ES2929818T3 - Nueva composición farmacéutica para la administración de fármacos - Google Patents
Nueva composición farmacéutica para la administración de fármacos Download PDFInfo
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- ES2929818T3 ES2929818T3 ES21728101T ES21728101T ES2929818T3 ES 2929818 T3 ES2929818 T3 ES 2929818T3 ES 21728101 T ES21728101 T ES 21728101T ES 21728101 T ES21728101 T ES 21728101T ES 2929818 T3 ES2929818 T3 ES 2929818T3
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| GBGB2018901.5A GB202018901D0 (en) | 2020-12-01 | 2020-12-01 | New pharmaceutical composition |
| PCT/GB2021/051191 WO2021234366A1 (en) | 2020-05-18 | 2021-05-18 | New pharmaceutical composition for drug delivery |
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| US10598672B2 (en) | 2014-02-18 | 2020-03-24 | Cyrano Therapeutics, Inc. | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
| JP7606530B2 (ja) | 2020-03-24 | 2024-12-25 | シラノ セラピューティクス， インコーポレイテッド | コロナウイルス感染症による化学感覚機能障害の治療 |
| RS63725B1 (sr) | 2020-05-18 | 2022-12-30 | Orexo Ab | Nova farmaceutska kompozicija za davanje leka |
| US12414916B2 (en) | 2021-06-10 | 2025-09-16 | Belhaven BioPharma Inc. | Dry powder formulations of epinephrine and associated methods |
| AR127780A1 (es) * | 2021-11-25 | 2024-02-28 | Orexo Ab | Nueva composición farmacéutica que comprende adrenalina |
| GB202117016D0 (en) * | 2021-11-25 | 2022-01-12 | Orexo Ab | New pharmaceutical device |
| AR127783A1 (es) * | 2021-11-25 | 2024-02-28 | Orexo Ab | Composición farmacéutica que comprende compuestos de drogas biofarmacéuticas |
| CN119278026A (zh) | 2022-03-31 | 2025-01-07 | 好利安科技有限公司 | 吸入复合材料和基于载体的制剂组合 |
| WO2023209662A1 (en) * | 2022-04-29 | 2023-11-02 | Pentide Therapeutics Limited | Pharmaceutical compositions of semaglutide and the methods of use thereof |
| US12029709B2 (en) | 2022-08-11 | 2024-07-09 | De Motu Cordis Pty Ltd | Inhalable epinephrine formulation |
| WO2024031148A1 (en) * | 2022-08-11 | 2024-02-15 | De Motu Cordis Pty Ltd | Inhalable epinephrine formulation |
| GB202301322D0 (en) * | 2023-01-30 | 2023-03-15 | Therakind Ltd | Antiemetic pharmaceutical compositions for nasal delivery |
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| EP4727536A1 (en) * | 2023-06-14 | 2026-04-22 | Genus Lifesciences Inc. | Pharmaceutical oral solid dosage forms including phenobarbital and methods of making and using the same |
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| BE759520A (fr) | 1969-11-28 | 1971-04-30 | Aspro Nicholas Ltd | Compositions d'aspirine |
| US5082669A (en) | 1989-07-20 | 1992-01-21 | Dainippon Pharmaceutical Co., Ltd. | Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked |
| SE8904296D0 (sv) | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Transdermal system |
| EP0657176B1 (en) | 1993-12-06 | 2000-09-20 | Takeda Chemical Industries, Ltd. | Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility |
| CH689139A5 (de) | 1995-04-03 | 1998-10-30 | Cerbios Pharma Sa | Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung. |
| DE19518810A1 (de) | 1995-05-26 | 1996-11-28 | Bayer Ag | Nasal-Applikator |
| DE69913113T2 (de) | 1998-03-10 | 2004-08-26 | Valois S.A.S. | Behälter, verfahren zur befüllung dieses behälter und abgabevorrichtung für das im behälter enthaltene pulver |
| KR100606857B1 (ko) * | 1998-07-08 | 2006-08-01 | 키린-암젠 인코포레이티드 | 고분자 의약품 함유 분말상 경점막 투여 제제 |
