ES2862335T3 - Péptidos de AXL modificados y su uso en la inhibición de la señalización de AXL en terapia anti-metastásica - Google Patents
Péptidos de AXL modificados y su uso en la inhibición de la señalización de AXL en terapia anti-metastásica Download PDFInfo
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
Landscapes
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| ES17196662T Active ES2862335T3 (es) | 2012-12-14 | 2013-12-12 | Péptidos de AXL modificados y su uso en la inhibición de la señalización de AXL en terapia anti-metastásica |
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| WO2011091305A2 (en) * | 2010-01-22 | 2011-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| WO2013090776A1 (en) | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| FI2931265T6 (fi) | 2012-12-14 | 2023-05-23 | Muokattuja axl-peptidejä ja niiden käyttö axl-viestinvälityksen estossa etäispesäkkeitä estävässä hoidossa | |
| CA2909669C (en) | 2014-10-20 | 2023-12-12 | Ruga Corporation | Antiviral activity of gas6 inhibitor |
| WO2016100738A2 (en) * | 2014-12-18 | 2016-06-23 | Ruga Corporation | Antifibrotic activity of gas6 inhibitor |
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| CN118510543A (zh) * | 2021-09-11 | 2024-08-16 | 艾拉维弗公司 | 使用axl诱饵受体作为一线疗法治疗局部晚期或转移性胰腺腺癌的方法 |
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| JP2005278631A (ja) | 2004-03-04 | 2005-10-13 | National Institute Of Advanced Industrial & Technology | Ａｘｌリガンド結合領域蛋白質、その製造方法及びそれを用いたスクリーニング方法 |
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| JP5219029B2 (ja) | 2005-05-02 | 2013-06-26 | 東レ株式会社 | 食道ガン及び食道ガン転移診断のための組成物及び方法 |
| WO2008098139A2 (en) | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
| WO2008128072A2 (en) | 2007-04-13 | 2008-10-23 | Supergen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
| CA2692320A1 (en) | 2007-07-02 | 2009-01-08 | Wyeth | Methods of treating bone disorders with modulators of axl |
| WO2010014755A1 (en) | 2008-07-29 | 2010-02-04 | The Regents Of The University Of Colorado | Methods and compounds for enhancing anti-cancer therapy |
| EA201100947A1 (ru) * | 2008-12-19 | 2012-02-28 | Новартис Аг | Растворимые полипептиды, предназначенные для применения при лечении аутоиммунных и воспалительных нарушений |
| EP2430050A1 (en) * | 2009-05-11 | 2012-03-21 | U3 Pharma GmbH | Humanized axl antibodies |
| US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| WO2011091305A2 (en) | 2010-01-22 | 2011-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| US10844106B2 (en) | 2010-11-08 | 2020-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| WO2013090776A1 (en) | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| FI2931265T6 (fi) | 2012-12-14 | 2023-05-23 | Muokattuja axl-peptidejä ja niiden käyttö axl-viestinvälityksen estossa etäispesäkkeitä estävässä hoidossa | |
| US20150315552A1 (en) | 2012-12-14 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL Signaling in Primary Tumor Therapy |
| US20160266136A1 (en) * | 2013-08-30 | 2016-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | High-affinity binding to gas6 |
| CA2909669C (en) * | 2014-10-20 | 2023-12-12 | Ruga Corporation | Antiviral activity of gas6 inhibitor |
| WO2016100738A2 (en) * | 2014-12-18 | 2016-06-23 | Ruga Corporation | Antifibrotic activity of gas6 inhibitor |
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2013
- 2013-12-12 FI FIEP13862780.7T patent/FI2931265T6/fi active
- 2013-12-12 AU AU2013359179A patent/AU2013359179B2/en not_active Ceased
- 2013-12-12 EP EP17196662.5A patent/EP3326622B1/en active Active
- 2013-12-12 PT PT138627807T patent/PT2931265T/pt unknown
- 2013-12-12 ES ES13862780T patent/ES2665323T7/es active Active
- 2013-12-12 JP JP2015547567A patent/JP6345690B2/ja active Active
- 2013-12-12 DK DK13862780.7T patent/DK2931265T6/da active
- 2013-12-12 CA CA2894539A patent/CA2894539C/en active Active
- 2013-12-12 WO PCT/US2013/074786 patent/WO2014093690A1/en not_active Ceased
- 2013-12-12 DK DK17196662.5T patent/DK3326622T3/da active
- 2013-12-12 US US14/650,854 patent/US9822347B2/en not_active Expired - Fee Related
- 2013-12-12 EP EP13862780.7A patent/EP2931265B3/en active Active
- 2013-12-12 PT PT171966625T patent/PT3326622T/pt unknown
- 2013-12-12 ES ES17196662T patent/ES2862335T3/es active Active
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2014
- 2014-06-30 NO NO14741534A patent/NO3049208T3/no unknown
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2017
- 2017-10-13 US US15/783,850 patent/US11136563B2/en not_active Expired - Fee Related
- 2017-12-06 AU AU2017272193A patent/AU2017272193A1/en not_active Abandoned
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2018
- 2018-05-23 JP JP2018098435A patent/JP6832887B2/ja not_active Expired - Fee Related
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2019
- 2019-08-02 AU AU2019210662A patent/AU2019210662B2/en not_active Ceased
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- 2021-09-02 US US17/465,203 patent/US20220220458A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| FI2931265T6 (fi) | 2023-05-23 |
| DK2931265T3 (en) | 2018-04-16 |
| EP2931265A1 (en) | 2015-10-21 |
| EP3326622B1 (en) | 2021-01-20 |
| US20220220458A1 (en) | 2022-07-14 |
| PT2931265T (pt) | 2018-04-16 |
| JP2016510309A (ja) | 2016-04-07 |
| AU2013359179A1 (en) | 2015-07-02 |
| HK1256071A1 (en) | 2019-09-13 |
| US20180030422A1 (en) | 2018-02-01 |
| WO2014093690A1 (en) | 2014-06-19 |
| ES2665323T3 (es) | 2018-04-25 |
| JP6832887B2 (ja) | 2021-02-24 |
| AU2019210662B2 (en) | 2021-07-01 |
| DK3326622T3 (da) | 2021-04-06 |
| EP3326622A1 (en) | 2018-05-30 |
| AU2013359179B2 (en) | 2017-10-05 |
| ES2665323T7 (es) | 2023-06-15 |
| CA2894539A1 (en) | 2014-06-19 |
| JP2018154641A (ja) | 2018-10-04 |
| NO3049208T3 (OSRAM) | 2018-04-14 |
| EP2931265B3 (en) | 2023-04-05 |
| AU2019210662A1 (en) | 2019-08-22 |
| DK2931265T6 (da) | 2023-05-01 |
| EP2931265B1 (en) | 2018-01-31 |
| US11136563B2 (en) | 2021-10-05 |
| EP2931265A4 (en) | 2016-08-31 |
| US9822347B2 (en) | 2017-11-21 |
| US20150315553A1 (en) | 2015-11-05 |
| PT3326622T (pt) | 2021-04-07 |
| AU2017272193A1 (en) | 2017-12-21 |
| JP6345690B2 (ja) | 2018-06-20 |
| CA2894539C (en) | 2021-09-28 |
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