ES2899929T3 - Uso de masitinib para el tratamiento de una subpoblación de pacientes con esclerosis lateral amiotrófica - Google Patents

Uso de masitinib para el tratamiento de una subpoblación de pacientes con esclerosis lateral amiotrófica Download PDF

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Publication number
ES2899929T3
ES2899929T3 ES17712175T ES17712175T ES2899929T3 ES 2899929 T3 ES2899929 T3 ES 2899929T3 ES 17712175 T ES17712175 T ES 17712175T ES 17712175 T ES17712175 T ES 17712175T ES 2899929 T3 ES2899929 T3 ES 2899929T3
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ES
Spain
Prior art keywords
inhibitor
als
masitinib
alsfrs
treatment
Prior art date
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Active
Application number
ES17712175T
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English (en)
Spanish (es)
Inventor
Alain Moussy
Jean-Pierre Kinet
Colin Mansfield
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AB Science SA
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AB Science SA
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Publication date
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Publication of ES2899929T3 publication Critical patent/ES2899929T3/es
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES17712175T 2016-03-25 2017-03-24 Uso de masitinib para el tratamiento de una subpoblación de pacientes con esclerosis lateral amiotrófica Active ES2899929T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16162490 2016-03-25
PCT/EP2017/057134 WO2017162884A1 (en) 2016-03-25 2017-03-24 Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation

Publications (1)

Publication Number Publication Date
ES2899929T3 true ES2899929T3 (es) 2022-03-15

Family

ID=55637258

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17712175T Active ES2899929T3 (es) 2016-03-25 2017-03-24 Uso de masitinib para el tratamiento de una subpoblación de pacientes con esclerosis lateral amiotrófica

Country Status (20)

Country Link
US (1) US10092564B2 (https=)
EP (1) EP3240538B1 (https=)
JP (2) JP7250312B2 (https=)
KR (1) KR102293847B1 (https=)
CN (1) CN108883108B (https=)
AU (1) AU2017236177B2 (https=)
BR (1) BR112018069515A2 (https=)
CA (1) CA3018635C (https=)
DK (1) DK3240538T3 (https=)
EA (1) EA038531B1 (https=)
ES (1) ES2899929T3 (https=)
HU (1) HUE057398T2 (https=)
IL (1) IL261856B (https=)
MX (1) MX390495B (https=)
NZ (1) NZ745778A (https=)
PL (1) PL3240538T3 (https=)
PT (1) PT3240538T (https=)
SG (1) SG11201808106YA (https=)
SI (1) SI3240538T1 (https=)
WO (1) WO2017162884A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
EP3563849A3 (en) 2012-10-25 2020-02-12 The General Hospital Corporation Combination therapies for the treatment of alzheimer's disease and related disorders
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
CN110305095A (zh) 2013-10-22 2019-10-08 综合医院公司 色甘酸衍生物以及成像和治疗的相关方法
JP2019524865A (ja) 2016-08-31 2019-09-05 ザ ジェネラル ホスピタル コーポレイション 神経変性疾患と関連する神経炎症におけるマクロファージ/ミクログリア
DK3425390T3 (da) 2016-11-25 2021-02-15 Genuv Inc Sammensætning til fremme af differentiering og beskyttelse af neurale stamceller og fremgangsmåde til induktion af neural regenerering ved anvendelse heraf
MX394840B (es) * 2017-03-28 2025-03-24 Novartis Ag Nuevos metodos para el tratamiento de la esclerosis multiple.
MY205552A (en) * 2017-05-30 2024-10-25 Deciphera Pharmaceuticals Inc Use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl ]-3-phenylurea and analogs for the treatment of cancers associated with genetic abnormalities in platelet derived growth factor receptor alpha
US11692029B2 (en) 2018-03-05 2023-07-04 The Schepens Eye Research Institute, Inc. Therapy for glaucoma and optic neuropathy by targeting colony stimulating factors
AU2019299347A1 (en) 2018-07-02 2021-01-21 Aztherapies, Inc. Powdered formulations of cromolyn sodium and alpha-lactose
MX2021006869A (es) 2018-12-10 2021-07-02 Massachusetts Gen Hospital Esteres de cromolin y usos de los mismos.
CN112618717A (zh) * 2019-09-24 2021-04-09 北京大学深圳研究生院 Btk抑制剂用于治疗肌萎缩侧索硬化症的用途
EP4084779B1 (en) * 2019-12-30 2024-10-09 Deciphera Pharmaceuticals, LLC Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
WO2021207060A1 (en) 2020-04-06 2021-10-14 The General Hospital Corporation Methods of treatment of coronavirus-induced inflammation conditions
WO2022146914A1 (en) 2020-12-28 2022-07-07 The General Hospital Corporation Cromolyn derivatives and uses thereof
WO2025113494A1 (zh) * 2023-11-27 2025-06-05 浙江径科医药有限公司 多环类化合物及其应用
WO2026015576A1 (en) * 2024-07-09 2026-01-15 PhenoNet, Inc. Methods and systems for treatment of neurodegenerative disease and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (https=) 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
MXPA05001277A (es) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit.
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8153792B2 (en) 2007-02-13 2012-04-10 Ab Science Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
US8906357B2 (en) 2010-04-20 2014-12-09 Ab Science Treatment of multiple sclerosis with masitinib
BR112014000742A2 (pt) 2011-07-13 2016-08-23 Andrew A Wolff terapia de combinação de als
US10238649B2 (en) * 2012-10-04 2019-03-26 Ab Science Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors
WO2014145909A2 (en) * 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
US20160263110A1 (en) 2013-11-04 2016-09-15 Ab Science Use of masitinib for treatment of amyotrophic lateral sclerosis

Also Published As

Publication number Publication date
SG11201808106YA (en) 2018-10-30
MX2018011349A (es) 2019-02-07
WO2017162884A1 (en) 2017-09-28
IL261856A (en) 2018-10-31
DK3240538T3 (da) 2021-12-06
BR112018069515A2 (pt) 2019-04-16
JP7250312B2 (ja) 2023-04-03
EA201800499A1 (ru) 2019-03-29
IL261856B (en) 2022-04-01
AU2017236177A1 (en) 2018-09-20
AU2017236177B2 (en) 2022-03-31
JP2022037132A (ja) 2022-03-08
US20180117037A1 (en) 2018-05-03
PL3240538T3 (pl) 2022-01-31
EP3240538B1 (en) 2021-09-29
SI3240538T1 (sl) 2022-02-28
PT3240538T (pt) 2021-12-07
CA3018635C (en) 2023-09-26
NZ745778A (en) 2022-07-01
MX390495B (es) 2025-03-20
JP2019515884A (ja) 2019-06-13
CN108883108B (zh) 2021-08-06
KR20180125966A (ko) 2018-11-26
HUE057398T2 (hu) 2022-05-28
US10092564B2 (en) 2018-10-09
EA038531B1 (ru) 2021-09-10
EP3240538A1 (en) 2017-11-08
CA3018635A1 (en) 2017-09-28
CN108883108A (zh) 2018-11-23
KR102293847B1 (ko) 2021-08-26

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