ES2829198T3 - Análisis digital de secuencia de la metilación de ADN - Google Patents
Análisis digital de secuencia de la metilación de ADN Download PDFInfo
- Publication number
- ES2829198T3 ES2829198T3 ES18179746T ES18179746T ES2829198T3 ES 2829198 T3 ES2829198 T3 ES 2829198T3 ES 18179746 T ES18179746 T ES 18179746T ES 18179746 T ES18179746 T ES 18179746T ES 2829198 T3 ES2829198 T3 ES 2829198T3
- Authority
- ES
- Spain
- Prior art keywords
- methylation
- loci
- cpg
- nucleic acid
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438649P | 2011-02-02 | 2011-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2829198T3 true ES2829198T3 (es) | 2021-05-31 |
Family
ID=46577813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12742758.1T Active ES2686309T3 (es) | 2011-02-02 | 2012-02-02 | Análisis digital de secuencia de la metilación de ADN |
| ES18179746T Active ES2829198T3 (es) | 2011-02-02 | 2012-02-02 | Análisis digital de secuencia de la metilación de ADN |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12742758.1T Active ES2686309T3 (es) | 2011-02-02 | 2012-02-02 | Análisis digital de secuencia de la metilación de ADN |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9637792B2 (enExample) |
| EP (3) | EP3441479B1 (enExample) |
| JP (1) | JP2014519310A (enExample) |
| CN (2) | CN103703173A (enExample) |
| AU (1) | AU2012212127B2 (enExample) |
| CA (1) | CA2826696C (enExample) |
| ES (2) | ES2686309T3 (enExample) |
| WO (1) | WO2012106525A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009102788A2 (en) | 2008-02-15 | 2009-08-20 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| WO2012106525A2 (en) | 2011-02-02 | 2012-08-09 | Exact Sciences Corporation | Digital sequence analysis of dna methylation |
| SG11201501465SA (en) * | 2012-08-31 | 2015-05-28 | Nat Defense Medical Ct | Method for screening cancer |
| WO2014046197A1 (ja) * | 2012-09-19 | 2014-03-27 | シスメックス株式会社 | 大腸癌に関する情報の取得方法、ならびに大腸癌に関する情報を取得するためのマーカーおよびキット |
| CN106170558B (zh) * | 2013-10-21 | 2021-10-29 | 金圣千 | 利用寡核苷酸的生物分子的分析方法及装置 |
| US10253358B2 (en) | 2013-11-04 | 2019-04-09 | Exact Sciences Development Company, Llc | Multiple-control calibrators for DNA quantitation |
| EP3084004A4 (en) | 2013-12-19 | 2017-08-16 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
| ES2812753T3 (es) | 2014-03-31 | 2021-03-18 | Mayo Found Medical Education & Res | Detección de neoplasma colorectal |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| CN105603061A (zh) * | 2015-12-11 | 2016-05-25 | 宁云山 | 一种基于数字PCR技术检测人Septin 9基因甲基化的方法及所用探针与引物及其试剂盒 |
| DE102015226843B3 (de) * | 2015-12-30 | 2017-04-27 | Technische Universität Dresden | Verfahren und Mittel zur Diagnostik von Tumoren |
| WO2017201400A1 (en) * | 2016-05-19 | 2017-11-23 | The Regents Of The University Of California | Determination of cell types in mixtures using targeted bisulfite sequencing |
| CN110475875B (zh) | 2017-01-27 | 2024-06-25 | 精密科学公司 | 通过分析甲基化dna检测结肠瘤形成 |
| US11965157B2 (en) | 2017-04-19 | 2024-04-23 | Singlera Genomics, Inc. | Compositions and methods for library construction and sequence analysis |
| CN111655869B (zh) | 2017-11-30 | 2024-06-28 | 梅约医学教育与研究基金会 | 检测乳腺癌 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| US12027237B2 (en) | 2018-03-13 | 2024-07-02 | Grail, Llc | Anomalous fragment detection and classification |
| CN108676878B (zh) * | 2018-05-23 | 2019-12-17 | 杭州诺辉健康科技有限公司 | 检测ndrg4基因甲基化位点的产品在制备结直肠癌早期检测的产品的用途 |
| US12234514B2 (en) | 2018-12-21 | 2025-02-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free DNA samples |
