ES2843952T3 - Composiciones para tratar el insomnio - Google Patents
Composiciones para tratar el insomnio Download PDFInfo
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- ES2843952T3 ES2843952T3 ES15851934T ES15851934T ES2843952T3 ES 2843952 T3 ES2843952 T3 ES 2843952T3 ES 15851934 T ES15851934 T ES 15851934T ES 15851934 T ES15851934 T ES 15851934T ES 2843952 T3 ES2843952 T3 ES 2843952T3
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- 230000003000 nontoxic effect Effects 0.000 description 1
- 201000005040 opiate dependence Diseases 0.000 description 1
- 239000008184 oral solid dosage form Substances 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- 238000004885 tandem mass spectrometry Methods 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201462067443P | 2014-10-23 | 2014-10-23 | |
| PCT/JP2015/080304 WO2016063995A1 (en) | 2014-10-23 | 2015-10-21 | Compositions and methods for treating insomnia |
Publications (1)
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| ES2843952T3 true ES2843952T3 (es) | 2021-07-21 |
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| ES15851934T Active ES2843952T3 (es) | 2014-10-23 | 2015-10-21 | Composiciones para tratar el insomnio |
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| EP (1) | EP3209298B1 (OSRAM) |
| JP (1) | JP6659681B2 (OSRAM) |
| KR (1) | KR102444608B1 (OSRAM) |
| CN (1) | CN107810006B (OSRAM) |
| AU (1) | AU2015336463B2 (OSRAM) |
| BR (1) | BR112017007063A2 (OSRAM) |
| CA (1) | CA2964504C (OSRAM) |
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| MX (1) | MX376164B (OSRAM) |
| RU (1) | RU2703297C2 (OSRAM) |
| SG (2) | SG10202007759RA (OSRAM) |
| WO (1) | WO2016063995A1 (OSRAM) |
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| MX376164B (es) | 2014-10-23 | 2025-03-07 | Eisai R&D Man Co Ltd | Composiciones y metodos para tratar el insomnio. |
| IL291791B2 (en) * | 2016-05-12 | 2025-09-01 | Eisai R&D Man Co Ltd | Methods for treating sleep timing disorders |
| PL3496722T3 (pl) * | 2016-08-10 | 2025-11-12 | F. Hoffmann-La Roche Ag | Kompozycje farmaceutyczne zawierające inhibitory kinazy białkowej Akt |
| WO2019024845A1 (zh) * | 2017-08-01 | 2019-02-07 | 苏州科睿思制药有限公司 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
| CA3119728A1 (en) | 2018-11-21 | 2020-05-28 | Tremeau Pharmaceuticals, Inc. | Purified forms of rofecoxib, methods of manufacture and use |
| JP2022538170A (ja) * | 2019-06-26 | 2022-08-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 睡眠問題の治療のためのレンボレキサント |
| CN114096251A (zh) * | 2019-06-26 | 2022-02-25 | 卫材R&D管理有限公司 | 用于治疗睡眠问题的莱博雷生 |
| WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
| AU2020346456A1 (en) * | 2019-09-13 | 2022-04-14 | Takeda Pharmaceutical Company Limited | TAK-925 for use in treating narcolepsy |
| CN114502167A (zh) * | 2019-09-13 | 2022-05-13 | 卫材R&D管理有限公司 | 用于治疗失眠的药物组合物 |
| WO2021127359A1 (en) | 2019-12-20 | 2021-06-24 | Eisai R&D Management Co., Ltd. | Use of lemborexant for treating insomnia |
| IL294033A (en) | 2020-01-16 | 2022-08-01 | Eisai R&D Man Co Ltd | Drug substance of lemborexant and medicinal composition comprising same |
| EP4138822A1 (en) | 2020-04-19 | 2023-03-01 | Idorsia Pharmaceuticals Ltd | Medical use of daridorexant |
| CN111450076A (zh) * | 2020-05-25 | 2020-07-28 | 安徽省逸欣铭医药科技有限公司 | 一种Lemborexant软胶囊组合物及其制备方法 |
