ES2908200T3 - Tratamiento para el cáncer de páncreas - Google Patents
Tratamiento para el cáncer de páncreas Download PDFInfo
- Publication number
- ES2908200T3 ES2908200T3 ES14853347T ES14853347T ES2908200T3 ES 2908200 T3 ES2908200 T3 ES 2908200T3 ES 14853347 T ES14853347 T ES 14853347T ES 14853347 T ES14853347 T ES 14853347T ES 2908200 T3 ES2908200 T3 ES 2908200T3
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- pancreatic cancer
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- cancer
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Landscapes
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| PCT/CA2014/050952 WO2015054781A1 (en) | 2013-10-18 | 2014-10-03 | Treatment for pancreatic cancer |
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| NZ602350A (en) | 2010-04-06 | 2014-05-30 | Univ Health Network | Kinase inhibitors and method of treating cancer with same |
| SI3057965T1 (sl) | 2013-10-18 | 2019-04-30 | University Health Network | Sol in kristalne oblike inhibitorja PLK-4 |
| CA3074876A1 (en) * | 2017-09-08 | 2019-03-14 | University Health Network | Combination therapies for inhibition of polo-like kinase 4 |
| BR112021021106A2 (pt) | 2019-04-24 | 2021-12-14 | Univ Health Network | Forma cristalina s4 do inibidor plk4 fumarato (ir,2s)-(e)-2-(3-(4-((cis-2,6-dimetilmorfolino)metil)estiril)-1h-imidazol-6-il)-5'-metoxiespiro[ciclopropano-1,3'-indolin]-2'ona |
| US20240270722A1 (en) | 2021-05-11 | 2024-08-15 | Oric Pharmaceuticals, Inc. | Polo like kinase 4 inhibitors |
| CN115677682B (zh) * | 2021-07-30 | 2023-07-18 | 上海齐鲁制药研究中心有限公司 | 螺环类plk4抑制剂及其用途 |
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| DE3310891A1 (de) | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| US5182397A (en) | 1990-05-31 | 1993-01-26 | American Cyanamid Company | Aryloxyspiroalkylindolinone herbicides |
| GB9507298D0 (en) | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| ATE308520T1 (de) | 1996-08-23 | 2005-11-15 | Sugen Inc | Kombinatorische bibliotheken von indolinone und verwandte produkte und verfahren zur behandlung von krankheiten |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| US6133305A (en) | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
| CA2383623A1 (en) | 1998-08-04 | 2000-02-17 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
| EP1165513A1 (en) | 1999-03-24 | 2002-01-02 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| EP1294688A2 (en) | 2000-06-02 | 2003-03-26 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| IL164209A0 (en) | 2002-05-31 | 2005-12-18 | Eisai Co Ltd | Pyrazole derivatives and pharmaceutical compositions containing the same |
| US7148249B2 (en) | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| US7205328B2 (en) | 2002-10-21 | 2007-04-17 | Irm Llc | Oxindoles with anti-HIV activity |
| WO2005058309A1 (en) | 2003-12-16 | 2005-06-30 | Leo Pharma A/S | Novel therapeutic use of indolinone derivatives |
| US7309787B2 (en) | 2005-07-13 | 2007-12-18 | Allergan, Inc. | Kinase inhibitors |
| WO2007058626A1 (en) | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Indazole compounds |
| US20070135509A1 (en) | 2005-12-09 | 2007-06-14 | Blackburn Thomas P | Indolone compounds useful to treat cognitive impairment |
| US20090209537A1 (en) * | 2006-06-30 | 2009-08-20 | Kyowa Hakko Kirin Co., Ltd. | Aurora inhibitors |
