ES2912267T3 - Métodos de tratamiento de enfermedades asociadas a S. aureus - Google Patents

Métodos de tratamiento de enfermedades asociadas a S. aureus Download PDF

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Publication number
ES2912267T3
ES2912267T3 ES13853844T ES13853844T ES2912267T3 ES 2912267 T3 ES2912267 T3 ES 2912267T3 ES 13853844 T ES13853844 T ES 13853844T ES 13853844 T ES13853844 T ES 13853844T ES 2912267 T3 ES2912267 T3 ES 2912267T3
Authority
ES
Spain
Prior art keywords
antibody
aureus
amino acid
seq
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13853844T
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English (en)
Spanish (es)
Inventor
Bret Sellman
Christine Tkaczyk
Melissa Hamilton
Lei Hua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Application granted granted Critical
Publication of ES2912267T3 publication Critical patent/ES2912267T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/085Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES13853844T 2012-11-06 2013-11-05 Métodos de tratamiento de enfermedades asociadas a S. aureus Active ES2912267T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261723128P 2012-11-06 2012-11-06
PCT/US2013/068385 WO2014074470A1 (en) 2012-11-06 2013-11-05 Methods of treating s. aureus-associated diseases

Publications (1)

Publication Number Publication Date
ES2912267T3 true ES2912267T3 (es) 2022-05-25

Family

ID=50685101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13853844T Active ES2912267T3 (es) 2012-11-06 2013-11-05 Métodos de tratamiento de enfermedades asociadas a S. aureus

Country Status (13)

Country Link
US (3) US9845348B2 (OSRAM)
EP (1) EP2928490B1 (OSRAM)
JP (2) JP6506172B2 (OSRAM)
KR (3) KR20150092738A (OSRAM)
CN (2) CN112316135A (OSRAM)
AU (2) AU2013341421A1 (OSRAM)
BR (1) BR112015010126B1 (OSRAM)
CA (1) CA2890385C (OSRAM)
ES (1) ES2912267T3 (OSRAM)
MX (1) MX367082B (OSRAM)
RU (1) RU2661406C2 (OSRAM)
SG (2) SG10201703677VA (OSRAM)
WO (1) WO2014074470A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2708977C2 (ru) 2011-06-10 2019-12-12 МЕДИММЬЮН, ЭлЭлСи Молекулы, связывающиеся с psl pseudomonas, и пути их применения
BR112014011028B1 (pt) 2011-11-07 2021-03-02 Medimmune, Llc anticorpo biespecífico, composição, e, uso da composição
MX367082B (es) * 2012-11-06 2019-08-05 Medimmune Llc Anticuerpos anti toxina alfa de s. aureus (anti-ta) y sus usos.
EP2917360B1 (en) * 2012-11-06 2020-01-08 Medlmmune, LLC Antibodies to s. aureus surface determinants
TWI719938B (zh) 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
TW202311284A (zh) 2017-01-03 2023-03-16 美商再生元醫藥公司 抗金黃色葡萄球菌溶血素a毒素之人類抗體
CA3107463A1 (en) 2018-07-24 2020-01-30 Medimmune, Llc Antibody directed against s. aureus clumping factor a (clfa)
BR112021006704A2 (pt) 2018-10-09 2021-08-10 Medimmune, Llc anticorpos dirigidos contra leucotoxinas de staphylococcus aureus
TW202035443A (zh) 2018-10-09 2020-10-01 美商麥迪紐有限責任公司 抗金黃色葡萄球菌抗體的組合
JP7682795B2 (ja) 2019-03-13 2025-05-26 メディミューン,エルエルシー コロニー形成患者における黄色ブドウ球菌(Staphylococcus aureus)感染症の低減
CN112538112B (zh) * 2019-09-20 2023-10-27 迈威(上海)生物科技股份有限公司 抗α-溶血素的抗体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007145689A1 (en) 2006-06-12 2007-12-21 Nabi Biopharmaceuticals Use of alpha-toxin for treating and preventing staphylococcus infections
JP5658564B2 (ja) 2007-08-31 2015-01-28 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物
EP2453881A2 (en) * 2009-07-16 2012-05-23 Georgia Health Sciences University Research Institute, Inc. Porous-wall hollow glass microspheres as carriers for biomolecules
EP2284193A1 (en) * 2009-08-10 2011-02-16 Kenta Biotech AG Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation
HRP20182017T4 (hr) 2011-02-08 2021-08-20 Medimmune, Llc Protutijela koja specifično vežu alfa toksin koji stvara staphylococcus aureus i postupci uporabe
JP2014507142A (ja) * 2011-02-08 2014-03-27 インテグレイテッド バイオセラピューティクス,インコーポレイテッド α溶血素オリゴペプチドを含む免疫原性組成物
MX367082B (es) * 2012-11-06 2019-08-05 Medimmune Llc Anticuerpos anti toxina alfa de s. aureus (anti-ta) y sus usos.
EP2917360B1 (en) 2012-11-06 2020-01-08 Medlmmune, LLC Antibodies to s. aureus surface determinants
TWI719938B (zh) 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
WO2017075188A2 (en) 2015-10-30 2017-05-04 Medimmune, Llc Methods of using anti-alpha toxin antibody

Also Published As

Publication number Publication date
EP2928490A1 (en) 2015-10-14
KR102272744B1 (ko) 2021-07-06
JP2019142888A (ja) 2019-08-29
KR20150092738A (ko) 2015-08-13
CA2890385C (en) 2022-07-12
AU2018236849A1 (en) 2018-10-18
CN104780934A (zh) 2015-07-15
MX367082B (es) 2019-08-05
CN112316135A (zh) 2021-02-05
WO2014074470A1 (en) 2014-05-15
US9845348B2 (en) 2017-12-19
US10457724B2 (en) 2019-10-29
AU2018236849B2 (en) 2020-05-21
EP2928490B1 (en) 2022-03-30
KR20200102533A (ko) 2020-08-31
MX2015005481A (es) 2016-01-14
RU2661406C2 (ru) 2018-07-16
RU2015121617A (ru) 2016-12-27
CA2890385A1 (en) 2014-05-15
JP6926138B2 (ja) 2021-08-25
AU2013341421A1 (en) 2015-06-04
JP6506172B2 (ja) 2019-04-24
US20190002540A1 (en) 2019-01-03
US10759849B2 (en) 2020-09-01
BR112015010126B1 (pt) 2022-11-01
BR112015010126A2 (OSRAM) 2017-08-22
SG10201703677VA (en) 2017-06-29
US20160257733A1 (en) 2016-09-08
EP2928490A4 (en) 2016-11-02
JP2015536951A (ja) 2015-12-24
US20200109191A1 (en) 2020-04-09
HK1215173A1 (zh) 2016-08-19
KR20210083389A (ko) 2021-07-06
SG11201503231YA (en) 2015-05-28

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