ES2887726T3 - Métodos, kits, y sistemas para la detección multiplexada de moléculas diana y sus usos - Google Patents
Métodos, kits, y sistemas para la detección multiplexada de moléculas diana y sus usos Download PDFInfo
- Publication number
- ES2887726T3 ES2887726T3 ES19183482T ES19183482T ES2887726T3 ES 2887726 T3 ES2887726 T3 ES 2887726T3 ES 19183482 T ES19183482 T ES 19183482T ES 19183482 T ES19183482 T ES 19183482T ES 2887726 T3 ES2887726 T3 ES 2887726T3
- Authority
- ES
- Spain
- Prior art keywords
- target
- sample
- probe
- probes
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361834111P | 2013-06-12 | 2013-06-12 | |
| US201361912054P | 2013-12-05 | 2013-12-05 | |
| US201461972940P | 2014-03-31 | 2014-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2887726T3 true ES2887726T3 (es) | 2021-12-27 |
Family
ID=52022666
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19183482T Active ES2887726T3 (es) | 2013-06-12 | 2014-06-03 | Métodos, kits, y sistemas para la detección multiplexada de moléculas diana y sus usos |
| ES14810839T Active ES2754177T3 (es) | 2013-06-12 | 2014-06-03 | Métodos para la detección multiplexada de moléculas diana y sus usos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14810839T Active ES2754177T3 (es) | 2013-06-12 | 2014-06-03 | Métodos para la detección multiplexada de moléculas diana y sus usos |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10266874B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3008201B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6600302B2 (cg-RX-API-DMAC7.html) |
| AU (3) | AU2014278537B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2915033C (cg-RX-API-DMAC7.html) |
| ES (2) | ES2887726T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014200767A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240118269A1 (en) * | 2022-09-28 | 2024-04-11 | Massachusetts Institute Of Technology | High Throughput Stochastic Bio-Molecular Sensor |
Families Citing this family (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| RS54482B1 (sr) | 2010-04-05 | 2016-06-30 | Prognosys Biosciences, Inc. | Biološka testiranja sa prostornim kodiranjem |
| US10941396B2 (en) | 2012-02-27 | 2021-03-09 | Becton, Dickinson And Company | Compositions and kits for molecular counting |
| BR112015003354A8 (pt) | 2012-08-14 | 2018-01-16 | 10X Genomics Inc | métodos e composições de microcápsula |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| EP3901280B1 (en) | 2012-10-17 | 2025-03-12 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP3567116A1 (en) | 2012-12-14 | 2019-11-13 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA2900481A1 (en) | 2013-02-08 | 2014-08-14 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| US10130711B2 (en) | 2013-06-19 | 2018-11-20 | The Regents Of The University Of California | Chemical structures for localized delivery of therapeutic agents |
| LT3013983T (lt) | 2013-06-25 | 2023-05-10 | Prognosys Biosciences, Inc. | Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį |
| EP3039158B1 (en) | 2013-08-28 | 2018-11-14 | Cellular Research, Inc. | Massively parallel single cell analysis |
| EP3116525B1 (en) | 2014-03-14 | 2021-06-23 | The Regents of the University of California | Tco conjugates and methods for delivery of therapeutic agents |
