ES2764419T5 - Tissue clipping device - Google Patents
Tissue clipping device Download PDFInfo
- Publication number
- ES2764419T5 ES2764419T5 ES16154270T ES16154270T ES2764419T5 ES 2764419 T5 ES2764419 T5 ES 2764419T5 ES 16154270 T ES16154270 T ES 16154270T ES 16154270 T ES16154270 T ES 16154270T ES 2764419 T5 ES2764419 T5 ES 2764419T5
- Authority
- ES
- Spain
- Prior art keywords
- capsule
- clamp
- socket
- tabs
- gripper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002775 capsule Substances 0.000 claims description 130
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 238000010586 diagram Methods 0.000 description 19
- 230000007246 mechanism Effects 0.000 description 16
- 206010052428 Wound Diseases 0.000 description 11
- 208000027418 Wounds and injury Diseases 0.000 description 11
- 239000002874 hemostatic agent Substances 0.000 description 10
- 238000000926 separation method Methods 0.000 description 8
- 210000003813 thumb Anatomy 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 238000005452 bending Methods 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 230000000452 restraining effect Effects 0.000 description 5
- 238000003466 welding Methods 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 235000019592 roughness Nutrition 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/128—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
- A61B17/1285—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
- A61B17/1227—Spring clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2926—Details of heads or jaws
- A61B2017/2927—Details of heads or jaws the angular position of the head being adjustable with respect to the shaft
- A61B2017/2929—Details of heads or jaws the angular position of the head being adjustable with respect to the shaft with a head rotatable about the longitudinal axis of the shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/03—Automatic limiting or abutting means, e.g. for safety
- A61B2090/037—Automatic limiting or abutting means, e.g. for safety with a frangible part, e.g. by reduced diameter
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91580607P | 2007-05-03 | 2007-05-03 | |
| US12/107,559 US8162959B2 (en) | 2007-05-03 | 2008-04-22 | Single stage hemostasis clipping device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2764419T3 ES2764419T3 (es) | 2020-06-03 |
| ES2764419T5 true ES2764419T5 (en) | 2025-03-26 |
Family
ID=39536026
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16159799T Active ES2755550T5 (es) | 2007-05-03 | 2008-04-23 | Dispositivo de pinzado de tejidos |
| ES08746665.2T Active ES2532281T3 (es) | 2007-05-03 | 2008-04-23 | Dispositivo de colocación de clips hemostáticos de etapa única |
| ES16154270T Active ES2764419T5 (en) | 2007-05-03 | 2008-04-23 | Tissue clipping device |
| ES14181780.9T Active ES2578105T3 (es) | 2007-05-03 | 2008-04-23 | Dispositivo de colocación de clips hemostáticos de etapa única |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16159799T Active ES2755550T5 (es) | 2007-05-03 | 2008-04-23 | Dispositivo de pinzado de tejidos |
| ES08746665.2T Active ES2532281T3 (es) | 2007-05-03 | 2008-04-23 | Dispositivo de colocación de clips hemostáticos de etapa única |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14181780.9T Active ES2578105T3 (es) | 2007-05-03 | 2008-04-23 | Dispositivo de colocación de clips hemostáticos de etapa única |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8162959B2 (enExample) |
