ES2959119T3 - Método de uso de ciclodextrina - Google Patents
Método de uso de ciclodextrina Download PDFInfo
- Publication number
- ES2959119T3 ES2959119T3 ES13775223T ES13775223T ES2959119T3 ES 2959119 T3 ES2959119 T3 ES 2959119T3 ES 13775223 T ES13775223 T ES 13775223T ES 13775223 T ES13775223 T ES 13775223T ES 2959119 T3 ES2959119 T3 ES 2959119T3
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- cholesterol
- cyclodextrin
- dkd
- pharmaceutical composition
- cellular
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| US201261624087P | 2012-04-13 | 2012-04-13 | |
| PCT/US2013/036484 WO2013155485A2 (en) | 2012-04-13 | 2013-04-12 | Method of using cyclodextrin |
Publications (1)
| Publication Number | Publication Date |
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| ES2959119T3 true ES2959119T3 (es) | 2024-02-20 |
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| ES13775223T Active ES2959119T3 (es) | 2012-04-13 | 2013-04-12 | Método de uso de ciclodextrina |
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| US (4) | US10195227B2 (https=) |
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| ES (1) | ES2959119T3 (https=) |
| MX (2) | MX392972B (https=) |
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| CN104244956B (zh) * | 2012-04-13 | 2020-04-17 | L&F研究有限公司 | 使用环糊精的方法 |
| CA2905788C (en) | 2013-03-12 | 2022-08-16 | Emily A. Stein | Dental composition comprising chelator and base |
| JP6418911B2 (ja) * | 2014-11-18 | 2018-11-07 | 学校法人中部大学 | Ｇｌｐ−１分泌促進剤 |
| CA2988529A1 (en) | 2015-06-10 | 2016-12-15 | Vtesse, Inc. | Hydroxypropyl beta-cyclodextrin compositions and methods |
| CN105395549A (zh) * | 2015-11-03 | 2016-03-16 | 天津医科大学总医院 | 烟酸的新用途 |
| CN109982718A (zh) * | 2016-09-19 | 2019-07-05 | 阿托恩波罗斯生命科学 | 基于环糊精的聚合物、方法、组合物及其应用 |
| WO2018075622A1 (en) * | 2016-10-19 | 2018-04-26 | University Of Miami | Materials and methods for modulating insulin signaling and preserving podocyte function |
| CN107982546A (zh) * | 2017-12-05 | 2018-05-04 | 中国药科大学 | 基于主客体相互作用的酸敏感超分子纳米粒及其应用 |
| US11925659B2 (en) | 2018-10-29 | 2024-03-12 | Cyclo Therapeutics, Inc. | Methods for treating Alzheimer's disease |
| JP7607935B2 (ja) | 2019-01-03 | 2025-01-06 | サイクラリティ・セラピューティクス・インコーポレイテッド | シクロデキストリン二量体、それらの組成物、及びそれらの使用 |
| WO2020213010A1 (en) * | 2019-04-16 | 2020-10-22 | Celagenex Research (India) Pvt. Ltd. | Synergistic lipid controlling compositions |
| EP4058570A4 (en) * | 2019-11-11 | 2023-12-27 | Atsuo Ochi | METHOD AND KIT FOR REPROGRAMMING SOMATIC CELLS |
| US12226431B2 (en) | 2021-09-11 | 2025-02-18 | Porosome Therapeutics, Inc. | Aerosol and topical administration of a formulation containing cyclodextrin, quercetin and zinc, in combination or separately, to mitigate infection by enveloped viruses |
| CA3189915A1 (en) * | 2020-08-27 | 2022-03-03 | Diana KERWIN | Methods for the treatment of cardiovascular disease with cyclodextrins |
| IL300881A (en) * | 2020-08-27 | 2023-04-01 | Beren Therapeutics P B C | Methods for preventing embolization of cholesterol crystals with cyclodextrins |
| KR20230096975A (ko) * | 2020-08-27 | 2023-06-30 | 베렌 테라퓨틱스 피.비.씨. | 사이클로덱스트린을 이용한 콜레스테롤 결정 색전증 치료 방법 |
| CN112089843B (zh) * | 2020-10-13 | 2022-11-04 | 合肥工业大学 | 一种抗心力衰竭的联用组合药物及其在制备抗心力衰竭药物中的应用 |
| AU2022222756A1 (en) * | 2021-02-18 | 2023-09-14 | Beren Therapeutics P.B.C. | Methods for the treatment of familial heterozygous and homozygous hypercholesterolemia with cyclodextrins |
| CN113295793B (zh) * | 2021-05-20 | 2022-11-04 | 复旦大学附属中山医院 | 预测早期糖尿病以及糖尿病发生的生物标志物、其检测方法与应用 |
| US20240238327A1 (en) * | 2021-09-01 | 2024-07-18 | Renatus Inc. | Pharmaceutical composition comprising gamma-cyclodextrin polymer and uses thereof |
| WO2023156966A1 (en) | 2022-02-18 | 2023-08-24 | Beren Therapeutics P.B.C. | Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0672100B2 (ja) * | 1989-11-15 | 1994-09-14 | 株式会社上野製薬応用研究所 | 利尿剤 |
