DK3725803T3 - Bindingsmolekyler som binder human komplementfaktor C2b, og anvendelser deraf - Google Patents

Bindingsmolekyler som binder human komplementfaktor C2b, og anvendelser deraf Download PDF

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Publication number
DK3725803T3
DK3725803T3 DK20165165.0T DK20165165T DK3725803T3 DK 3725803 T3 DK3725803 T3 DK 3725803T3 DK 20165165 T DK20165165 T DK 20165165T DK 3725803 T3 DK3725803 T3 DK 3725803T3
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Denmark
Prior art keywords
binding molecules
complement factor
human complement
bind human
bind
Prior art date
Application number
DK20165165.0T
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Danish (da)
English (en)
Inventor
Cornelis Erik Hack
Cafer Yildiz
Louis Boon
Petrus Johannes Simons
Original Assignee
Broteio Pharma B V
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Publication of DK3725803T3 publication Critical patent/DK3725803T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK20165165.0T 2013-05-23 2014-05-22 Bindingsmolekyler som binder human komplementfaktor C2b, og anvendelser deraf DK3725803T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13168941 2013-05-23
EP14729463.1A EP2999714B1 (en) 2013-05-23 2014-05-22 Binding molecules that bind human complement factor c2 and uses thereof

Publications (1)

Publication Number Publication Date
DK3725803T3 true DK3725803T3 (da) 2022-03-07

Family

ID=48485015

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20165165.0T DK3725803T3 (da) 2013-05-23 2014-05-22 Bindingsmolekyler som binder human komplementfaktor C2b, og anvendelser deraf
DK14729463.1T DK2999714T3 (da) 2013-05-23 2014-05-22 Bindingsmolekyler som binder til human komplementfaktor C2 og anvendelser deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14729463.1T DK2999714T3 (da) 2013-05-23 2014-05-22 Bindingsmolekyler som binder til human komplementfaktor C2 og anvendelser deraf

Country Status (14)

Country Link
US (2) US9944717B2 (enExample)
EP (2) EP3725803B1 (enExample)
JP (3) JP2016520313A (enExample)
CN (1) CN105492461B (enExample)
AU (1) AU2014269193C1 (enExample)
CA (1) CA2913318C (enExample)
DK (2) DK3725803T3 (enExample)
ES (2) ES2904709T3 (enExample)
HU (2) HUE049769T2 (enExample)
LT (2) LT2999714T (enExample)
MX (1) MX366046B (enExample)
PL (2) PL3725803T3 (enExample)
PT (2) PT3725803T (enExample)
WO (1) WO2014189378A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS63212B1 (sr) 2012-11-02 2022-06-30 Bioverativ Usa Inc Antikomplementna c1s antitela i njihove primene
DK3725803T3 (da) * 2013-05-23 2022-03-07 Broteio Pharma B V Bindingsmolekyler som binder human komplementfaktor C2b, og anvendelser deraf
EP3525583B8 (en) 2016-10-12 2025-09-10 Bioverativ USA Inc. Anti-c1s antibodies and methods of use thereof
FI3893924T3 (fi) * 2018-12-13 2024-10-04 argenx BV Ihmisen komplementtitekijän C2B vasta-aineita sekä niiden käyttötapoja
GB2584105B (en) 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
US20220332804A1 (en) * 2019-08-12 2022-10-20 Csl Innovation Pty Ltd. Complement C2 Binding Proteins and Uses Thereof
EP4469475A1 (en) * 2022-01-29 2024-12-04 Kira Pharmaceuticals (Suzhou) Ltd. Anti-c2 antibodies and uses thereof
GB202407051D0 (en) 2024-05-17 2024-07-03 argenx BV Methods of treating osteoarthritis pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ATE435873T1 (de) 2000-03-23 2009-07-15 Genentech Inc Anti-c2/c2a inhibitoren zur komplement aktivierung
DK3725803T3 (da) 2013-05-23 2022-03-07 Broteio Pharma B V Bindingsmolekyler som binder human komplementfaktor C2b, og anvendelser deraf

Also Published As

Publication number Publication date
AU2014269193B2 (en) 2019-08-15
DK2999714T3 (da) 2020-06-02
CN105492461B (zh) 2019-11-26
EP2999714B1 (en) 2020-04-01
HUE057858T2 (hu) 2022-06-28
MX2015016120A (es) 2016-10-28
AU2014269193C1 (en) 2020-02-20
MX366046B (es) 2019-06-26
JP2023002684A (ja) 2023-01-10
PT2999714T (pt) 2020-04-30
CA2913318C (en) 2024-03-26
US10717785B2 (en) 2020-07-21
US20160108134A1 (en) 2016-04-21
US20180319895A1 (en) 2018-11-08
JP7163254B2 (ja) 2022-10-31
EP3725803B1 (en) 2021-12-15
PL3725803T3 (pl) 2022-04-04
JP2020007318A (ja) 2020-01-16
US9944717B2 (en) 2018-04-17
EP2999714A1 (en) 2016-03-30
ES2904709T3 (es) 2022-04-05
LT3725803T (lt) 2022-03-10
WO2014189378A1 (en) 2014-11-27
PL2999714T3 (pl) 2020-10-19
JP7414929B2 (ja) 2024-01-16
AU2014269193A1 (en) 2015-12-17
ES2784616T3 (es) 2020-09-29
JP2016520313A (ja) 2016-07-14
HUE049769T2 (hu) 2020-10-28
PT3725803T (pt) 2021-12-24
CN105492461A (zh) 2016-04-13
LT2999714T (lt) 2020-07-10
EP3725803A1 (en) 2020-10-21
CA2913318A1 (en) 2014-11-27
HK1223385A1 (zh) 2017-07-28

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