CA2826696C - Digital sequence analysis of dna methylation - Google Patents
Digital sequence analysis of dna methylation Download PDFInfo
- Publication number
- CA2826696C CA2826696C CA2826696A CA2826696A CA2826696C CA 2826696 C CA2826696 C CA 2826696C CA 2826696 A CA2826696 A CA 2826696A CA 2826696 A CA2826696 A CA 2826696A CA 2826696 C CA2826696 C CA 2826696C
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- methylation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438649P | 2011-02-02 | 2011-02-02 | |
| US61/438,649 | 2011-02-02 | ||
| PCT/US2012/023646 WO2012106525A2 (en) | 2011-02-02 | 2012-02-02 | Digital sequence analysis of dna methylation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2826696A1 CA2826696A1 (en) | 2012-08-09 |
| CA2826696C true CA2826696C (en) | 2019-12-03 |
Family
ID=46577813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2826696A Active CA2826696C (en) | 2011-02-02 | 2012-02-02 | Digital sequence analysis of dna methylation |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9637792B2 (enExample) |
| EP (3) | EP3441479B1 (enExample) |
| JP (1) | JP2014519310A (enExample) |
| CN (2) | CN110129436A (enExample) |
| AU (1) | AU2012212127B2 (enExample) |
| CA (1) | CA2826696C (enExample) |
| ES (2) | ES2829198T3 (enExample) |
| WO (1) | WO2012106525A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| ES2829198T3 (es) | 2011-02-02 | 2021-05-31 | Exact Sciences Dev Co Llc | Análisis digital de secuencia de la metilación de ADN |
| WO2014032205A1 (zh) * | 2012-08-31 | 2014-03-06 | 国防医学院 | 一种癌症筛检的方法 |
| JP6269491B2 (ja) * | 2012-09-19 | 2018-01-31 | シスメックス株式会社 | 大腸癌に関する情報の取得方法、ならびに大腸癌に関する情報を取得するためのマーカーおよびキット |
| EP3061831A4 (en) | 2013-10-21 | 2017-04-19 | KIM, Sung-Chun | Method and apparatus for analyzing biomolecules by using oligonucleotide |
| WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
| WO2015095689A1 (en) | 2013-12-19 | 2015-06-25 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
| EP3126529B1 (en) | 2014-03-31 | 2020-05-27 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| CN105603061A (zh) * | 2015-12-11 | 2016-05-25 | 宁云山 | 一种基于数字PCR技术检测人Septin 9基因甲基化的方法及所用探针与引物及其试剂盒 |
| DE102015226843B3 (de) * | 2015-12-30 | 2017-04-27 | Technische Universität Dresden | Verfahren und Mittel zur Diagnostik von Tumoren |
| WO2017201400A1 (en) * | 2016-05-19 | 2017-11-23 | The Regents Of The University Of California | Determination of cell types in mixtures using targeted bisulfite sequencing |
| CA3049459A1 (en) | 2017-01-27 | 2018-08-02 | Exact Sciences Development Company, Llc | Detection of colon neoplasia by analysis of methylated dna |
| WO2018195217A1 (en) | 2017-04-19 | 2018-10-25 | Singlera Genomics, Inc. | Compositions and methods for library construction and sequence analysis |
| US10975443B2 (en) | 2017-11-30 | 2021-04-13 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| TW202434742A (zh) | 2018-03-13 | 2024-09-01 | 美商格瑞爾有限責任公司 | 異常片段偵測及分類 |
| CN108676878B (zh) * | 2018-05-23 | 2019-12-17 | 杭州诺辉健康科技有限公司 | 检测ndrg4基因甲基化位点的产品在制备结直肠癌早期检测的产品的用途 |
| US12234514B2 (en) | 2018-12-21 | 2025-02-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free DNA samples |
| AU2020374985A1 (en) | 2019-10-31 | 2022-05-26 | Exact Sciences Corporation | Detecting ovarian cancer |
| CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
| CN114561464A (zh) * | 2021-12-20 | 2022-05-31 | 上海锐翌生物科技有限公司 | 用于进展期腺瘤诊断、检测或筛查的引物探针组及试剂盒 |
