CN107427464B - 眼用悬浮液组合物 - Google Patents

眼用悬浮液组合物 Download PDF

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Publication number
CN107427464B
CN107427464B CN201680016825.XA CN201680016825A CN107427464B CN 107427464 B CN107427464 B CN 107427464B CN 201680016825 A CN201680016825 A CN 201680016825A CN 107427464 B CN107427464 B CN 107427464B
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China
Prior art keywords
ophthalmic
suspension
formulation
particles
ophthalmic suspension
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CN201680016825.XA
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English (en)
Chinese (zh)
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CN107427464A (zh
Inventor
M·沙维尔
E·菲利普斯
M·J·科菲
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Bausch and Lomb Inc
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Bausch and Lomb Inc
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Publication of CN107427464A publication Critical patent/CN107427464A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680016825.XA 2015-01-26 2016-01-26 眼用悬浮液组合物 Active CN107427464B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562107696P 2015-01-26 2015-01-26
US62/107,696 2015-01-26
PCT/US2016/014872 WO2016123079A1 (en) 2015-01-26 2016-01-26 Ophthalmic suspension composition

Publications (2)

Publication Number Publication Date
CN107427464A CN107427464A (zh) 2017-12-01
CN107427464B true CN107427464B (zh) 2022-04-05

Family

ID=55359733

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680016825.XA Active CN107427464B (zh) 2015-01-26 2016-01-26 眼用悬浮液组合物

Country Status (15)

Country Link
US (3) US10596107B2 (enExample)
EP (5) EP4268850B1 (enExample)
JP (1) JP2018507252A (enExample)
KR (1) KR102538370B1 (enExample)
CN (1) CN107427464B (enExample)
AU (3) AU2016211745A1 (enExample)
BR (1) BR112017016016B1 (enExample)
CA (1) CA2975106A1 (enExample)
ES (5) ES3031414T3 (enExample)
HU (5) HUE048564T2 (enExample)
MX (1) MX390671B (enExample)
PL (5) PL4082531T3 (enExample)
PT (3) PT3721868T (enExample)
SI (1) SI4268850T1 (enExample)
WO (1) WO2016123079A1 (enExample)

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CA3073195A1 (en) 2017-08-15 2019-02-21 Nephron Pharmaceuticals Corporation Aqueous nebulization composition
CN113227304A (zh) * 2018-09-21 2021-08-06 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法
JP6994061B2 (ja) * 2019-02-15 2022-01-14 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
JP2022520410A (ja) * 2019-02-15 2022-03-30 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの結晶形態及びその製剤
JP2023505409A (ja) * 2019-08-18 2023-02-09 アイビュー セラピューティクス（ズーハイ）カンパニー リミテッド 持続型の眼用薬物送達システムとしてシクロスポリンミセルを含むｉｎ－ｓｉｔｕゲル
KR102271247B1 (ko) * 2020-11-04 2021-06-30 삼천당제약주식회사 안과용 현탁액 조성물의 제조방법
CN115554238A (zh) * 2022-10-25 2023-01-03 苏州欧康维视生物科技有限公司 眼用混悬液及其制备方法
CN115887372A (zh) * 2022-10-25 2023-04-04 苏州欧康维视生物科技有限公司 丙酸氟替卡松混悬液及其制备方法

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Publication number Publication date
EP4268850B1 (en) 2025-04-16
PL3470059T3 (pl) 2020-11-30
PL3250185T3 (pl) 2019-05-31
ES2966595T3 (es) 2024-04-23
AU2016211745A1 (en) 2017-08-31
EP3250185A1 (en) 2017-12-06
EP4082531B1 (en) 2023-10-11
PT4268850T (pt) 2025-06-04
ES2787039T3 (es) 2020-10-14
HUE066045T2 (hu) 2024-07-28
KR20170105610A (ko) 2017-09-19
JP2018507252A (ja) 2018-03-15
EP3470059A1 (en) 2019-04-17
AU2021203027B2 (en) 2023-07-13
HUE041945T2 (hu) 2019-06-28
US11534395B2 (en) 2022-12-27
US20230140895A1 (en) 2023-05-11
HUE048564T2 (hu) 2020-08-28
EP4082531A1 (en) 2022-11-02
WO2016123079A1 (en) 2016-08-04
KR102538370B1 (ko) 2023-06-01
PT4082531T (pt) 2023-12-14
PT3721868T (pt) 2022-08-12
MX390671B (es) 2025-03-21
PL3721868T3 (pl) 2022-11-07
CN107427464A (zh) 2017-12-01
US20160213609A1 (en) 2016-07-28
US10596107B2 (en) 2020-03-24
EP4268850A1 (en) 2023-11-01
EP3721868A1 (en) 2020-10-14
HUE059639T2 (hu) 2022-12-28
AU2023248145B2 (en) 2025-08-28
PL4268850T3 (pl) 2025-08-04
EP3470059B1 (en) 2020-04-01
EP3721868B1 (en) 2022-06-01
ES2704125T3 (es) 2019-03-14
EP3721868B2 (en) 2025-09-03
EP3250185B1 (en) 2018-12-05
MX2017009699A (es) 2017-10-23
US20200214977A1 (en) 2020-07-09
BR112017016016B1 (pt) 2023-12-19
PL4082531T3 (pl) 2024-04-08
HUE071679T2 (hu) 2025-09-28
AU2023248145A1 (en) 2023-11-02
BR112017016016A2 (pt) 2018-03-20
AU2021203027A1 (en) 2021-06-10
ES2924645T3 (es) 2022-10-10
CA2975106A1 (en) 2016-08-04
ES3031414T3 (en) 2025-07-08
SI4268850T1 (sl) 2025-07-31

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