KR102666158B1 - T 세포 전구체(progenitor)의 생성 방법 - Google Patents

T 세포 전구체(progenitor)의 생성 방법 Download PDF

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KR102666158B1
KR102666158B1 KR1020197024529A KR20197024529A KR102666158B1 KR 102666158 B1 KR102666158 B1 KR 102666158B1 KR 1020197024529 A KR1020197024529 A KR 1020197024529A KR 20197024529 A KR20197024529 A KR 20197024529A KR 102666158 B1 KR102666158 B1 KR 102666158B1
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KR20190117550A (ko
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이자벨 안드레
마리나 카바자나
쿠이잉 마
존 첸
타예베흐-샤비 소헬리
모이랑뎀 란지타 데비
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아시스땅스 퍼블리끄-오삐또 드 빠리
폰데이션 이메진 - 인스티튜트 데스 말라다이스 제네티크
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸)
유니베르시떼 파리 시테
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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Wood Science & Technology (AREA)
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  • Hematology (AREA)
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  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020197024529A 2017-02-13 2018-02-12 T 세포 전구체(progenitor)의 생성 방법 Active KR102666158B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305161 2017-02-13
EP17305161.6 2017-02-13
PCT/EP2018/053406 WO2018146297A1 (en) 2017-02-13 2018-02-12 Method for generating t cells progenitors

Publications (2)

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KR20190117550A KR20190117550A (ko) 2019-10-16
KR102666158B1 true KR102666158B1 (ko) 2024-05-16

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US (5) US20200046767A1 (https=)
EP (2) EP4067482A1 (https=)
JP (2) JP7164798B2 (https=)
KR (1) KR102666158B1 (https=)
CN (1) CN110506110B (https=)
AU (1) AU2018217404B2 (https=)
BR (1) BR112019016672A8 (https=)
CA (1) CA3053294A1 (https=)
DK (1) DK3580330T3 (https=)
ES (1) ES2931530T3 (https=)
HU (1) HUE060548T2 (https=)
IL (1) IL268641B2 (https=)
MA (1) MA47541A (https=)
PL (1) PL3580330T3 (https=)
PT (1) PT3580330T (https=)
WO (1) WO2018146297A1 (https=)
ZA (1) ZA201905470B (https=)

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ES2931530T3 (es) * 2017-02-13 2022-12-30 Hopitaux Paris Assist Publique Método para generar progenitores de células T
CA3077344A1 (en) * 2017-09-29 2019-04-04 Regents Of The University Of Minnesota Methods of making, expanding, and using a human progenitor t cell
CA3091158A1 (en) 2018-02-14 2019-08-22 Sunnybrook Research Institute Method for generating cells of the t cell lineage
AU2019336221B2 (en) 2018-09-07 2025-05-15 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
EP3963082A4 (en) * 2019-05-01 2023-01-04 Immunebridge Inc. Methods of making oligopotent and unipotent precursors
EP3986427A1 (en) * 2019-06-24 2022-04-27 Childrens Hospital Los Angeles Bcl11b overexpression to enhance human thymopoiesis and t cell function
JP2023502965A (ja) * 2019-11-14 2023-01-26 ウィリアム ザンドストラ，ピーター 前駆ｔ細胞を製造するための培地処方および方法
JPWO2021200901A1 (https=) * 2020-03-31 2021-10-07
JP2023553313A (ja) 2020-11-30 2023-12-21 チョ ファーマ インコーポレイテッド 細胞を富化するための抗体
AU2022228364A1 (en) * 2021-03-05 2023-09-14 Factor Bioscience Inc. Engineered immune cell therapies
WO2022248354A1 (en) * 2021-05-25 2022-12-01 Universiteit Gent Generating t cell precursors via agonizing tumor necrosis factor receptor 2
WO2023079082A1 (en) * 2021-11-04 2023-05-11 Aphp (Assistance Publique - Hôpitaux De Paris) Method for generating nk cells
FR3130843A1 (fr) * 2021-12-21 2023-06-23 Universite Claude Bernard Lyon 1 Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
JP2026504155A (ja) 2023-01-27 2026-02-03 ノッチ セラピューティクス（カナダ）インコーポレイテッド 幹細胞／前駆細胞からｔ細胞系統集団を生成するための方法
KR20250152088A (ko) * 2023-02-22 2025-10-22 메이라지티엑스 셀 테라피스 흉선 재생 방법
US20250332260A1 (en) 2024-04-10 2025-10-30 Garuda Therapeutics, Inc. Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025219552A1 (en) 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) * 2024-12-21 2025-08-08 湖南农业大学 OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

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US20210169934A1 (en) 2021-06-10
US20200390817A1 (en) 2020-12-17
IL268641B1 (en) 2024-06-01
IL268641B2 (en) 2024-10-01
PT3580330T (pt) 2022-12-06
KR20190117550A (ko) 2019-10-16
JP7164798B2 (ja) 2022-11-02
RU2019125600A3 (https=) 2021-11-03
US20210169935A1 (en) 2021-06-10
EP4067482A1 (en) 2022-10-05
EP3580330A1 (en) 2019-12-18
WO2018146297A1 (en) 2018-08-16
RU2019125600A (ru) 2021-03-15
ZA201905470B (en) 2024-12-18
US11426430B2 (en) 2022-08-30
AU2018217404A2 (en) 2019-09-19
BR112019016672A2 (pt) 2020-04-14
DK3580330T3 (da) 2022-12-05
ES2931530T3 (es) 2022-12-30
MA47541A (fr) 2019-12-18
JP2020513844A (ja) 2020-05-21
HUE060548T2 (hu) 2023-03-28
BR112019016672A8 (pt) 2022-11-22
CA3053294A1 (en) 2018-08-16
JP2022185024A (ja) 2022-12-13
PL3580330T3 (pl) 2023-01-16
CN110506110A (zh) 2019-11-26
US11638723B2 (en) 2023-05-02
US20230293586A1 (en) 2023-09-21
CN110506110B (zh) 2024-09-06
EP3580330B1 (en) 2022-08-31
AU2018217404A1 (en) 2019-09-05
IL268641A (en) 2019-10-31
AU2018217404B2 (en) 2024-03-28
US20200046767A1 (en) 2020-02-13
US11642376B2 (en) 2023-05-09

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