ES2931530T3 - Método para generar progenitores de células T - Google Patents

Método para generar progenitores de células T Download PDF

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Publication number
ES2931530T3
ES2931530T3 ES18704551T ES18704551T ES2931530T3 ES 2931530 T3 ES2931530 T3 ES 2931530T3 ES 18704551 T ES18704551 T ES 18704551T ES 18704551 T ES18704551 T ES 18704551T ES 2931530 T3 ES2931530 T3 ES 2931530T3
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Prior art keywords
cells
alpha
cell
tnf
vitro method
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English (en)
Spanish (es)
Inventor
Isabelle Andre
Marina Cavazzana
Kuiying Ma
John Tchen
Tayebeh-Shabi Soheili
Moirangthem Ranjita Devi
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Fondation Imagine Inst Des Maladies Genetiques
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Cite
Original Assignee
Fondation Imagine Inst Des Maladies Genetiques
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Cite
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/125Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/145Thrombopoietin [TPO]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2307Interleukin-7 (IL-7)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/26Flt-3 ligand (CD135L, flk-2 ligand)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/42Notch; Delta; Jagged; Serrate
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
ES18704551T 2017-02-13 2018-02-12 Método para generar progenitores de células T Active ES2931530T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17305161 2017-02-13
PCT/EP2018/053406 WO2018146297A1 (en) 2017-02-13 2018-02-12 Method for generating t cells progenitors

Publications (1)

Publication Number Publication Date
ES2931530T3 true ES2931530T3 (es) 2022-12-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES18704551T Active ES2931530T3 (es) 2017-02-13 2018-02-12 Método para generar progenitores de células T

Country Status (17)

Country Link
US (5) US20200046767A1 (https=)
EP (2) EP3580330B1 (https=)
JP (2) JP7164798B2 (https=)
KR (1) KR102666158B1 (https=)
CN (1) CN110506110B (https=)
AU (1) AU2018217404B2 (https=)
BR (1) BR112019016672A8 (https=)
CA (1) CA3053294A1 (https=)
DK (1) DK3580330T3 (https=)
ES (1) ES2931530T3 (https=)
HU (1) HUE060548T2 (https=)
IL (1) IL268641B2 (https=)
MA (1) MA47541A (https=)
PL (1) PL3580330T3 (https=)
PT (1) PT3580330T (https=)
WO (1) WO2018146297A1 (https=)
ZA (1) ZA201905470B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors
WO2019067811A1 (en) * 2017-09-29 2019-04-04 Regents Of The University Of Minnesota METHODS OF MANUFACTURING, EXPANDING AND USING HUMAN PROGENITOR CELL
JP2021514185A (ja) 2018-02-14 2021-06-10 サニーブルック リサーチ インスティチュート T細胞系列の細胞を発生させるための方法
US12497593B2 (en) 2018-09-07 2025-12-16 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
AU2020265737A1 (en) * 2019-05-01 2021-12-02 Immunebridge Inc. Methods of making oligopotent and unipotent precursors
AU2020301413A1 (en) * 2019-06-24 2022-02-10 Children's Hospital Los Angeles BCL11B overexpression to enhance human thymopoiesis T cell function
EP4058562A4 (en) * 2019-11-14 2023-12-20 Zandstra, Peter William MEDIA FORMULATIONS AND PROCESSES FOR PRODUCING PROGENITOR T CELLS
WO2021200901A1 (ja) * 2020-03-31 2021-10-07 国立大学法人京都大学 T前駆細胞の製造方法
EP4251651A4 (en) 2020-11-30 2025-07-09 Cho Pharma Inc ANTIBODIES FOR CELL ENRICHMENT
CN117377756A (zh) * 2021-03-05 2024-01-09 菲克特生物科学股份有限公司 工程化免疫细胞疗法
EP4347793A1 (en) * 2021-05-25 2024-04-10 Universiteit Gent Generating t cell precursors via agonizing tumor necrosis factor receptor 2
EP4426319A1 (en) * 2021-11-04 2024-09-11 APHP (Assistance Publique - Hôpitaux de Paris) Method for generating nk cells
FR3130843A1 (fr) * 2021-12-21 2023-06-23 Universite Claude Bernard Lyon 1 Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
WO2024156066A1 (en) 2023-01-27 2024-08-02 Notch Therapeutics (Canada), Inc. Method for generating t cell lineage populations from stem/progenitor cells
KR20250152088A (ko) * 2023-02-22 2025-10-22 메이라지티엑스 셀 테라피스 흉선 재생 방법
US20250332260A1 (en) 2024-04-10 2025-10-30 Garuda Therapeutics, Inc. Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025219552A1 (en) 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) * 2024-12-21 2025-08-08 湖南农业大学 OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

