ES274572A1 - A process for the preparation of hydroxycobalamin from cyanocobalamin - Google Patents

A process for the preparation of hydroxycobalamin from cyanocobalamin

Info

Publication number
ES274572A1
ES274572A1 ES0274572A ES274572A ES274572A1 ES 274572 A1 ES274572 A1 ES 274572A1 ES 0274572 A ES0274572 A ES 0274572A ES 274572 A ES274572 A ES 274572A ES 274572 A1 ES274572 A1 ES 274572A1
Authority
ES
Spain
Prior art keywords
hydroxycobalamin
cyanocobalamin
solution
preparation
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0274572A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Publication of ES274572A1 publication Critical patent/ES274572A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Hydroxycobalamin is obtained by adding acid to an aqueous solution of cyanocobalamin to bring the pH to below 4, warming to 25 DEG to 50 DEG C., reducing, e.g. with iron or zinc, aerating, and then contacting the solution with an ion-exchange resin charged with hydroxyl ions. The acid used may be hydrochloric, sulphuric, hydrobromic or nitric acid. The hydroxycobalamin may be precipitated from solution with acetone. Specifications 916,186 and 1,007,973 are referred to.
ES0274572A 1961-09-07 1962-02-13 A process for the preparation of hydroxycobalamin from cyanocobalamin Expired ES274572A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3217261A GB1012360A (en) 1961-09-07 1961-09-07 A process for the preparation of hydroxycobalamin from cyanocobalamin

Publications (1)

Publication Number Publication Date
ES274572A1 true ES274572A1 (en) 1962-05-16

Family

ID=10334431

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0274572A Expired ES274572A1 (en) 1961-09-07 1962-02-13 A process for the preparation of hydroxycobalamin from cyanocobalamin

Country Status (4)

Country Link
AT (1) AT251205B (en)
CH (1) CH414059A (en)
ES (1) ES274572A1 (en)
GB (1) GB1012360A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3085320B2 (en) * 1991-09-17 2000-09-04 日石三菱株式会社 Method for producing hydroxocobalamin
US11324771B2 (en) 2020-02-12 2022-05-10 RK Pharma Solutions LLC Process for the preparation of hydroxocobalamin hydrochloride

Also Published As

Publication number Publication date
CH414059A (en) 1966-05-31
AT251205B (en) 1966-12-27
GB1012360A (en) 1965-12-08

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