ES2897659T3 - Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas - Google Patents

Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas Download PDF

Info

Publication number
ES2897659T3
ES2897659T3 ES14843082T ES14843082T ES2897659T3 ES 2897659 T3 ES2897659 T3 ES 2897659T3 ES 14843082 T ES14843082 T ES 14843082T ES 14843082 T ES14843082 T ES 14843082T ES 2897659 T3 ES2897659 T3 ES 2897659T3
Authority
ES
Spain
Prior art keywords
vaccine
composition
excipients
influenza
measles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14843082T
Other languages
English (en)
Spanish (es)
Inventor
Matthew Joseph Mistilis
William Christopher Edens
Andreas Sebastian Bommarius
Mark Prausnitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Institute
Georgia Tech Research Corp
Original Assignee
Georgia Tech Research Institute
Georgia Tech Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Research Institute, Georgia Tech Research Corp filed Critical Georgia Tech Research Institute
Application granted granted Critical
Publication of ES2897659T3 publication Critical patent/ES2897659T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165—Mumps or measles virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16311—Influenzavirus C, i.e. influenza C virus
    • C12N2760/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
ES14843082T 2013-09-03 2014-09-03 Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas Active ES2897659T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361873032P 2013-09-03 2013-09-03
US201361873419P 2013-09-04 2013-09-04
PCT/US2014/053902 WO2015034924A1 (en) 2013-09-03 2014-09-03 Thermally stable vaccine formulations and microneedles

Publications (1)

Publication Number Publication Date
ES2897659T3 true ES2897659T3 (es) 2022-03-02

Family

ID=52628897

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14843082T Active ES2897659T3 (es) 2013-09-03 2014-09-03 Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas

Country Status (8)

Country Link
US (1) US10736840B2 (https=)
EP (1) EP3041504B1 (https=)
JP (2) JP6611720B2 (https=)
CN (1) CN105579059B (https=)
CA (1) CA2923010C (https=)
ES (1) ES2897659T3 (https=)
RU (1) RU2720808C2 (https=)
WO (1) WO2015034924A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
WO2015163488A1 (en) 2014-04-25 2015-10-29 Ajinomoto Co., Inc. Immunostimulating agent
AU2016214968B2 (en) 2015-02-02 2021-02-25 Vaxxas Pty Limited Microprojection array applicator and method
US20160296149A1 (en) * 2015-04-08 2016-10-13 Sandia Corporation In Vivo Extraction of Interstitial Fluid Using Hollow Microneedles
CN104984357B (zh) 2015-06-02 2018-01-30 长春百克生物科技股份公司 不含明胶的疫苗保护剂组合物及流感减毒活疫苗
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981B1 (en) 2015-09-28 2025-11-19 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
EA036412B1 (ru) * 2015-10-06 2020-11-09 Янссен Вэксинс Энд Превеншн Б.В. Способ обеспечения защиты аденовируса от разрушения, вызванного взаимодействием с пластиком, и применение 2-гидроксипропил--циклодекстрина для защиты аденовируса
JP2018536645A (ja) 2015-10-28 2018-12-13 味の素株式会社 免疫賦活剤
WO2017090769A1 (ja) * 2015-11-27 2017-06-01 日東電工株式会社 インフルエンザワクチン乾燥製剤、及び、インフルエンザワクチン乾燥製剤の製造方法
TW201722472A (zh) * 2015-11-27 2017-07-01 Nitto Denko Corp 口腔內投與用疫苗醫藥組合物及口腔內投與用疫苗醫藥組合物之製造方法
WO2017090767A1 (ja) * 2015-11-27 2017-06-01 日東電工株式会社 インフルエンザワクチン乾燥製剤、及び、インフルエンザワクチン乾燥製剤の製造方法
JP2019511255A (ja) 2016-01-11 2019-04-25 バーンダリ，インク． マイクロニードル組成物およびそれを使用する方法
RU2018134360A (ru) * 2016-03-01 2020-04-01 Джорджия Тек Рисёч Корпорейшн Микроигольные частицы, композиции и способы лечения и доставки представляющего интерес вещества
EP3606760B1 (en) 2017-03-31 2023-09-27 Vaxxas Pty Limited Device and method for coating surfaces
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
EP3664838A4 (en) * 2017-08-10 2021-04-28 Vaxxas Pty Limited DIFFERENTIAL COATING OF MICRO PROJECTIONS AND MICRON NEEDLES ON FIELDS
CN110870913A (zh) * 2018-08-31 2020-03-10 成都夸常奥普医疗科技有限公司 氨基酸类营养素作为疫苗佐剂的应用以及包含氨基酸营养素作为佐剂的疫苗
JP7660514B2 (ja) * 2019-02-15 2025-04-11 セラム インスティチュート オブ インディア プライベイト リミテッド 弱毒生インフルエンザワクチン組成物及びその調製プロセス
WO2020196810A1 (ja) * 2019-03-28 2020-10-01 富士フイルム株式会社 インフルエンザワクチンを含有するマイクロニードルアレイ及びマイクロニードルアレイの製造方法
EP3946549A4 (en) * 2019-03-29 2023-01-25 Vaxxas Pty Limited VACCINATION USING HIGH DENSITY MICROPROJECTION FIELD PATCH
WO2021102369A1 (en) * 2019-11-22 2021-05-27 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
CN111154833B (zh) * 2020-01-03 2022-08-23 浙江夸克生物科技有限公司 一种α-L-岩藻糖苷酶测定试剂盒
WO2021252962A1 (en) * 2020-06-11 2021-12-16 Aquavit Pharmaceuticals, Inc, Methods and compositions for delivering bioactive compositions to ocular tissue using microneedle devices
CN114681605A (zh) * 2020-12-30 2022-07-01 辽宁成大生物股份有限公司 一种热稳定的手足口疫苗可溶性微针贴及其制备方法
EP4313250A4 (en) * 2021-03-23 2025-01-01 Veradermics Incorporated PERILSIONAL TREATMENT OF SKIN DISEASES
AR127783A1 (es) * 2021-11-25 2024-02-28 Orexo Ab Composición farmacéutica que comprende compuestos de drogas biofarmacéuticas
WO2025013783A1 (ja) * 2023-07-07 2025-01-16 ナガセヴィータ株式会社 タンパク質の変性抑制用組成物
US20250325286A1 (en) 2024-04-17 2025-10-23 Micron Biomedical, Inc. Methods and Microneedle Devices for Vaccinations with Enhanced Delivery and Acceptance