| EP (5) | EP2837339B1 (enExample) |
| JP (3) | JP5349458B2 (enExample) |
| CA (1) | CA2685375C (enExample) |
| ES (4) | ES2755550T5 (enExample) |
| WO (1) | WO2008137326A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101078544B1 (ko) * | 2003-03-17 | 2011-11-01 | 스미또모 베이크라이트 가부시키가이샤 | 클립 및 생체 조직의 클립 장치 |
| ES2717309T3 (es) | 2004-10-08 | 2019-06-20 | Covidien Lp | Aplicador endoscópico de grapas quirúrgicas |
| US8409222B2 (en) | 2004-10-08 | 2013-04-02 | Covidien Lp | Endoscopic surgical clip applier |
| JP5329526B2 (ja) | 2007-04-11 | 2013-10-30 | コヴィディエン リミテッド パートナーシップ | 外科用クリップアプライヤ |
| US8162959B2 (en) | 2007-05-03 | 2012-04-24 | Boston Scientific Scimed, Inc. | Single stage hemostasis clipping device |
| US20090187198A1 (en) | 2008-01-22 | 2009-07-23 | Barry Weitzner | Resolution Clip |
| EP2823776B1 (en) * | 2008-06-19 | 2016-05-25 | Boston Scientific Scimed, Inc. | Hemostatic clipping device |
| US8465502B2 (en) | 2008-08-25 | 2013-06-18 | Covidien Lp | Surgical clip applier and method of assembly |
| US8056565B2 (en) | 2008-08-25 | 2011-11-15 | Tyco Healthcare Group Lp | Surgical clip applier and method of assembly |
| US9358015B2 (en) | 2008-08-29 | 2016-06-07 | Covidien Lp | Endoscopic surgical clip applier with wedge plate |
| US8267944B2 (en) | 2008-08-29 | 2012-09-18 | Tyco Healthcare Group Lp | Endoscopic surgical clip applier with lock out |
| US8409223B2 (en) | 2008-08-29 | 2013-04-02 | Covidien Lp | Endoscopic surgical clip applier with clip retention |
| US8585717B2 (en) | 2008-08-29 | 2013-11-19 | Covidien Lp | Single stroke endoscopic surgical clip applier |
| WO2011021158A2 (en) * | 2009-08-18 | 2011-02-24 | Fund For Medical Research, Development Of Infrastructure And Health Services Rambam Medical Center | Surgical techniques and closure devices for direct cardiac catheterization |
| WO2011022246A1 (en) * | 2009-08-19 | 2011-02-24 | Boston Scientific Scimed, Inc. | Multifunctional core for two-piece hemostasis clip |
| US9044240B2 (en) * | 2010-03-10 | 2015-06-02 | Boston Scientific Scimed, Inc. | Hemostasis clip |
| EP2615987B1 (en) * | 2010-09-14 | 2014-05-14 | Boston Scientific Scimed, Inc. | Release mechanism for hemostasis clip |
| WO2013067662A1 (zh) * | 2011-11-11 | 2013-05-16 | Zhu Jian | 一种夹持或结扎装置 |
| US20130158566A1 (en) * | 2011-12-15 | 2013-06-20 | Boston Scientific Scimed, Inc. | Rotational mechanism for endoscopic devices |
| US20130165950A1 (en) * | 2011-12-27 | 2013-06-27 | Boston Scientific Scimed, Inc. | System and method to achieve reciprocating rotational motion of the distal member of a device by applying translational forces |
| AU2013226309B2 (en) * | 2012-02-28 | 2015-11-12 | Boston Scientific Scimed, Inc. | Omnidirectional closure clip |
| AU2015264936B2 (en) * | 2012-05-09 | 2018-03-22 | Boston Scientific Scimed, Inc. | Bushing arm deformation mechanism |
| AU2013259633B2 (en) * | 2012-05-09 | 2015-09-24 | Boston Scientific Scimed, Inc. | Bushing arm deformation mechanism |
| US20140088616A1 (en) * | 2012-09-24 | 2014-03-27 | Boston Scientific Scimed, Inc. | Release mechanism for hemostatic clip |
| CN105431094A (zh) * | 2013-07-10 | 2016-03-23 | 波士顿科学国际有限公司 | 抓持组织和闭合伤口的夹钳装置 |
