ES2958948T3 - Derivados de 2,3-dihidro-1H-pirrolo[3,4-c]piridin-1-ona como inhibidores de HPK1 para el tratamiento del cáncer - Google Patents
Derivados de 2,3-dihidro-1H-pirrolo[3,4-c]piridin-1-ona como inhibidores de HPK1 para el tratamiento del cáncer Download PDFInfo
- Publication number
- ES2958948T3 ES2958948T3 ES19813943T ES19813943T ES2958948T3 ES 2958948 T3 ES2958948 T3 ES 2958948T3 ES 19813943 T ES19813943 T ES 19813943T ES 19813943 T ES19813943 T ES 19813943T ES 2958948 T3 ES2958948 T3 ES 2958948T3
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- alkyl
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- optionally substituted
- halogen
- alkoxy
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- 210000001835 viscera Anatomy 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UANOWFITUWBPCF-UHFFFAOYSA-L zinc;trifluoromethanesulfinate Chemical compound [Zn+2].[O-]S(=O)C(F)(F)F.[O-]S(=O)C(F)(F)F UANOWFITUWBPCF-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862767602P | 2018-11-15 | 2018-11-15 | |
| US201962909970P | 2019-10-03 | 2019-10-03 | |
| PCT/IB2019/059702 WO2020100027A1 (en) | 2018-11-15 | 2019-11-12 | 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-one derivatives as hpk1 inhibitors for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2958948T3 true ES2958948T3 (es) | 2024-02-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19813943T Active ES2958948T3 (es) | 2018-11-15 | 2019-11-12 | Derivados de 2,3-dihidro-1H-pirrolo[3,4-c]piridin-1-ona como inhibidores de HPK1 para el tratamiento del cáncer |
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| JP (1) | JP7118267B2 (ro) |
| KR (1) | KR20210090675A (ro) |
| CN (1) | CN113316576A (ro) |
| AU (1) | AU2019378184B2 (ro) |
| BR (1) | BR112021008991A2 (ro) |
| CA (1) | CA3061392A1 (ro) |
| CL (1) | CL2021001190A1 (ro) |
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| CR (1) | CR20210251A (ro) |
| CU (1) | CU20210035A7 (ro) |
| DK (1) | DK3880676T3 (ro) |
| DO (1) | DOP2021000088A (ro) |
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| FI (1) | FI3880676T3 (ro) |
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| HR (1) | HRP20231089T1 (ro) |
| HU (1) | HUE063367T2 (ro) |
| IL (1) | IL283149A (ro) |
| LT (1) | LT3880676T (ro) |
| MD (1) | MD3880676T2 (ro) |
| MX (1) | MX2021005754A (ro) |
| PE (1) | PE20211868A1 (ro) |
| PH (1) | PH12021551117A1 (ro) |
| PL (1) | PL3880676T3 (ro) |
| PT (1) | PT3880676T (ro) |
| RS (1) | RS64655B1 (ro) |
| SG (1) | SG11202104394XA (ro) |
| SI (1) | SI3880676T1 (ro) |
| TW (1) | TWI718758B (ro) |
| UA (1) | UA127426C2 (ro) |
| UY (1) | UY38471A (ro) |
| WO (1) | WO2020100027A1 (ro) |
| ZA (1) | ZA202103099B (ro) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202103839UA (en) | 2018-10-31 | 2021-05-28 | Gilead Sciences Inc | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
| AU2019373221B2 (en) | 2018-10-31 | 2022-05-26 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity |
| WO2020237025A1 (en) | 2019-05-23 | 2020-11-26 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| AU2021265578B2 (en) * | 2020-05-01 | 2024-03-28 | Pfizer Inc. | Azalactam compounds as HPK1 inhibitors |
| CN112409268A (zh) * | 2020-12-03 | 2021-02-26 | 西南交通大学 | 靶向Fam20C抑制剂的制备及其抗三阴性乳腺癌作用 |
| WO2022258044A1 (zh) * | 2021-06-11 | 2022-12-15 | 杭州中美华东制药有限公司 | 吡咯并吡啶酮类化合物及其制备方法和用途 |
| JP2024527623A (ja) | 2021-07-20 | 2024-07-25 | アストラゼネカ・アクチエボラーグ | 癌の治療のためのｈｐｋ１阻害剤としての置換ピラジン－２－カルボキサミド阻害剤 |
| WO2023023942A1 (en) * | 2021-08-24 | 2023-03-02 | Biofront Ltd (Cayman) | Hpk1 inhibitors, compositions comprising hpk1 inhibitor, and methods of using the same |
| CN118103369A (zh) * | 2021-09-03 | 2024-05-28 | 浙江海正药业股份有限公司 | 吡啶并内酰胺类衍生物及其制备方法和用途 |
| WO2023057883A1 (en) * | 2021-10-05 | 2023-04-13 | Pfizer Inc. | Crystalline form of azalactam compound |
| KR20240077873A (ko) | 2022-11-25 | 2024-06-03 | 충남대학교산학협력단 | 이미다조피리딘 유도체, 이를 유효성분으로 포함하는 약제학적 조성물 및 이를 이용하는 암의 치료 방법 |
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| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5243049A (en) * | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| AU2008279776B2 (en) * | 2007-07-19 | 2013-05-23 | Merck Sharp & Dohme Corp. | Heterocyclic amide compounds as protein kinase inhibitors |
| US10800773B2 (en) | 2016-09-12 | 2020-10-13 | Integral Health, Inc. | Monocyclic compounds useful as GPR120 modulators |
| CN110402248B (zh) | 2017-03-15 | 2023-01-06 | 豪夫迈·罗氏有限公司 | 作为hpk1抑制剂的氮杂吲哚类 |
| TW201908306A (zh) | 2017-07-18 | 2019-03-01 | 大陸商南京聖和藥業股份有限公司 | 作為ask抑制劑的雜環化合物及其應用 |
| US20220324835A1 (en) | 2018-01-26 | 2022-10-13 | Nurix Therapeutics, Inc. | Inhibitors of cbl-b and methods of use thereof |
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2019
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- 2019-11-12 WO PCT/IB2019/059702 patent/WO2020100027A1/en active Application Filing
- 2019-11-12 ES ES19813943T patent/ES2958948T3/es active Active
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2021
- 2021-05-06 CL CL2021001190A patent/CL2021001190A1/es unknown
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- 2021-05-14 PH PH12021551117A patent/PH12021551117A1/en unknown
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