ES2940087T3 - Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) - Google Patents

Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) Download PDF

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Publication number
ES2940087T3
ES2940087T3 ES18742985T ES18742985T ES2940087T3 ES 2940087 T3 ES2940087 T3 ES 2940087T3 ES 18742985 T ES18742985 T ES 18742985T ES 18742985 T ES18742985 T ES 18742985T ES 2940087 T3 ES2940087 T3 ES 2940087T3
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cancer
fsps
fsp
cvp
fsm
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Spanish (es)
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Alfredo Nicosia
Elisa Scarselli
Guido Leoni
Armin Lahm
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Nouscom AG
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Nouscom AG
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10Sequence alignment; Homology search
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES18742985T 2017-07-12 2018-07-12 Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) Active ES2940087T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17181026 2017-07-12
PCT/EP2018/069032 WO2019012082A1 (en) 2017-07-12 2018-07-12 UNIVERSAL VACCINE BASED ON SHARED TUMOR NEO-ANTIGENS FOR THE PREVENTION AND TREATMENT OF MICRO-SATELLITE INSTABILITY CANCER (MSI)

Publications (1)

Publication Number Publication Date
ES2940087T3 true ES2940087T3 (es) 2023-05-03

Family

ID=59366234

Family Applications (1)

Application Number Title Priority Date Filing Date
ES18742985T Active ES2940087T3 (es) 2017-07-12 2018-07-12 Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI)

Country Status (19)

Country Link
US (1) US11578109B2 (OSRAM)
EP (1) EP3652606B1 (OSRAM)
JP (1) JP7274223B2 (OSRAM)
KR (1) KR102709778B1 (OSRAM)
CN (1) CN111328420B (OSRAM)
AU (1) AU2018298849B2 (OSRAM)
BR (1) BR112020000590A2 (OSRAM)
CA (1) CA3069047A1 (OSRAM)
DK (1) DK3652606T5 (OSRAM)
ES (1) ES2940087T3 (OSRAM)
FI (1) FI3652606T3 (OSRAM)
HU (1) HUE061840T2 (OSRAM)
IL (1) IL271966B2 (OSRAM)
MX (1) MX2020000413A (OSRAM)
NZ (1) NZ759940A (OSRAM)
PL (1) PL3652606T3 (OSRAM)
PT (1) PT3652606T (OSRAM)
SG (1) SG11202000250PA (OSRAM)
WO (1) WO2019012082A1 (OSRAM)

Families Citing this family (12)

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IL321692A (en) 2018-07-26 2025-08-01 Curevac Netherlands B V Cancer vaccines for colorectal cancer
EP3827265A1 (en) 2018-07-26 2021-06-02 Frame Pharmaceuticals B.V. Cancer vaccines for kidney cancer
IL321690A (en) 2018-07-26 2025-08-01 Curevac Netherlands B V Cancer vaccines for uterine cancer
US20210252123A1 (en) 2018-07-26 2021-08-19 Frame Pharmaceuticals B.V. ARID1A, CDKN2A, KMT2B, KMT2D, TP53 and PTEN VACCINES FOR CANCER
IL321689A (en) 2018-07-26 2025-08-01 Curevac Netherlands B V Vaccines against breast cancer
IL280110B2 (en) * 2018-07-26 2025-07-01 Curevac Netherlands B V Cancer vaccines ready for use
TWI852977B (zh) * 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
WO2020163802A1 (en) * 2019-02-07 2020-08-13 Arizona Board Of Regents On Behalf Of Arizona State University Cancer specific frameshift vaccines
PH12022551208A1 (en) 2019-11-18 2023-04-24 Janssen Biotech Inc Vaccines based on mutant calr and jak2 and their uses
WO2021228999A1 (en) * 2020-05-12 2021-11-18 Institut Curie Neoantigenic epitopes associated with sf3b1 mutations
WO2022009052A2 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022216856A1 (en) * 2021-04-06 2022-10-13 Board Of Regents, The University Of Texas System Methods and compositions comprising mhc class i peptides

Family Cites Families (18)