| JP6267795B2 (ja) * | 2013-08-20 | 2018-01-24 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 医療用挿入デバイス |
| CN105764430B (zh) | 2013-08-21 | 2019-05-17 | 波士顿科学国际有限公司 | 用于管腔闭塞的装置 |
| US9707005B2 (en) | 2014-02-14 | 2017-07-18 | Ethicon Llc | Lockout mechanisms for surgical devices |
| US11033287B2 (en) | 2015-05-27 | 2021-06-15 | Coloplast A/S | Grasping tool |
| EP3305215B1 (en) * | 2015-05-27 | 2025-07-16 | Olympus Corporation | Device for endoscope |
| EP3977946A3 (en) * | 2015-12-03 | 2022-06-29 | Boston Scientific Scimed, Inc. | Electrocautery hemostasis clip |
| JP6632930B2 (ja) * | 2016-04-11 | 2020-01-22 | 野村ユニソン株式会社 | 結紮装置用クリップユニット及び該クリップユニットの係合方法 |
| DE202017007428U1 (de) | 2016-09-22 | 2021-06-11 | Boston Scientific Limited | Mehrfaches Öffnen/Schließen eines Clips |
| KR101868442B1 (ko) * | 2016-10-17 | 2018-06-20 | 강익주 | 엔도클립장치 |
| JP6761898B2 (ja) * | 2016-11-22 | 2020-09-30 | ボストン サイエンティフィック リミテッド | 再充填可能止血クリップ解放機構 |
| JP2019528884A (ja) * | 2016-12-06 | 2019-10-17 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 再装填可能な止血クリップ止め装置用圧縮カプラ |
| WO2018201406A1 (zh) * | 2017-05-04 | 2018-11-08 | 杭州安杰思医学科技有限公司 | 端部执行器械、端部执行装置、输送装置、及装配盒 |
| US10863992B2 (en) | 2017-08-08 | 2020-12-15 | Covidien Lp | Endoscopic surgical clip applier |
| CN117017405A (zh) * | 2017-09-28 | 2023-11-10 | 波士顿科学国际有限公司 | 可重新加载且可旋转的夹子 |
| EP3709898B1 (en) * | 2017-11-15 | 2021-09-22 | United States Endoscopy Group, Inc. | Clip and clip assembly |
| DE102018208555A1 (de) | 2018-05-30 | 2019-12-05 | Kardion Gmbh | Vorrichtung zum Verankern eines Herzunterstützungssystems in einem Blutgefäß, Verfahren zum Betreiben und Herstellverfahren zum Herstellen einer Vorrichtung und Herzunterstützungssystem |
| DE102018211297A1 (de) | 2018-07-09 | 2020-01-09 | Kardion Gmbh | Herzunterstützungssystem und Verfahren zur Überwachung der Integrität einer Haltestruktur eines Herzunterstützungssystems |
| WO2020096981A1 (en) | 2018-11-08 | 2020-05-14 | Cedars-Sinai Medical Center | A novel tool for hemostasis and tissue approximation |
| CN114533180B (zh) * | 2018-11-09 | 2024-05-14 | 奥林巴斯株式会社 | 内窥镜夹具及其制造方法、夹具的张开宽度的调整方法 |
| US11234707B2 (en) * | 2019-01-22 | 2022-02-01 | Beijing Donglin Fushi Medical Devices Co., Ltd. | Disposable hemostatic clip system |
| EP3725244A1 (en) * | 2019-04-17 | 2020-10-21 | Micro-Tech (Nanjing) Co., Ltd. | Medical device for causing the hemostasis of a blood vessel |
| EP3725242B1 (en) | 2019-04-17 | 2023-11-29 | Micro-Tech (Nanjing) Co., Ltd. | Medical device for causing the hemostasis of a blood vessel |
| EP3763298B1 (en) | 2019-07-10 | 2023-11-29 | Micro-Tech (Nanjing) Co., Ltd. | Medical device for causing the hemostasis of a blood vessel |
| CN217793203U (zh) | 2019-04-17 | 2022-11-15 | 南微医学科技股份有限公司 | 用于使组织止血或闭合的夹钳装置和医疗器械 |
| CN110051398A (zh) * | 2019-04-18 | 2019-07-26 | 浙江朗特医疗科技有限公司 | 具有限位保护装置的双重锁闭组织夹 |
| US11524141B2 (en) * | 2019-07-08 | 2022-12-13 | Boston Scientific Scimed, Inc. | Endoscopic medical device and method of use |
| CN114126512B (zh) * | 2019-07-24 | 2024-10-11 | 波士顿科学国际有限公司 | 用于消除脱落部件的止血夹二级置放机构 |
| EP3927250B1 (en) | 2019-07-24 | 2025-02-26 | Boston Scientific Scimed, Inc. | Clipping system for treating tissue |
| ES3033770T3 (en) | 2019-11-01 | 2025-08-07 | Conmed Corp | Devices and methods for applying a hemostatic clip assembly |