| KR102596508B1 (ko) | 2014-04-10 | 2023-10-30 | 10엑스 제노믹스, 인크. | 시약을 캡슐화 및 구획화하기 위한 유체 디바이스, 시스템, 및 방법, 및 이의 응용 |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| EP4574974A3 (en) | 2014-06-26 | 2025-10-08 | 10x Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| KR20170026383A (ko) | 2014-06-26 | 2017-03-08 | 10엑스 제노믹스, 인크. | 핵산 서열의 분석 |
| SG11201705615UA (en) | 2015-01-12 | 2017-08-30 | 10X Genomics Inc | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
| US10697000B2 (en) | 2015-02-24 | 2020-06-30 | 10X Genomics, Inc. | Partition processing methods and systems |
| US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| JP7508191B2 (ja) | 2015-03-30 | 2024-07-01 | ベクトン・ディキンソン・アンド・カンパニー | コンビナトリアルバーコーディングのための方法および組成物 |
| HK1250245A1 (zh) | 2015-04-10 | 2018-12-07 | Spatial Transcriptomics Ab | 生物样本的空间区别、多重核酸分析 |
| WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
| AU2016297513B2 (en) * | 2015-07-17 | 2021-02-25 | Board Of Regents, The University Of Texas System | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
| ES2975362T3 (es) | 2015-07-17 | 2024-07-04 | Nanostring Technologies Inc | Cuantificación simultánea de la expresión génica en una región definida por el usuario de un tejido seccionado transversalmente |
| US10828373B2 (en) | 2015-09-10 | 2020-11-10 | Tambo, Inc. | Bioorthogonal compositions |
| KR102395450B1 (ko) | 2015-09-11 | 2022-05-09 | 셀룰러 리서치, 인크. | 핵산 라이브러리 정규화를 위한 방법 및 조성물 |
| US11371094B2 (en) | 2015-11-19 | 2022-06-28 | 10X Genomics, Inc. | Systems and methods for nucleic acid processing using degenerate nucleotides |
| EP4144861B1 (en) | 2015-12-04 | 2024-09-11 | 10X Genomics, Inc. | Methods and compositions for nucleic acid analysis |
| JP6920334B2 (ja) * | 2016-03-25 | 2021-08-18 | ザ ジェネラル ホスピタル コーポレイション | 偏光に基づく蛍光核酸検出 |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| JP6940532B2 (ja) * | 2016-06-30 | 2021-09-29 | バイオイズ カンパニー リミテッド | 二本鎖核酸信号プローブおよびこれを用いた標的分子の検出方法 |
| WO2018017469A1 (en) * | 2016-07-18 | 2018-01-25 | Yale University | Multiplex detection of intracellular or surface molecular targets in single cells |
| CA3031586A1 (en) | 2016-07-27 | 2018-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Highly-multiplexed fluorescent imaging |
| EP3516400B1 (en) * | 2016-09-26 | 2023-08-16 | Becton, Dickinson and Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| US11667951B2 (en) | 2016-10-24 | 2023-06-06 | Geneinfosec, Inc. | Concealing information present within nucleic acids |
| CN110121364A (zh) * | 2016-12-19 | 2019-08-13 | 文塔纳医疗系统公司 | 肽核酸缀合物 |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP4310183B1 (en) | 2017-01-30 | 2025-07-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
| US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
| WO2018148700A1 (en) | 2017-02-13 | 2018-08-16 | Yale University | High-throughput single-cell polyomics |
| EP3606559B1 (en) | 2017-04-07 | 2024-06-05 | Tambo, Inc. | Bioorthogonal compositions |
| EP3620529A4 (en) * | 2017-05-02 | 2021-02-24 | The University of Tokyo | PROCESS FOR MONITORING DYNAMIC CHANGES IN CELLS OR A SUBSTANCE DERIVED THEREOF, AND PROCESS FOR CELL CLASSIFICATION USING THIS MONITORING PROCEDURE |
| US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| CN109526228B (zh) | 2017-05-26 | 2022-11-25 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| JP7536450B2 (ja) | 2017-06-05 | 2024-08-20 | ベクトン・ディキンソン・アンド・カンパニー | 単一細胞用のサンプルインデックス付加 |
