ES2786374T3 - Compuesto antimicótico - Google Patents
Compuesto antimicótico Download PDFInfo
- Publication number
- ES2786374T3 ES2786374T3 ES15817507T ES15817507T ES2786374T3 ES 2786374 T3 ES2786374 T3 ES 2786374T3 ES 15817507 T ES15817507 T ES 15817507T ES 15817507 T ES15817507 T ES 15817507T ES 2786374 T3 ES2786374 T3 ES 2786374T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- tetrahydrofuran
- methoxy
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(C*c(cc1)ncc1F)C(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(C)c1OC[C@@](C1)COC1(C[n]1ncnc1)c(c(F)c1)ccc1F)=O Chemical compound CC(C*c(cc1)ncc1F)C(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(C)c1OC[C@@](C1)COC1(C[n]1ncnc1)c(c(F)c1)ccc1F)=O 0.000 description 2
- WFNHCYCXBZKQCD-ULUUSGLTSA-N CC(C(OC[C@@H]1CO[C@](Cc(c(F)c2)ccc2F)(C[n]2ncnc2)C1)=CC1)=NC1N(CC1)CCN1c(cc1)ccc1C(Nc(cc1)ccc1F)=O Chemical compound CC(C(OC[C@@H]1CO[C@](Cc(c(F)c2)ccc2F)(C[n]2ncnc2)C1)=CC1)=NC1N(CC1)CCN1c(cc1)ccc1C(Nc(cc1)ccc1F)=O WFNHCYCXBZKQCD-ULUUSGLTSA-N 0.000 description 1
- GQIRIWDEZSKOCN-UHFFFAOYSA-N CC(C)=C(N(C)C)Cl Chemical compound CC(C)=C(N(C)C)Cl GQIRIWDEZSKOCN-UHFFFAOYSA-N 0.000 description 1
- BKZZMIVRYFQESP-NHRFMIRVSA-N COC(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(C#N)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F)=O Chemical compound COC(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(C#N)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F)=O BKZZMIVRYFQESP-NHRFMIRVSA-N 0.000 description 1
- KHBQCBSBXNSQPV-BVFDSDPOSA-N Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(c(F)c2)ccc2F)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(c(F)c2)ccc2F)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F KHBQCBSBXNSQPV-BVFDSDPOSA-N 0.000 description 1
- NDLCJJMTKCEVHW-GQYNZBDXSA-N Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(cc2)cc(F)c2F)=O)c1O/C=C(/C1)\CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(cc2)cc(F)c2F)=O)c1O/C=C(/C1)\CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F NDLCJJMTKCEVHW-GQYNZBDXSA-N 0.000 description 1
- CRWRYMSOZYXPJP-JLKRBFOBSA-N Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(cc2)ncc2OC(F)(F)F)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(cc2)ncc2OC(F)(F)F)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F CRWRYMSOZYXPJP-JLKRBFOBSA-N 0.000 description 1
- TUGNZJDXBUXNEH-CWRQMEKBSA-N Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc2nc(C#N)ccc2)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(cc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc2nc(C#N)ccc2)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F TUGNZJDXBUXNEH-CWRQMEKBSA-N 0.000 description 1
- FNXDFTQQYCOPJC-MUVVOIGYSA-N Cc(nc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(cc2)ncc2F)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F Chemical compound Cc(nc(cc1)N(CC2)CCN2c(cc2)ccc2C(Nc(cc2)ncc2F)=O)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(c(F)c1)ccc1F FNXDFTQQYCOPJC-MUVVOIGYSA-N 0.000 description 1
- CEPCPXLLFXPZGW-UHFFFAOYSA-N Nc(c(F)c1)ccc1F Chemical compound Nc(c(F)c1)ccc1F CEPCPXLLFXPZGW-UHFFFAOYSA-N 0.000 description 1
- KRZCOLNOCZKSDF-UHFFFAOYSA-N Nc(cc1)ccc1F Chemical compound Nc(cc1)ccc1F KRZCOLNOCZKSDF-UHFFFAOYSA-N 0.000 description 1
- SDHQETYBUXCNBO-WRAWZCCESA-N O=C(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(F)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(ccc(F)c1)c1F)Nc(cc1)ccc1F Chemical compound O=C(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(F)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(ccc(F)c1)c1F)Nc(cc1)ccc1F SDHQETYBUXCNBO-WRAWZCCESA-N 0.000 description 1
- DHOZDJOEIBRFIX-PNBVQZGLSA-N O=C(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(F)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(ccc(F)c1)c1F)Nc(cc1)ncc1F Chemical compound O=C(c(cc1)ccc1N(CC1)CCN1c(cc1)cc(F)c1OC[C@@H](C1)CO[C@@]1(C[n]1ncnc1)c(ccc(F)c1)c1F)Nc(cc1)ncc1F DHOZDJOEIBRFIX-PNBVQZGLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
