ES2896678T3 - Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 - Google Patents
Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 Download PDFInfo
- Publication number
- ES2896678T3 ES2896678T3 ES17199778T ES17199778T ES2896678T3 ES 2896678 T3 ES2896678 T3 ES 2896678T3 ES 17199778 T ES17199778 T ES 17199778T ES 17199778 T ES17199778 T ES 17199778T ES 2896678 T3 ES2896678 T3 ES 2896678T3
- Authority
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- Spain
- Prior art keywords
- compound
- acid
- salt
- deuterium
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)CC(C*(CC1)C(C2)c(cc3OC(O)(O)O)c1cc3OC(O)(O)O)C2=O Chemical compound CC(C)CC(C*(CC1)C(C2)c(cc3OC(O)(O)O)c1cc3OC(O)(O)O)C2=O 0.000 description 1
- MKJIEFSOBYUXJB-UHFFFAOYSA-N CC(C)CC(CN(CCc1c2)C(C3)c1cc(OC)c2OC)C3=O Chemical compound CC(C)CC(CN(CCc1c2)C(C3)c1cc(OC)c2OC)C3=O MKJIEFSOBYUXJB-UHFFFAOYSA-N 0.000 description 1
- NSLJVQUDZCZJLK-UHFFFAOYSA-N COc(cc(CCN=C1)c1c1)c1OC Chemical compound COc(cc(CCN=C1)c1c1)c1OC NSLJVQUDZCZJLK-UHFFFAOYSA-N 0.000 description 1
- RYCILAQAGRSENS-UHFFFAOYSA-N C[N]1(CN(C2)C3)CN3CN2C1 Chemical compound C[N]1(CN(C2)C3)CN3CN2C1 RYCILAQAGRSENS-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9789608P | 2008-09-18 | 2008-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2896678T3 true ES2896678T3 (es) | 2022-02-25 |
Family
ID=42107127
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17199778T Active ES2896678T3 (es) | 2008-09-18 | 2009-09-18 | Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 |
| ES13160950.5T Active ES2563820T3 (es) | 2008-09-18 | 2009-09-18 | Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 |
| ES15185548.3T Active ES2652289T3 (es) | 2008-09-18 | 2009-09-18 | Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 |
| ES09820972T Active ES2425623T3 (es) | 2008-09-18 | 2009-09-18 | Inhibidores benzoquinolínicos de transportador vesicular de monoaminas 2 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13160950.5T Active ES2563820T3 (es) | 2008-09-18 | 2009-09-18 | Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 |
| ES15185548.3T Active ES2652289T3 (es) | 2008-09-18 | 2009-09-18 | Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2 |
| ES09820972T Active ES2425623T3 (es) | 2008-09-18 | 2009-09-18 | Inhibidores benzoquinolínicos de transportador vesicular de monoaminas 2 |
Country Status (20)
| Country | Link |
|---|---|
| US (16) | US8524733B2 (enExample) |
| EP (4) | EP2326643B1 (enExample) |
| JP (3) | JP5616345B2 (enExample) |
| CN (2) | CN102186848B (enExample) |
| AU (1) | AU2009303758B8 (enExample) |
| BR (1) | BRPI0913457B8 (enExample) |
| CA (2) | CA2972242A1 (enExample) |
| CY (1) | CY1120060T1 (enExample) |
| DK (2) | DK3061760T3 (enExample) |
| ES (4) | ES2896678T3 (enExample) |
| HR (1) | HRP20180239T1 (enExample) |
| HU (1) | HUE038158T2 (enExample) |
| LT (1) | LT3061760T (enExample) |
| NO (1) | NO3061760T3 (enExample) |
| NZ (1) | NZ591615A (enExample) |
| PL (1) | PL3061760T3 (enExample) |
| PT (1) | PT3061760T (enExample) |
| SI (1) | SI3061760T1 (enExample) |
| SM (1) | SMT201800067T1 (enExample) |
| WO (1) | WO2010044981A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3061760T1 (en) * | 2008-09-18 | 2018-04-30 | Auspex Pharmaceuticals, Inc. | Deuterated benzoquinolizine derivatives as inhibitors of vesicular monoamine transporter 2 |
| EP2676958B1 (en) * | 2009-11-10 | 2015-07-01 | Pfizer Inc. | N1-Pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| EP2576552A4 (en) * | 2010-06-01 | 2013-11-13 | Aupex Pharmaceutical Inc | BENZOQUINOLONE INHIBITORS OF VMAT2 |
| US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
| EP3673893A1 (en) | 2010-08-27 | 2020-07-01 | Sienna Biopharmaceuticals, Inc. | Compositions and methods for targeted thermomodulation |
| WO2012081031A1 (en) | 2010-12-15 | 2012-06-21 | Enaltec Labs Pvt. Ltd. | Process for preparing tetrabenazine |