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US5922315A (en) 1997-01-24 1999-07-13 Genetic Therapy, Inc. Adenoviruses having altered hexon proteins
WO2003087162A2 (en) * 2002-04-18 2003-10-23 Mtm Laboratories Ag Neopeptides and methods useful for detection and treatment of cancer
WO2004092338A2 (en) * 2003-04-11 2004-10-28 Diadexus, Inc. Compositions, splice variants and methods relating to cancer specific genes and proteins
CN1824325A (zh) * 2005-12-16 2006-08-30 武汉大学 人乳头病毒dna嵌合疫苗及制备方法和应用
BRPI0717651A2 (pt) * 2006-10-17 2013-12-24 Oncotherapy Science Inc Vacinas de peptídeo para cânceres que expressam polipeptídeos mphosph1 ou depdc1
TW201102081A (en) * 2009-05-11 2011-01-16 Oncotherapy Science Inc TTK peptides and vaccines including the same
ES2511051T3 (es) 2009-05-29 2014-10-22 Morphosys Ag Colección de anticuerpos sintéticos para tratar enfermedades
JP2013523084A (ja) * 2010-04-09 2013-06-17 オンコセラピー・サイエンス株式会社 Cdca5ペプチドおよびそれを含むワクチン
EP2688907B1 (en) * 2011-03-24 2016-04-27 Institut National de la Sante et de la Recherche Medicale (INSERM) Dominant negative hsp110 mutant and its use in prognosing and treating cancers
MX350220B (es) * 2011-08-12 2017-08-30 Oncotherapy Science Inc Peptidos de mphosph1 y vacunas que incluyen los mismos.
KR101810840B1 (ko) * 2012-12-13 2017-12-20 루프레히트-칼스-유니페어지테트 하이델베르크 암의 예방 및 치료용 msi-특이적 프레임쉬프트 펩티드(fsp)
US9205140B2 (en) * 2012-12-13 2015-12-08 Ruprecht-Karls-Universität MSI-specific frameshift peptides (FSP) for prevention and treatment of cancer
JP5890769B2 (ja) * 2012-12-13 2016-03-22 ループレヒト−カルルス・ウニヴェルジテート・ハイデルベルクRuprecht−Karls−Universitaet Heidelberg がんの予防及び治療のためのmsi特異的なフレームシフトペプチド(fsp)
US20140235456A1 (en) * 2012-12-17 2014-08-21 Virginia Tech Intellectual Properties, Inc. Methods and Compositions for Identifying Global Microsatellite Instability and for Characterizing Informative Microsatellite Loci
WO2015112930A1 (en) * 2014-01-27 2015-07-30 Yale University Novel methods of identifying patients responsive to immunotherapeutic strategies
WO2016187508A2 (en) * 2015-05-20 2016-11-24 The Broad Institute Inc. Shared neoantigens
CN106350578A (zh) * 2015-07-13 2017-01-25 中国人民解放军第二军医大学 Ny-eso-1在微卫星不稳定性肠癌的诊断和治疗中的应用
WO2017020026A1 (en) 2015-07-30 2017-02-02 Modernatx, Inc. Concatemeric peptide epitopes rnas

Also Published As

Publication number Publication date
EP3652606A1 (en) 2020-05-20
KR20200029443A (ko) 2020-03-18
JP2020532288A (ja) 2020-11-12
MX2020000413A (es) 2020-09-28
DK3652606T5 (da) 2024-08-26
PL3652606T3 (pl) 2023-04-24
CA3069047A1 (en) 2019-01-17
PT3652606T (pt) 2023-03-16
AU2018298849B2 (en) 2022-07-14
FI3652606T3 (fi) 2023-03-16
KR102709778B1 (ko) 2024-09-26
CN111328420A (zh) 2020-06-23
WO2019012082A9 (en) 2019-05-02
AU2018298849A1 (en) 2020-01-02
CN111328420B (zh) 2023-07-25
DK3652606T3 (da) 2023-03-13
IL271966A (en) 2020-02-27
EP3652606B1 (en) 2023-01-11
NZ759940A (en) 2023-07-28
RU2019144505A (ru) 2021-08-12
RU2019144505A3 (OSRAM) 2021-08-12
SG11202000250PA (en) 2020-02-27
WO2019012082A1 (en) 2019-01-17
US11578109B2 (en) 2023-02-14
US20200222519A1 (en) 2020-07-16
HUE061840T2 (hu) 2023-08-28
BR112020000590A2 (pt) 2020-07-14
JP7274223B2 (ja) 2023-05-16
IL271966B2 (en) 2025-01-01
IL271966B1 (en) 2024-09-01

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