ES2895626T3 - Derivados de imidazol condensados como inhibidores de TGF-beta - Google Patents

Derivados de imidazol condensados como inhibidores de TGF-beta Download PDF

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Publication number
ES2895626T3
ES2895626T3 ES15801080T ES15801080T ES2895626T3 ES 2895626 T3 ES2895626 T3 ES 2895626T3 ES 15801080 T ES15801080 T ES 15801080T ES 15801080 T ES15801080 T ES 15801080T ES 2895626 T3 ES2895626 T3 ES 2895626T3
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Spain
Prior art keywords
imidazol
pyrrolo
dihydro
alkyl
methylphenyl
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ES15801080T
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English (en)
Spanish (es)
Inventor
Rajinder Singh
Todd Kinsella
Jiaxin Yu
Marina Gelman
Ihab Darwish
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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ES15801080T 2014-11-21 2015-11-16 Derivados de imidazol condensados como inhibidores de TGF-beta Active ES2895626T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462082959P 2014-11-21 2014-11-21
US201562141509P 2015-04-01 2015-04-01
PCT/US2015/060872 WO2016081364A1 (en) 2014-11-21 2015-11-16 Fused imidazole derivatives as tgf-beta inhibitors

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ES2895626T3 true ES2895626T3 (es) 2022-02-22

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ES15801080T Active ES2895626T3 (es) 2014-11-21 2015-11-16 Derivados de imidazol condensados como inhibidores de TGF-beta

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US (1) US10696693B2 (OSRAM)
EP (1) EP3221318B1 (OSRAM)
JP (1) JP6789941B2 (OSRAM)
CN (1) CN107207531B (OSRAM)
ES (1) ES2895626T3 (OSRAM)
WO (1) WO2016081364A1 (OSRAM)

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JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
JP2020512400A (ja) 2017-03-23 2020-04-23 クラヴィウス ファーマシューティカルズ，エルエルシー ＴＧＦβの阻害のための三置換イミダゾールおよび治療方法
JP7147048B2 (ja) * 2018-08-22 2022-10-04 クラヴィウス ファーマシューティカルズ，エルエルシー Ｔｇｆ－ベータを阻害するための置換イミダゾールおよび処置方法
AU2019396360A1 (en) 2018-12-11 2021-05-27 Theravance Biopharma R&D Ip, Llc Naphthyridine and quinoline derivatives useful as ALK5 inhibitors
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