| WO2019060857A1 (en) * | 2017-09-25 | 2019-03-28 | Plexium, Inc. | CHEMICAL LIBRARIES CODED BY OLIGONUCLEOTIDES |
| US20200256862A1 (en) * | 2017-10-23 | 2020-08-13 | Massachusetts Institute Of Technology | Functionalized solid support |
| WO2019099751A1 (en) | 2017-11-15 | 2019-05-23 | 10X Genomics, Inc. | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| WO2019118355A1 (en) * | 2017-12-12 | 2019-06-20 | 10X Genomics, Inc. | Systems and methods for single cell processing |
| WO2019120635A1 (en) | 2017-12-18 | 2019-06-27 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
| JP7158642B2 (ja) * | 2018-01-16 | 2022-10-24 | 国立大学法人山梨大学 | 質量分析装置及び質量分析システム |
| KR101911859B1 (ko) * | 2018-02-02 | 2018-12-28 | 주식회사 바이오이즈 | 이중가닥 핵산 신호 프로브 및 이를 이용한 표적분자의 검출방법 |
| KR102879375B1 (ko) | 2018-02-12 | 2025-10-30 | 브루커 스페이셜 바이올로지, 인크. | 유전자 및 단백질 발현을 검출하는 생체 분자 프로브 및 방법 |
| CN112005115A (zh) | 2018-02-12 | 2020-11-27 | 10X基因组学有限公司 | 表征来自单个细胞或细胞群体的多种分析物的方法 |
| SG11202009889VA (en) | 2018-04-06 | 2020-11-27 | 10X Genomics Inc | Systems and methods for quality control in single cell processing |
| CN118910215A (zh) | 2018-05-03 | 2024-11-08 | 贝克顿迪金森公司 | 在相对的转录物末端进行分子条形码化 |
| CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| EP3797171B1 (en) * | 2018-05-21 | 2025-08-27 | The Regents of The University of California | Single cell mapping and transcriptome analysis |
| US20200020419A1 (en) * | 2018-07-16 | 2020-01-16 | Flagship Pioneering Innovations Vi, Llc. | Methods of analyzing cells |
| US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
| US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
| US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
| US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
| EP4567127A3 (en) | 2018-12-10 | 2025-09-03 | 10x Genomics, Inc. | Methods for determining a location of a biological analyte in a biological sample |
| CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11845983B1 (en) | 2019-01-09 | 2023-12-19 | 10X Genomics, Inc. | Methods and systems for multiplexing of droplet based assays |
| EP4242322B1 (en) | 2019-01-23 | 2024-08-21 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
| WO2020185312A2 (en) | 2019-01-25 | 2020-09-17 | President And Fellows Of Harvard College | Compositions and method for synthesizing nucleic acids |
| US11851683B1 (en) | 2019-02-12 | 2023-12-26 | 10X Genomics, Inc. | Methods and systems for selective analysis of cellular samples |
| US12071617B2 (en) | 2019-02-14 | 2024-08-27 | Becton, Dickinson And Company | Hybrid targeted and whole transcriptome amplification |
| CN114174531A (zh) | 2019-02-28 | 2022-03-11 | 10X基因组学有限公司 | 用空间条码化寡核苷酸阵列对生物分析物进行概况分析 |
| CN114127309A (zh) | 2019-03-15 | 2022-03-01 | 10X基因组学有限公司 | 使用空间阵列进行单细胞测序的方法 |
| EP3887542A1 (en) | 2019-03-22 | 2021-10-06 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| JP7183899B2 (ja) * | 2019-03-25 | 2022-12-06 | 株式会社Ｊｖｃケンウッド | 分析装置及び分析方法 |
| CN113874727A (zh) * | 2019-03-27 | 2021-12-31 | 富鲁达加拿大公司 | 冷冻干燥的抗体组 |
| WO2020214642A1 (en) | 2019-04-19 | 2020-10-22 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| KR102406463B1 (ko) * | 2019-09-03 | 2022-06-10 | 재단법인 오송첨단의료산업진흥재단 | 단백질 생산성 향상을 위한 개별 바코딩 시스템 도입한 시그널 펩타이드 초고속 선별방법 |
| US12235262B1 (en) | 2019-09-09 | 2025-02-25 | 10X Genomics, Inc. | Methods and systems for single cell protein analysis |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長ｖ（ｄ）ｊ情報を得るためのランダムプライミングの使用 |