| CN114317775B (zh) * | 2022-01-12 | 2023-06-30 | 中国人民解放军军事科学院军事医学研究院 | 一种NCOA4的RNA m6A修饰作为γ射线辐射标志物的应用 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US563961A (en) | 1896-07-14 | Alfred john keys | ||
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5288609A (en) | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| US6800617B1 (en) | 1989-03-29 | 2004-10-05 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5362623A (en) | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| US6677312B1 (en) | 1989-03-29 | 2004-01-13 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US6872816B1 (en) | 1996-01-24 | 2005-03-29 | Third Wave Technologies, Inc. | Nucleic acid detection kits |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| ATE248224T1 (de) | 1994-04-25 | 2003-09-15 | Avitech Diagnostics Inc | Die bestimmung von mutationen durch spaltung mit resolvase |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| WO1996020287A2 (en) | 1994-12-23 | 1996-07-04 | Behringwerke Aktiengesellschaft | Detection of nucleic acids by target-catalyzed product formation |
| US5882867A (en) | 1995-06-07 | 1999-03-16 | Dade Behring Marburg Gmbh | Detection of nucleic acids by formation of template-dependent product |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| WO1997023647A1 (en) | 1995-12-22 | 1997-07-03 | Behringwerke Aktiengesellschaft | Homogeneous amplification and detection of nucleic acids |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US5741650A (en) | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| JP3898228B2 (ja) | 1996-04-12 | 2007-03-28 | ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク | 検出プローブ、キット及びアッセイ |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| DE69902996T2 (de) | 1998-02-04 | 2003-04-30 | Variagenics, Inc. | Techniken zu detektion von fehlpaarungen |
| US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| WO2001057247A2 (de) | 2000-02-04 | 2001-08-09 | Qiagen Gmbh | Nukleinsäure-isolierung aus stuhlproben und anderen biologischen materialien, die reich an inhibitoren sind |
| US7611869B2 (en) * | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
| WO2003031932A2 (en) | 2001-10-05 | 2003-04-17 | Case Western Reserve University | Methods and compositions for detecting colon cancers |
| AU2002352745A1 (en) * | 2001-11-16 | 2003-06-10 | The Johns Hopkins University School Of Medicine | Method of detection of prostate cancer |
| WO2003064701A2 (en) * | 2002-01-30 | 2003-08-07 | Epigenomics Ag | Method for the analysis of cytosine methylation patterns |
| EP1340818A1 (en) | 2002-02-27 | 2003-09-03 | Epigenomics AG | Method and nucleic acids for the analysis of a colon cell proliferative disorder |
| ES2431944T3 (es) * | 2002-06-26 | 2013-11-28 | Cold Spring Harbor Laboratory | Métodos para determinar los perfiles de metilación |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| CA2535910C (en) | 2003-08-14 | 2016-04-26 | Case Western Reserve University | Methods and compositions for detecting colon cancers |
| EP2354253A3 (en) | 2003-09-05 | 2011-11-16 | Trustees of Boston University | Method for non-invasive prenatal diagnosis |
| US20070059753A1 (en) * | 2005-09-15 | 2007-03-15 | Tatiana Vener | Detecting gene methylation |
| EP2423334A3 (en) | 2006-02-02 | 2012-04-18 | The Board of Trustees of The Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| US20100092981A1 (en) * | 2006-04-03 | 2010-04-15 | Genzyme Corporation | Methods of detecting hypermethylation |