| WO2008152014A2 (en) | 2007-06-12 | 2008-12-18 | Boehringer Ingelheim International Gmbh | 3-hetrocyclylidene-indolinone derivatives as inhibitors of specific cell cycle kinases |
| AU2008340991B2 (en) | 2007-12-21 | 2012-02-23 | University Health Network | Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer |
| JP2009173629A (ja) | 2007-12-21 | 2009-08-06 | Banyu Pharmaceut Co Ltd | Ｒｓｋ１阻害作用を有する新規スピロインダン誘導体 |
| EP2262499B1 (en) | 2008-03-11 | 2016-12-21 | University Health Network | Mk-0557 for use in the treatment of cancer |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| DE102008040187A1 (de) | 2008-07-04 | 2010-01-07 | Robert Bosch Gmbh | Sensorelement, Verfahren zu seiner Herstellung sowie Verwendung |
| ES2465971T3 (es) | 2009-04-06 | 2014-06-09 | University Health Network | Inhibidores de quinasa y método para tratar cáncer con los mismos |
| WO2011069298A1 (en) | 2009-12-11 | 2011-06-16 | F. Hoffmann-La Roche Ag | Novel cyclopropane indolinone derivatives |
| JP5056876B2 (ja) | 2010-03-19 | 2012-10-24 | Ｊｆｅスチール株式会社 | 冷間加工性と焼入れ性に優れた熱延鋼板およびその製造方法 |
| NZ602350A (en) * | 2010-04-06 | 2014-05-30 | Univ Health Network | Kinase inhibitors and method of treating cancer with same |
| EP2588110B1 (en) | 2010-07-02 | 2018-10-17 | University Health Network | Methods of targeting pten mutant diseases and compositions therefor |
| WO2012048411A1 (en) | 2010-10-13 | 2012-04-19 | University Health Network | Plk-4 inhibitors and method of treating cancer with same |
| JP2014511389A (ja) | 2011-02-28 | 2014-05-15 | エピザイム インコーポレイテッド | 置換６，５−縮合二環式ヘテロアリール化合物 |
| CA3101968A1 (en) | 2017-06-29 | 2019-01-03 | Quanticision Diagnostics Canada, Inc. | Apparatus and method for absolute quantification of biomarkers for solid tumor diagnosis |
-
2014
- 2014-10-03 CA CA2927612A patent/CA2927612C/en active Active
- 2014-10-03 JP JP2016524100A patent/JP6525983B2/ja active Active
- 2014-10-03 MX MX2016004967A patent/MX357763B/es active IP Right Grant
- 2014-10-03 US US15/029,269 patent/US9642856B2/en not_active Expired - Fee Related
- 2014-10-03 SG SG11201602882VA patent/SG11201602882VA/en unknown
- 2014-10-03 EP EP14853347.4A patent/EP3057593B1/en active Active
- 2014-10-03 CN CN201480064033.0A patent/CN105764515B/zh not_active Expired - Fee Related
- 2014-10-03 EA EA201690763A patent/EA030089B1/ru not_active IP Right Cessation
- 2014-10-03 ES ES14853347T patent/ES2908200T3/es active Active
- 2014-10-03 AU AU2014336917A patent/AU2014336917B2/en not_active Ceased
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|---|---|
| IL245037B (en) | 2019-06-30 |
| KR102195494B1 (ko) | 2020-12-28 |
| SG11201602882VA (en) | 2016-05-30 |
| JP2016533373A (ja) | 2016-10-27 |
| AU2014336917A1 (en) | 2016-05-05 |
| US9642856B2 (en) | 2017-05-09 |
| CA2927612A1 (en) | 2015-04-23 |
| EA030089B1 (ru) | 2018-06-29 |
| AU2014336917B2 (en) | 2018-11-29 |
| JP6525983B2 (ja) | 2019-06-05 |
| CN105764515B (zh) | 2020-02-28 |
| MX357763B (es) | 2018-07-23 |
| WO2015054781A1 (en) | 2015-04-23 |
| EP3057593A1 (en) | 2016-08-24 |
| US20160250220A1 (en) | 2016-09-01 |
| EA201690763A1 (ru) | 2016-09-30 |
| CN105764515A (zh) | 2016-07-13 |
| CA2927612C (en) | 2022-08-30 |
| EP3057593B1 (en) | 2021-12-08 |
| MX2016004967A (es) | 2016-11-18 |
| NZ718923A (en) | 2021-11-26 |
| KR20160062176A (ko) | 2016-06-01 |
| EP3057593A4 (en) | 2017-03-08 |
| IL245037A0 (en) | 2016-05-31 |
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