ES2859487T3 - Métodos para tratar las lesiones renales agudas - Google Patents

Métodos para tratar las lesiones renales agudas Download PDF

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Publication number
ES2859487T3
ES2859487T3 ES17787773T ES17787773T ES2859487T3 ES 2859487 T3 ES2859487 T3 ES 2859487T3 ES 17787773 T ES17787773 T ES 17787773T ES 17787773 T ES17787773 T ES 17787773T ES 2859487 T3 ES2859487 T3 ES 2859487T3
Authority
ES
Spain
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
patient
kidney injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17787773T
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English (en)
Spanish (es)
Inventor
Bharat Lagu
Michael Patane
Effie Tozzo
Scott Trzaska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitobridge Inc
Original Assignee
Mitobridge Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitobridge Inc filed Critical Mitobridge Inc
Application granted granted Critical
Publication of ES2859487T3 publication Critical patent/ES2859487T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
ES17787773T 2016-10-05 2017-10-05 Métodos para tratar las lesiones renales agudas Active ES2859487T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662404390P 2016-10-05 2016-10-05
PCT/US2017/055400 WO2018067857A1 (en) 2016-10-05 2017-10-05 Methods of treating acute kidney injury

Publications (1)

Publication Number Publication Date
ES2859487T3 true ES2859487T3 (es) 2021-10-04

Family

ID=60153507

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17787773T Active ES2859487T3 (es) 2016-10-05 2017-10-05 Métodos para tratar las lesiones renales agudas

Country Status (33)

Country Link
US (1) US20210283116A1 (enExample)
EP (1) EP3522880B1 (enExample)
JP (1) JP7065839B2 (enExample)
KR (1) KR20190062502A (enExample)
CN (1) CN109789117B (enExample)
AU (1) AU2017340760B2 (enExample)
BR (1) BR112019005539A2 (enExample)
CA (1) CA3036723A1 (enExample)
CO (1) CO2019004561A2 (enExample)
CY (1) CY1124759T1 (enExample)
DK (1) DK3522880T3 (enExample)
ES (1) ES2859487T3 (enExample)
HR (1) HRP20210294T1 (enExample)
HU (1) HUE053557T2 (enExample)
IL (1) IL265749A (enExample)
JO (1) JOP20190056B1 (enExample)
LT (1) LT3522880T (enExample)
MA (1) MA46459B1 (enExample)
MD (1) MD3522880T2 (enExample)
MX (1) MX387518B (enExample)
MY (1) MY192385A (enExample)
PH (1) PH12019500725A1 (enExample)
PL (1) PL3522880T3 (enExample)
PT (1) PT3522880T (enExample)
RS (1) RS61573B1 (enExample)
RU (1) RU2753607C2 (enExample)
SG (1) SG11201901925RA (enExample)
SI (1) SI3522880T1 (enExample)
SM (1) SMT202100111T1 (enExample)
TW (1) TWI778982B (enExample)
UA (1) UA124019C2 (enExample)
WO (1) WO2018067857A1 (enExample)
ZA (1) ZA201901743B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2949852T3 (es) 2015-10-07 2023-10-03 Mitobridge Inc Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos
BR112018069930B1 (pt) * 2016-04-13 2024-02-20 Mitobridge, Inc Compostos agonistas de ppar, uso dos mesmos e composição farmacêutica
MA46460A (fr) * 2016-10-05 2021-03-17 Mitobridge Inc Formes cristallines et salines de composés agonistes de ppar
KR20220042150A (ko) * 2019-07-19 2022-04-04 비포르 (인터내셔날) 아게 신장 손상의 예방 및 치료에의 용도를 위한 페로포틴 억제제
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
KR20240019753A (ko) * 2021-03-08 2024-02-14 아비오닉스 파마 에스에이 간 질환을 치료하는 데 유용한 화합물
CN115813901B (zh) * 2022-10-20 2024-10-22 南京市儿童医院 3-苯基戊二酸衍生物类小分子在制备防治顺铂诱导的急性肾损伤药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA009119B1 (ru) * 2003-09-19 2007-10-26 Янссен Фармацевтика Н. В. 4-((феноксиалкил)тио)феноксиуксусные кислоты и аналоги
AU2005247473A1 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Substituted triazoles as modulators of PPAR and methods of their preparation
RU2320341C1 (ru) * 2006-06-13 2008-03-27 Государственное учреждение Научный центр реконструктивной и восстановительной хирургии Восточно-Сибирского научного центра Сибирского отделения Российской Академии медицинских наук Средство для лечения острой обструкции верхних мочевыводящих путей
KR20090071829A (ko) * 2007-12-28 2009-07-02 주식회사 머젠스 신장질환의 치료 및 예방을 위한 약제 조성물
CN102209532B (zh) * 2008-10-17 2015-07-22 西玛贝治疗公司 减少小而致密的ldl颗粒的方法
US7928067B2 (en) * 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
CN105324395A (zh) * 2013-03-08 2016-02-10 艾伯维公司 治疗急性肾损伤的方法
AU2014247953A1 (en) * 2013-04-05 2015-11-12 Mitobridge, Inc. PPAR agonists
EP2862574A1 (en) * 2013-10-15 2015-04-22 Sanofi {4-[5-(3-chloro-phenoxy)-oxazolo[5,4 d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid for use in the prevention or treatment of acute kidney injury
US10300108B2 (en) * 2013-12-03 2019-05-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016057656A1 (en) * 2014-10-08 2016-04-14 Mitobridge, Inc. Ppar-delta agonists for use for treating mitochondrial, vascular, muscular, and demyelinating diseases
WO2016057658A1 (en) * 2014-10-08 2016-04-14 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
ES2949852T3 (es) * 2015-10-07 2023-10-03 Mitobridge Inc Agonistas de PPAR, compuestos, composiciones farmacéuticas y métodos de uso de los mismos

