ES2940620T3 - Métodos de preparación de muestras de ácido nucleico para la secuenciación del repertorio inmunitario - Google Patents
Métodos de preparación de muestras de ácido nucleico para la secuenciación del repertorio inmunitario Download PDFInfo
- Publication number
- ES2940620T3 ES2940620T3 ES17868046T ES17868046T ES2940620T3 ES 2940620 T3 ES2940620 T3 ES 2940620T3 ES 17868046 T ES17868046 T ES 17868046T ES 17868046 T ES17868046 T ES 17868046T ES 2940620 T3 ES2940620 T3 ES 2940620T3
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- Prior art keywords
- nucleic acid
- primer
- target
- sequence
- adapter
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416677P | 2016-11-02 | 2016-11-02 | |
| PCT/US2017/059804 WO2018085599A2 (en) | 2016-11-02 | 2017-11-02 | Methods of nucleic acid sample preparation for immune repertoire sequencing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2940620T3 true ES2940620T3 (es) | 2023-05-09 |
Family
ID=62077010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17868046T Active ES2940620T3 (es) | 2016-11-02 | 2017-11-02 | Métodos de preparación de muestras de ácido nucleico para la secuenciación del repertorio inmunitario |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10947582B2 (enExample) |
| EP (2) | EP4198140B1 (enExample) |
| JP (2) | JP7161991B2 (enExample) |
| CN (1) | CN110191959B (enExample) |
| AU (2) | AU2017355460B2 (enExample) |
| CA (1) | CA3042391A1 (enExample) |
| ES (1) | ES2940620T3 (enExample) |
| WO (1) | WO2018085599A2 (enExample) |
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| EP2847353B1 (en) | 2012-05-10 | 2022-01-19 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
| US9410173B2 (en) * | 2012-10-24 | 2016-08-09 | Clontech Laboratories, Inc. | Template switch-based methods for producing a product nucleic acid |
| JP7016215B2 (ja) | 2014-01-27 | 2022-02-04 | ザ ジェネラル ホスピタル コーポレイション | 配列決定のために核酸を調製する方法 |
| CN120425026A (zh) | 2015-04-10 | 2025-08-05 | 十程基因技术瑞典公司 | 生物样本的空间区别、多重核酸分析 |
| CA3037185A1 (en) | 2016-09-15 | 2018-03-22 | ArcherDX, Inc. | Methods of nucleic acid sample preparation |
| JP6997773B2 (ja) | 2016-09-15 | 2022-01-18 | アーチャーディーエックス， エルエルシー | 無細胞ｄｎａの分析用の核酸サンプル調製の方法 |
| CN110191959B (zh) * | 2016-11-02 | 2024-04-09 | 阿谢尔德克斯有限责任公司 | 用于免疫组库测序的核酸样品制备方法 |
| US12188014B1 (en) * | 2018-07-25 | 2025-01-07 | 10X Genomics, Inc. | Compositions and methods for nucleic acid processing using blocking agents |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| US20220290217A1 (en) | 2018-12-10 | 2022-09-15 | 10X Genomics, Inc. | Resolving spatial arrays using deconvolution |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020229437A1 (en) * | 2019-05-14 | 2020-11-19 | F. Hoffmann-La Roche Ag | Devices and methods for sample analysis |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| CN111139286B (zh) * | 2019-11-07 | 2023-11-21 | 南方医科大学南方医院 | 一种bcr高通量测序文库的构建方法 |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| CN121022991A (zh) | 2019-12-23 | 2025-11-28 | 10X基因组学有限公司 | 使用rna模板化连接进行空间分析的方法 |
| EP4081656A1 (en) | 2019-12-23 | 2022-11-02 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| EP4081777B1 (en) | 2019-12-23 | 2026-02-18 | 10X Genomics, Inc. | Reversible fixing reagents and methods of use thereof |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| WO2021216708A1 (en) | 2020-04-22 | 2021-10-28 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| EP4414459B1 (en) | 2020-05-22 | 2025-09-03 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
| EP4158054B1 (en) | 2020-06-02 | 2025-04-16 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| EP4446430A3 (en) | 2020-06-10 | 2024-12-18 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
| WO2021263111A1 (en) | 2020-06-25 | 2021-12-30 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
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-
2017
- 2017-11-02 CN CN201780080046.0A patent/CN110191959B/zh active Active
- 2017-11-02 WO PCT/US2017/059804 patent/WO2018085599A2/en not_active Ceased
- 2017-11-02 AU AU2017355460A patent/AU2017355460B2/en active Active
- 2017-11-02 EP EP22209186.0A patent/EP4198140B1/en active Active
- 2017-11-02 EP EP17868046.8A patent/EP3535405B1/en active Active
- 2017-11-02 JP JP2019522907A patent/JP7161991B2/ja active Active
- 2017-11-02 ES ES17868046T patent/ES2940620T3/es active Active
- 2017-11-02 CA CA3042391A patent/CA3042391A1/en active Pending
- 2017-11-02 US US15/802,408 patent/US10947582B2/en active Active
-
2021
- 2021-02-17 US US17/177,740 patent/US20210180118A1/en not_active Abandoned
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2022
- 2022-10-17 JP JP2022166273A patent/JP7483824B2/ja active Active
-
2023
- 2023-03-06 AU AU2023201370A patent/AU2023201370B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022185155A (ja) | 2022-12-13 |
| AU2023201370B2 (en) | 2025-08-28 |
| US20210180118A1 (en) | 2021-06-17 |
| EP3535405A2 (en) | 2019-09-11 |
| EP3535405A4 (en) | 2020-07-15 |
| EP4198140B1 (en) | 2024-09-04 |
| AU2017355460B2 (en) | 2022-12-08 |
| JP7483824B2 (ja) | 2024-05-15 |
| US10947582B2 (en) | 2021-03-16 |
| EP3535405B1 (en) | 2022-12-21 |
| US20180155767A1 (en) | 2018-06-07 |
| AU2017355460A1 (en) | 2019-05-23 |
| JP7161991B2 (ja) | 2022-10-27 |
| CN110191959A (zh) | 2019-08-30 |
| WO2018085599A2 (en) | 2018-05-11 |
| JP2019537439A (ja) | 2019-12-26 |
| EP4198140A1 (en) | 2023-06-21 |
| AU2023201370A1 (en) | 2023-04-13 |
| EP4198140C0 (en) | 2024-09-04 |
| CA3042391A1 (en) | 2018-05-11 |
| WO2018085599A3 (en) | 2018-06-07 |
| CN110191959B (zh) | 2024-04-09 |
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