ES2809734T3 - Terapia génica y electroporación para el tratamiento de neoplasias malignas - Google Patents
Terapia génica y electroporación para el tratamiento de neoplasias malignas Download PDFInfo
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- ES2809734T3 ES2809734T3 ES16735524T ES16735524T ES2809734T3 ES 2809734 T3 ES2809734 T3 ES 2809734T3 ES 16735524 T ES16735524 T ES 16735524T ES 16735524 T ES16735524 T ES 16735524T ES 2809734 T3 ES2809734 T3 ES 2809734T3
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- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
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- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
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- Medicinal Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
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Applications Claiming Priority (3)
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| US201562101850P | 2015-01-09 | 2015-01-09 | |
| US201562126300P | 2015-02-27 | 2015-02-27 | |
| PCT/US2016/012759 WO2016112359A1 (en) | 2015-01-09 | 2016-01-08 | Method for the treatment of malignancies |
Publications (1)
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| ES2809734T3 true ES2809734T3 (es) | 2021-03-05 |
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| ES16735524T Active ES2809734T3 (es) | 2015-01-09 | 2016-01-08 | Terapia génica y electroporación para el tratamiento de neoplasias malignas |
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| ES2809734T3 (es) * | 2015-01-09 | 2021-03-05 | Oncosec Medical Inc | Terapia génica y electroporación para el tratamiento de neoplasias malignas |
| EP4209190A1 (en) | 2016-06-27 | 2023-07-12 | Galvanize Therapeutics, Inc. | System comprising a generator and a catheter with an electrode for treating a lung passageway |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| JP2021508533A (ja) | 2017-12-26 | 2021-03-11 | ギャラリー，インコーポレイテッド | 様々な用途のためのエネルギー送達の最適化 |
| MX2020011618A (es) * | 2018-05-02 | 2021-02-16 | Oncosec Medical Inc | Sistemas, métodos y aparatos de electroporación. |
| KR102753455B1 (ko) * | 2018-08-08 | 2025-01-10 | 세다르스-신나이 메디칼 센터 | 암 및 자가면역 질환을 치료하기 위한 조성물 및 방법 |
| JP7586890B2 (ja) | 2019-07-16 | 2024-11-19 | ガルヴァナイズ セラピューティクス，インコーポレイテッド | パルス電界による生殖器の治療 |
| CN114127121B (zh) | 2019-08-12 | 2025-04-11 | 北京恩瑞尼生物科技股份有限公司 | 用于通过cd39表达细胞的adcc靶向促进和增强t细胞介导的免疫反应的方法和组合物 |
| TW202128775A (zh) | 2019-10-16 | 2021-08-01 | 英商阿法克塔生命科學有限公司 | PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分 |
| GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| EP4413038A1 (en) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
| TW202332694A (zh) | 2021-10-07 | 2023-08-16 | 英商阿凡克塔生命科學公司 | 血清半衰期延長之ｐｄ－ｌ１結合多肽 |
| CN119213021A (zh) | 2022-02-10 | 2024-12-27 | 艾菲赛尔治疗株式会社 | 与CD40L特异性结合的Stefin A蛋白变体及其用途 |
| KR20250006965A (ko) | 2022-04-29 | 2025-01-13 | 퓨리노미아 바이오테크, 아이엔씨. | 호산구에 의해 유발되는 질환 및 장애의 치료를 위한 방법 및 조성물 |
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| US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US20030049696A1 (en) | 2001-06-07 | 2003-03-13 | Norment Anne M. | Regulatory T cells and uses thereof |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7245963B2 (en) | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US20110142887A1 (en) * | 2009-12-15 | 2011-06-16 | Immunovative Therapies Ltd. | Methods and compositions for liquidation of tumors |
| US8802643B1 (en) * | 2003-05-30 | 2014-08-12 | University Of South Florida | Method for the treatment of malignancies |
| EA200501937A1 (ru) * | 2003-05-30 | 2006-08-25 | Университет Южной Флориды | Способ лечения злокачественных опухолей |
| US7923251B2 (en) | 2005-02-23 | 2011-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for avalanche-mediated transfer of agents into cells |
| US8101169B2 (en) | 2005-02-23 | 2012-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Ocular gene therapy using avalanche-mediated transfection |
| WO2007120368A2 (en) * | 2006-01-09 | 2007-10-25 | The Regents Of The University Of California | Immunostimulatory combinations for vaccine adjuvants |
| WO2010030002A1 (ja) * | 2008-09-12 | 2010-03-18 | 国立大学法人三重大学 | 外来性ｇｉｔｒリガンド発現細胞 |
| KR102445129B1 (ko) * | 2011-12-12 | 2022-09-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 il-12 유전적 컨스트럭트 및 백신을 포함하는 조성물, 면역치료제 및 이를 이용하는 방법 |
| ES2809734T3 (es) * | 2015-01-09 | 2021-03-05 | Oncosec Medical Inc | Terapia génica y electroporación para el tratamiento de neoplasias malignas |
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| JP7111384B2 (ja) | 2022-08-02 |
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| CA2973390A1 (en) | 2016-07-14 |
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| US20180000895A1 (en) | 2018-01-04 |
| JP2022137203A (ja) | 2022-09-21 |
| EP3242947A1 (en) | 2017-11-15 |
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