| EP4055185A1 (en) | 2019-11-08 | 2022-09-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| EP4058598B1 (en) | 2019-11-13 | 2025-04-23 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2021119402A1 (en) | 2019-12-12 | 2021-06-17 | President And Fellows Of Harvard College | Compositions and methods for light-directed biomolecular barcoding |
| WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
| ES2993319T3 (en) | 2020-01-29 | 2024-12-27 | Becton Dickinson Co | Barcoded wells for spatial mapping of single cells through sequencing |
| US12399123B1 (en) | 2020-02-14 | 2025-08-26 | 10X Genomics, Inc. | Spatial targeting of analytes |
| JP7647736B2 (ja) * | 2020-02-14 | 2025-03-18 | ソニーグループ株式会社 | 分析方法、分析システム、及び分析用表面 |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| CN115151810A (zh) | 2020-02-25 | 2022-10-04 | 贝克顿迪金森公司 | 实现使用单细胞样品作为单色补偿对照的双特异性探针 |
| US20240018607A1 (en) * | 2020-03-31 | 2024-01-18 | Logicink Corporation | Molecular beacons |
| CN115997030A (zh) | 2020-04-30 | 2023-04-21 | 德迈逊科技有限公司 | 用于大分子操作的装置和方法 |
| CN115605614A (zh) | 2020-05-14 | 2023-01-13 | 贝克顿迪金森公司（Us） | 用于免疫组库谱分析的引物 |
| WO2021243285A1 (en) * | 2020-05-29 | 2021-12-02 | Seer, Inc. | Systems and methods for rapid identification of proteins |
| CN115803445A (zh) | 2020-06-02 | 2023-03-14 | 贝克顿迪金森公司 | 用于5撇基因表达测定的寡核苷酸和珠 |
| EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| WO2022109343A1 (en) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| JPWO2022118862A1 (cg-RX-API-DMAC7.html) * | 2020-12-01 | 2022-06-09 | ||
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| US20240076723A1 (en) | 2020-12-30 | 2024-03-07 | 10X Genomics, Inc. | Cleavage of capture probes for spatial analysis |
| AU2022238446A1 (en) | 2021-03-18 | 2023-09-07 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
| EP4341848A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Marker, method and device for analyzing a biological sample |
| EP4341847A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Marker, method and device for analyzing a biological sample |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| EP4396581A1 (en) * | 2021-08-31 | 2024-07-10 | Becton, Dickinson and Company | Multiplexed proteomics analysis using oligonucleotide-conjugated antibodies |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| US20250144110A1 (en) * | 2022-01-28 | 2025-05-08 | Washington University | Compositions of autophagy modulating agents and uses thereof |
| WO2023250077A1 (en) | 2022-06-22 | 2023-12-28 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4343326B1 (en) * | 2022-09-20 | 2025-03-12 | Miltenyi Biotec B.V. & Co. KG | Biological conjugates having an photogenerated acidic or basic releasable detection moiety on top of biological tissues |
| WO2024064866A2 (en) * | 2022-09-22 | 2024-03-28 | Astrin Biosciences, Inc. | Tumor cell profiling-based therapeutic targeting of cancer |
| WO2024145491A1 (en) | 2022-12-30 | 2024-07-04 | 10X Genomics, Inc. | Methods, compositions, and kits for multiple barcoding and/or high-density spatial barcoding |
| KR102869006B1 (ko) * | 2023-03-14 | 2025-10-14 | 재단법인 아산사회복지재단 | 다중면역형광염색을 이용한 세포 시료에서 표적 단백질을 검출하는 방법 |
| WO2025049491A1 (en) * | 2023-08-29 | 2025-03-06 | Genopheno, Llc. | Novel sampling and genetic comparison and analysis of cannabis components for commercial differentiation |