| EP2099931A4 (en) | 2006-12-19 | 2010-11-24 | Cornell Res Foundation Inc | EVALUATION OF THE CANCER STATE BY METHYLATION OF THE PROMOTING GENE OF LECITHIN-RETINOL ACYLTRANSFERASE |
| GB0700374D0 (en) * | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| US9290803B2 (en) * | 2007-04-12 | 2016-03-22 | University Of Southern California | DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight |
| CA2718011C (en) | 2008-03-15 | 2015-05-19 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules during amplification reaction using footprint probes |
| US8609327B2 (en) * | 2008-07-10 | 2013-12-17 | International Business Machines Corporation | Forming sub-lithographic patterns using double exposure |
| US20100124747A1 (en) * | 2008-11-03 | 2010-05-20 | University Of Southern California | Compositions and methods for diagnosis or prognosis of testicular cancer |
| US20100273164A1 (en) | 2009-03-24 | 2010-10-28 | President And Fellows Of Harvard College | Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation |
| WO2010118016A2 (en) * | 2009-04-06 | 2010-10-14 | The Johns Hopkins University | Digital quantification of dna methylation |
| US8916344B2 (en) * | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| ES2829198T3 (es) | 2011-02-02 | 2021-05-31 | Exact Sciences Dev Co Llc | Análisis digital de secuencia de la metilación de ADN |
-
2012
- 2012-02-02 ES ES18179746T patent/ES2829198T3/es active Active
- 2012-02-02 EP EP18179746.5A patent/EP3441479B1/en active Active
- 2012-02-02 AU AU2012212127A patent/AU2012212127B2/en active Active
- 2012-02-02 JP JP2013552632A patent/JP2014519310A/ja active Pending
- 2012-02-02 EP EP12742758.1A patent/EP2670893B1/en active Active
- 2012-02-02 ES ES12742758.1T patent/ES2686309T3/es active Active
- 2012-02-02 US US13/364,978 patent/US9637792B2/en active Active
- 2012-02-02 WO PCT/US2012/023646 patent/WO2012106525A2/en not_active Ceased
- 2012-02-02 CA CA2826696A patent/CA2826696C/en active Active
- 2012-02-02 CN CN201910145167.XA patent/CN110129436A/zh active Pending
- 2012-02-02 EP EP20193533.5A patent/EP3795699B1/en active Active
- 2012-02-02 CN CN201280016745.6A patent/CN103703173A/zh active Pending
-
2016
- 2016-09-28 US US15/278,697 patent/US10519510B2/en active Active
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2019
- 2019-10-28 US US16/665,738 patent/US10870893B2/en active Active
-
2020
- 2020-11-23 US US17/101,904 patent/US11952633B2/en active Active
-
2024
- 2024-04-05 US US18/628,011 patent/US20240368702A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012106525A2 (en) | 2012-08-09 |
| CA2826696A1 (en) | 2012-08-09 |
| US10519510B2 (en) | 2019-12-31 |
| EP3795699A1 (en) | 2021-03-24 |
| US20240368702A1 (en) | 2024-11-07 |
| ES2829198T3 (es) | 2021-05-31 |
| WO2012106525A3 (en) | 2014-02-20 |
| EP3441479B1 (en) | 2020-09-02 |
| US20200048720A1 (en) | 2020-02-13 |
| ES2686309T3 (es) | 2018-10-17 |
| AU2012212127A1 (en) | 2013-08-22 |
| EP2670893A2 (en) | 2013-12-11 |
| US20210095350A1 (en) | 2021-04-01 |
| CN110129436A (zh) | 2019-08-16 |
| US9637792B2 (en) | 2017-05-02 |
| AU2012212127B2 (en) | 2016-06-02 |
| US20120196756A1 (en) | 2012-08-02 |
| EP3441479A1 (en) | 2019-02-13 |
| US10870893B2 (en) | 2020-12-22 |
| US11952633B2 (en) | 2024-04-09 |
| EP3795699B1 (en) | 2023-12-20 |
| EP2670893B1 (en) | 2018-06-27 |
| JP2014519310A (ja) | 2014-08-14 |
| US20170073771A1 (en) | 2017-03-16 |
| EP2670893A4 (en) | 2015-11-11 |
| CN103703173A (zh) | 2014-04-02 |
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