ES2962460T3 - Inhibidores de mdm2 y combinaciones de estos - Google Patents
Inhibidores de mdm2 y combinaciones de estos Download PDFInfo
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- ES2962460T3 ES2962460T3 ES16760803T ES16760803T ES2962460T3 ES 2962460 T3 ES2962460 T3 ES 2962460T3 ES 16760803 T ES16760803 T ES 16760803T ES 16760803 T ES16760803 T ES 16760803T ES 2962460 T3 ES2962460 T3 ES 2962460T3
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Landscapes
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| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
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| WO2019040511A1 (en) * | 2017-08-22 | 2019-02-28 | University Of Maryland Batimore | DOUBLE INHIBITORS OF BCL-2 AND HDM2 FAMILIES BY CO-MIMETTISM OF ALPHA BH3 AND P53 PROPELLERS |
| EP3687981A4 (en) * | 2017-09-26 | 2021-03-31 | The Regents of the University of California | COMPOSITIONS AND METHODS OF TREATMENT OF CANCER |
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| EP3731841A4 (en) * | 2017-12-31 | 2021-09-29 | Evergreen Biosciences | CELL STORAGE COMPOSITIONS AND THEIR METHODS OF USE |
| US11639355B2 (en) | 2018-03-12 | 2023-05-02 | Luoxin Pharmaceutical (Shanghai) Co., Ltd. | Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors |
| BR112020018755A2 (pt) * | 2018-03-20 | 2021-01-05 | Novartis Ag | Combinações farmacêuticas |
| CN110772521A (zh) | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
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| TWI752335B (zh) * | 2018-07-31 | 2022-01-11 | 大陸商蘇州亞盛藥業有限公司 | Bcl-2抑制劑與MDM2抑制劑的組合產品及其在預防及/或治療疾病中的用途 |
| UA125241C2 (uk) | 2018-07-31 | 2022-02-02 | Есентейдж Фарма (Сучжоу) Ко., Лтд. | СИНЕРГІЧНИЙ ПРОТИПУХЛИННИЙ ЕФЕКТ ІНГІБІТОРА Bcl-2 В ПОЄДНАННІ З РИТУКСИМАБОМ ТА/АБО БЕНДАМУСТИНОМ АБО ІНГІБІТОРА Bcl-2 В ПОЄДНАННІ З CHOP |
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| CN112294965B (zh) | 2019-07-26 | 2023-03-14 | 苏州亚盛药业有限公司 | Mdm2抑制剂的药物组合物及其在预防和/或治疗疾病中的用途 |
| TWI772992B (zh) | 2019-12-03 | 2022-08-01 | 大陸商蘇州亞盛藥業有限公司 | 作為bcl-2抑制劑的n-(苯基磺醯基)苯甲醯胺及相關化合物 |
| WO2021242547A1 (en) * | 2020-05-26 | 2021-12-02 | Hanmi Pharm. Co., Ltd. | Belvarafenib for use in cancer treatment |
| CN115124533A (zh) * | 2021-03-26 | 2022-09-30 | 浙江海正药业股份有限公司 | 四环类衍生物、其制备方法和其医药上的用途 |
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| US20120115896A1 (en) * | 2008-12-03 | 2012-05-10 | Alberto Bardelli | Isogenic human cell lines comprising mutated cancer alleles and process using the cell lines |
| CU24130B1 (es) | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| US8859535B2 (en) * | 2011-06-20 | 2014-10-14 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
| US20140348819A1 (en) * | 2011-06-24 | 2014-11-27 | Dana-Farber Cancer Institute, Inc. | Methods of Treating Cancer |
| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2752191A1 (en) | 2013-01-07 | 2014-07-09 | Sanofi | Compositions and methods using hdm2 antagonist and mek inhibitor |
| KR102305351B1 (ko) * | 2013-11-11 | 2021-09-24 | 암젠 인크 | 암의 치료를 위한, mdm2 억제제 및 하나 이상의 추가적 약제학적 활성 제제를 포함하는 조합 요법 |
| WO2015084804A1 (en) * | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| WO2015095834A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using erk1/2 and bcl-2 family inhibitors |
| KR20160100975A (ko) | 2013-12-23 | 2016-08-24 | 노파르티스 아게 | 제약 조합물 |
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2016
- 2016-08-24 US US15/756,094 patent/US20190060309A1/en not_active Abandoned
- 2016-08-24 RU RU2020142739A patent/RU2020142739A/ru unknown
- 2016-08-24 RU RU2018110770A patent/RU2740091C2/ru active
- 2016-08-24 ES ES16760803T patent/ES2962460T3/es active Active
- 2016-08-24 AU AU2016314082A patent/AU2016314082B2/en not_active Ceased
- 2016-08-24 KR KR1020187005360A patent/KR20180041677A/ko not_active Ceased
- 2016-08-24 EP EP23177095.9A patent/EP4241850A3/en not_active Withdrawn
- 2016-08-24 WO PCT/IB2016/055050 patent/WO2017037579A1/en not_active Ceased
- 2016-08-24 CA CA2992221A patent/CA2992221C/en active Active
- 2016-08-24 CN CN202010783071.9A patent/CN111821306A/zh not_active Withdrawn
- 2016-08-24 JP JP2018510877A patent/JP2018528206A/ja active Pending
- 2016-08-24 EP EP16760803.3A patent/EP3340989B1/en not_active Revoked
- 2016-08-24 CN CN201680062336.8A patent/CN108348520A/zh active Pending
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2018
- 2018-01-18 IL IL257015A patent/IL257015B/en unknown
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2019
- 2019-07-09 AU AU2019204938A patent/AU2019204938B2/en not_active Ceased
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2020
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2021
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2023
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| Publication number | Publication date |
|---|---|
| CA2992221C (en) | 2023-06-27 |
| AU2019204938A1 (en) | 2019-07-25 |
| IL257015B (en) | 2022-02-01 |
| EP3340989A1 (en) | 2018-07-04 |
| EP4241850A3 (en) | 2023-11-08 |
| US20230398115A1 (en) | 2023-12-14 |
| US20190060309A1 (en) | 2019-02-28 |
| EP3340989B1 (en) | 2023-08-16 |
| AU2016314082A1 (en) | 2018-02-08 |
| CA2992221A1 (en) | 2017-03-09 |
| IL277239A (en) | 2020-10-29 |
| JP2021042222A (ja) | 2021-03-18 |
| IL257015A (en) | 2018-03-29 |
| AU2019204938B2 (en) | 2020-07-16 |
| WO2017037579A1 (en) | 2017-03-09 |
| AU2016314082B2 (en) | 2019-07-25 |
| RU2020142739A (ru) | 2021-01-15 |
| CN111821306A (zh) | 2020-10-27 |
| RU2740091C2 (ru) | 2021-01-11 |
| EP4241850A2 (en) | 2023-09-13 |
| JP2018528206A (ja) | 2018-09-27 |
| RU2018110770A (ru) | 2019-09-30 |
| CN108348520A (zh) | 2018-07-31 |
| KR20180041677A (ko) | 2018-04-24 |
| US20210260059A1 (en) | 2021-08-26 |
| RU2020142739A3 (OSRAM) | 2021-05-20 |
| IL277239B (en) | 2022-04-01 |
| RU2018110770A3 (OSRAM) | 2020-01-15 |
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