ES2968559T3 - Derivados de haloquinolina sustituidos, método de preparación y aplicaciones de los mismos - Google Patents
Derivados de haloquinolina sustituidos, método de preparación y aplicaciones de los mismos Download PDFInfo
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- ES2968559T3 ES2968559T3 ES19700067T ES19700067T ES2968559T3 ES 2968559 T3 ES2968559 T3 ES 2968559T3 ES 19700067 T ES19700067 T ES 19700067T ES 19700067 T ES19700067 T ES 19700067T ES 2968559 T3 ES2968559 T3 ES 2968559T3
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18305005 | 2018-01-05 | ||
| PCT/EP2019/050175 WO2019134975A1 (en) | 2018-01-05 | 2019-01-04 | Substituted halo-quinoline derivatives, method of preparation and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2968559T3 true ES2968559T3 (es) | 2024-05-10 |
Family
ID=60972161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19700067T Active ES2968559T3 (es) | 2018-01-05 | 2019-01-04 | Derivados de haloquinolina sustituidos, método de preparación y aplicaciones de los mismos |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200360365A1 (de) |
| EP (2) | EP3735408B1 (de) |
| JP (1) | JP7268053B2 (de) |
| CN (1) | CN112055706B (de) |
| AU (1) | AU2019205595B2 (de) |
| CA (1) | CA3087211A1 (de) |
| ES (1) | ES2968559T3 (de) |
| WO (2) | WO2019134975A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019134975A1 (en) | 2018-01-05 | 2019-07-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Substituted halo-quinoline derivatives, method of preparation and applications thereof |
| CN113549018B (zh) * | 2020-04-24 | 2024-02-27 | 中国药科大学 | 蛋白激酶抑制剂及其衍生物，制备方法、药物组合物和应用 |
| EP4169904A1 (de) | 2021-10-25 | 2023-04-26 | Yukin Therapeutics | Substituierte chinoline als verbesserte nik inhibitoren |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075981A (en) | 1958-04-03 | 1963-01-29 | Sterling Drug Inc | 1-[aromatic-(lower-alkyl)]-4-(aromaticimino)-1, 4-dihydroquinolines and their preparation |
| BE640616A (de) | 1962-12-19 | |||
| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| ATE300521T1 (de) | 1996-09-25 | 2005-08-15 | Astrazeneca Ab | Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern |
| JP2007509985A (ja) | 2003-10-31 | 2007-04-19 | ニューロジェン・コーポレーション | カプサイシン受容体作動薬 |
| US20080194557A1 (en) * | 2007-01-18 | 2008-08-14 | Joseph Barbosa | Methods and compositions for the treatment of pain, inflammation and cancer |
| US20080234267A1 (en) | 2007-03-20 | 2008-09-25 | Karen Elizabeth Lackey | Compounds and Methods of Treatment |
| WO2011073322A1 (en) | 2009-12-16 | 2011-06-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | 7-chloro-quinolin-4-amine compounds and uses thereof for the prevention or treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the app metabolism occurs |
| CN102249997A (zh) | 2011-05-25 | 2011-11-23 | 沈阳化工大学 | 一组具有抗肿瘤活性的4-取代苯氨基喹啉化合物 |
| CN102846623A (zh) | 2011-07-01 | 2013-01-02 | 中国科学院上海药物研究所 | 氯喹或其衍生物与糖皮质激素受体的配体联合应用方法 |
| US10322125B2 (en) | 2013-02-22 | 2019-06-18 | Emory University | TGF-beta enhancing compositions for cartilage repair and methods related thereto |
| CN103232444B (zh) | 2013-04-18 | 2015-07-22 | 中国人民解放军军事医学科学院微生物流行病研究所 | 萘酚喹衍生物及其制备和其应用 |
| WO2017198196A1 (zh) | 2016-05-18 | 2017-11-23 | 王子厚 | 具有抗肿瘤活性的喹啉衍生物 |
| US20200181089A1 (en) | 2016-07-08 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | 4-anilino-quinoline compounds as anti-cancer agents |
| WO2019134975A1 (en) | 2018-01-05 | 2019-07-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Substituted halo-quinoline derivatives, method of preparation and applications thereof |
| WO2019173482A1 (en) | 2018-03-06 | 2019-09-12 | Sanford Burnham Prebys Medical Discovery Institute | 4-aminoquinoline compounds for the treatment of angiogenesis |
-
2019
- 2019-01-04 WO PCT/EP2019/050175 patent/WO2019134975A1/en unknown
- 2019-01-04 CN CN201980006967.1A patent/CN112055706B/zh active Active
- 2019-01-04 JP JP2020557388A patent/JP7268053B2/ja active Active
- 2019-01-04 EP EP19700067.2A patent/EP3735408B1/de active Active
- 2019-01-04 US US16/959,950 patent/US20200360365A1/en not_active Abandoned
- 2019-01-04 US US16/959,954 patent/US12048693B2/en active Active
- 2019-01-04 WO PCT/EP2019/050159 patent/WO2019134969A1/en unknown
- 2019-01-04 AU AU2019205595A patent/AU2019205595B2/en not_active Ceased
- 2019-01-04 EP EP19700065.6A patent/EP3735407A1/de active Pending
- 2019-01-04 ES ES19700067T patent/ES2968559T3/es active Active
- 2019-01-04 CA CA3087211A patent/CA3087211A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3735408B1 (de) | 2023-11-29 |
| US20200361872A1 (en) | 2020-11-19 |
| JP7268053B2 (ja) | 2023-05-02 |
| WO2019134969A1 (en) | 2019-07-11 |
| CA3087211A1 (en) | 2019-07-11 |
| EP3735408A1 (de) | 2020-11-11 |
| CN112055706B (zh) | 2023-11-10 |
| CN112055706A (zh) | 2020-12-08 |
| EP3735408C0 (de) | 2023-11-29 |
| AU2019205595B2 (en) | 2023-01-05 |
| EP3735407A1 (de) | 2020-11-11 |
| US20200360365A1 (en) | 2020-11-19 |
| US12048693B2 (en) | 2024-07-30 |
| JP2021510176A (ja) | 2021-04-15 |
| AU2019205595A1 (en) | 2020-07-09 |
| WO2019134975A1 (en) | 2019-07-11 |
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