ES2784616T3 - Moléculas de unión que se unen al factor C2 del complemento y usos de las mismas - Google Patents

Moléculas de unión que se unen al factor C2 del complemento y usos de las mismas Download PDF

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Publication number
ES2784616T3
ES2784616T3 ES14729463T ES14729463T ES2784616T3 ES 2784616 T3 ES2784616 T3 ES 2784616T3 ES 14729463 T ES14729463 T ES 14729463T ES 14729463 T ES14729463 T ES 14729463T ES 2784616 T3 ES2784616 T3 ES 2784616T3
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seq
resp
amino acid
antibody
human
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Active
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ES14729463T
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English (en)
Spanish (es)
Inventor
Cornelis Erik Hack
Cafer Yildiz
Louis Boon
Petrus Johannes Simons
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BROTEIO PHARMA BV
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BROTEIO PHARMA BV
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES14729463T 2013-05-23 2014-05-22 Moléculas de unión que se unen al factor C2 del complemento y usos de las mismas Active ES2784616T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13168941 2013-05-23
PCT/NL2014/050327 WO2014189378A1 (en) 2013-05-23 2014-05-22 Binding molecules that bind human complement factor c2 and uses thereof

Publications (1)

Publication Number Publication Date
ES2784616T3 true ES2784616T3 (es) 2020-09-29

Family

ID=48485015

Family Applications (2)

Application Number Title Priority Date Filing Date
ES14729463T Active ES2784616T3 (es) 2013-05-23 2014-05-22 Moléculas de unión que se unen al factor C2 del complemento y usos de las mismas
ES20165165T Active ES2904709T3 (es) 2013-05-23 2014-05-22 Moléculas de unión que se unen al factor C2B del complemento humano y usos de las mismas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES20165165T Active ES2904709T3 (es) 2013-05-23 2014-05-22 Moléculas de unión que se unen al factor C2B del complemento humano y usos de las mismas

Country Status (14)

Country Link
US (2) US9944717B2 (enExample)
EP (2) EP2999714B1 (enExample)
JP (3) JP2016520313A (enExample)
CN (1) CN105492461B (enExample)
AU (1) AU2014269193C1 (enExample)
CA (1) CA2913318C (enExample)
DK (2) DK3725803T3 (enExample)
ES (2) ES2784616T3 (enExample)
HU (2) HUE057858T2 (enExample)
LT (2) LT2999714T (enExample)
MX (1) MX366046B (enExample)
PL (2) PL2999714T3 (enExample)
PT (2) PT2999714T (enExample)
WO (1) WO2014189378A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2509260B (en) 2012-11-02 2016-05-04 True North Therapeutics Inc Anti-complement C1s antibodies and uses thereof
HUE057858T2 (hu) * 2013-05-23 2022-06-28 Broteio Pharma B V Humán komplement faktor C2B-t megkötõ kötõ molekulák és alkalmazásaik
MY198182A (en) * 2016-10-12 2023-08-09 Bioverativ Usa Inc Anti-C1s Antibodies and Methods of use Thereof
CN119371526A (zh) 2018-12-13 2025-01-28 阿尔金克斯有限公司 针对人补体因子C2b的抗体及使用方法
GB2584105B (en) * 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
CN114502583A (zh) * 2019-08-12 2022-05-13 杰特创新股份有限公司 补体c2结合蛋白及其用途
CN118475606A (zh) * 2022-01-29 2024-08-09 科越医药(苏州)有限公司 抗c2抗体及其用途
GB202407051D0 (en) 2024-05-17 2024-07-03 argenx BV Methods of treating osteoarthritis pain
WO2025257157A1 (en) 2024-06-10 2025-12-18 argenx BV Treatment or prevention of ischemia reperfusion injury in organ tranplantation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP1265929B1 (en) * 2000-03-23 2009-07-08 Genentech, Inc. Anti-c2/c2a inhibitors of complement activation
HUE057858T2 (hu) * 2013-05-23 2022-06-28 Broteio Pharma B V Humán komplement faktor C2B-t megkötõ kötõ molekulák és alkalmazásaik

Also Published As

Publication number Publication date
US20160108134A1 (en) 2016-04-21
DK2999714T3 (da) 2020-06-02
HUE057858T2 (hu) 2022-06-28
EP3725803A1 (en) 2020-10-21
MX366046B (es) 2019-06-26
LT2999714T (lt) 2020-07-10
DK3725803T3 (da) 2022-03-07
HUE049769T2 (hu) 2020-10-28
WO2014189378A1 (en) 2014-11-27
US9944717B2 (en) 2018-04-17
JP2020007318A (ja) 2020-01-16
MX2015016120A (es) 2016-10-28
CA2913318A1 (en) 2014-11-27
JP7163254B2 (ja) 2022-10-31
AU2014269193C1 (en) 2020-02-20
ES2904709T3 (es) 2022-04-05
JP7414929B2 (ja) 2024-01-16
JP2023002684A (ja) 2023-01-10
US10717785B2 (en) 2020-07-21
EP3725803B1 (en) 2021-12-15
JP2016520313A (ja) 2016-07-14
HK1223385A1 (zh) 2017-07-28
CN105492461B (zh) 2019-11-26
AU2014269193A1 (en) 2015-12-17
PT3725803T (pt) 2021-12-24
CA2913318C (en) 2024-03-26
PT2999714T (pt) 2020-04-30
PL3725803T3 (pl) 2022-04-04
EP2999714B1 (en) 2020-04-01
EP2999714A1 (en) 2016-03-30
LT3725803T (lt) 2022-03-10
AU2014269193B2 (en) 2019-08-15
US20180319895A1 (en) 2018-11-08
CN105492461A (zh) 2016-04-13
PL2999714T3 (pl) 2020-10-19

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