ES2814157T3 - Formulaciones liofilizadas para antídoto del factor Xa - Google Patents
Formulaciones liofilizadas para antídoto del factor Xa Download PDFInfo
- Publication number
- ES2814157T3 ES2814157T3 ES15834421T ES15834421T ES2814157T3 ES 2814157 T3 ES2814157 T3 ES 2814157T3 ES 15834421 T ES15834421 T ES 15834421T ES 15834421 T ES15834421 T ES 15834421T ES 2814157 T3 ES2814157 T3 ES 2814157T3
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- Prior art keywords
- formulation
- mannitol
- arginine
- sucrose
- seq
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Classifications
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Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
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| US201462039809P | 2014-08-20 | 2014-08-20 | |
| PCT/US2015/046173 WO2016029061A1 (en) | 2014-08-20 | 2015-08-20 | Lyophilized formulations for factor xa antidote |
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| ES2814157T3 true ES2814157T3 (es) | 2021-03-26 |
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| ES15834421T Active ES2814157T3 (es) | 2014-08-20 | 2015-08-20 | Formulaciones liofilizadas para antídoto del factor Xa |
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| SG (1) | SG11201701247RA (enExample) |
| WO (1) | WO2016029061A1 (enExample) |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3121271B1 (en) * | 2009-03-30 | 2019-07-24 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| EA036091B1 (ru) | 2014-08-20 | 2020-09-25 | Портола Фармасьютикалз, Инк. | ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ |
| WO2017147522A1 (en) | 2016-02-24 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Lyophilized formulations for factor xa antidote |
| CN110167575B (zh) * | 2016-06-17 | 2024-03-15 | 阿雷克森制药公司 | 因子xa衍生物的制备 |
| US11590237B2 (en) * | 2017-05-18 | 2023-02-28 | Merck Sharp & Dohme Llc | Pharmaceutical formulation comprising incretin-insulin conjugates |
| TWI840360B (zh) * | 2018-05-21 | 2024-05-01 | 日商中外製藥股份有限公司 | 密封於玻璃容器之凍結乾燥的製劑、套組、製造凍結乾燥製劑的方法、防止或減低凍結乾燥製劑的玻璃容器成霧的方法、及容器內面經過硫酸銨處理或ｖｉｓｔ處理之玻璃容器 |
| CN110760479A (zh) * | 2019-05-17 | 2020-02-07 | 上海交通大学医学院附属瑞金医院 | 靶向血小板表达的凝血因子Xa及其应用 |
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| EP0675899B1 (en) | 1992-12-15 | 1999-03-17 | Corvas International, Inc. | NOVEL INHIBITORS OF FACTOR Xa |
| CZ307715B6 (cs) * | 1999-02-22 | 2019-03-06 | University Of Connecticut | Způsob lyofilizace vodné farmaceutické formulace faktoru VIII prosté albuminu |
| US6586574B1 (en) * | 1999-08-17 | 2003-07-01 | Nn A/S | Stabilization of freeze-dried cake |
| AU2001245353A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| US6586584B2 (en) * | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
| JP2008500942A (ja) * | 2003-01-08 | 2008-01-17 | カイロン コーポレイション | 組織因子経路インヒビターまたは組織因子経路インヒビター改変体を含有する安定化凍結乾燥組成物 |
| CN102336702B (zh) | 2005-11-08 | 2015-02-11 | 米伦纽姆医药公司 | Xa因子抑制剂n-(5-氯-2-吡啶基)-2-[[4-[(二甲氨基)亚氨基甲基]苯甲酰基]氨基]-5-甲氧基-苯甲酰胺的医药盐和多晶型 |
| JO3324B1 (ar) * | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| PL2915564T3 (pl) * | 2007-09-28 | 2021-07-19 | Alexion Pharmaceuticals, Inc. | Antidota dla inhibitorów czynnika Xa i sposoby ich stosowania |
| PL2337580T3 (pl) | 2008-09-03 | 2012-08-31 | Octapharma Ag | Stabilizowane kompozycje czynnika VIII produkowanego metodami rekombinacji genetycznej |
| WO2010056765A2 (en) | 2008-11-14 | 2010-05-20 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| EP3121271B1 (en) * | 2009-03-30 | 2019-07-24 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| JP6163304B2 (ja) * | 2009-07-15 | 2017-07-12 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法 |
| EP2458990B1 (en) * | 2009-07-28 | 2016-03-30 | Merck Sharp & Dohme Corp. | Methods for producing high concentration lyophilized pharmaceutical formulations |
| US20130165459A1 (en) * | 2010-01-12 | 2013-06-27 | Norvartis Pharma Ag | Pharmaceutical composition and dosage forms of elinogrel and methods of use thereof |
| DK2561070T3 (en) * | 2010-04-20 | 2015-08-17 | Octapharma Ag | NEW STABILIZER FOR PHARMACEUTICAL PROTEINS |
| JP2013544271A (ja) * | 2010-12-03 | 2013-12-12 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 式（ｉ）の化合物の薬学的組成物、投薬形態、および新規の形態、ならびにその使用方法 |
| CN103945863A (zh) * | 2011-08-01 | 2014-07-23 | 爱默蕾大学 | 包含配体的vlp及其相关方法 |
| WO2013049804A1 (en) * | 2011-09-30 | 2013-04-04 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating hemostasis |
| GB201310946D0 (en) * | 2013-06-19 | 2013-07-31 | Cambridge Entpr Ltd | Antidote |
| EA036091B1 (ru) * | 2014-08-20 | 2020-09-25 | Портола Фармасьютикалз, Инк. | ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ |
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2015
- 2015-08-20 EA EA201790415A patent/EA036091B1/ru unknown
- 2015-08-20 KR KR1020227045749A patent/KR102867491B1/ko active Active
- 2015-08-20 EA EA202091385A patent/EA202091385A3/ru unknown
- 2015-08-20 WO PCT/US2015/046173 patent/WO2016029061A1/en not_active Ceased
- 2015-08-20 CA CA2961739A patent/CA2961739C/en active Active
- 2015-08-20 KR KR1020177007503A patent/KR102482517B1/ko active Active
- 2015-08-20 ES ES15834421T patent/ES2814157T3/es active Active
- 2015-08-20 AU AU2015305413A patent/AU2015305413B2/en active Active
- 2015-08-20 DK DK15834421.8T patent/DK3182993T3/da active
- 2015-08-20 CN CN202110363277.0A patent/CN113171447B/zh active Active
- 2015-08-20 EP EP20170763.5A patent/EP3750556A1/en active Pending
- 2015-08-20 EP EP15834421.8A patent/EP3182993B1/en active Active
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2016
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2017
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2019
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2020
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2021
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2023
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2024
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