IL251759B - Compositions and methods for treating insomnia - Google Patents
Compositions and methods for treating insomniaInfo
- Publication number
- IL251759B IL251759B IL251759A IL25175917A IL251759B IL 251759 B IL251759 B IL 251759B IL 251759 A IL251759 A IL 251759A IL 25175917 A IL25175917 A IL 25175917A IL 251759 B IL251759 B IL 251759B
- Authority
- IL
- Israel
- Prior art keywords
- preparations
- methods
- treating insomnia
- insomnia
- treating
- Prior art date
Links
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title 1
- 206010022437 insomnia Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067443P | 2014-10-23 | 2014-10-23 | |
| PCT/JP2015/080304 WO2016063995A1 (en) | 2014-10-23 | 2015-10-21 | Compositions and methods for treating insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL251759A0 IL251759A0 (en) | 2017-06-29 |
| IL251759B true IL251759B (en) | 2021-01-31 |
Family
ID=55761025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL251759A IL251759B (en) | 2014-10-23 | 2017-04-18 | Compositions and methods for treating insomnia |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10188652B2 (OSRAM) |
| EP (1) | EP3209298B1 (OSRAM) |
| JP (1) | JP6659681B2 (OSRAM) |
| KR (1) | KR102444608B1 (OSRAM) |
| CN (1) | CN107810006B (OSRAM) |
| AU (1) | AU2015336463B2 (OSRAM) |
| BR (1) | BR112017007063A2 (OSRAM) |
| CA (1) | CA2964504C (OSRAM) |
| ES (1) | ES2843952T3 (OSRAM) |
| IL (1) | IL251759B (OSRAM) |
| MX (1) | MX376164B (OSRAM) |
| RU (1) | RU2703297C2 (OSRAM) |
| SG (2) | SG11201703064WA (OSRAM) |
| WO (1) | WO2016063995A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016063995A1 (en) | 2014-10-23 | 2016-04-28 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
| CN109640998A (zh) * | 2016-05-12 | 2019-04-16 | 卫材研究发展管理有限公司 | 治疗昼夜节律性睡眠障碍的方法 |
| EP4613333A3 (en) | 2016-08-10 | 2025-10-29 | F. Hoffmann-La Roche AG | Pharmaceutical compositions comprising akt protein kinase inhibitors |
| JP7179049B2 (ja) | 2017-08-01 | 2022-11-28 | ベルゲン ファーマシューティカル、 エルエルシー | オレキシン受容体拮抗薬の結晶形及びその製造方法並びに用途 |
| MX2021005967A (es) | 2018-11-21 | 2021-10-13 | Tremeau Pharmaceuticals Inc | Formas purificadas de rofecoxib, métodos de fabricación y uso. |
| JP2022538170A (ja) * | 2019-06-26 | 2022-08-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 睡眠問題の治療のためのレンボレキサント |
| WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
| KR20220027981A (ko) * | 2019-06-26 | 2022-03-08 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 수면 문제를 치료하기 위한 렘보렉산트 |
| BR112022004587A2 (pt) * | 2019-09-13 | 2022-06-14 | Takeda Pharmaceuticals Co | Métodos para tratar narcolepsia tipo 1, diminuir eventos tipo cataplexia, aumentar concentração de cálcio intracelular, aumentar latência de sono em manutenção de teste de insônia, melhorar classificação de escaça de sonolência de karolinska, tratar uma doença associada a nível de orexina reduzido, aumentar alerta, melhorar classificação de escala de sonolência epworth, e, composição farmacêutica |
| CN114502167A (zh) * | 2019-09-13 | 2022-05-13 | 卫材R&D管理有限公司 | 用于治疗失眠的药物组合物 |
| JP2023508011A (ja) * | 2019-12-20 | 2023-02-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 不眠症を治療するためのレンボレキサントの使用 |
| JPWO2021145373A1 (OSRAM) * | 2020-01-16 | 2021-07-22 | ||
| BR112022020924A2 (pt) | 2020-04-19 | 2023-02-14 | Idorsia Pharmaceuticals Ltd | Métodos de tratamento de um transtorno do sono, a sonolência diurna em um indivíduo, a insônia, e, daridorexante na forma de sal livre ou farmaceuticamente aceitável |
| CN111450076A (zh) * | 2020-05-25 | 2020-07-28 | 安徽省逸欣铭医药科技有限公司 | 一种Lemborexant软胶囊组合物及其制备方法 |