| WO2025188805A1 (en) * | 2024-03-04 | 2025-09-12 | University Of Denver | Blood based rapid diagnostic system for brain hemorrhage detection and associated methods |
| WO2025226877A1 (en) * | 2024-04-23 | 2025-10-30 | Delfi Diagnostics, Inc. | Workflows for discovery and deployment of diagnostic assays combining proteomic and genomic information |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US5093268A (en) | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU663053B2 (en) | 1990-06-11 | 1995-09-28 | Gilead Sciences, Inc. | Nucleic acid ligands |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| US6136540A (en) | 1994-10-03 | 2000-10-24 | Ikonisys Inc. | Automated fluorescence in situ hybridization detection of genetic abnormalities |
| US5430175A (en) | 1993-11-30 | 1995-07-04 | Cornell Research Foundation, Inc. | Caged carboxyl compounds and use thereof |
| US5888829A (en) | 1994-11-08 | 1999-03-30 | Molecular Probes, Inc. | Photolabile caged ionophores and method of using in a membrane separation process |
| US5635608A (en) | 1994-11-08 | 1997-06-03 | Molecular Probes, Inc. | α-carboxy caged compounds |
| CN1661115A (zh) | 1995-03-10 | 2005-08-31 | 梅索磅秤技术有限公司 | 多阵列、多特异性的电化学发光检验 |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5872243A (en) | 1995-06-30 | 1999-02-16 | Molecular Probes, Inc. | Caged nucleotides |
| US6043065A (en) | 1997-12-23 | 2000-03-28 | University Of Maryland Biotechnology Institute | Photosensitive organic compounds that release 2,5,-di(tert-butyl)hydroquinone upon illumination |
| US6472541B2 (en) | 1998-11-20 | 2002-10-29 | The Regents Of The University Of California | Protecting groups with increased photosensitivities |
| US20070009931A1 (en) * | 2000-08-04 | 2007-01-11 | Kirsch Wolff M | Negative correlation between IRP-2 and Transferrin receptor expression as a diagnostic of Alzheimer's disease |
| US6958216B2 (en) | 2001-01-10 | 2005-10-25 | The Trustees Of Boston College | DNA-bridged carbon nanotube arrays |
| US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| WO2003048295A1 (en) | 2001-11-30 | 2003-06-12 | Fluidigm Corporation | Microfluidic device and methods of using same |
| US20030194711A1 (en) | 2002-04-10 | 2003-10-16 | Matthew Zapala | System and method for analyzing gene expression data |
| JP2006504105A (ja) | 2002-10-28 | 2006-02-02 | ユニバーシティ オブ ワシントン | 波長調節可能な表面プラズモン共振センサ |
| US20050079520A1 (en) * | 2003-07-21 | 2005-04-14 | Jie Wu | Multiplexed analyte detection |
| AU2005301593A1 (en) * | 2004-11-01 | 2006-05-11 | Synthera Technologies Co., Ltd. | Method of detecting target substances |
| US8986926B2 (en) | 2005-12-23 | 2015-03-24 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| ES2620398T3 (es) | 2006-05-22 | 2017-06-28 | Nanostring Technologies, Inc. | Sistemas y métodos para analizar nanoindicadores |
| JP5555157B2 (ja) * | 2007-04-10 | 2014-07-23 | ナノストリング テクノロジーズ， インコーポレイテッド | ナノレポーターにおける使用のための標的特異的配列を同定するための方法およびコンピュータシステム |
| US8865401B2 (en) * | 2007-12-14 | 2014-10-21 | The Johns Hopkins University | Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification |
| US7923562B2 (en) * | 2008-06-16 | 2011-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Photocleavable linker methods and compositions |
| US9000142B2 (en) | 2008-07-07 | 2015-04-07 | Syntrix Biosystems, Inc. | Photocleavable sense-antisense complex |
