EA030089B1 - Лечение рака поджелудочной железы - Google Patents
Лечение рака поджелудочной железы Download PDFInfo
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- EA030089B1 EA030089B1 EA201690763A EA201690763A EA030089B1 EA 030089 B1 EA030089 B1 EA 030089B1 EA 201690763 A EA201690763 A EA 201690763A EA 201690763 A EA201690763 A EA 201690763A EA 030089 B1 EA030089 B1 EA 030089B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- cancer
- pancreatic cancer
- compound
- use according
- tumor
- Prior art date
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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| US201361892887P | 2013-10-18 | 2013-10-18 | |
| PCT/CA2014/050952 WO2015054781A1 (en) | 2013-10-18 | 2014-10-03 | Treatment for pancreatic cancer |
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| ES2465971T3 (es) | 2009-04-06 | 2014-06-09 | University Health Network | Inhibidores de quinasa y método para tratar cáncer con los mismos |
| NZ602350A (en) | 2010-04-06 | 2014-05-30 | Univ Health Network | Kinase inhibitors and method of treating cancer with same |
| SI3057965T1 (sl) | 2013-10-18 | 2019-04-30 | University Health Network | Sol in kristalne oblike inhibitorja PLK-4 |
| CA3074876A1 (en) * | 2017-09-08 | 2019-03-14 | University Health Network | Combination therapies for inhibition of polo-like kinase 4 |
| BR112021021106A2 (pt) | 2019-04-24 | 2021-12-14 | Univ Health Network | Forma cristalina s4 do inibidor plk4 fumarato (ir,2s)-(e)-2-(3-(4-((cis-2,6-dimetilmorfolino)metil)estiril)-1h-imidazol-6-il)-5'-metoxiespiro[ciclopropano-1,3'-indolin]-2'ona |
| US20240270722A1 (en) | 2021-05-11 | 2024-08-15 | Oric Pharmaceuticals, Inc. | Polo like kinase 4 inhibitors |
| CN115677682B (zh) * | 2021-07-30 | 2023-07-18 | 上海齐鲁制药研究中心有限公司 | 螺环类plk4抑制剂及其用途 |
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| WO2012048411A1 (en) * | 2010-10-13 | 2012-04-19 | University Health Network | Plk-4 inhibitors and method of treating cancer with same |
| US8263596B2 (en) * | 2010-04-06 | 2012-09-11 | University Health Network | Kinase inhibitors and method of treating cancer |
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| DE3310891A1 (de) | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| US5182397A (en) | 1990-05-31 | 1993-01-26 | American Cyanamid Company | Aryloxyspiroalkylindolinone herbicides |
| GB9507298D0 (en) | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| ATE308520T1 (de) | 1996-08-23 | 2005-11-15 | Sugen Inc | Kombinatorische bibliotheken von indolinone und verwandte produkte und verfahren zur behandlung von krankheiten |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| US6133305A (en) | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
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| CA2756568A1 (en) * | 2009-04-06 | 2010-10-14 | University Health Network | Kinase inhibitors and method of treating cancer with same |
| US8481525B2 (en) * | 2009-04-06 | 2013-07-09 | University Of Health Network | Kinase inhibitors and method of treating cancer with same |
| US8263596B2 (en) * | 2010-04-06 | 2012-09-11 | University Health Network | Kinase inhibitors and method of treating cancer |
| WO2012048411A1 (en) * | 2010-10-13 | 2012-04-19 | University Health Network | Plk-4 inhibitors and method of treating cancer with same |
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| IL245037B (en) | 2019-06-30 |
| KR102195494B1 (ko) | 2020-12-28 |
| SG11201602882VA (en) | 2016-05-30 |
| JP2016533373A (ja) | 2016-10-27 |
| AU2014336917A1 (en) | 2016-05-05 |
| US9642856B2 (en) | 2017-05-09 |
| CA2927612A1 (en) | 2015-04-23 |
| AU2014336917B2 (en) | 2018-11-29 |
| JP6525983B2 (ja) | 2019-06-05 |
| ES2908200T3 (es) | 2022-04-28 |
| CN105764515B (zh) | 2020-02-28 |
| MX357763B (es) | 2018-07-23 |
| WO2015054781A1 (en) | 2015-04-23 |
| EP3057593A1 (en) | 2016-08-24 |
| US20160250220A1 (en) | 2016-09-01 |
| EA201690763A1 (ru) | 2016-09-30 |
| CN105764515A (zh) | 2016-07-13 |
| CA2927612C (en) | 2022-08-30 |
| EP3057593B1 (en) | 2021-12-08 |
| MX2016004967A (es) | 2016-11-18 |
| NZ718923A (en) | 2021-11-26 |
| KR20160062176A (ko) | 2016-06-01 |
| EP3057593A4 (en) | 2017-03-08 |
| IL245037A0 (en) | 2016-05-31 |
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