| JP2000178184A (ja) | 1998-12-17 | 2000-06-27 | Lion Corp | 粒状組成物、錠剤及び粒状組成物の製造方法 |
| GB9908921D0 (en) | 1999-04-19 | 1999-06-16 | Britannia Pharmaceuticals Ltd | Spray dispenser for opiod antagonists |
| US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| GB0003782D0 (en) | 2000-02-17 | 2000-04-05 | Dumex Ltd As | Process |
| US6316029B1 (en) | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| KR20010107754A (ko) | 2000-05-26 | 2001-12-07 | 민경윤 | 경구투여용 속용정의 제조 방법 |
| FR2817847B1 (fr) | 2000-12-08 | 2003-03-28 | Tebro | Dispositif de distribution de produit fluide ou pulverulent |
| IN192750B (https=) | 2000-12-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
| US6443152B1 (en) | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
| LU90825B1 (en) | 2001-09-06 | 2003-03-07 | Iee Sarl | Method for the determination of one or more parameters of a seat passenger |
| ITMI20012174A1 (it) | 2001-10-18 | 2003-04-18 | Univ Parma | Polvere per somministrazione nasale di farmaci |
| FR2834212B1 (fr) | 2001-12-27 | 2004-07-09 | Besins Int Belgique | Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques |
| GB0201367D0 (en) | 2002-01-22 | 2002-03-13 | Ml Lab Plc | Composition |
| AU2006207868A1 (en) | 2002-03-20 | 2006-09-28 | Alkermes, Inc. | Method and apparatus for producing dry particles |
| WO2004002551A2 (en) | 2002-06-28 | 2004-01-08 | Advanced Inhalation Research, Inc. | Inhalable epinephrine |
| WO2004054511A2 (en) | 2002-12-13 | 2004-07-01 | The Regents Of The University Of California | Analgesic combination comprising nalbuphine |
| CN1777411B (zh) | 2003-02-24 | 2013-01-02 | 药品生产公司 | 经粘膜药物递送系统 |
| WO2004100857A2 (en) | 2003-05-07 | 2004-11-25 | Akina, Inc. | Highly plastic granules for making fast melting tablets |
| US20060115529A1 (en) | 2003-05-07 | 2006-06-01 | Seonghoon Jeong | Fast-melting tablets having taste-masking and sustained release properties |
| CA2528064C (en) * | 2003-06-13 | 2010-01-12 | Advanced Inhalation Research, Inc. | Low dose pharmaceutical powders for inhalation |
| CN100471497C (zh) | 2003-06-25 | 2009-03-25 | 中国人民解放军军事医学科学院毒物药物研究所 | 盐酸纳洛酮鼻粉剂 |
| US20050042178A1 (en) | 2003-08-18 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Microparticles containing the CGRP-antagonist 1-[N2-[3,5-dibrom-N-[[4-(3,4-dihydro-2(1H)-oxoquinazoline-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine, process for preparing and the use thereof as inhalation powder |
| AU2003272959A1 (en) | 2003-10-09 | 2005-04-27 | Bioactis Limited | Powdery medicine dispensing device for nasal cavity |
| WO2005044186A2 (en) | 2003-10-28 | 2005-05-19 | Glaxo Group Limited | Inhalable pharmaceutical formulations employing desiccating agents and methods of administering the same |
| CN1640402A (zh) | 2004-01-02 | 2005-07-20 | 广东奇方药业有限公司 | 一种稳定的纳洛酮粉针剂 |
| IL159729A0 (en) | 2004-01-06 | 2004-06-20 | Doron I Friedman | Non-aqueous composition for oral delivery of insoluble bioactive agents |
| US8642079B2 (en) | 2004-02-23 | 2014-02-04 | Hormos Medical Corporation | Solid formulations of ospemifene |
| US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| CN1615867A (zh) | 2004-10-22 | 2005-05-18 | 北京阳光润禾科技有限公司 | 注射用盐酸纳洛酮冻干粉针制剂 |
| CN1781479B (zh) | 2004-12-02 | 2010-06-30 | 和记黄埔医药企业有限公司 | 一种马蔺子素分散体系及其制备方法 |
| CN101132769A (zh) | 2005-02-10 | 2008-02-27 | 奥瑞克索股份公司 | 用于药物的跨黏膜给药的药物组合物 |
| KR101233235B1 (ko) | 2005-08-26 | 2013-02-15 | 에스케이케미칼주식회사 | 초기 용출율이 개선된 프란루카스트 고체분산체의 약제학적조성물 및 그의 제조방법 |