| JP5836803B2 (ja) | 2008-08-14 | 2015-12-24 | ナノストリング テクノロジーズ， インコーポレイテッド | 安定したナノレポーター |
| EP2380025B1 (en) * | 2009-01-14 | 2013-09-11 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Ratio based biomarkers and methods of use thereof |
| CA2775613C (en) | 2009-10-13 | 2018-06-12 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
| WO2011097644A2 (en) * | 2010-02-08 | 2011-08-11 | Isis Pharmaceuticals, Inc. | Selective reduction of allelic variants |
| EP2516681B1 (en) * | 2010-02-11 | 2017-10-18 | Nanostring Technologies, Inc | Compositions and methods for the detection of preferably small rnas by bridge hybridisation and ligation |
| EP2547795B1 (en) | 2010-03-16 | 2015-01-14 | Nanostring Technologies, Inc | Compositions and methods for the detection of genomic features |
| WO2011143583A1 (en) * | 2010-05-13 | 2011-11-17 | Illumina, Inc. | Binding assays for markers |
| US9110079B2 (en) * | 2010-09-29 | 2015-08-18 | Biomerieux | Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS |
| WO2012135340A2 (en) | 2011-03-28 | 2012-10-04 | Nanostring Technologies, Inc. | Compositions and methods for diagnosing cancer |
| JP2013027387A (ja) * | 2011-06-21 | 2013-02-07 | Tohoku Univ | 膵臓癌バイオマーカー |
| US20130017971A1 (en) | 2011-06-24 | 2013-01-17 | Nanostring Technologies, Inc. | Multivariate Diagnostic Assays and Methods for Using Same |
| EP2769225A4 (en) * | 2011-10-17 | 2015-06-10 | Nuclea Biotechnologies Inc | BIOLOGICAL MARKERS PREDICTIVE FOR BREAST CANCER |
| WO2013078332A1 (en) | 2011-11-23 | 2013-05-30 | The General Hospital Corporation | Analyte detection using magnetic hall effect |
| US20140037620A1 (en) | 2012-06-29 | 2014-02-06 | British Columbia Cancer Agency Branch | Methods of Treating Breast Cancer with Gemcitabine Therapy |
| EP2976642A4 (en) * | 2013-03-15 | 2016-09-21 | Harvard College | METHOD AND COMPOSITIONS FOR IMPROVING THE DETECTION AND / OR RECORDING OF A TARGET UNIT |
-
2014
- 2014-06-03 EP EP14810839.2A patent/EP3008201B1/en active Active
- 2014-06-03 ES ES19183482T patent/ES2887726T3/es active Active
- 2014-06-03 CA CA2915033A patent/CA2915033C/en active Active
- 2014-06-03 JP JP2016519541A patent/JP6600302B2/ja active Active
- 2014-06-03 US US14/897,025 patent/US10266874B2/en active Active
- 2014-06-03 EP EP19183482.9A patent/EP3587585B1/en active Active
- 2014-06-03 WO PCT/US2014/040731 patent/WO2014200767A1/en not_active Ceased
- 2014-06-03 ES ES14810839T patent/ES2754177T3/es active Active
- 2014-06-03 AU AU2014278537A patent/AU2014278537B2/en active Active
-
2018
- 2018-06-14 AU AU2018204228A patent/AU2018204228B2/en active Active
-
2019
- 2019-03-04 US US16/291,643 patent/US10655163B2/en active Active
- 2019-05-30 JP JP2019100854A patent/JP6785338B2/ja active Active
-
2020
- 2020-07-03 AU AU2020204460A patent/AU2020204460B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240118269A1 (en) * | 2022-09-28 | 2024-04-11 | Massachusetts Institute Of Technology | High Throughput Stochastic Bio-Molecular Sensor |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3587585A1 (en) | 2020-01-01 |
| EP3008201B1 (en) | 2019-08-07 |
| US10655163B2 (en) | 2020-05-19 |
| EP3008201A4 (en) | 2017-02-15 |
| AU2018204228A1 (en) | 2018-07-05 |
| US20190256888A1 (en) | 2019-08-22 |
| JP6785338B2 (ja) | 2020-11-18 |
| AU2020204460B2 (en) | 2022-08-25 |
| AU2014278537B2 (en) | 2018-04-19 |
| ES2754177T3 (es) | 2020-04-16 |
| AU2014278537A1 (en) | 2016-01-07 |
