ES2966595T3 - Composición de suspensión oftálmica - Google Patents

Composición de suspensión oftálmica Download PDF

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Publication number
ES2966595T3
ES2966595T3 ES22175139T ES22175139T ES2966595T3 ES 2966595 T3 ES2966595 T3 ES 2966595T3 ES 22175139 T ES22175139 T ES 22175139T ES 22175139 T ES22175139 T ES 22175139T ES 2966595 T3 ES2966595 T3 ES 2966595T3
Authority
ES
Spain
Prior art keywords
suspension
ophthalmic
formulation
active ingredient
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES22175139T
Other languages
English (en)
Spanish (es)
Inventor
Mohannad Shawer
Eric Phillips
Martin J Coffey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Inc
Original Assignee
Bausch and Lomb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55359733&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2966595(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bausch and Lomb Inc filed Critical Bausch and Lomb Inc
Application granted granted Critical
Publication of ES2966595T3 publication Critical patent/ES2966595T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES22175139T 2015-01-26 2016-01-26 Composición de suspensión oftálmica Active ES2966595T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562107696P 2015-01-26 2015-01-26

Publications (1)

Publication Number Publication Date
ES2966595T3 true ES2966595T3 (es) 2024-04-23

Family

ID=55359733

Family Applications (5)

Application Number Title Priority Date Filing Date
ES22175139T Active ES2966595T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica
ES23196938T Active ES3031414T3 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES18209003T Active ES2787039T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica
ES20166312T Active ES2924645T5 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES16704744T Active ES2704125T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES23196938T Active ES3031414T3 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES18209003T Active ES2787039T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica
ES20166312T Active ES2924645T5 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES16704744T Active ES2704125T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica

Country Status (15)

Country Link
US (3) US10596107B2 (enExample)
EP (5) EP3250185B1 (enExample)
JP (1) JP2018507252A (enExample)
KR (1) KR102538370B1 (enExample)
CN (1) CN107427464B (enExample)
AU (4) AU2016211745A1 (enExample)
BR (1) BR112017016016B1 (enExample)
CA (1) CA2975106A1 (enExample)
ES (5) ES2966595T3 (enExample)
HU (5) HUE048564T2 (enExample)
MX (1) MX390671B (enExample)
PL (5) PL3470059T3 (enExample)
PT (3) PT4082531T (enExample)
SI (1) SI4268850T1 (enExample)
WO (1) WO2016123079A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE048564T2 (hu) 2015-01-26 2020-08-28 Bausch & Lomb Szemészeti szuszpenzió készítmény
US11000475B2 (en) 2015-10-16 2021-05-11 Sun Pharma Advanced Research Company Limited Ophthalmic solution of difluprednate
LT3245988T (lt) 2016-05-18 2024-02-12 Sonikure Holdings Limited Ultragarsu pagerinto transsklerinio vaistų pristatymo sistema
CA3073195A1 (en) 2017-08-15 2019-02-21 Nephron Pharmaceuticals Corporation Aqueous nebulization composition
CA3112278A1 (en) * 2018-09-21 2020-03-26 Ps Therapy Ltd. Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
JP6994061B2 (ja) * 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP2022520410A (ja) * 2019-02-15 2022-03-30 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの結晶形態及びその製剤
CA3148362C (en) * 2019-08-18 2024-02-13 Bo Liang In-situ gel forming ophthalmic formulations containing difluprednate
KR102271247B1 (ko) * 2020-11-04 2021-06-30 삼천당제약주식회사 안과용 현탁액 조성물의 제조방법
CN115887372A (zh) * 2022-10-25 2023-04-04 苏州欧康维视生物科技有限公司 丙酸氟替卡松混悬液及其制备方法
CN115554238A (zh) * 2022-10-25 2023-01-03 苏州欧康维视生物科技有限公司 眼用混悬液及其制备方法
FR3170261A1 (fr) 2024-12-23 2026-06-26 Horus Pharma Composition ophtalmique sous forme de gel comprenant du polycarbophile

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JPH0830004B2 (ja) 1983-11-14 1996-03-27 コロンビア ラボラトリーズ インコーポレイテッド 生物接着性組成物およびそれにより治療する方法
NZ226171A (en) 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
IE63392B1 (en) 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5124154A (en) 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5252318A (en) 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
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Also Published As

Publication number Publication date
CA2975106A1 (en) 2016-08-04
EP3470059B1 (en) 2020-04-01
AU2021203027A1 (en) 2021-06-10
PL3721868T5 (pl) 2025-12-22
JP2018507252A (ja) 2018-03-15
CN107427464A (zh) 2017-12-01
PL4082531T3 (pl) 2024-04-08
EP3470059A1 (en) 2019-04-17
AU2021203027B2 (en) 2023-07-13
EP4268850B1 (en) 2025-04-16
SI4268850T1 (sl) 2025-07-31
ES2924645T3 (es) 2022-10-10
PT4268850T (pt) 2025-06-04
EP3250185B1 (en) 2018-12-05
BR112017016016B1 (pt) 2023-12-19
US20230140895A1 (en) 2023-05-11
EP4082531B1 (en) 2023-10-11
EP4082531A1 (en) 2022-11-02
PL3250185T3 (pl) 2019-05-31
BR112017016016A2 (pt) 2018-03-20
PT3721868T (pt) 2022-08-12
EP3470059B2 (en) 2026-08-12
ES2787039T3 (es) 2020-10-14
HUE066045T2 (hu) 2024-07-28
AU2023248145A1 (en) 2023-11-02
PL3721868T3 (pl) 2022-11-07
EP3721868B1 (en) 2022-06-01
EP3721868A1 (en) 2020-10-14
PL3470059T3 (pl) 2020-11-30
US20160213609A1 (en) 2016-07-28
US12589069B2 (en) 2026-03-31
US10596107B2 (en) 2020-03-24
WO2016123079A1 (en) 2016-08-04
PL4268850T3 (pl) 2025-08-04
US11534395B2 (en) 2022-12-27
HUE041945T2 (hu) 2019-06-28
US20200214977A1 (en) 2020-07-09
HUE059639T2 (hu) 2022-12-28
EP3250185A1 (en) 2017-12-06
PT4082531T (pt) 2023-12-14
EP4268850A1 (en) 2023-11-01
ES2704125T3 (es) 2019-03-14
KR102538370B1 (ko) 2023-06-01
HUE048564T2 (hu) 2020-08-28
AU2016211745A1 (en) 2017-08-31
ES3031414T3 (en) 2025-07-08
ES2924645T5 (en) 2025-12-15
HUE071679T2 (hu) 2025-09-28
EP3721868B2 (en) 2025-09-03
MX390671B (es) 2025-03-21
CN107427464B (zh) 2022-04-05
AU2023248145B2 (en) 2025-08-28
KR20170105610A (ko) 2017-09-19
AU2025271194A1 (en) 2025-12-18
MX2017009699A (es) 2017-10-23

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