ES2752455T3 - Inhibidores de la indolamina 2,3-dioxigenasa - Google Patents
Inhibidores de la indolamina 2,3-dioxigenasa Download PDFInfo
- Publication number
- ES2752455T3 ES2752455T3 ES16735943T ES16735943T ES2752455T3 ES 2752455 T3 ES2752455 T3 ES 2752455T3 ES 16735943 T ES16735943 T ES 16735943T ES 16735943 T ES16735943 T ES 16735943T ES 2752455 T3 ES2752455 T3 ES 2752455T3
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- Prior art keywords
- compound
- mmol
- oxadiazol
- bromo
- pharmaceutically acceptable
- Prior art date
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- 235000009518 sodium iodide Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical class [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
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- 229960004559 theobromine Drugs 0.000 description 1
- ZFEAMMNVDPDEGE-LGRGJMMZSA-N tifuvirtide Chemical compound C([C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(C)=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CC=C(O)C=C1 ZFEAMMNVDPDEGE-LGRGJMMZSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187937P | 2015-07-02 | 2015-07-02 | |
| PCT/IB2016/053947 WO2017002078A1 (en) | 2015-07-02 | 2016-06-30 | Inhibitors of indoleamine 2,3-dioxygenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2752455T3 true ES2752455T3 (es) | 2020-04-06 |
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| ES16735943T Active ES2752455T3 (es) | 2015-07-02 | 2016-06-30 | Inhibidores de la indolamina 2,3-dioxigenasa |
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| Country | Link |
|---|---|
| US (1) | US10239894B2 (enExample) |
| EP (1) | EP3317287B1 (enExample) |
| JP (1) | JP6654208B2 (enExample) |
| KR (1) | KR20180022988A (enExample) |
| CN (1) | CN107709338A (enExample) |
| AU (1) | AU2016285483B2 (enExample) |
| BR (1) | BR112017028456A2 (enExample) |
| CA (1) | CA2990335A1 (enExample) |
| ES (1) | ES2752455T3 (enExample) |
| RU (1) | RU2018101431A (enExample) |
| WO (1) | WO2017002078A1 (enExample) |
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| CN108530444B (zh) * | 2018-06-11 | 2021-08-24 | 药康众拓(江苏)医药科技有限公司 | 一种新型nampt和ido双重抑制剂及其制备方法和医药用途 |
| CA3117556A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
| TWI721624B (zh) | 2018-10-31 | 2021-03-11 | 美商基利科學股份有限公司 | 經取代之6-氮雜苯并咪唑化合物 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| CN110156629A (zh) * | 2019-05-30 | 2019-08-23 | 广州药本君安医药科技股份有限公司 | 丙卡巴肼的合成方法 |
| US20240091202A1 (en) | 2021-03-05 | 2024-03-21 | Universität Basel | Compositions for the treatment of ebv associated diseases or conditions |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| WO2025119216A1 (zh) * | 2023-12-04 | 2025-06-12 | 珠海联邦制药股份有限公司 | 硼酸类β-内酰胺酶抑制剂及其制备方法和应用 |
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| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| WO2002074769A1 (en) | 2001-03-19 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient |
| DK2559690T3 (en) * | 2005-05-10 | 2016-04-25 | Incyte Holdings Corp | Modulators of indoleamine 2,3-dioxygenase and methods of use thereof |
| ES2434946T3 (es) | 2005-08-31 | 2013-12-18 | Celgene Corporation | Compuestos de isoindol imida y composiciones que los comprenden y métodos para usarlo |
| NZ590268A (en) * | 2008-07-08 | 2012-11-30 | Incyte Corp | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
| WO2012067663A1 (en) * | 2010-11-18 | 2012-05-24 | Glaxo Group Limited | Compounds |
| WO2014066834A1 (en) * | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
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- 2016-06-30 EP EP16735943.9A patent/EP3317287B1/en active Active
- 2016-06-30 AU AU2016285483A patent/AU2016285483B2/en not_active Ceased
- 2016-06-30 CA CA2990335A patent/CA2990335A1/en not_active Abandoned
- 2016-06-30 US US15/578,861 patent/US10239894B2/en not_active Expired - Fee Related
- 2016-06-30 WO PCT/IB2016/053947 patent/WO2017002078A1/en not_active Ceased
- 2016-06-30 CN CN201680039221.7A patent/CN107709338A/zh active Pending
- 2016-06-30 RU RU2018101431A patent/RU2018101431A/ru not_active Application Discontinuation
- 2016-06-30 JP JP2017568056A patent/JP6654208B2/ja not_active Expired - Fee Related
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- 2016-06-30 KR KR1020187003254A patent/KR20180022988A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN107709338A (zh) | 2018-02-16 |
| BR112017028456A2 (pt) | 2018-08-28 |
| US20180298035A1 (en) | 2018-10-18 |
| EP3317287A1 (en) | 2018-05-09 |
| AU2016285483B2 (en) | 2018-07-19 |
| JP6654208B2 (ja) | 2020-02-26 |
| CA2990335A1 (en) | 2017-01-05 |
| AU2016285483A1 (en) | 2018-01-04 |
| WO2017002078A1 (en) | 2017-01-05 |
| JP2018521056A (ja) | 2018-08-02 |
| US10239894B2 (en) | 2019-03-26 |
| KR20180022988A (ko) | 2018-03-06 |
| EP3317287B1 (en) | 2019-07-31 |
| RU2018101431A (ru) | 2019-08-05 |
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