| EP4345100A3 (en) * | 2012-09-18 | 2024-04-10 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| PL2906286T3 (pl) | 2012-10-11 | 2018-03-30 | Nanocomposix, Inc. | Kompozycje zawierające nanopłytki srebra i sposoby ich przygotowywania |
| EP2951178A4 (en) | 2013-01-31 | 2016-07-06 | Auspex Pharmaceuticals Inc | VMAT2 INHIBITORS OF BENZOQUINOLONE TYPE |
| HK1221645A1 (zh) * | 2013-09-27 | 2017-06-09 | Auspex Pharmaceuticals, Inc. | Vmat2的苯并喹啉抑制剂 |
| US20160303110A1 (en) * | 2013-11-22 | 2016-10-20 | Auspex Pharmaceuticals, Inc. | Methods of treating abnormal muscular activity |
| WO2015077521A1 (en) * | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CN105873589B (zh) | 2013-12-03 | 2019-11-01 | 奥斯拜客斯制药有限公司 | 制造苯并喹啉化合物的方法 |
| CA2936823A1 (en) * | 2014-01-27 | 2015-07-30 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| JP6718376B2 (ja) | 2014-02-07 | 2020-07-08 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 |
| WO2015120110A2 (en) | 2014-02-07 | 2015-08-13 | Auspex Pharmaceuticals, Inc. | Novel pharmaceutical formulations |
| KR20200133003A (ko) | 2014-05-06 | 2020-11-25 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 과다운동성 운동 장애의 치료를 위한 vmat2 억제제 |
| MA41557A (fr) * | 2015-02-18 | 2017-12-26 | Auspex Pharmaceuticals Inc | Inhibiteurs diméthoxyphényles du transporteur vésiculaire des monoamines 2 |
| DK3265085T3 (da) * | 2015-03-06 | 2022-10-03 | Auspex Pharmaceuticals Inc | Fremgangsmåder til behandling af forstyrrelser med abnorme ufrivillige bevægelser |
| WO2016154017A1 (en) * | 2015-03-20 | 2016-09-29 | Sienna Biopharmaceuticals, Inc. | Enhanced efficacy and targeted topical delivery of drugs to skin with nanoparticles |
| TN2018000121A1 (en) | 2015-10-30 | 2019-10-04 | Neurocrine Biosciences Inc | Valbenazine salts and polymorphs thereof |
| LT3394057T (lt) | 2015-12-23 | 2022-06-27 | Neurocrine Biosciences, Inc. | Sintezės būdas, skirtas pagaminti (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1-a]izochinolin-2-ilo 2-amino-3-metilbutanoato di(4-metilbenzensulfonatą) |
| WO2017182916A1 (en) | 2016-04-22 | 2017-10-26 | Lupin Limited | Novel process for preparation of tetrabenazine and deutetrabenazine |
| WO2017221169A1 (en) | 2016-06-24 | 2017-12-28 | Lupin Limited | Premixes of deutetrabenazine |
| CN107936008B (zh) * | 2016-10-13 | 2022-06-14 | 泰州华元医药科技有限公司 | 氘代化合物及其医药用途 |
| TW202515564A (zh) | 2016-12-02 | 2025-04-16 | 美商紐羅克里生物科學有限公司 | 戊苯那嗪（valbenazine）於治療精神分裂症或情感性精神分裂症之用途 |
| WO2018130345A1 (en) | 2017-01-10 | 2018-07-19 | Sandoz Ag | Crystalline valbenazine free base |
| WO2018140092A1 (en) | 2017-01-27 | 2018-08-02 | Obrien Christopher F | Methods for the administration of certain vmat2 inhibitors |
| JP2020508337A (ja) | 2017-02-27 | 2020-03-19 | サンド・アクチエンゲゼルシヤフト | バルベナジン塩の結晶形態 |
| WO2018164996A1 (en) | 2017-03-06 | 2018-09-13 | Neurocrine Biosciences, Inc. | Dosing regimen for valbenazine |
| JP7608050B2 (ja) | 2017-03-15 | 2025-01-06 | オースペックス ファーマシューティカルズ インコーポレイテッド | デューテトラベナジンの類似体、その調製及び使用 |
| JOP20190239A1 (ar) | 2017-04-19 | 2019-10-09 | Neurocrine Biosciences Inc | مركبات مثبطة لـ vmat2 وتركيبات منها |
| WO2018200605A1 (en) | 2017-04-26 | 2018-11-01 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
| US20200276184A1 (en) | 2017-09-21 | 2020-09-03 | Neurocrine Biosciences, Inc. | High Dosage Valbenazine Formulation and Compositions, Methods, and Kits Related Thereto |
| EA202090932A1 (ru) | 2017-10-10 | 2021-05-20 | Нейрокрин Байосайенсиз, Инк | Способы введения некоторых vmat2-ингибиторов |
| US10786495B2 (en) * | 2017-10-10 | 2020-09-29 | The Regents Of The University Of California | Vesicular monoamine transporter 2 inhibitors for treating stuttering |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| WO2019130252A2 (en) | 2017-12-29 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing deutetrabenazine |
