PCT/US2017/016058 WO2017139153A1 (en) 2016-02-10 2017-02-01 Novel anti-lam and anti-pim6/lam monoclonal antibodies for diagnosis and treatment of mycobacterium tuberculosis infections

Publications (3)

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RU2018131622A RU2018131622A (ru) 2020-03-10
RU2018131622A3 RU2018131622A3 (https=) 2020-04-13
RU2732502C2 true RU2732502C2 (ru) 2020-09-18

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US (4) US10729771B2 (https=)
EP (2) EP3414573B1 (https=)
JP (4) JP2019506412A (https=)
CN (2) CN110092830B (https=)
AU (2) AU2017218415B2 (https=)
CA (1) CA3013904C (https=)
ES (1) ES2970828T3 (https=)
RU (1) RU2732502C2 (https=)
WO (1) WO2017139153A1 (https=)
ZA (3) ZA201805990B (https=)

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WO2020018806A1 (en) 2018-07-19 2020-01-23 Rutgers, The State University Of New Jersey Methods for dual detection and differentiation of infection by mycobactierum tuberculosis complex and nontuberculous mycobacteria
JP7130045B2 (ja) * 2018-08-31 2022-09-02 富士フイルム株式会社 イムノクロマトグラフキットおよび結核菌の検出方法
CN114341639A (zh) 2019-09-30 2022-04-12 富士胶片株式会社 免疫检查方法及浓缩用夹具
JP7274595B2 (ja) 2019-09-30 2023-05-16 富士フイルム株式会社 イムノクロマトグラフィー
CN111337665A (zh) * 2020-01-16 2020-06-26 卢氏实验室公司 一种用于检测肺结核感染的免疫层析试纸条及其制备方法
WO2021152966A1 (ja) 2020-01-31 2021-08-05 富士フイルム株式会社 イムノクロマトグラフィー
JP7350100B2 (ja) 2020-01-31 2023-09-25 富士フイルム株式会社 イムノクロマトグラフィー
WO2021153127A1 (ja) 2020-01-31 2021-08-05 富士フイルム株式会社 免疫検査方法
CN111153992A (zh) * 2020-02-21 2020-05-15 首都医科大学附属北京胸科医院 结核分枝杆菌lam的单克隆抗体及其用途
EP4178610A4 (en) * 2020-07-07 2024-08-28 The Regents Of The University Of California METHODS FOR DETECTION OF ANTIGENS FROM DIRECT CLINICAL SAMPLES
EP4192429A4 (en) * 2020-08-05 2024-10-09 The Administrators of The Tulane Educational Fund METHOD FOR DETECTING TB IN BODY FLUID SAMPLES
JP7554275B2 (ja) 2020-09-11 2024-09-19 富士フイルム株式会社 検体液の濃縮方法、及び、検体液の検査方法
JP7590441B2 (ja) 2020-09-11 2024-11-26 富士フイルム株式会社 濃縮デバイス、検体液の濃縮方法、検体液の検査方法、及び、検査キット
CN116113826B (zh) 2020-09-11 2026-02-27 富士胶片株式会社 浓缩器件、被检体液的浓缩方法、被检体液的检查方法、及检查试剂盒
WO2022081716A1 (en) * 2020-10-13 2022-04-21 Accubit LLC - Biotechnology Methods of treating iga nephropathy with thiol-containing molecules
EP4263598A4 (en) * 2020-12-15 2025-04-09 Albert Einstein College of Medicine High-affinity mycobacterium tuberculosis capsule-specific human monoclonal antibodies
CN113480659B (zh) * 2021-06-30 2022-10-21 迪比康(上海)生物科技有限公司 人源抗结核分枝杆菌复合群lam单克隆抗体及其制备和应用
CN114984870A (zh) * 2022-03-15 2022-09-02 齐欣 一种重组蛋白质微球及其制备方法和应用
CN117247450B (zh) * 2023-10-10 2025-02-25 广州市雷德生物科技有限公司 一种lam抗体及其应用
CN118178640B (zh) * 2024-03-08 2025-11-21 中国农业大学 含有牛分枝杆菌表面多糖的佐剂及其应用

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EA013228B1 (ru) * 2004-07-20 2010-04-30 Чемоджен, Инк. Способ получения обогащённого поликлонального антитела, высокоспецифичного к антигену поверхностного полисахарида липоарабиноманнана микобактерий, и способы его применения
US20130309237A1 (en) * 2011-01-24 2013-11-21 Dso National Laboratories Pathogenic Mycobacteria-Derived Mannose-Capped Lipoarabinomannan Antigen Binding Proteins
EP2821415A1 (en) * 2012-02-29 2015-01-07 Otsuka Pharmaceutical Co., Ltd. Anti-lipoarabinomannan antibody and immunoassay for mycobacteriosis using said antibody

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US20240307535A1 (en) 2024-09-19
US10729771B2 (en) 2020-08-04
US11707525B2 (en) 2023-07-25
EP3414573B1 (en) 2023-11-08
AU2017218415A1 (en) 2018-09-27
JP7813481B2 (ja) 2026-02-13
ZA201805990B (en) 2023-01-25
US12303562B2 (en) 2025-05-20
AU2017218415B2 (en) 2024-05-02
RU2018131622A3 (https=) 2020-04-13
JP2019506412A (ja) 2019-03-07
CN109073649A (zh) 2018-12-21
ES2970828T3 (es) 2024-05-30
CA3013904C (en) 2023-12-12
CN110092830A (zh) 2019-08-06
WO2017139153A1 (en) 2017-08-17
CN110092830B (zh) 2023-07-04
RU2018131622A (ru) 2020-03-10
US20200316199A1 (en) 2020-10-08
US11273220B2 (en) 2022-03-15
EP3414573A4 (en) 2019-10-30
JP2023075196A (ja) 2023-05-30
JP2021105034A (ja) 2021-07-26
ZA202209045B (en) 2023-12-20
US20220168420A1 (en) 2022-06-02
BR112018016226A2 (pt) 2019-01-02
JP2024174883A (ja) 2024-12-17
AU2024205286A1 (en) 2024-08-22
EP3414573A1 (en) 2018-12-19
JP7316685B2 (ja) 2023-07-28
US20190038747A1 (en) 2019-02-07
EP4299072A3 (en) 2024-05-01
BR112018016226A8 (pt) 2023-10-24
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EP4299072A2 (en) 2024-01-03
CA3013904A1 (en) 2017-08-17

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