ES2778059T3 - Combinaciones farmacéuticas de un inhibidor de CDK4/6 y un inhibidor de B-Raf - Google Patents
Combinaciones farmacéuticas de un inhibidor de CDK4/6 y un inhibidor de B-Raf Download PDFInfo
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- ES2778059T3 ES2778059T3 ES13745540T ES13745540T ES2778059T3 ES 2778059 T3 ES2778059 T3 ES 2778059T3 ES 13745540 T ES13745540 T ES 13745540T ES 13745540 T ES13745540 T ES 13745540T ES 2778059 T3 ES2778059 T3 ES 2778059T3
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| SI2976106T1 (sl) * | 2013-03-21 | 2021-08-31 | Array Biopharma Inc. | Kombinacijska terapija, ki vsebuje zaviralec B-Raf in drugi zaviralec |
| JP2018502089A (ja) * | 2014-12-23 | 2018-01-25 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｒａｆ阻害剤及びａｕｒｏｒａキナーゼ阻害剤の組み合わせ |
| CN105753869B (zh) * | 2015-04-01 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| US10323035B2 (en) * | 2015-04-01 | 2019-06-18 | Crystal Pharmatech Co., Ltd. | Co-crystal of a CDK inhibitor and an MEK inhibitor and process of preparation thereof |
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| CN105732642B (zh) * | 2015-11-18 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
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| WO2018081211A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
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| WO2018218633A1 (en) | 2017-06-02 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Combination therapies for treating cancers |
| CN111837146B (zh) | 2018-01-08 | 2024-10-15 | G1治疗公司 | G1t38优异剂量方案 |
| CA3089592A1 (en) | 2018-02-15 | 2019-08-22 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| WO2019195959A1 (en) * | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| US11633401B2 (en) * | 2018-07-06 | 2023-04-25 | Memorial Sloan Kettering Cancer Center | Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer |
| WO2020128878A1 (en) * | 2018-12-20 | 2020-06-25 | Novartis Ag | Combination therapy with a raf inhibitor and a cdk4/6 inhibitor for use in the treatment of cancer |
| US12187703B2 (en) | 2019-05-13 | 2025-01-07 | Novartis Ag | Crystalline forms of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as Raf inhibitors for the treatment of cancer |
| WO2021047573A1 (zh) * | 2019-09-11 | 2021-03-18 | 江苏恒瑞医药股份有限公司 | 一种mek抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤的药物中的用途 |
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| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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| EP3000810B1 (en) * | 2002-03-13 | 2017-07-19 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivative as mek inhibitor |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| BRPI0509580A (pt) * | 2004-03-30 | 2007-11-27 | Pfizer Prod Inc | combinações de inibidores de transdução de sinal |
| KR20110028651A (ko) * | 2008-07-11 | 2011-03-21 | 노파르티스 아게 | (ａ) 포스포이노시타이드 3-키나제 억제제 및 (ｂ) ｒａｓ/ｒａｆ/ｍｅｋ 경로의 조절제의 조합물 |
| PL2331547T3 (pl) * | 2008-08-22 | 2015-01-30 | Novartis Ag | Związki pirolopirymidynowe jako inhibitory CDK |
| JO3002B1 (ar) * | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| US20130035336A1 (en) * | 2010-04-13 | 2013-02-07 | Novartis Ag | Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase (cdk4/6) inhibitor for treating cancer |
-
2013
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- 2013-07-25 TW TW102126726A patent/TWI599357B/zh active
- 2013-07-25 CA CA2874860A patent/CA2874860C/en active Active
- 2013-07-25 JO JOP/2013/0223A patent/JO3776B1/ar active
- 2013-07-25 EP EP13745540.8A patent/EP2877174B1/en active Active
- 2013-07-25 KR KR1020157001594A patent/KR102113363B1/ko active Active
- 2013-07-25 AU AU2013295771A patent/AU2013295771B2/en active Active
- 2013-07-25 US US14/414,998 patent/US9700557B2/en active Active
- 2013-07-25 WO PCT/US2013/051990 patent/WO2014018725A1/en active Application Filing
- 2013-07-25 CN CN201380039725.5A patent/CN104507474B/zh active Active
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- 2013-07-25 IN IN376DEN2015 patent/IN2015DN00376A/en unknown
- 2013-07-25 ES ES13745540T patent/ES2778059T3/es active Active
- 2013-07-25 JP JP2015524444A patent/JP6320379B2/ja active Active
- 2013-07-25 MX MX2015001122A patent/MX360045B/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| TWI599357B (zh) | 2017-09-21 |
| HK1210721A1 (en) | 2016-05-06 |
| US20150164897A1 (en) | 2015-06-18 |
| RU2685250C2 (ru) | 2019-04-17 |
| WO2014018725A1 (en) | 2014-01-30 |
| KR20150036146A (ko) | 2015-04-07 |
| BR112014033118A8 (pt) | 2023-01-31 |
| IN2015DN00376A (OSRAM) | 2015-06-12 |
| MX2015001122A (es) | 2015-04-08 |
| TW201412316A (zh) | 2014-04-01 |
| JP6320379B2 (ja) | 2018-05-09 |
| CN104507474B (zh) | 2018-01-02 |
| MX360045B (es) | 2018-10-19 |
| AU2013295771A1 (en) | 2014-12-11 |
| CA2874860C (en) | 2020-06-23 |
| CN104507474A (zh) | 2015-04-08 |
| JP2015523397A (ja) | 2015-08-13 |
| CA2874860A1 (en) | 2014-01-30 |
| RU2015106524A (ru) | 2016-09-20 |
| US9700557B2 (en) | 2017-07-11 |
| KR102113363B1 (ko) | 2020-05-21 |
| JO3776B1 (ar) | 2021-01-31 |
| BR112014033118A2 (pt) | 2017-06-27 |
| AR091876A1 (es) | 2015-03-04 |
| EP2877174A1 (en) | 2015-06-03 |
| EP2877174B1 (en) | 2020-01-01 |
| AU2013295771B2 (en) | 2016-08-11 |
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