KR102664829B1 - 항체 제작 동안 핑크색의 형성을 제어하는 방법 - Google Patents

항체 제작 동안 핑크색의 형성을 제어하는 방법 Download PDF

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KR102664829B1
KR102664829B1 KR1020197035852A KR20197035852A KR102664829B1 KR 102664829 B1 KR102664829 B1 KR 102664829B1 KR 1020197035852 A KR1020197035852 A KR 1020197035852A KR 20197035852 A KR20197035852 A KR 20197035852A KR 102664829 B1 KR102664829 B1 KR 102664829B1
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South Korea
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antibody
cbl
mab
hydrogen peroxide
reduction
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Korean (ko)
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KR20200004355A (ko
Inventor
쳉 두
아메야 우메쉬 보르완카르
준 총 이
지준 탄
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020197035852A 2017-05-09 2018-05-08 항체 제작 동안 핑크색의 형성을 제어하는 방법 Active KR102664829B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762503615P 2017-05-09 2017-05-09
US62/503,615 2017-05-09
PCT/US2018/031542 WO2018208743A1 (en) 2017-05-09 2018-05-08 Method of controlling the formation of pink color during antibody manufacturing

Publications (2)

Publication Number Publication Date
KR20200004355A KR20200004355A (ko) 2020-01-13
KR102664829B1 true KR102664829B1 (ko) 2024-05-09

Family

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KR1020197035852A Active KR102664829B1 (ko) 2017-05-09 2018-05-08 항체 제작 동안 핑크색의 형성을 제어하는 방법

Country Status (7)

Country Link
US (1) US12241107B2 (https=)
EP (1) EP3621989B1 (https=)
JP (2) JP7453788B2 (https=)
KR (1) KR102664829B1 (https=)
CN (1) CN110831964A (https=)
ES (1) ES2951287T3 (https=)
WO (1) WO2018208743A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7621284B2 (ja) 2020-01-31 2025-01-24 中外製薬株式会社 着色を抑制したポリペプチドを含む組成物の製造方法
KR20250069604A (ko) * 2022-09-15 2025-05-19 사노피 단백질 환원 민감성의 결정 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2689458B2 (ja) * 1988-02-09 1997-12-10 武田薬品工業株式会社 粒状ないし粉末状のビタミンｂ▲下１▼▲下２▼類含有組成物
JP2734709B2 (ja) * 1990-01-05 1998-04-02 東レ株式会社 インクジェット染色用布帛およびそれを用いてなるインクジェット染色法
SE525083C2 (sv) * 2003-04-23 2004-11-23 Kemira Kemi Ab Sätt att behandla rötslam
AU2005310305A1 (en) * 2004-10-22 2006-06-08 Amgen Inc. Methods for refolding polypeptides
EP1971488A2 (en) * 2005-12-05 2008-09-24 Lifeline Cell Technology Cell culture medium container assembly
KR102055873B1 (ko) * 2007-07-09 2019-12-13 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
CA2765220A1 (en) 2009-07-14 2011-01-20 Biogen Idec Ma Inc. Methods for inhibiting yellow color and peroxide formation in a composition
KR20160088930A (ko) 2013-12-04 2016-07-26 이뮤노젠 아이엔씨 항체 생산용 조성물 및 항체 생성 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Journal of Pharmaceutical Sciences, 제94권, 제304-316면 (2005년)*
mAbs, 제5권, 제6호, 제974-981면 (2013년)*
mAbs, 제6권, 제3호, 제679-688면 (2014년)*

Also Published As

Publication number Publication date
ES2951287T3 (es) 2023-10-19
WO2018208743A9 (en) 2019-12-05
EP3621989B1 (en) 2023-06-28
US12241107B2 (en) 2025-03-04
WO2018208743A1 (en) 2018-11-15
JP2023182593A (ja) 2023-12-26
JP2020519265A (ja) 2020-07-02
JP7453788B2 (ja) 2024-03-21
EP3621989A1 (en) 2020-03-18
CN110831964A (zh) 2020-02-21
US20230103511A1 (en) 2023-04-06
KR20200004355A (ko) 2020-01-13

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