ES2966595T3 - Composición de suspensión oftálmica - Google Patents

Composición de suspensión oftálmica Download PDF

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Publication number
ES2966595T3
ES2966595T3 ES22175139T ES22175139T ES2966595T3 ES 2966595 T3 ES2966595 T3 ES 2966595T3 ES 22175139 T ES22175139 T ES 22175139T ES 22175139 T ES22175139 T ES 22175139T ES 2966595 T3 ES2966595 T3 ES 2966595T3
Authority
ES
Spain
Prior art keywords
suspension
ophthalmic
formulation
active ingredient
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES22175139T
Other languages
English (en)
Spanish (es)
Inventor
Mohannad Shawer
Eric Phillips
Martin J Coffey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Inc
Original Assignee
Bausch and Lomb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55359733&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2966595(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bausch and Lomb Inc filed Critical Bausch and Lomb Inc
Application granted granted Critical
Publication of ES2966595T3 publication Critical patent/ES2966595T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES22175139T 2015-01-26 2016-01-26 Composición de suspensión oftálmica Active ES2966595T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562107696P 2015-01-26 2015-01-26

Publications (1)

Publication Number Publication Date
ES2966595T3 true ES2966595T3 (es) 2024-04-23

Family

ID=55359733

Family Applications (5)

Application Number Title Priority Date Filing Date
ES22175139T Active ES2966595T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica
ES20166312T Active ES2924645T5 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES16704744T Active ES2704125T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica
ES23196938T Active ES3031414T3 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES18209003T Active ES2787039T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES20166312T Active ES2924645T5 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES16704744T Active ES2704125T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica
ES23196938T Active ES3031414T3 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition
ES18209003T Active ES2787039T3 (es) 2015-01-26 2016-01-26 Composición de suspensión oftálmica

Country Status (15)

Country Link
US (3) US10596107B2 (enExample)
EP (5) EP3470059B1 (enExample)
JP (1) JP2018507252A (enExample)
KR (1) KR102538370B1 (enExample)
CN (1) CN107427464B (enExample)
AU (4) AU2016211745A1 (enExample)
BR (1) BR112017016016B1 (enExample)
CA (1) CA2975106A1 (enExample)
ES (5) ES2966595T3 (enExample)
HU (5) HUE048564T2 (enExample)
MX (1) MX390671B (enExample)
PL (5) PL4268850T3 (enExample)
PT (3) PT4082531T (enExample)
SI (1) SI4268850T1 (enExample)
WO (1) WO2016123079A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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EP3470059B1 (en) 2015-01-26 2020-04-01 Bausch & Lomb Incorporated Ophthalmic suspension composition
US11000475B2 (en) 2015-10-16 2021-05-11 Sun Pharma Advanced Research Company Limited Ophthalmic solution of difluprednate
LT3245988T (lt) 2016-05-18 2024-02-12 Sonikure Holdings Limited Ultragarsu pagerinto transsklerinio vaistų pristatymo sistema
CA3073195A1 (en) 2017-08-15 2019-02-21 Nephron Pharmaceuticals Corporation Aqueous nebulization composition
CA3112278A1 (en) * 2018-09-21 2020-03-26 Ps Therapy Ltd. Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
US12600702B2 (en) * 2019-02-15 2026-04-14 Bausch + Lomb Ireland Limited Crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile and formulations thereof
US20230172946A1 (en) * 2019-08-18 2023-06-08 Iview Therapeutics, Inc. In-situ Gel Forming Ophthalmic Formulations Containing Difluprednate
KR102271247B1 (ko) * 2020-11-04 2021-06-30 삼천당제약주식회사 안과용 현탁액 조성물의 제조방법
CN115887372A (zh) * 2022-10-25 2023-04-04 苏州欧康维视生物科技有限公司 丙酸氟替卡松混悬液及其制备方法
CN115554238A (zh) * 2022-10-25 2023-01-03 苏州欧康维视生物科技有限公司 眼用混悬液及其制备方法

