RU2018101431A - Ингибиторы индоламин-2,3-диоксигеназы - Google Patents

Ингибиторы индоламин-2,3-диоксигеназы Download PDF

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Publication number
RU2018101431A
RU2018101431A RU2018101431A RU2018101431A RU2018101431A RU 2018101431 A RU2018101431 A RU 2018101431A RU 2018101431 A RU2018101431 A RU 2018101431A RU 2018101431 A RU2018101431 A RU 2018101431A RU 2018101431 A RU2018101431 A RU 2018101431A
Authority
RU
Russia
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
indolamin
Prior art date
Application number
RU2018101431A
Other languages
English (en)
Russian (ru)
Inventor
Веслав Мечислав Казмерский
ЛА РОЗА Марта Алисия ДЕ
Висенте Самано
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед filed Critical Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
Publication of RU2018101431A publication Critical patent/RU2018101431A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2018101431A 2015-07-02 2016-06-30 Ингибиторы индоламин-2,3-диоксигеназы RU2018101431A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562187937P 2015-07-02 2015-07-02
US62/187,937 2015-07-02
PCT/IB2016/053947 WO2017002078A1 (en) 2015-07-02 2016-06-30 Inhibitors of indoleamine 2,3-dioxygenase

Publications (1)

Publication Number Publication Date
RU2018101431A true RU2018101431A (ru) 2019-08-05

Family

ID=56363880

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018101431A RU2018101431A (ru) 2015-07-02 2016-06-30 Ингибиторы индоламин-2,3-диоксигеназы

Country Status (11)

Country Link
US (1) US10239894B2 (enExample)
EP (1) EP3317287B1 (enExample)
JP (1) JP6654208B2 (enExample)
KR (1) KR20180022988A (enExample)
CN (1) CN107709338A (enExample)
AU (1) AU2016285483B2 (enExample)
BR (1) BR112017028456A2 (enExample)
CA (1) CA2990335A1 (enExample)
ES (1) ES2752455T3 (enExample)
RU (1) RU2018101431A (enExample)
WO (1) WO2017002078A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108530444B (zh) * 2018-06-11 2021-08-24 药康众拓(江苏)医药科技有限公司 一种新型nampt和ido双重抑制剂及其制备方法和医药用途
EP3873608A1 (en) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
EP4371987B9 (en) 2018-10-31 2025-11-26 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
US11453681B2 (en) 2019-05-23 2022-09-27 Gilead Sciences, Inc. Substituted eneoxindoles and uses thereof
CN110156629A (zh) * 2019-05-30 2019-08-23 广州药本君安医药科技股份有限公司 丙卡巴肼的合成方法
BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions
CN122374319A (zh) * 2023-12-04 2026-07-10 珠海联邦制药股份有限公司 硼酸类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB427857A (en) 1934-08-02 1935-05-01 Newsum Sons & Company Ltd H A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
WO2002074769A1 (en) 2001-03-19 2002-09-26 Ono Pharmaceutical Co., Ltd. Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
DK1879573T3 (da) * 2005-05-10 2013-02-25 Incyte Corp Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf
CA2822094C (en) 2005-08-31 2015-10-27 Celgene Corporation Isoindole-imide compounds and compositions comprising and methods of using the same
CA3012229C (en) * 2008-07-08 2020-11-10 Incyte Holdings Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
AU2011329485A1 (en) * 2010-11-18 2013-04-18 Glaxo Group Limited Compounds
CA2889182A1 (en) 2012-10-26 2014-05-01 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer

Also Published As

Publication number Publication date
EP3317287B1 (en) 2019-07-31
WO2017002078A1 (en) 2017-01-05
CN107709338A (zh) 2018-02-16
ES2752455T3 (es) 2020-04-06
CA2990335A1 (en) 2017-01-05
EP3317287A1 (en) 2018-05-09
US10239894B2 (en) 2019-03-26
JP6654208B2 (ja) 2020-02-26
US20180298035A1 (en) 2018-10-18
AU2016285483A1 (en) 2018-01-04
JP2018521056A (ja) 2018-08-02
AU2016285483B2 (en) 2018-07-19
KR20180022988A (ko) 2018-03-06
BR112017028456A2 (pt) 2018-08-28

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Effective date: 20190701