ES2960598T3 - Compuestos para el tratamiento de enfermedades y trastornos oftálmicos - Google Patents
Compuestos para el tratamiento de enfermedades y trastornos oftálmicos Download PDFInfo
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- ES2960598T3 ES2960598T3 ES15720340T ES15720340T ES2960598T3 ES 2960598 T3 ES2960598 T3 ES 2960598T3 ES 15720340 T ES15720340 T ES 15720340T ES 15720340 T ES15720340 T ES 15720340T ES 2960598 T3 ES2960598 T3 ES 2960598T3
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
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| EP14167490 | 2014-05-08 | ||
| EP14170616 | 2014-05-30 | ||
| PCT/EP2015/060166 WO2015169944A1 (en) | 2014-05-08 | 2015-05-08 | Compounds for treating ophthalmic diseases and disorders |
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| ES2960598T3 true ES2960598T3 (es) | 2024-03-05 |
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| CA (1) | CA2947067C (enExample) |
| CL (1) | CL2016002812A1 (enExample) |
| ES (1) | ES2960598T3 (enExample) |
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| IL (1) | IL248732B (enExample) |
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| WO (1) | WO2015169944A1 (enExample) |
| ZA (1) | ZA201607260B (enExample) |
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| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| JP6629840B2 (ja) * | 2014-05-08 | 2020-01-15 | パノプテス・ファーマ・ゲーエムベーハー | 眼の疾患および障害を処置するための化合物 |
| PE20171138A1 (es) | 2014-12-23 | 2017-08-09 | 4D Pharma Res Ltd | Modulacion inmunitaria |
| DK3193901T3 (en) | 2014-12-23 | 2018-05-28 | 4D Pharma Res Ltd | PIRIN POLYPEPTIDE AND IMMUNMODULATION |
| PE20180243A1 (es) | 2015-06-15 | 2018-01-31 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| LT3360559T (lt) | 2015-06-15 | 2019-12-27 | 4D Pharma Research Limited | Kompozicijos, apimančios bakterijų kamienus |
| EP3662917A1 (en) | 2015-06-15 | 2020-06-10 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| MA41013A (fr) | 2015-11-20 | 2017-08-30 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| MX2018008169A (es) * | 2015-12-30 | 2019-02-20 | Agios Pharmaceuticals Inc | Tratamiento de tumores que incorpora isocitrato deshidrogenasa mutante. |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| MX373290B (es) | 2016-03-04 | 2020-06-18 | 4D Pharma Plc | Composiciones que comprenden cepas bacterianas. |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US20180369206A1 (en) | 2017-04-24 | 2018-12-27 | Aurigene Discovery Technologies Limited | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
| CA3060390A1 (en) | 2017-04-24 | 2018-11-01 | Aurigene Discovery Technologies Limited | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| MA48940A (fr) | 2017-05-22 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA41708A (fr) | 2017-05-24 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| TWI767013B (zh) | 2017-06-14 | 2022-06-11 | 英商4D製藥研究有限公司 | 包含細菌品系之組成物 |
| PL3638271T3 (pl) | 2017-06-14 | 2021-03-22 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| JP2020523326A (ja) | 2017-06-14 | 2020-08-06 | フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ | 細菌株を含む組成物 |
| WO2018230713A1 (ja) * | 2017-06-16 | 2018-12-20 | 学校法人同志社 | カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用 |
| EP3639854B1 (en) | 2017-06-16 | 2026-01-07 | The Doshisha | Mtor-inhibitor-containing medicine for treating or preventing fuchs' endothelial corneal dystrophy |
| CA3091792A1 (en) | 2018-02-20 | 2019-08-29 | Agios Pharmaceuticals, Inc. | Methods of use for trisubstituted benzotriazole derivatives |
| AU2019232153B2 (en) | 2018-03-09 | 2023-07-13 | Panoptes Pharma Ges.M.B.H. | Ophthalmic formulation |
| MD3765439T2 (ro) * | 2018-03-16 | 2024-08-31 | Immunic Ag | Polimorfi noi ai sării de calciu ca agenti anti-inflamatori, imunomodulatori și anti-proliferatori |
| EP3773579A4 (en) | 2018-03-26 | 2022-03-09 | Clear Creek Bio, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE |
| US12076315B2 (en) | 2020-03-20 | 2024-09-03 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| JP7723987B2 (ja) * | 2020-04-21 | 2025-08-15 | ユニバーシティ オブ マサチューセッツ | 加齢性黄斑変性を処置するための方法および組成物 |
| CN111638341A (zh) * | 2020-07-01 | 2020-09-08 | 山东凯歌智能机器有限公司 | 一种检测小细胞肺癌患者外周血循环肿瘤细胞pd-l1基因突变的试剂盒及检测方法 |
| US20230390276A1 (en) * | 2020-10-15 | 2023-12-07 | Aslan Pharmaceuticals Pte. Ltd. | Treatment of autoimmune diseases with a dihydroorotate hehydrogenase (dhodh) inhibitor |
| KR20240007144A (ko) | 2021-04-09 | 2024-01-16 | 이뮤닉 아게 | 중수소화 dhodh 억제제 |
| UY40087A (es) * | 2021-12-23 | 2023-06-30 | Immunic Ag | Inhibidores de DHODH que contienen un bioisóstero de ácido carboxílico. |