| US5840713A (en) * | 1995-04-03 | 1998-11-24 | Weisz; Paul B. | Therapy for tissue membrane insufficiency |
| CA2348292A1 (en) | 1998-10-30 | 2000-05-11 | Takeda Chemical Industries, Ltd. | Betacellulin protein-containing preparation |
| US6756504B2 (en) * | 2000-04-19 | 2004-06-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sphingolipids |
| US20040121983A1 (en) * | 2002-08-12 | 2004-06-24 | Council Of Scientific And Industrial Research | Method for treating leishmaniasis using methyl-beta-cyclodextrin |
| ES2457017T3 (es) | 2002-08-19 | 2014-04-24 | Soho Flordis International Pty Ltd | Composiciones que comprenden formadores de complejos con la grasa de la dieta y procedimientos para su uso |
| JP2004323443A (ja) * | 2003-04-25 | 2004-11-18 | Tokai Univ | 抗血栓薬 |
| WO2005000217A2 (en) * | 2003-06-06 | 2005-01-06 | Merck & Co., Inc. | Combination therapy for the treatment of dyslipidemia |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| US7393826B2 (en) * | 2003-07-03 | 2008-07-01 | Lipid Sciences, Inc. | Methods and apparatus for creating particle derivatives of HDL with reduced lipid content |
| US7276351B2 (en) | 2003-09-10 | 2007-10-02 | Seahorse Bioscience | Method and device for measuring multiple physiological properties of cells |
| US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
| CN1282425C (zh) * | 2004-06-22 | 2006-11-01 | 王美岭 | 苹果醋营养品及其生产方法 |
| US20060128653A1 (en) | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of decitabine |
| JP2006191830A (ja) * | 2005-01-12 | 2006-07-27 | Unitika Ltd | 脂肪の蓄積を抑制する食品 |
| CA2595606C (en) * | 2005-01-27 | 2014-12-16 | Erimos Pharmaceuticals Llc | Oral formulations for delivery of catecholic butanes including ndga compounds |
| WO2007056435A2 (en) | 2005-11-08 | 2007-05-18 | The General Hospital Corporation | Dynamin mediated diseases and associated methods and products |
| US20090324624A1 (en) * | 2006-06-16 | 2009-12-31 | Florida Atlantic University | Chitin micro-particles as an adjuvant |
| EP1894924A1 (en) * | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| MY150649A (en) * | 2006-10-20 | 2014-02-14 | Icos Corp | Compositions of chk1 inhibitors |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| WO2010042202A1 (en) | 2008-10-07 | 2010-04-15 | Fibrogen, Inc. | Methods for treatment of podocyte injury |
| CN102438614A (zh) * | 2008-10-10 | 2012-05-02 | 利默里克生物制药公司 | 用于治疗的吡喃酮类似物 |
| US8202702B2 (en) | 2008-10-14 | 2012-06-19 | Seahorse Bioscience | Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision |
| US8263413B1 (en) | 2008-10-17 | 2012-09-11 | Andrew S Hansen | Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry |
| EP2352502A4 (en) | 2008-11-06 | 2012-12-26 | Univ Miami | LIMITED PROTEOLYSIS OF CD2AP AND PROGRESSION OF NURSE DISEASE |
| WO2010103823A1 (ja) | 2009-03-12 | 2010-09-16 | パナソニック株式会社 | 画像表示装置および画像表示方法 |
| JP5847721B2 (ja) * | 2009-10-08 | 2016-01-27 | ソン、ホ、バイオメッド、カンパニー、リミテッドＳｏｎｇ Ｈｏ Ｂｉｏｍｅｄ Ｃｏ．， Ｌｔｄ | 高水溶性２−ヒドロキシプロピル−ベータシクロデキストリンを有効成分として含有する、肥満疾患の予防および治療用組成物 |
| US20120251527A1 (en) | 2009-11-06 | 2012-10-04 | University Of Miami | Podocyte specific assays and uses thereof |
| US8372877B2 (en) * | 2010-04-16 | 2013-02-12 | Cumberland Pharmaceuticals | Stabilized statin formulations |
| EP2595623B1 (en) | 2010-07-19 | 2018-02-28 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Use of delta tocopherol for the treatment of lysosomal storage disorders |
| US10052345B2 (en) | 2010-10-19 | 2018-08-21 | University Of Miami | Assays, methods and kits for predicting renal disease and personalized treatment strategies |
| CN104244956B (zh) * | 2012-04-13 | 2020-04-17 | L&F研究有限公司 | 使用环糊精的方法 |
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