| AU2023347307A1 (en) | 2022-09-23 | 2025-03-13 | Eisai R&D Management Co., Ltd. | Methods of reducing neurodegeneration associated with neurodegenerative diseases |
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| JPH06328057A (ja) | 1993-05-26 | 1994-11-29 | Sanyo Electric Co Ltd | 厨芥処理装置 |
| CA2220036A1 (en) | 1995-05-05 | 1996-11-07 | Human Genome Sciences, Inc. | Human neuropeptide receptor |
| US6001963A (en) | 1996-12-17 | 1999-12-14 | Smithkline Beecham Corporation | Ligands of the neuropeptide receptor HFGAN72 |
| US6309854B1 (en) | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
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| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| KR100848747B1 (ko) | 2004-03-01 | 2008-07-25 | 액테리온 파마슈티칼 리미티드 | 치환된 1,2,3,4-테트라하이드로이소퀴놀린 유도체 |
| EP1794156A2 (en) | 2004-09-23 | 2007-06-13 | Pfizer Products Incorporated | Trombopoietin receptor agonists |
| JP2006328057A (ja) | 2005-04-25 | 2006-12-07 | Eisai R & D Management Co Ltd | 抗不安薬及びそのスクリーニング方法 |
| CA2644010A1 (en) | 2006-03-15 | 2007-09-20 | Actelion Pharmaceuticals Ltd | Tetrahydroisoquinoline derivatives to enhance memory function |
| WO2007129188A1 (en) | 2006-05-10 | 2007-11-15 | Pfizer Japan Inc. | Cyclopropanecarboxamide compound |
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| AR064561A1 (es) | 2006-12-28 | 2009-04-08 | Actelion Pharmaceuticals Ltd | Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. |
| AU2008303975B2 (en) | 2007-09-21 | 2013-05-16 | Sanofi | (Cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament |
| PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
| US9276724B2 (en) * | 2010-02-15 | 2016-03-01 | Koninklijke Philips N.V. | Mitigation of control channel interference |
| RS54101B1 (sr) * | 2010-09-22 | 2015-10-30 | Eisai R&D Management Co. Ltd. | Ciklopropansko jedinjenje |
| US20120165339A1 (en) | 2010-12-22 | 2012-06-28 | Eisai R&D Management Co., Ltd. | Cyclopropane derivatives |
| MX376164B (es) | 2014-10-23 | 2025-03-07 | Eisai R&D Man Co Ltd | Composiciones y metodos para tratar el insomnio. |
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| AU2015336463B2 (en) | 2020-06-18 |
| RU2017112308A3 (OSRAM) | 2019-05-08 |
| EP3209298A4 (en) | 2018-06-20 |
| JP2017531683A (ja) | 2017-10-26 |
| IL251759B (en) | 2021-01-31 |
| BR112017007063A2 (pt) | 2018-02-14 |
| SG10202007759RA (en) | 2020-09-29 |
| SG11201703064WA (en) | 2017-05-30 |
| US10188652B2 (en) | 2019-01-29 |
| KR20170068478A (ko) | 2017-06-19 |
| CN107810006A (zh) | 2018-03-16 |
| JP6659681B2 (ja) | 2020-03-04 |
| US20190201399A1 (en) | 2019-07-04 |
| CA2964504C (en) | 2022-08-23 |
| RU2017112308A (ru) | 2018-11-26 |
| MX2017004950A (es) | 2018-01-16 |
| US10702529B2 (en) | 2020-07-07 |
| RU2703297C2 (ru) | 2019-10-16 |
| CA2964504A1 (en) | 2016-04-28 |
| CN107810006B (zh) | 2021-03-30 |
| WO2016063995A1 (en) | 2016-04-28 |
| MX376164B (es) | 2025-03-07 |
| US11026944B2 (en) | 2021-06-08 |
| AU2015336463A1 (en) | 2017-05-04 |
| EP3209298B1 (en) | 2020-12-02 |
| US20200268754A1 (en) | 2020-08-27 |
| IL251759A0 (en) | 2017-06-29 |
| KR102444608B1 (ko) | 2022-09-20 |
| US20170252342A1 (en) | 2017-09-07 |
| EP3209298A1 (en) | 2017-08-30 |
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