ES2951287T3 - Método para controlar la formación del color rosa durante la fabricación de anticuerpos - Google Patents

Método para controlar la formación del color rosa durante la fabricación de anticuerpos Download PDF

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Publication number
ES2951287T3
ES2951287T3 ES18734651T ES18734651T ES2951287T3 ES 2951287 T3 ES2951287 T3 ES 2951287T3 ES 18734651 T ES18734651 T ES 18734651T ES 18734651 T ES18734651 T ES 18734651T ES 2951287 T3 ES2951287 T3 ES 2951287T3
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ES
Spain
Prior art keywords
antibody
cbl
cell culture
mab
hydrogen peroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18734651T
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English (en)
Spanish (es)
Inventor
Cheng Du
Ameya Umesh Borwankar
Joon Chong Yee
Zhijun Tan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2951287T3 publication Critical patent/ES2951287T3/es
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES18734651T 2017-05-09 2018-05-08 Método para controlar la formación del color rosa durante la fabricación de anticuerpos Active ES2951287T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762503615P 2017-05-09 2017-05-09
PCT/US2018/031542 WO2018208743A1 (en) 2017-05-09 2018-05-08 Method of controlling the formation of pink color during antibody manufacturing

Publications (1)

Publication Number Publication Date
ES2951287T3 true ES2951287T3 (es) 2023-10-19

Family

ID=62751522

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18734651T Active ES2951287T3 (es) 2017-05-09 2018-05-08 Método para controlar la formación del color rosa durante la fabricación de anticuerpos

Country Status (7)

Country Link
US (1) US12241107B2 (https=)
EP (1) EP3621989B1 (https=)
JP (2) JP7453788B2 (https=)
KR (1) KR102664829B1 (https=)
CN (1) CN110831964A (https=)
ES (1) ES2951287T3 (https=)
WO (1) WO2018208743A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7621284B2 (ja) 2020-01-31 2025-01-24 中外製薬株式会社 着色を抑制したポリペプチドを含む組成物の製造方法
KR20250069604A (ko) * 2022-09-15 2025-05-19 사노피 단백질 환원 민감성의 결정 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2689458B2 (ja) * 1988-02-09 1997-12-10 武田薬品工業株式会社 粒状ないし粉末状のビタミンｂ▲下１▼▲下２▼類含有組成物
JP2734709B2 (ja) * 1990-01-05 1998-04-02 東レ株式会社 インクジェット染色用布帛およびそれを用いてなるインクジェット染色法
SE525083C2 (sv) * 2003-04-23 2004-11-23 Kemira Kemi Ab Sätt att behandla rötslam
AU2005310305A1 (en) * 2004-10-22 2006-06-08 Amgen Inc. Methods for refolding polypeptides
EP1971488A2 (en) * 2005-12-05 2008-09-24 Lifeline Cell Technology Cell culture medium container assembly
KR102055873B1 (ko) * 2007-07-09 2019-12-13 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
CA2765220A1 (en) 2009-07-14 2011-01-20 Biogen Idec Ma Inc. Methods for inhibiting yellow color and peroxide formation in a composition
KR20160088930A (ko) 2013-12-04 2016-07-26 이뮤노젠 아이엔씨 항체 생산용 조성물 및 항체 생성 방법

Also Published As

Publication number Publication date
WO2018208743A9 (en) 2019-12-05
EP3621989B1 (en) 2023-06-28
US12241107B2 (en) 2025-03-04
WO2018208743A1 (en) 2018-11-15
JP2023182593A (ja) 2023-12-26
JP2020519265A (ja) 2020-07-02
JP7453788B2 (ja) 2024-03-21
EP3621989A1 (en) 2020-03-18
CN110831964A (zh) 2020-02-21
KR102664829B1 (ko) 2024-05-09
US20230103511A1 (en) 2023-04-06
KR20200004355A (ko) 2020-01-13

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