| US20070202163A1 (en) | 2005-09-09 | 2007-08-30 | Mutasem Rawas-Qalaji | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| CN1939358A (zh) | 2005-09-30 | 2007-04-04 | 江西本草天工科技有限责任公司 | 肿节风分散片 |
| CN1813739A (zh) | 2005-11-25 | 2006-08-09 | 王颖 | 一种注射用盐酸纳美芬冻干粉针制剂 |
| JP2009524646A (ja) | 2006-01-27 | 2009-07-02 | ザ・プロヴォスト，フェローズ・アンド・スカラーズ・オブ・ザ・カレッジ・オブ・ザ・ホーリー・アンド・アンディヴァイデッド・トリニティー・オブ・クイーン・エリザベス，ニア・ダブリン | 多孔性微粒子の製造方法 |
| WO2007096906A2 (en) | 2006-02-27 | 2007-08-30 | Panacea Biotec Ltd. | Novel buccoadhesive compositions and process of preparation thereof |
| US20100226979A1 (en) | 2006-03-21 | 2010-09-09 | Jubilant Organosys Limited | Taste Masked Phamaceutical Composition for Oral Solid Dosage form and Process for Preparing the Same Using Magnesium Aluminium Silicate |
| US20090208576A1 (en) | 2006-03-31 | 2009-08-20 | Gandhi Anilkumar S | Orally Disintegrating Tablets |
| EP2061427B1 (en) | 2006-09-15 | 2011-07-20 | Echo Pharmaceuticals B.V. | Granulate containing a pharmaceutically active substance and an emulsifier and method for its manufacture |
| US20080269347A1 (en) | 2006-09-28 | 2008-10-30 | Azopharma, Inc. | Epinephrine formulations |
| CA2678455C (en) | 2007-01-10 | 2019-02-12 | Board Of Regents The University Of Texas System | Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery |
| WO2009040595A1 (en) | 2007-09-28 | 2009-04-02 | Wockhardt Research Centre | Multi-dose pharmaceutical composition of analgesic for nasal administration |
| CA2718255C (en) | 2008-03-11 | 2016-08-23 | Aska Pharmaceutical Co., Ltd. | Solid dispersion and pharmaceutical composition of the same, and production processes thereof |
| US20090246256A1 (en) | 2008-03-27 | 2009-10-01 | Al-Ghananeem Abeer M | Compositions and Methods for Transmucosal Delivery of Lofexidine |
| US20090264530A1 (en) | 2008-04-16 | 2009-10-22 | Nickell Robert P | Combined nsaid and acetaminophen formulation and method |
| US8715715B2 (en) | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
| DK2432502T3 (en) * | 2009-05-20 | 2018-03-12 | Aeras | STABLE, SPRAY DRIED, IMMUNOGENE, VIRUS COMPOSITIONS |
| MX337126B (es) * | 2009-05-29 | 2016-02-12 | Pearl Therapeutics Inc | Administracion respiratoria de agentes activos. |
| EP2266563A1 (en) | 2009-06-11 | 2010-12-29 | Charité-Universitätsmedizin Berlin (Charité) | Use of opioid receptor antagonists for acute treatment of paraphilic arousal states |
| US20110097401A1 (en) | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
| CA2775404C (en) | 2009-09-25 | 2017-01-03 | Dr. Reddy's Laboratories Limited | Formulations comprising triptan compounds |
| CA2809263A1 (en) | 2010-08-27 | 2012-03-01 | Eleni Dokou | Pharmaceutical composition and administrations thereof |
| AU2011296343B2 (en) * | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| MY165826A (en) | 2010-10-01 | 2018-05-17 | Cipla Ltd | Pharmaceutical composition |
| CA2819663C (en) | 2010-12-02 | 2019-12-24 | Adare Pharmaceuticals, Inc. | Rapidly dispersing granules, orally disintegrating tablets and methods |
| MX359670B (es) | 2011-02-18 | 2018-10-05 | Biolingus Ip Llc | Proceso para preparar productos que comprenden activos estabilizados y composiciones que los comprenden. |
| MY194947A (en) | 2011-05-13 | 2022-12-27 | Euro Celtique Sa | Intranasal pharmaceutical dosage forms comprising naloxone |
| JP6054380B2 (ja) | 2012-05-11 | 2016-12-27 | 株式会社アクティバスファーマ | 有機化合物ナノ粉体、その製造方法ならびに懸濁液 |