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US4540930A (en) 1983-09-12 1985-09-10 Wisconsin Alumni Research Foundation Plywheel-powered mobile X-ray apparatus
ATE151286T1 (de) 1983-11-14 1997-04-15 Columbia Lab Inc Bioadhäsive mittel
NZ226171A (en) 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
IE63392B1 (en) 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5124154A (en) 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5252318A (en) 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
CA2134376C (en) 1993-12-20 2001-10-23 Haresh G. Bhagat Combinations of polymers for use in physiological tear compositions
US5556848A (en) * 1993-12-27 1996-09-17 Senju Pharmaceutical Co., Ltd. Ophthalmic suspension containing diflupredonate
GB9718568D0 (en) * 1997-09-03 1997-11-05 Chauvin Pharmaceuticals Limite Compositions
TWI227143B (en) 1999-12-15 2005-02-01 Guo-Jiun Sung In situ gel formation for ophthalmic delivery by combining Pluronic/Carbopol medic composition and its preparing method
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
EP2283864A1 (en) * 2002-07-16 2011-02-16 Elan Pharma International Ltd. Liquid dosage compositions fo stable nanoparticulate active agents
CA2527712C (en) * 2003-06-13 2014-08-05 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
US20050197303A1 (en) 2003-10-31 2005-09-08 Bausch & Lomb Incorporated Combination of loteprednol etabonate and tobramycin for topical ophthalmic use
US20050182039A1 (en) * 2004-02-13 2005-08-18 Bausch & Lomb Incorporated Use of Loteprednol etabonate for the treatment of dry eye
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Also Published As

Publication number Publication date
AU2016211745A1 (en) 2017-08-31
PT4082531T (pt) 2023-12-14
KR102538370B1 (ko) 2023-06-01
JP2018507252A (ja) 2018-03-15
CN107427464B (zh) 2022-04-05
US10596107B2 (en) 2020-03-24
EP3721868B2 (en) 2025-09-03
EP4268850B1 (en) 2025-04-16
ES2924645T3 (es) 2022-10-10
EP3470059B1 (en) 2020-04-01
HUE048564T2 (hu) 2020-08-28
PL4268850T3 (pl) 2025-08-04
BR112017016016B1 (pt) 2023-12-19
PT4268850T (pt) 2025-06-04
US20230140895A1 (en) 2023-05-11
ES2787039T3 (es) 2020-10-14
SI4268850T1 (sl) 2025-07-31
US20200214977A1 (en) 2020-07-09
AU2025271194A1 (en) 2025-12-18
PL3250185T3 (pl) 2019-05-31
PL3721868T5 (pl) 2025-12-22
EP4268850A1 (en) 2023-11-01
WO2016123079A1 (en) 2016-08-04
MX2017009699A (es) 2017-10-23
PT3721868T (pt) 2022-08-12
ES2924645T5 (en) 2025-12-15
AU2023248145A1 (en) 2023-11-02
MX390671B (es) 2025-03-21
US20160213609A1 (en) 2016-07-28
EP3250185A1 (en) 2017-12-06
CA2975106A1 (en) 2016-08-04
EP3721868B1 (en) 2022-06-01
AU2021203027B2 (en) 2023-07-13
HUE066045T2 (hu) 2024-07-28
US12589069B2 (en) 2026-03-31
ES3031414T3 (en) 2025-07-08
EP4082531B1 (en) 2023-10-11
EP4082531A1 (en) 2022-11-02
PL3721868T3 (pl) 2022-11-07
EP3250185B1 (en) 2018-12-05
HUE041945T2 (hu) 2019-06-28
AU2023248145B2 (en) 2025-08-28
ES2704125T3 (es) 2019-03-14
US11534395B2 (en) 2022-12-27
PL3470059T3 (pl) 2020-11-30
KR20170105610A (ko) 2017-09-19
AU2021203027A1 (en) 2021-06-10
HUE059639T2 (hu) 2022-12-28
HUE071679T2 (hu) 2025-09-28
EP3721868A1 (en) 2020-10-14
EP3470059A1 (en) 2019-04-17
CN107427464A (zh) 2017-12-01
PL4082531T3 (pl) 2024-04-08
BR112017016016A2 (pt) 2018-03-20

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