| WO2023168176A1 (en) * | 2022-03-01 | 2023-09-07 | Kiora Pharmaceuticals Gmbh | Salts of a dihydroorotate dehydrogenase (dhod) inhibitor |
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| WO2024138064A1 (en) * | 2022-12-22 | 2024-06-27 | Cavalry Biosciences, Inc. | Compositions and methods for treating meibomain gland dysfunction |
| UY40805A (es) | 2023-06-28 | 2025-01-15 | Immunic Ag | Inhibidores de dhodh heteroaromáticos |
| WO2026074007A1 (en) | 2024-10-02 | 2026-04-09 | Immunic Ag | Nurr1 agonists with replacement of the carboxylic acid or carboxamide moiety for use in the treatment of neurodegenerative diseases |
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| JPS61103836A (ja) | 1984-10-24 | 1986-05-22 | Green Cross Corp:The | フイブロネクチン製剤 |
| DD297328A5 (de) | 1989-08-18 | 1992-01-09 | �������@���������k���Kk�� | 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen |
| DE69730476T2 (de) | 1996-04-19 | 2005-11-17 | Tsubota, Kazuo, Funabashi | Albumin als aktiver Bestandteil zur Behandlung von Bindehaut- und Hornhautverletzungen und von trockenen Augen |
| HUP9701554D0 (en) | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
| AU2003301347A1 (en) * | 2002-10-17 | 2004-05-04 | Control Delivery Systems, Inc. | Methods for monitoring treatment of disease |
| WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| WO2004056747A1 (en) * | 2002-12-23 | 2004-07-08 | 4Sc Ag | Dhodh-inhibitors and method for their identification |
| US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| PT1578741E (pt) | 2002-12-23 | 2011-10-17 | 4Sc Ag | Compostos aromáticos como agentes antiinflamatórios, imunoreguladores e antiproliferativos |
| JP4051398B2 (ja) | 2004-03-11 | 2008-02-20 | アクテリオン ファマシューティカルズ リミテッド | テトラヒドロピリドインドール誘導体 |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| JP2006089485A (ja) | 2004-08-24 | 2006-04-06 | Santen Pharmaceut Co Ltd | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| US20070082841A1 (en) * | 2005-09-27 | 2007-04-12 | Aciont, Inc. | Ocular administration of immunosuppressive agents |
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| UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
| JP2009270356A (ja) | 2008-05-08 | 2009-11-19 | Yoshinobu Hayashi | アスベスト含有被覆層剥ぎ取り物の処理方法 |
| TWI530286B (zh) | 2009-05-04 | 2016-04-21 | 帕納特斯製藥格斯有限公司 | 作為抑制病毒化合物之抗發炎劑 |
| US20110021465A1 (en) * | 2009-07-23 | 2011-01-27 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Synergistic composition and method of retarding and ameliorating photo induced retinal damage and cataracts while ameliorating dry eye syndrome |
| US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
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| RU2016144238A (ru) | 2014-04-11 | 2018-05-11 | Паноптес Фарма Гмбх | Противовоспалительные средства в качестве вирусостатических соединений |
| JP6629840B2 (ja) * | 2014-05-08 | 2020-01-15 | パノプテス・ファーマ・ゲーエムベーハー | 眼の疾患および障害を処置するための化合物 |
| MX2018008169A (es) | 2015-12-30 | 2019-02-20 | Agios Pharmaceuticals Inc | Tratamiento de tumores que incorpora isocitrato deshidrogenasa mutante. |
| AU2019232153B2 (en) | 2018-03-09 | 2023-07-13 | Panoptes Pharma Ges.M.B.H. | Ophthalmic formulation |
| KR20240007144A (ko) | 2021-04-09 | 2024-01-16 | 이뮤닉 아게 | 중수소화 dhodh 억제제 |
| WO2023168176A1 (en) | 2022-03-01 | 2023-09-07 | Kiora Pharmaceuticals Gmbh | Salts of a dihydroorotate dehydrogenase (dhod) inhibitor |
| EP4489745A4 (en) | 2022-03-09 | 2025-10-15 | Kiora Pharmaceuticals Gmbh | POLYMORPHS OF A DIHYDROOROTATE DEHYDROGENASE (DHOD) INHIBITOR |
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| BR112016025997A2 (pt) | 2017-08-15 |
| US12364680B2 (en) | 2025-07-22 |
| KR20160147023A (ko) | 2016-12-21 |
| CN106572968A (zh) | 2017-04-19 |
| MX378707B (es) | 2025-03-10 |
| US20170071904A1 (en) | 2017-03-16 |
| PL3139914T3 (pl) | 2023-11-27 |
| WO2015169944A1 (en) | 2015-11-12 |
| SG11201608835VA (en) | 2016-11-29 |
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| EP3139914B1 (en) | 2023-07-26 |
| CA2947067C (en) | 2023-02-14 |
| BR112016025997A8 (pt) | 2021-07-06 |
| EP3139914C0 (en) | 2023-07-26 |
| AU2015257651A1 (en) | 2016-11-10 |
| MX2016014634A (es) | 2017-04-10 |
| NZ725574A (en) | 2022-08-26 |
| JP6629840B2 (ja) | 2020-01-15 |
| US20250381167A1 (en) | 2025-12-18 |
| IL248732B (en) | 2019-07-31 |
| CA2947067A1 (en) | 2015-11-12 |
| ZA201607260B (en) | 2018-05-30 |
| US11730716B2 (en) | 2023-08-22 |
| CN116077665A (zh) | 2023-05-09 |
| EP3139914A1 (en) | 2017-03-15 |
| CL2016002812A1 (es) | 2017-03-17 |
| HK1231417A1 (zh) | 2017-12-22 |
| KR102312186B1 (ko) | 2021-10-14 |
| AU2015257651B2 (en) | 2020-01-23 |
| JP2017514917A (ja) | 2017-06-08 |
| US20230285355A1 (en) | 2023-09-14 |
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