| CA3169368A1 (en) * | 2012-06-15 | 2014-01-09 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| US9789071B2 (en) * | 2012-06-27 | 2017-10-17 | G2B Pharma, Inc. | Intranasal formulation of epinephrine for the treatment of anaphylaxis |
| WO2014004400A2 (en) | 2012-06-28 | 2014-01-03 | The Governt. Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services | Nasal dry powder delivery system for vaccines and other treatment agents |
| FR3007992B1 (fr) | 2013-07-05 | 2018-01-26 | Aptar France Sas | Dispositif de distribution de produit fluide ou pulverulent. |
| AU2014315459A1 (en) | 2013-09-03 | 2016-04-07 | G2B Pharma Inc. | Intranasal formulation for the treatment of cardiopulmonary resuscitation (CPR), cardiac life support (CLS), anaphylaxis and/or anaphylactoid reactions |
| EP2886107A1 (en) | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Oral formulations of pyrrolydine derivatives |
| WO2015095389A1 (en) | 2013-12-18 | 2015-06-25 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US9192570B2 (en) | 2013-12-20 | 2015-11-24 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| US10085937B2 (en) | 2014-03-14 | 2018-10-02 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| DK3125875T3 (da) * | 2014-04-04 | 2023-07-24 | Ai Therapeutics Inc | Inhalerbar rapamycinformulering til behandling af aldersrelaterede tilstande |
| US20190008759A1 (en) | 2014-07-03 | 2019-01-10 | Darren Rubin | Safer and more effective methods of transmucosal delivery for raising blood pressure and stimulating the body |
| US11135155B2 (en) | 2014-07-08 | 2021-10-05 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| EP3174534A1 (en) | 2014-08-01 | 2017-06-07 | KRKA, d.d., Novo mesto | Pharmaceutical formulation comprising an opioid agonist and an opioid antagonist prepared by melt granulation using lipid esters |
| CA2961829C (en) | 2014-09-18 | 2023-09-12 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
| JP6919093B2 (ja) | 2014-10-08 | 2021-08-18 | ザンボン ソシエタ ペル アチオニ | 配合物の安定性を高めるために噴霧乾燥によって得られる少なくとも１種の乾燥粉末を含む組成物 |
| ES2949137T3 (es) | 2014-11-14 | 2023-09-25 | Asoltech Srl | Composición a base de coq10 campo de la invención |
| EP3025705B8 (en) | 2014-11-25 | 2018-11-28 | Sanofi Ilaç Sanayi ve Ticaret Anonim Sirketi | Stable ivabradine formulations |
| CN104547220A (zh) | 2014-12-30 | 2015-04-29 | 陈宏� | 一种治疗儿童视觉疲劳的中药组合物及其制剂 |
| US10166197B2 (en) | 2015-02-13 | 2019-01-01 | St. John's University | Sugar ester nanoparticle stabilizers |
| EA034820B1 (ru) | 2015-02-17 | 2020-03-25 | Эли Лилли Энд Компани | Порошковый состав для интраназального введения для лечения гипогликемии |
| US20170189352A1 (en) | 2015-03-13 | 2017-07-06 | Par Pharmaceutical, Inc. | Epinephrine formulations |
| EP3280740A4 (en) | 2015-04-08 | 2019-03-27 | Ling, Chang-Chun | PHARMACEUTICAL COMPOSITIONS OF POLYANIONIC AND NONIONIC CYCLODEXTRIN BASED DENDRIMERS AND USES THEREOF |
| KR20180002750A (ko) | 2015-05-01 | 2018-01-08 | 키비타스 테라퓨틱스, 인코포레이티드. | 폐 전달용 졸미트립탄 분말 |
| US10039710B2 (en) | 2015-09-18 | 2018-08-07 | Insys Development Company, Inc. | Epinephrine spray formulations |
| JP6953414B2 (ja) | 2016-01-20 | 2021-10-27 | フラリー パウダーズ エルエルシーＦｌｕｒｒｙ Ｐｏｗｄｅｒｓ，Ｌｌｃ | 親油性成分を含む吸入に好適な分散性の噴霧乾燥粉末を製造する方法 |
| ITUB20161027A1 (it) * | 2016-02-24 | 2017-08-24 | Altergon Sa | Preparazioni farmaceutiche oromucosali ad elevata biodisponibilita’ a base di ciclodestrina e sucralosio |
