KR102666158B1 - T 세포 전구체(progenitor)의 생성 방법 - Google Patents

T 세포 전구체(progenitor)의 생성 방법 Download PDF

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KR102666158B1
KR102666158B1 KR1020197024529A KR20197024529A KR102666158B1 KR 102666158 B1 KR102666158 B1 KR 102666158B1 KR 1020197024529 A KR1020197024529 A KR 1020197024529A KR 20197024529 A KR20197024529 A KR 20197024529A KR 102666158 B1 KR102666158 B1 KR 102666158B1
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KR20190117550A (ko
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이자벨 안드레
마리나 카바자나
쿠이잉 마
존 첸
타예베흐-샤비 소헬리
모이랑뎀 란지타 데비
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아시스땅스 퍼블리끄-오삐또 드 빠리
폰데이션 이메진 - 인스티튜트 데스 말라다이스 제네티크
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸)
유니베르시떼 파리 시테
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020197024529A 2017-02-13 2018-02-12 T 세포 전구체(progenitor)의 생성 방법 Active KR102666158B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305161.6 2017-02-13
EP17305161 2017-02-13
PCT/EP2018/053406 WO2018146297A1 (en) 2017-02-13 2018-02-12 Method for generating t cells progenitors

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KR20190117550A KR20190117550A (ko) 2019-10-16
KR102666158B1 true KR102666158B1 (ko) 2024-05-16

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US (5) US20200046767A1 (https=)
EP (2) EP3580330B1 (https=)
JP (2) JP7164798B2 (https=)
KR (1) KR102666158B1 (https=)
CN (1) CN110506110B (https=)
AU (1) AU2018217404B2 (https=)
BR (1) BR112019016672A8 (https=)
CA (1) CA3053294A1 (https=)
DK (1) DK3580330T3 (https=)
ES (1) ES2931530T3 (https=)
HU (1) HUE060548T2 (https=)
IL (1) IL268641B2 (https=)
MA (1) MA47541A (https=)
PL (1) PL3580330T3 (https=)
PT (1) PT3580330T (https=)
WO (1) WO2018146297A1 (https=)
ZA (1) ZA201905470B (https=)

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IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors
WO2019067811A1 (en) * 2017-09-29 2019-04-04 Regents Of The University Of Minnesota METHODS OF MANUFACTURING, EXPANDING AND USING HUMAN PROGENITOR CELL
JP2021514185A (ja) 2018-02-14 2021-06-10 サニーブルック リサーチ インスティチュート Ｔ細胞系列の細胞を発生させるための方法
US12497593B2 (en) 2018-09-07 2025-12-16 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
AU2020265737A1 (en) * 2019-05-01 2021-12-02 Immunebridge Inc. Methods of making oligopotent and unipotent precursors
AU2020301413A1 (en) * 2019-06-24 2022-02-10 Children's Hospital Los Angeles BCL11B overexpression to enhance human thymopoiesis T cell function
EP4058562A4 (en) * 2019-11-14 2023-12-20 Zandstra, Peter William MEDIA FORMULATIONS AND PROCESSES FOR PRODUCING PROGENITOR T CELLS
WO2021200901A1 (ja) * 2020-03-31 2021-10-07 国立大学法人京都大学 Ｔ前駆細胞の製造方法
EP4251651A4 (en) 2020-11-30 2025-07-09 Cho Pharma Inc ANTIBODIES FOR CELL ENRICHMENT
CN117377756A (zh) * 2021-03-05 2024-01-09 菲克特生物科学股份有限公司 工程化免疫细胞疗法
EP4347793A1 (en) * 2021-05-25 2024-04-10 Universiteit Gent Generating t cell precursors via agonizing tumor necrosis factor receptor 2
EP4426319A1 (en) * 2021-11-04 2024-09-11 APHP (Assistance Publique - Hôpitaux de Paris) Method for generating nk cells
FR3130843A1 (fr) * 2021-12-21 2023-06-23 Universite Claude Bernard Lyon 1 Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
WO2024156066A1 (en) 2023-01-27 2024-08-02 Notch Therapeutics (Canada), Inc. Method for generating t cell lineage populations from stem/progenitor cells
KR20250152088A (ko) * 2023-02-22 2025-10-22 메이라지티엑스 셀 테라피스 흉선 재생 방법
US20250332260A1 (en) 2024-04-10 2025-10-30 Garuda Therapeutics, Inc. Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025219552A1 (en) 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) * 2024-12-21 2025-08-08 湖南农业大学 OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

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IL268641A (en) 2019-10-31
AU2018217404A2 (en) 2019-09-19
BR112019016672A2 (pt) 2020-04-14
US20200046767A1 (en) 2020-02-13
US20200390817A1 (en) 2020-12-17
JP2020513844A (ja) 2020-05-21
JP2022185024A (ja) 2022-12-13
AU2018217404A1 (en) 2019-09-05
MA47541A (fr) 2019-12-18
WO2018146297A1 (en) 2018-08-16
DK3580330T3 (da) 2022-12-05
HUE060548T2 (hu) 2023-03-28
EP4067482A1 (en) 2022-10-05
US11426430B2 (en) 2022-08-30
IL268641B1 (en) 2024-06-01
IL268641B2 (en) 2024-10-01
RU2019125600A3 (https=) 2021-11-03
EP3580330B1 (en) 2022-08-31
US11642376B2 (en) 2023-05-09
ZA201905470B (en) 2024-12-18
US20230293586A1 (en) 2023-09-21
PT3580330T (pt) 2022-12-06
CN110506110A (zh) 2019-11-26
US11638723B2 (en) 2023-05-02
CN110506110B (zh) 2024-09-06
EP3580330A1 (en) 2019-12-18
CA3053294A1 (en) 2018-08-16
ES2931530T3 (es) 2022-12-30
KR20190117550A (ko) 2019-10-16
RU2019125600A (ru) 2021-03-15
BR112019016672A8 (pt) 2022-11-22
US20210169934A1 (en) 2021-06-10
AU2018217404B2 (en) 2024-03-28
PL3580330T3 (pl) 2023-01-16
JP7164798B2 (ja) 2022-11-02
US20210169935A1 (en) 2021-06-10

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