| WO2019147934A1 (en) | 2018-01-29 | 2019-08-01 | Sackner Bernstein Jonathan | Methods for dopamine modulation in human neurologic diseases |
| US11505549B2 (en) * | 2018-02-01 | 2022-11-22 | Lakshmi Prasad ALAPARTHI | Process for preparation of Deutetrabenazine |
| WO2019166962A1 (en) | 2018-03-01 | 2019-09-06 | Mylan Laboratories Ltd | Deutetrabenazine polymorphs and methods for their preparation |
| DK3784237T3 (da) * | 2018-04-25 | 2024-01-08 | Shinkei Therapeutics Inc | Indretning til transdermal levering af tetrabenazin |
| US10632107B2 (en) | 2018-05-14 | 2020-04-28 | Apotex Inc. | Crystalline forms of benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| AU2019287524A1 (en) | 2018-06-14 | 2020-12-24 | Neurocrine Biosciences, Inc. | VMAT2 inhibitor compounds, compositions, and methods relating thereto |
| CN108794337A (zh) * | 2018-07-10 | 2018-11-13 | 上海华堇生物技术有限责任公司 | 一种3,4-二羟基-β-硝基苯乙烯的新制备方法 |
| JP2021528481A (ja) | 2018-08-15 | 2021-10-21 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 特定のｖｍａｔ２阻害剤を投与するための方法 |
| CN112930214B (zh) | 2018-10-18 | 2025-05-16 | 肿瘤多肽创新股份公司 | 含氘化合物 |
| US11324732B2 (en) | 2018-12-13 | 2022-05-10 | Auspex Pharmaceuticals, Inc. | Methods for the treatment of dyskinesia in cerebral palsy |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| LT4153136T (lt) | 2020-06-10 | 2024-03-25 | Auspex Pharmaceuticals, Inc. | Osmosinės vaisto formos, apimančios deutetrabenaziną ir jo vartojimo būdai |
| JP2023542676A (ja) | 2020-09-17 | 2023-10-11 | オースペックス ファーマシューティカルズ インコーポレイテッド | デューテトラベナジンを含む多粒子投薬形態 |
| WO2022081532A1 (en) | 2020-10-12 | 2022-04-21 | Auspex Pharmaceuticals, Inc. | Gastro retentive dosage forms comprising deutetrabenazine |
| CN117062815A (zh) | 2021-03-22 | 2023-11-14 | 纽罗克里生物科学有限公司 | Vmat2抑制剂及使用方法 |
| US20240342159A1 (en) | 2021-06-30 | 2024-10-17 | Neurocrine Biosciences, Inc. | Valbenazine for use in the add-on treatment of schizophrenia |
| MX2024003271A (es) | 2021-09-17 | 2024-06-21 | Auspex Pharmaceuticals Inc | Formas farmaceuticas multiparticulas que comprenden deutetrabenazina. |
| JP2025504379A (ja) | 2022-01-05 | 2025-02-12 | ケイ３６・セラピューティクス・インコーポレイテッド | 重水素濃縮ピペリジニル－メチル－プリンアミン及び関連化合物、ならびに疾患及び状態の治療におけるそれらの使用 |
| WO2023172849A1 (en) | 2022-03-07 | 2023-09-14 | Neurocrine Biosciences, Inc. | Valbenazine, a vmat2 inhibitor, as a free base a tosylate or ditosylate salt, for use in the treatment of chorea associated with huntington's disease |
| IL317235A (en) | 2022-06-08 | 2025-01-01 | Auspex Pharmaceuticals Inc | Osmotic dosage forms comprising ditetrabenzene and methods of using the same |
| TW202521119A (zh) | 2023-08-17 | 2025-06-01 | 美商紐羅克里生物科學有限公司 | 用於投與特定vmat2抑制劑之方法 |
| WO2025038959A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
| WO2025096823A1 (en) | 2023-11-01 | 2025-05-08 | Neurocrine Biosciences, Inc. | Improvement, maintenance or reduction of decline of motor function associated with huntington disease using valbenazine |
| WO2025259267A1 (en) | 2024-06-11 | 2025-12-18 | Vector Vitale Ip Llc | Pharmaceutical compositions for modulating inflammation and oxidative stress comprising chemically enriched elements |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2830993A (en) | 1958-04-15 | Quinolizine derivatives | ||
| US3045021A (en) | 1959-09-24 | 1962-07-17 | Hoffmann La Roche | Preparation of substituted 2-oxobenzoquinolizines |
| DE1253271B (de) * | 1961-03-28 | 1967-11-02 | Mta | Verfahren zur Herstellung von 2-Oxo-1, 2, 3, 4, 6, 7-hexahydro-11bH-benzo[a]chinolizinen |
| US4316897A (en) | 1980-09-10 | 1982-02-23 | Hoffmann-La Roche Inc. | Method of lowering serum prolactin |
| CA2186371A1 (en) | 1994-03-25 | 1995-10-05 | Robert T. Foster | Enhancement of the efficacy of dihydropyridines by deuteration |
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