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US6887484B2 (en) * 2001-07-31 2005-05-03 Posco Vaccine composition containing a promoter peptide
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
WO2004024224A1 (en) 2002-09-16 2004-03-25 Sung-Yun Kwon Solid micro-perforators and methods of use
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
WO2005000382A2 (en) 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
US9744227B2 (en) 2004-06-02 2017-08-29 Universal Stabilization Technologies, Inc. Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof
GB0416694D0 (en) * 2004-07-27 2004-09-01 Univ Strathclyde Process for preparing microcrystals
WO2006128034A1 (en) 2005-05-25 2006-11-30 Georgia Tech Research Corporation Microneedles and methods for microinfusion
EP1893130A4 (en) 2005-06-17 2015-08-26 Georgia Tech Res Inst COATED MICROSTRUCTURES AND METHOD FOR THE PRODUCTION THEREOF
PT1954308E (pt) * 2005-09-16 2011-11-03 Merial Ltd Estabilizadores para vacinas liofilizadas
US20090182306A1 (en) 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
AR065640A1 (es) 2007-03-09 2009-06-17 Otsuka Pharma Co Ltd Preparado liofilizado que contiene una vacuna contra la influenza y metodo para producir la misma
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
GB0725018D0 (en) 2007-12-21 2008-01-30 Univ Cardiff Monitoring system for microneedle delivery
JP2011514337A (ja) 2008-02-25 2011-05-06 ノババックス，インコーポレイテッド 糖ガラス化ウィルス様粒子（ｖｌｐ）
ES2615390T3 (es) * 2008-03-05 2017-06-06 Sanofi Pasteur Proceso para estabilizar una composición de vacuna que contiene adyuvante
TWI489994B (zh) 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
EP2327419B1 (en) 2008-06-30 2020-05-13 Hisamitsu Pharmaceutical Co., Inc. Microneedle device for enhancing the efficacy of influenza vaccine by using microneedle device
CA2754691C (en) * 2009-03-26 2019-07-30 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
CN102549152B (zh) * 2009-07-31 2015-11-25 帕克斯瓦克斯股份有限公司 基于腺病毒的载体
US20110243988A1 (en) * 2009-10-01 2011-10-06 Aridis Pharmaceuticals Methods and Compositions for Stabilization of a Virus Vaccine
US8557253B2 (en) * 2009-10-07 2013-10-15 Sanofi Pasteur Sa Stabilizing excipient for inactivated whole virus vaccine
HUE026885T2 (en) * 2010-03-31 2016-08-29 Stabilitech Ltd Stabilize virus fragments
CN102933230B (zh) 2010-04-15 2016-03-02 株式会社新日本科学 用于鼻内递送的方法和组合物
GB201007207D0 (en) 2010-04-29 2010-06-16 Univ Cork Method
CA2801151A1 (en) 2010-06-01 2011-12-08 Novartis Ag Concentration of vaccine antigens with lyophilization
WO2011156641A2 (en) 2010-06-09 2011-12-15 Kaspar Roger L Microneedle arrays for active agent delivery
JP5808102B2 (ja) 2010-07-22 2015-11-10 コスメディ製薬株式会社 抗原を含有する経皮免疫製剤およびその製造方法
ES2531577T3 (es) 2010-08-20 2015-03-17 Novartis Ag Conjuntos de agujas para la administración de vacuna soluble contra la gripe
JP5558311B2 (ja) 2010-10-27 2014-07-23 株式会社バイオセレンタック ワクチン抗原表皮デリバリー用溶解性３層マイクロニードル・アレイ・パッチ
US9089677B2 (en) 2011-01-25 2015-07-28 The Regents Of The University Of California Transcutaneous multimodal delivery system (TMDS)
AU2012245198B2 (en) * 2011-04-21 2017-07-13 Trustees Of Tufts College Compositions and methods for stabilization of active agents
AU2012255132B2 (en) 2011-05-17 2017-05-25 Soligenix, Inc. Thermostable vaccine compositions and methods of preparing same
US20130096532A1 (en) 2011-10-17 2013-04-18 Rutgers, The State University Of New Jersey Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery
EP2785406A4 (en) * 2011-11-30 2015-10-21 3M Innovative Properties Co MICRONADEL DEVICE WITH A PEPTIDE THERAPEUTIC AND AN AMINO ACID AND METHOD FOR THE PRODUCTION AND USE THEREOF
CN104185475A (zh) 2012-04-03 2014-12-03 谢拉杰克特股份有限公司 面颊给药的可溶微针阵列疫苗
US20130345638A1 (en) 2012-06-25 2013-12-26 Flugen, Inc. Multiple drug delivery device
EP2968162B1 (en) 2013-03-15 2020-12-02 Incube Labs, Llc Multi-stage biodegradable drug delivery platform
CA2966191A1 (en) 2014-11-03 2016-05-12 Merial, Inc. Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus

Also Published As

Publication number Publication date
US10736840B2 (en) 2020-08-11
CA2923010C (en) 2022-08-30
WO2015034924A1 (en) 2015-03-12
EP3041504B1 (en) 2021-08-25
CN105579059A (zh) 2016-05-11
RU2720808C2 (ru) 2020-05-13
CN105579059B (zh) 2020-07-31
JP6611720B2 (ja) 2019-11-27
JP2016535065A (ja) 2016-11-10
JP2019163271A (ja) 2019-09-26
EP3041504A4 (en) 2018-02-21
RU2016111354A3 (https=) 2018-07-16
JP7358068B2 (ja) 2023-10-10
CA2923010A1 (en) 2015-03-12
EP3041504A1 (en) 2016-07-13
US20160220483A1 (en) 2016-08-04
RU2016111354A (ru) 2017-10-09

Similar Documents

Publication Publication Date Title
ES2897659T3 (es) Formulaciones de vacunas térmicamente estables, procesos y microagujas que incluyen las formulaciones de vacunas
Dumpa et al. Stability of vaccines
Kim et al. Formulation of microneedles coated with influenza virus-like particle vaccine
Kim et al. Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity
Amorij et al. Development of stable influenza vaccine powder formulations: challenges and possibilities
KR102136036B1 (ko) 비강내 전달을 위한 방법 및 조성물
ES2673823T3 (es) Formulaciones de alfavirus y de partículas de replicones de alfavirus y métodos relacionados
RU2560675C2 (ru) Стабилизирующий эксципиент для вакцины с инактивированными целыми вирусами
US11918646B2 (en) Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration
CA2680193C (en) Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
JP2015509529A (ja) 乾燥された生物学的材料を安定化するための方法及び組成物
US20250057936A1 (en) Vaccine composition
EP3127550A1 (en) Stabilizing composition for dry formulation of virus
ES2731636T3 (es) Composición adyuvante que contiene citrulina
Wang et al. Dry powder vaccines for mucosal administration: critical factors in manufacture and delivery
US20220325250A1 (en) Method for obtaining efficient compositions comprising viral vectors for vaccination or gene therapy
US20230115214A1 (en) Dry powder compositions of oil-in-water (o/w) emulsion adjuvanted vaccines
Beukema Intradermal administration of influenza accine ith trehalose and pullulan-based dissol ing microneedle arra s
ES2788324T3 (es) Métodos y composiciones para estabilizar materiales biológicos secos
TW202535439A (zh) 海藻糖疫苗調配物
AU2024273927A1 (en) Formulations to stabilize virus-based therapeutics
Soema Formulation of influenza T cell peptides: in search of a universal influenza vaccine
Edens Measles and Polio Vaccination Using a Microneedle Patch to Increase Vaccination Coverage in the Developing World
Mistilis Thermostabilization of Influenza Vaccine in Microneedle Patches
JP2012219041A (ja) 経鼻投与用医薬組成物