ES2911292T3 - Inhibidores de desmetilasas de histonas - Google Patents

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Publication number

ES2911292T3

ES2911292T3 ES15842092T ES15842092T ES2911292T3 ES 2911292 T3 ES2911292 T3 ES 2911292T3 ES 15842092 T ES15842092 T ES 15842092T ES 15842092 T ES15842092 T ES 15842092T ES 2911292 T3 ES2911292 T3 ES 2911292T3

Authority

ES

Spain

Prior art keywords

alkyl

mmol

aryl

compound

carbocyclyl

Prior art date

2014-09-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108010074870 Histone Demethylases Proteins 0.000 title description 10
• 102000008157 Histone Demethylases Human genes 0.000 title description 10
• 239000003112 inhibitor Substances 0.000 title description 7
• 150000001875 compounds Chemical class 0.000 claims abstract description 170
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 73
• 125000003118 aryl group Chemical group 0.000 claims abstract description 45
• 150000003839 salts Chemical class 0.000 claims abstract description 45
• 125000001072 heteroaryl group Chemical class 0.000 claims abstract description 41
• 125000004452 carbocyclyl group Chemical group 0.000 claims abstract description 40
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 40
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 30
• 229910052736 halogen Inorganic materials 0.000 claims abstract description 28
• 150000002367 halogens Chemical group 0.000 claims abstract description 28
• 125000004415 heterocyclylalkyl group Chemical class 0.000 claims abstract description 28
• 239000001257 hydrogen Substances 0.000 claims abstract description 28
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 28
• 125000003710 aryl alkyl group Chemical class 0.000 claims abstract description 27
• 125000004446 heteroarylalkyl group Chemical class 0.000 claims abstract description 25
• 125000005884 carbocyclylalkyl group Chemical class 0.000 claims abstract description 24
• 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract description 17
• 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 11
• 125000003545 alkoxy group Chemical group 0.000 claims abstract description 9
• 150000001345 alkine derivatives Chemical class 0.000 claims abstract description 5
• 150000001336 alkenes Chemical class 0.000 claims abstract description 4
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 3
• -1 1,2,3,4-tetrahydronaphthyl Chemical group 0.000 claims description 125
• 125000002947 alkylene group Chemical group 0.000 claims description 52
• 239000008194 pharmaceutical composition Substances 0.000 claims description 10
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
• 238000011282 treatment Methods 0.000 claims description 9
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• 201000011510 cancer Diseases 0.000 claims description 7
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
• 201000002528 pancreatic cancer Diseases 0.000 claims description 5
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
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• 206010006187 Breast cancer Diseases 0.000 claims description 4
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• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
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• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
• 201000005202 lung cancer Diseases 0.000 claims description 3
• 208000020816 lung neoplasm Diseases 0.000 claims description 3
• 201000001441 melanoma Diseases 0.000 claims description 3
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
• 239000011737 fluorine Substances 0.000 claims description 2
• 229910052731 fluorine Inorganic materials 0.000 claims description 2
• 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims description 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
• 125000003282 alkyl amino group Chemical group 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
• 125000001624 naphthyl group Chemical group 0.000 claims 2
• JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical group F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 1
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• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 32
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 29
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