Also Published As

Publication number Publication date
HRP20210294T1 (hr) 2021-04-16
CO2019004561A2 (es) 2019-07-31
AU2017340760B2 (en) 2023-07-27
RU2019111421A3 (enExample) 2021-02-05
MX2019003949A (es) 2019-06-10
CY1124759T1 (el) 2022-07-22
TWI778982B (zh) 2022-10-01
BR112019005539A2 (pt) 2019-06-18
US20210283116A1 (en) 2021-09-16
MY192385A (en) 2022-08-18
MA46459A (fr) 2019-08-14
PH12019500725A1 (en) 2019-08-05
UA124019C2 (uk) 2021-07-07
KR20190062502A (ko) 2019-06-05
ZA201901743B (en) 2022-04-28
JP2019533660A (ja) 2019-11-21
JOP20190056A1 (ar) 2019-03-24
MA46459B1 (fr) 2021-03-31
MD3522880T2 (ro) 2021-03-31
SMT202100111T1 (it) 2021-05-07
HUE053557T2 (hu) 2021-07-28
RS61573B1 (sr) 2021-04-29
EP3522880A1 (en) 2019-08-14
JP7065839B2 (ja) 2022-05-12
LT3522880T (lt) 2021-03-25
SI3522880T1 (sl) 2021-07-30
CN109789117B (zh) 2022-08-23
IL265749A (en) 2019-06-30
MX387518B (es) 2025-03-18
AU2017340760A1 (en) 2019-03-21
CN109789117A (zh) 2019-05-21
DK3522880T3 (en) 2021-01-18
TW201815391A (zh) 2018-05-01
CA3036723A1 (en) 2018-04-12
SG11201901925RA (en) 2019-04-29
EP3522880B1 (en) 2020-12-02
RU2753607C2 (ru) 2021-08-18
WO2018067857A1 (en) 2018-04-12
JOP20190056B1 (ar) 2022-03-14
PL3522880T3 (pl) 2021-08-23
PT3522880T (pt) 2021-02-22
RU2019111421A (ru) 2020-11-06

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