- G06F1/26—Power supply means, e.g. regulation thereof
- G06F1/32—Means for saving power
- G06F1/3203—Power management, i.e. event-based initiation of a power-saving mode
- G06F1/3234—Power saving characterised by the action undertaken
- G06F1/325—Power saving in peripheral device
- G06F1/3268—Power saving in hard disk drive
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
- G11C11/21—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements
- G11C11/34—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices
- G11C11/40—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors
- G11C11/401—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells
- G11C11/4063—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing
- G11C11/407—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing for memory cells of the field-effect type
- G11C11/4074—Power supply or voltage generation circuits, e.g. bias voltage generators, substrate voltage generators, back-up power, power control circuits
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196662 | 2014-12-05 | ||
| PCT/GB2015/053733 WO2016087880A1 (en) | 2014-12-05 | 2015-12-04 | Antimycotic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2786374T3 true ES2786374T3 (es) | 2020-10-09 |
Family
ID=52006914
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15817507T Active ES2786374T3 (es) | 2014-12-05 | 2015-12-04 | Compuesto antimicótico |
| ES15808770T Active ES2790875T3 (es) | 2014-12-05 | 2015-12-04 | Compuesto antimicótico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15808770T Active ES2790875T3 (es) | 2014-12-05 | 2015-12-04 | Compuesto antimicótico |
Country Status (18)
| Country | Link |
|---|---|
| US (12) | US10106531B2 (enExample) |
| EP (2) | EP3227278B1 (enExample) |
| JP (2) | JP6669751B2 (enExample) |
| KR (1) | KR102579848B1 (enExample) |
| CN (2) | CN112375073B (enExample) |
| AU (1) | AU2015356795B2 (enExample) |
| BR (1) | BR112017008481B1 (enExample) |
| CA (1) | CA2963625C (enExample) |
| DK (2) | DK3227277T3 (enExample) |
| EA (1) | EA033736B1 (enExample) |
| ES (2) | ES2786374T3 (enExample) |
| HU (2) | HUE048905T2 (enExample) |
| IL (1) | IL251631B (enExample) |
| MX (1) | MX370412B (enExample) |
| PL (1) | PL3227277T3 (enExample) |
| PT (1) | PT3227277T (enExample) |
| SG (1) | SG11201702835RA (enExample) |
| WO (2) | WO2016087880A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016087880A1 (en) * | 2014-12-05 | 2016-06-09 | Pulmocide Limited | Antimycotic compound |
| US10160772B2 (en) | 2014-12-18 | 2018-12-25 | Pulmocide Limited | 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives |
| ES2790723T3 (es) | 2015-05-21 | 2020-10-29 | Pulmocide Ltd | Antifúngico 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-il)metil)-5-(2,4-difluorofenil)tetrahidrofurano-3-il)metoxi)-3-metilfenil)piperazina-1-il)-N -(2-hidroxiciclohexil)benzamida, o una sal farmacéuticamente aceptable del mismo |
| WO2017093491A1 (en) * | 2015-12-04 | 2017-06-08 | Pulmocide Limited | Antimycotic triazole compound |
| CN110198707A (zh) * | 2016-11-28 | 2019-09-03 | 赛力克斯生物私人有限公司 | 用于治疗口腔感染性疾病的组合物和方法 |
| US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
| GB201917867D0 (en) * | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| EP3858357A1 (en) * | 2020-01-28 | 2021-08-04 | Diaccurate | Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib |
| RU2770598C1 (ru) * | 2021-06-29 | 2022-04-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | ПРИМЕНЕНИЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА НА ОСНОВЕ 2-((4-R1-5-R2-3-(ЭТОКСИКАРБОНИЛ)ТИОФЕН-2-ИЛ)АМИНО)-4-ОКСО-4-R3-БУТ-2-ЕНОВЫХ КИСЛОТ ПО ОТНОШЕНИЮ К Candida aldicans |
| TW202541814A (zh) | 2023-11-30 | 2025-11-01 | 瑞士商巴塞利亞阿爾斯維爾藥業國際股份有限公司 | 用於治療真菌感染的藥物組合 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533466A (en) * | 1978-07-14 | 1980-03-08 | Janssen Pharmaceutica Nv | Novel azole derivatives and their manufacture |
| CH655103A5 (de) * | 1983-03-11 | 1986-03-27 | Sandoz Ag | Azolderivate, verfahren zu ihrer herstellung und ihre verwendung. |
| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| DE3609598A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| AU2811689A (en) | 1987-11-20 | 1989-06-14 | Schering Corporation | Tri-and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5039678A (en) | 1989-03-23 | 1991-08-13 | Wake Forest University | Method of increasing cranial vessel proliferation by administering nimodipine |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| DK0736030T3 (da) | 1993-12-21 | 2001-10-29 | Schering Corp | Fungicide tetrahydrofuraner |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| ES2199291T3 (es) | 1995-06-02 | 2004-02-16 | Schering Corporation | Antifungicos de tetrahidrofurano. |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| PL212985B1 (pl) | 2001-04-03 | 2012-12-31 | Schering Corp | Ciekla zawiesina zawierajaca przeciwgrzybiczo skuteczna ilosc posakonazolu oraz zastosowanie zmikronizowanych czastek posakonazolu |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| WO2013012848A1 (en) * | 2011-07-18 | 2013-01-24 | Merck Patent Gmbh | Benzamides |
| WO2013036866A1 (en) | 2011-09-07 | 2013-03-14 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| WO2016087880A1 (en) * | 2014-12-05 | 2016-06-09 | Pulmocide Limited | Antimycotic compound |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
-
2015
- 2015-12-04 WO PCT/GB2015/053733 patent/WO2016087880A1/en not_active Ceased
- 2015-12-04 JP JP2017528775A patent/JP6669751B2/ja active Active
- 2015-12-04 ES ES15817507T patent/ES2786374T3/es active Active
- 2015-12-04 BR BR112017008481-3A patent/BR112017008481B1/pt active IP Right Grant
- 2015-12-04 AU AU2015356795A patent/AU2015356795B2/en active Active
- 2015-12-04 HU HUE15808770A patent/HUE048905T2/hu unknown
- 2015-12-04 CN CN202011308132.2A patent/CN112375073B/zh active Active
- 2015-12-04 PL PL15808770T patent/PL3227277T3/pl unknown
- 2015-12-04 JP JP2017528789A patent/JP6666345B2/ja active Active
- 2015-12-04 PT PT158087700T patent/PT3227277T/pt unknown
- 2015-12-04 CN CN201580066092.6A patent/CN107001343B/zh active Active
- 2015-12-04 ES ES15808770T patent/ES2790875T3/es active Active
- 2015-12-04 DK DK15808770.0T patent/DK3227277T3/da active
- 2015-12-04 EP EP15817507.5A patent/EP3227278B1/en active Active
- 2015-12-04 WO PCT/GB2015/053731 patent/WO2016087878A1/en not_active Ceased
- 2015-12-04 SG SG11201702835RA patent/SG11201702835RA/en unknown
- 2015-12-04 DK DK15817507.5T patent/DK3227278T3/da active
- 2015-12-04 EP EP15808770.0A patent/EP3227277B1/en active Active
- 2015-12-04 KR KR1020177013730A patent/KR102579848B1/ko active Active
- 2015-12-04 US US15/524,505 patent/US10106531B2/en active Active
- 2015-12-04 MX MX2017007188A patent/MX370412B/es active IP Right Grant
- 2015-12-04 HU HUE15817507A patent/HUE048685T2/hu unknown
- 2015-12-04 CA CA2963625A patent/CA2963625C/en active Active
- 2015-12-04 EA EA201791174A patent/EA033736B1/ru not_active IP Right Cessation
-
2016
- 2016-10-20 US US15/298,431 patent/US10093659B2/en active Active
-
2017
- 2017-04-06 IL IL251631A patent/IL251631B/en active IP Right Grant
-
2018
- 2018-09-12 US US16/129,322 patent/US10487073B2/en active Active
- 2018-09-24 US US16/139,591 patent/US10344022B2/en active Active
-
2019
- 2019-05-24 US US16/422,062 patent/US10450304B2/en active Active
- 2019-09-12 US US16/569,128 patent/US10662179B2/en active Active
- 2019-10-04 US US16/593,444 patent/US10800762B2/en active Active
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2020
- 2020-04-15 US US16/849,476 patent/US10858345B2/en active Active
- 2020-09-04 US US17/012,685 patent/US11008307B2/en active Active
- 2020-11-04 US US17/089,441 patent/US11661415B2/en active Active
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2021
- 2021-04-14 US US17/230,009 patent/US20210238169A1/en not_active Abandoned
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2023
- 2023-04-18 US US18/302,557 patent/US12269814B2/en active Active
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