| US20190364946A1 (en) | 2016-03-16 | 2019-12-05 | Omegatri As | Powders and tablets comprising omega-3 fatty acid derivatives and methods for their production |
| US20170312226A1 (en) | 2016-04-28 | 2017-11-02 | Ascent Pharmaceuticals, Inc. | Pharmaceutical dosage forms |
| EP3463375A1 (en) | 2016-06-03 | 2019-04-10 | M Et P Pharma AG | Nasal pharmaceutical compositions with a porous excipient |
| US20190350881A1 (en) | 2016-06-17 | 2019-11-21 | Ys Pharmtech | Stabilization of epinephrine formulations |
| RU2747237C2 (ru) | 2016-07-06 | 2021-04-29 | Маккормик Энд Компани, Инкорпорейтед | Природные инкапсулированные ароматизирующие продукты |
| WO2018025089A2 (en) | 2016-08-05 | 2018-02-08 | Shin Nippon Biomedical Laboratories, Ltd. | Pharmaceutical compositions |
| US20190231707A1 (en) | 2016-09-28 | 2019-08-01 | Chrono Therapeutics Inc. | Transdermal drug delivery device for delivering opioids |
| WO2018064672A1 (en) | 2016-09-30 | 2018-04-05 | Opiant Pharmaceuticals, Inc. | Treatment with intranasal naloxone |
| US20180092839A1 (en) | 2016-10-03 | 2018-04-05 | Lance L. Gooberman | Medicated spray for treatment of substance abuse, overdose, addiction and impulse control disorders |
| WO2018089709A1 (en) | 2016-11-09 | 2018-05-17 | Opiant Pharmaceuticals, Inc. | Compositions, devices, and methods for the treatment of opioid-receptor-mediated conditions |
| CN110139651A (zh) | 2016-11-18 | 2019-08-16 | 欧邦特制药公司 | 用于治疗阿片样物质过量的组合物和方法 |
| WO2018148382A1 (en) | 2017-02-10 | 2018-08-16 | Mucodel Pharma Llc | Chemically stable compositions of a pharmaceutical active agent in a multi-chambered delivery system for mucosal delivery |
| WO2018195029A1 (en) | 2017-04-17 | 2018-10-25 | Insys Development Company, Inc. | Epinephrine spray formulations |
| US11331270B2 (en) | 2017-08-20 | 2022-05-17 | Nasus Pharma Ltd. | Dry powder compositions for intranasal delivery |
| US20180193332A1 (en) | 2017-10-09 | 2018-07-12 | Adapt Pharma Operations Limited | Low-temperature stable opioid antagonist solutions |
| WO2019139865A1 (en) | 2018-01-10 | 2019-07-18 | Insys Development Company. Inc. | Methods of stabilizing epinephrine |
| WO2019157099A1 (en) | 2018-02-06 | 2019-08-15 | Aegis Therapeutics, Llc | Intranasal epinephrine formulations and methods for the treatment of disease |
| WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
| CN112512506A (zh) | 2018-06-13 | 2021-03-16 | 希克玛药物美国股份有限公司 | 肾上腺素喷雾制剂 |
| WO2020205663A1 (en) | 2019-03-29 | 2020-10-08 | The Regents Of The University Of California | Inhaled statins as bronchodilators to improve lung function in respiratory diseases |
| US10653690B1 (en) | 2019-07-09 | 2020-05-19 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| US10729687B1 (en) | 2019-07-09 | 2020-08-04 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| US11400045B2 (en) | 2020-03-16 | 2022-08-02 | Nasus Pharma Ltd. | Treatment with powdered intranasal epinephrine |
| RS63725B1 (sr) | 2020-05-18 | 2022-12-30 | Orexo Ab | Nova farmaceutska kompozicija za davanje leka |
| US11617716B2 (en) | 2021-06-10 | 2023-04-04 | Belhaven BioPharma Inc. | Dry powder formulations of epinephrine and associated methods |
| AR127780A1 (es) | 2021-11-25 | 2024-02-28 | Orexo Ab | Nueva composición farmacéutica que comprende adrenalina |
| GB202117016D0 (en) | 2021-11-25 | 2022-01-12 | Orexo Ab | New pharmaceutical device |
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