| KR20220092561A (ko) | 2019-10-31 | 2022-07-01 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 난소암 검출 |
| AU2021228737A1 (en) * | 2020-02-28 | 2022-09-22 | Grail, LLC. | Identifying methylation patterns that discriminate or indicate a cancer condition |
| CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
| CN114561464A (zh) * | 2021-12-20 | 2022-05-31 | 上海锐翌生物科技有限公司 | 用于进展期腺瘤诊断、检测或筛查的引物探针组及试剂盒 |
| CN114317775B (zh) * | 2022-01-12 | 2023-06-30 | 中国人民解放军军事科学院军事医学研究院 | 一种NCOA4的RNA m6A修饰作为γ射线辐射标志物的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US563961A (en) | 1896-07-14 | Alfred john keys | ||
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| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
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| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
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| US20100273164A1 (en) * | 2009-03-24 | 2010-10-28 | President And Fellows Of Harvard College | Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation |
| EP3327139A1 (en) * | 2009-04-06 | 2018-05-30 | The Johns Hopkins University | Digital quantification of dna methylation |
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| WO2012106525A2 (en) | 2011-02-02 | 2012-08-09 | Exact Sciences Corporation | Digital sequence analysis of dna methylation |
-
2012
- 2012-02-02 WO PCT/US2012/023646 patent/WO2012106525A2/en not_active Ceased
- 2012-02-02 EP EP18179746.5A patent/EP3441479B1/en active Active
- 2012-02-02 ES ES12742758.1T patent/ES2686309T3/es active Active
- 2012-02-02 AU AU2012212127A patent/AU2012212127B2/en active Active
- 2012-02-02 JP JP2013552632A patent/JP2014519310A/ja active Pending
- 2012-02-02 CN CN201280016745.6A patent/CN103703173A/zh active Pending
- 2012-02-02 EP EP20193533.5A patent/EP3795699B1/en active Active
- 2012-02-02 CN CN201910145167.XA patent/CN110129436A/zh active Pending
- 2012-02-02 ES ES18179746T patent/ES2829198T3/es active Active
- 2012-02-02 CA CA2826696A patent/CA2826696C/en active Active
- 2012-02-02 EP EP12742758.1A patent/EP2670893B1/en active Active
- 2012-02-02 US US13/364,978 patent/US9637792B2/en active Active
-
2016
- 2016-09-28 US US15/278,697 patent/US10519510B2/en active Active
-
2019
- 2019-10-28 US US16/665,738 patent/US10870893B2/en active Active
-
2020
- 2020-11-23 US US17/101,904 patent/US11952633B2/en active Active
-
2024
- 2024-04-05 US US18/628,011 patent/US20240368702A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170073771A1 (en) | 2017-03-16 |
| CA2826696A1 (en) | 2012-08-09 |
| AU2012212127A1 (en) | 2013-08-22 |
| JP2014519310A (ja) | 2014-08-14 |
| US11952633B2 (en) | 2024-04-09 |
| EP3441479A1 (en) | 2019-02-13 |
| WO2012106525A3 (en) | 2014-02-20 |
| EP3795699B1 (en) | 2023-12-20 |
| EP3441479B1 (en) | 2020-09-02 |
| WO2012106525A2 (en) | 2012-08-09 |
| CN110129436A (zh) | 2019-08-16 |
| EP2670893A4 (en) | 2015-11-11 |
| ES2686309T3 (es) | 2018-10-17 |
| US20200048720A1 (en) | 2020-02-13 |
| US9637792B2 (en) | 2017-05-02 |
| EP2670893A2 (en) | 2013-12-11 |
| EP2670893B1 (en) | 2018-06-27 |
| US20210095350A1 (en) | 2021-04-01 |
| EP3795699A1 (en) | 2021-03-24 |
| AU2012212127B2 (en) | 2016-06-02 |
| CA2826696C (en) | 2019-12-03 |
| US20120196756A1 (en) | 2012-08-02 |
| CN103703173A (zh) | 2014-04-02 |
| US10519510B2 (en) | 2019-12-31 |
| US20240368702A1 (en) | 2024-11-07 |
| US10870893B2 (en) | 2020-12-22 |
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