| US12402887B2 (en) | 2019-11-01 | 2025-09-02 | Conmed Corporation | Devices and methods for applying a hemostasis clip assembly |
| WO2021226400A1 (en) | 2020-05-08 | 2021-11-11 | Cedars-Sinai Medical Center | Systems and methods for hemoclip deployment |
| CN111544075B (zh) * | 2020-06-12 | 2024-10-01 | 南微医学科技股份有限公司 | 一种新型止血夹 |
| JP7553420B2 (ja) | 2020-10-16 | 2024-09-18 | オリンパスメディカルシステムズ株式会社 | 湾曲可能なクリップデバイス |
| EP4262576A1 (en) | 2020-12-16 | 2023-10-25 | Boston Scientific Scimed, Inc. | Device and systems for grasping tissue at a muscular level |
| WO2023028250A1 (en) | 2021-08-25 | 2023-03-02 | GastroLogic LLC | Endoscopic clip apparatus and methods |
| CN113855147B (zh) * | 2021-11-04 | 2024-11-29 | 南微医学科技股份有限公司 | 推送机构和止血夹 |
| CN116458952B (zh) * | 2022-01-20 | 2025-12-16 | 奥林巴斯医疗株式会社 | 夹具系统 |
| EP4510944A1 (en) * | 2022-09-27 | 2025-02-26 | Boston Scientific Scimed Inc. | Locking feature for hemostasis clip |
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-
2008
- 2008-04-22 US US12/107,559 patent/US8162959B2/en active Active
- 2008-04-23 ES ES16159799T patent/ES2755550T5/es active Active
- 2008-04-23 EP EP14181780.9A patent/EP2837339B1/en active Active
- 2008-04-23 WO PCT/US2008/061283 patent/WO2008137326A1/en not_active Ceased
- 2008-04-23 EP EP19197434.4A patent/EP3643256B1/en active Active
- 2008-04-23 JP JP2010506454A patent/JP5349458B2/ja active Active
- 2008-04-23 EP EP16159799.2A patent/EP3053532B2/en active Active
- 2008-04-23 ES ES08746665.2T patent/ES2532281T3/es active Active
- 2008-04-23 EP EP16154270.9A patent/EP3050518B2/en active Active
- 2008-04-23 EP EP08746665.2A patent/EP2142108B1/en active Active
- 2008-04-23 ES ES16154270T patent/ES2764419T5/es active Active
- 2008-04-23 ES ES14181780.9T patent/ES2578105T3/es active Active
- 2008-04-23 CA CA2685375A patent/CA2685375C/en not_active Expired - Fee Related
-
2012
- 2012-03-21 US US13/426,297 patent/US9895154B2/en active Active
-
2013
- 2013-08-20 JP JP2013170280A patent/JP6067512B2/ja active Active
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2015
- 2015-07-23 JP JP2015145416A patent/JP2015186650A/ja active Pending
-
2018
- 2018-01-09 US US15/866,196 patent/US20180125497A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2532281T3 (es) | 2015-03-25 |
| JP2015186650A (ja) | 2015-10-29 |
| US20120179171A1 (en) | 2012-07-12 |
| EP2142108B1 (en) | 2015-02-18 |
| US20080306491A1 (en) | 2008-12-11 |
| ES2755550T3 (es) | 2020-04-22 |
| EP3050518B1 (en) | 2019-10-30 |
| EP3643256B1 (en) | 2024-05-29 |
| JP5349458B2 (ja) | 2013-11-20 |
| EP3053532A1 (en) | 2016-08-10 |
| US9895154B2 (en) | 2018-02-20 |
| EP3643256A1 (en) | 2020-04-29 |
| EP3050518A1 (en) | 2016-08-03 |
| EP3053532B1 (en) | 2019-09-18 |
| EP3050518B2 (en) | 2025-01-15 |
| JP2013255827A (ja) | 2013-12-26 |
| JP6067512B2 (ja) | 2017-01-25 |
| EP2837339B1 (en) | 2016-04-06 |
| ES2578105T3 (es) | 2016-07-20 |
| CA2685375A1 (en) | 2008-11-13 |
| EP3053532B2 (en) | 2024-03-06 |
| EP2837339A1 (en) | 2015-02-18 |
| CA2685375C (en) | 2014-08-05 |
| EP2142108A1 (en) | 2010-01-13 |
| ES2755550T5 (es) | 2024-12-02 |
| WO2008137326A1 (en) | 2008-11-13 |
| US20180125497A1 (en) | 2018-05-10 |
| US8162959B2 (en) | 2012-04-24 |
| JP2010525879A (ja) | 2010-07-29 |
| ES2764419T3 (es) | 2020-06-03 |
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