| CA3266968A1 (en) | 2022-09-23 | 2024-03-28 | Eisai R&D Management Co., Ltd. | Methods of reducing neurodegeneration associated with neurodegenerative diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120095031A1 (en) * | 2010-09-22 | 2012-04-19 | Eisai R&D Management Co., Ltd. | Cyclopropane compound |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06328057A (ja) | 1993-05-26 | 1994-11-29 | Sanyo Electric Co Ltd | 厨芥処理装置 |
| CA2220036A1 (en) | 1995-05-05 | 1996-11-07 | Human Genome Sciences, Inc. | Human neuropeptide receptor |
| US6001963A (en) | 1996-12-17 | 1999-12-14 | Smithkline Beecham Corporation | Ligands of the neuropeptide receptor HFGAN72 |
| US6309854B1 (en) | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US5935814A (en) | 1997-04-30 | 1999-08-10 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72Y receptor |
| US6020157A (en) | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| PT1751111E (pt) | 2004-03-01 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina substituída |
| MX2007003377A (es) | 2004-09-23 | 2007-05-10 | Pfizer Prod Inc | Agonistas del receptor de trombopoyetina. |
| JP2006328057A (ja) | 2005-04-25 | 2006-12-07 | Eisai R & D Management Co Ltd | 抗不安薬及びそのスクリーニング方法 |
| US20090082394A1 (en) | 2006-03-15 | 2009-03-26 | Actelion Pharmaceuticals, Ltd. | Tetrahydroisoquinoline Derivatives to Enhance Memory Function |
| WO2007129188A1 (en) | 2006-05-10 | 2007-11-15 | Pfizer Japan Inc. | Cyclopropanecarboxamide compound |
| US7691893B2 (en) | 2006-09-11 | 2010-04-06 | Glaxo Group Limited | Chemical compounds |
| CL2007002809A1 (es) | 2006-09-29 | 2008-04-18 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 3-aza biciclo [3.1.0]hexano; y su uso en el tratamiento de enfermedades tales como desordenes psicoticos y de ansiedad, desordenes del sueno, uso y abuso de sustancias psicoactivas, demencia y deterioro de funciones cognitivas |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| CL2007003827A1 (es) | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras. |
| MX2010002419A (es) | 2007-09-21 | 2010-03-30 | Sanofi Aventis | (ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento. |
| PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
| WO2011098955A1 (en) * | 2010-02-15 | 2011-08-18 | Koninklijke Philips Electronics N.V. | Mitigation of control channel interference |
| US20120165339A1 (en) | 2010-12-22 | 2012-06-28 | Eisai R&D Management Co., Ltd. | Cyclopropane derivatives |
| WO2016063995A1 (en) | 2014-10-23 | 2016-04-28 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
-
2015
- 2015-10-21 WO PCT/JP2015/080304 patent/WO2016063995A1/en not_active Ceased
- 2015-10-21 MX MX2017004950A patent/MX376164B/es active IP Right Grant
- 2015-10-21 JP JP2017522213A patent/JP6659681B2/ja active Active
- 2015-10-21 SG SG11201703064WA patent/SG11201703064WA/en unknown
- 2015-10-21 SG SG10202007759RA patent/SG10202007759RA/en unknown
- 2015-10-21 EP EP15851934.8A patent/EP3209298B1/en active Active
- 2015-10-21 CA CA2964504A patent/CA2964504C/en active Active
- 2015-10-21 ES ES15851934T patent/ES2843952T3/es active Active
- 2015-10-21 RU RU2017112308A patent/RU2703297C2/ru active
- 2015-10-21 AU AU2015336463A patent/AU2015336463B2/en active Active
- 2015-10-21 KR KR1020177009858A patent/KR102444608B1/ko active Active
- 2015-10-21 US US15/519,676 patent/US10188652B2/en active Active
- 2015-10-21 BR BR112017007063-4A patent/BR112017007063A2/pt not_active Application Discontinuation