| EP3587585B1 (en) | 2021-03-24 |
| US20170275669A1 (en) | 2017-09-28 |
| CA2915033C (en) | 2023-08-29 |
| AU2018204228B2 (en) | 2020-04-16 |
| US10266874B2 (en) | 2019-04-23 |
| EP3008201A1 (en) | 2016-04-20 |
| AU2020204460A1 (en) | 2020-07-23 |
| JP2016525344A (ja) | 2016-08-25 |
| JP2019165741A (ja) | 2019-10-03 |
| JP6600302B2 (ja) | 2019-10-30 |
| CA2915033A1 (en) | 2014-12-18 |
| WO2014200767A1 (en) | 2014-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2887726T3 (es) | Métodos, kits, y sistemas para la detección multiplexada de moléculas diana y sus usos | |
| Duo et al. | Aggregation-induced emission luminogen: role in biopsy for precision medicine | |
| Tu et al. | Specific and quantitative detection of albumin in biological fluids by tetrazolate-functionalized water-soluble AIEgens | |
| Samanta et al. | Solo smart fluorogenic probe for potential cancer diagnosis and tracking in vivo tumorous lymphatic systems via distinct emission signals | |
| Zhang et al. | Fluorescence discrimination of cancer from inflammation by molecular response to COX-2 enzymes | |
| Qiang et al. | Aptamer/polydopamine nanospheres nanocomplex for in situ molecular sensing in living cells | |
| Scott et al. | A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies | |
| Kim et al. | Early detection of pancreatic cancer | |
| Tenchov et al. | Biomarkers for early cancer detection: A landscape view of recent advancements, spotlighting pancreatic and liver cancers | |
| Xu et al. | Quantum dot-based, quantitative, and multiplexed assay for tissue staining | |
| Wang et al. | Ag-ion-modified Au nanoclusters for fluorometric analysis of alkaline phosphatase | |
| Miyata‐Takata et al. | A case of diffuse large B‐cell lymphoma transformed from primary duodenal follicular lymphoma | |
| Wang et al. | Imaging investigation of hepatocellular carcinoma progress via monitoring γ-glutamyltranspeptidase level with a near-infrared fluorescence/photoacoustic bimodal probe | |
| Grumezescu | Design of nanostructures for theranostics applications | |
| Ruan et al. | Assay of single-cell apoptosis by ensemble and single-molecule fluorescence methods: annexin-V/polyethylene glycol-functionalized quantum dots as probes | |
| Yang et al. | Proximity-guaranteed DNA machine for accurate identification of breast cancer extracellular vesicles | |
| Liu et al. | Discovery of turn-on fluorescent probes for detecting Bcl-2 protein | |
| Ladame et al. | Bioengineering innovative solutions for cancer | |
| Li et al. | Clusterbody enables flow sorting-assisted single-cell mass spectrometry analysis for identifying reversal agent of chemoresistance | |
| Shinozuka et al. | Site-specific protein biomarkers in gastric cancer: a comprehensive review of novel biomarkers and clinical applications | |
| Liu et al. | Coordination of nanoconjugation with an antigen/antibody for efficient detection of gynecological tumors | |
| HK1225071B (en) | Methods, kits, and systems for multiplexed detection of target molecules and uses | |
| HK1225071A1 (en) | Methods, kits, and systems for multiplexed detection of target molecules and uses | |
| Huang et al. | Imaging hypoxia for head and neck cancer: current status, challenges, and prospects | |
| Jing et al. | Dual-environment-sensitive probe to detect protein aggregation in stressed laryngeal carcinoma cells and tissues |