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US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
JP2001525176A (ja) 1997-12-04 2001-12-11 デューク・ユニバーシティー Cd7+cd34−lin−造血細胞を単離し、使用する方法
WO2009097140A1 (en) 2008-01-30 2009-08-06 Memorial Sloan-Kettering Cancer Center Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors
BRPI0919020B8 (pt) 2008-09-12 2021-05-25 Cryopraxis Criobiologia Ltda uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris
JP5756017B2 (ja) 2008-11-07 2015-07-29 サニーブルック ヘルス サイエンシズ センター ヒト前駆t細胞
US8871510B2 (en) 2009-12-03 2014-10-28 University Of Utah Research Foundation Methods for generating T lymphocytes from hematopoietic stem cells
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
CA2858069C (en) * 2011-12-08 2020-02-11 Novartis Ag Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US20150352180A1 (en) 2013-01-11 2015-12-10 The Trustee Of The University Of Pennsylvania Notch Ligand Bound Biocompatible Substrates And Their Use In Bone Formation
CA2954168C (en) 2013-08-02 2023-09-19 The Regents Of The University Of California Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors
WO2015099134A1 (ja) 2013-12-26 2015-07-02 アストリム株式会社 再構成されたt細胞レセプター遺伝子を有する多能性幹細胞由来のt前駆細胞を用いる免疫細胞療法
KR20160145802A (ko) 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
JP6661544B2 (ja) * 2014-04-24 2020-03-11 ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 遺伝子改変したt細胞の自動生成法
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FR3026744B1 (fr) * 2014-10-06 2024-04-19 Hopitaux Paris Assist Publique Methode de generation de progeniteurs de cellules t
CA2989858A1 (en) 2015-06-17 2016-12-22 The Uab Research Foundation Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
JP7049261B2 (ja) 2016-04-08 2022-04-06 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント 幹細胞および/または前駆細胞からt前駆細胞を作製する方法ならびに該t前駆細胞の使用
IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors

Also Published As

Publication number Publication date
IL268641A (en) 2019-10-31
AU2018217404A2 (en) 2019-09-19
BR112019016672A2 (pt) 2020-04-14
US20200046767A1 (en) 2020-02-13
US20200390817A1 (en) 2020-12-17
JP2020513844A (ja) 2020-05-21
JP2022185024A (ja) 2022-12-13
AU2018217404A1 (en) 2019-09-05
MA47541A (fr) 2019-12-18
WO2018146297A1 (en) 2018-08-16
DK3580330T3 (da) 2022-12-05
HUE060548T2 (hu) 2023-03-28
EP4067482A1 (en) 2022-10-05
US11426430B2 (en) 2022-08-30
IL268641B1 (en) 2024-06-01
IL268641B2 (en) 2024-10-01
RU2019125600A3 (https=) 2021-11-03
EP3580330B1 (en) 2022-08-31
US11642376B2 (en) 2023-05-09
ZA201905470B (en) 2024-12-18
US20230293586A1 (en) 2023-09-21
PT3580330T (pt) 2022-12-06
CN110506110A (zh) 2019-11-26
US11638723B2 (en) 2023-05-02
CN110506110B (zh) 2024-09-06
EP3580330A1 (en) 2019-12-18
CA3053294A1 (en) 2018-08-16
KR20190117550A (ko) 2019-10-16
RU2019125600A (ru) 2021-03-15
BR112019016672A8 (pt) 2022-11-22
US20210169934A1 (en) 2021-06-10
KR102666158B1 (ko) 2024-05-16
AU2018217404B2 (en) 2024-03-28
PL3580330T3 (pl) 2023-01-16
JP7164798B2 (ja) 2022-11-02
US20210169935A1 (en) 2021-06-10

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