- 2015-10-21 CN CN201580055472.XA patent/CN107810006B/zh active Active
-
2017
- 2017-04-18 IL IL251759A patent/IL251759B/en active IP Right Grant
-
2019
- 2019-01-23 US US16/255,116 patent/US10702529B2/en active Active
-
2020
- 2020-03-16 US US16/819,341 patent/US11026944B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120095031A1 (en) * | 2010-09-22 | 2012-04-19 | Eisai R&D Management Co., Ltd. | Cyclopropane compound |
Non-Patent Citations (1)
| Title |
|---|
| PAOLO BETTICA ET AL, PHASE I STUDIES ON THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF SB-649868, A NOVEL DUAL OREXIN RECEPTOR ANTAGONIST, 5 July 2011 (2011-07-05) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107810006A (zh) | 2018-03-16 |
| WO2016063995A1 (en) | 2016-04-28 |
| JP2017531683A (ja) | 2017-10-26 |
| EP3209298A4 (en) | 2018-06-20 |
| US20170252342A1 (en) | 2017-09-07 |
| RU2703297C2 (ru) | 2019-10-16 |
| AU2015336463A1 (en) | 2017-05-04 |
| KR102444608B1 (ko) | 2022-09-20 |
| ES2843952T3 (es) | 2021-07-21 |
| US20200268754A1 (en) | 2020-08-27 |
| CN107810006B (zh) | 2021-03-30 |
| EP3209298A1 (en) | 2017-08-30 |
| US10702529B2 (en) | 2020-07-07 |
| IL251759A0 (en) | 2017-06-29 |
| MX376164B (es) | 2025-03-07 |
| US11026944B2 (en) | 2021-06-08 |
| CA2964504C (en) | 2022-08-23 |
| CA2964504A1 (en) | 2016-04-28 |
| SG11201703064WA (en) | 2017-05-30 |
| US10188652B2 (en) | 2019-01-29 |
| SG10202007759RA (en) | 2020-09-29 |
| JP6659681B2 (ja) | 2020-03-04 |
| MX2017004950A (es) | 2018-01-16 |
| US20190201399A1 (en) | 2019-07-04 |
| BR112017007063A2 (pt) | 2018-02-14 |
| EP3209298B1 (en) | 2020-12-02 |
| KR20170068478A (ko) | 2017-06-19 |
| AU2015336463B2 (en) | 2020-06-18 |
| RU2017112308A3 (OSRAM) | 2019-05-08 |
| RU2017112308A (ru) | 2018-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL280209A (en) | Compositions and methods for the treatment of meibomian gland dysfunction | |
| IL282570B (en) | Methods and devices for treating pulmonary edema | |
| IL296080B1 (en) | Method for treating cancer | |
| IL282372A (en) | Haploid induction compositions and methods for use therefor | |
| IL266458A (en) | Equipment and methods for treating objects | |
| IL258955A (en) | Compositions and methods for treatment of cancer | |
| IL251759B (en) | Compositions and methods for treating insomnia | |
| IL257105A (en) | Modified cells and methods of therapy | |
| IL255261A0 (en) | Methods for treating cancer | |
| IL251215B (en) | Cannabinoid composition and method for treating pain | |
| IL255615A (en) | Use of cannabis to treat fibromyalgia, methods and compositions thereof | |
| DK3215147T3 (da) | Neurodæmpende norketamin-forbindelser og fremgangsmåder | |
| EP3205103C0 (en) | INTER AND INTRA UNIFICATION BLOCK COPY | |
| MA40933A (fr) | Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines | |
| GB201404470D0 (en) | Therapeutic methods and materials | |
| BR112016027102A2 (pt) | método e aparelho | |
| HUE054673T2 (hu) | Rák kezelésére szolgáló eljárások és készítmények | |
| HUE050944T2 (hu) | Kezelési eljárás tradipitant alkalmazásával | |
| KR20180084747A (ko) | Galgt2 유전자 치료 방법 및 물질 | |
| IL246607B (en) | Improved cell compositions and methods for cancer therapy | |
| EP3302207A4 (en) | Surface treatment apparatuses and methods | |
| PL3393468T3 (pl) | Metody leczenia niedoboru odporności | |
| IL268570B (en) | Oligonucleotide compositions and methods of making the same | |
| PL3236960T3 (pl) | Fluralaner do zastosowania w leczeniu demodekozy | |
| GB201416293D0 (en) | Methods and preparations |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |