ES2743412T3 - Productos conjugados de hexosa y compuestos de coordinación de metales para la generación de imágenes - Google Patents
Productos conjugados de hexosa y compuestos de coordinación de metales para la generación de imágenes Download PDFInfo
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- ES2743412T3 ES2743412T3 ES09736724T ES09736724T ES2743412T3 ES 2743412 T3 ES2743412 T3 ES 2743412T3 ES 09736724 T ES09736724 T ES 09736724T ES 09736724 T ES09736724 T ES 09736724T ES 2743412 T3 ES2743412 T3 ES 2743412T3
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Classifications
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
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| US19478208P | 2008-09-30 | 2008-09-30 | |
| PCT/US2009/058379 WO2010039609A2 (en) | 2008-09-30 | 2009-09-25 | A version of fdg detectable by single-photon emission computed tomography |
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| ES2743412T3 true ES2743412T3 (es) | 2020-02-19 |
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| ES09736724T Active ES2743412T3 (es) | 2008-09-30 | 2009-09-25 | Productos conjugados de hexosa y compuestos de coordinación de metales para la generación de imágenes |
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| EP (1) | EP2341944B1 (enExample) |
| JP (1) | JP6013735B2 (enExample) |
| CA (1) | CA2738786C (enExample) |
| ES (1) | ES2743412T3 (enExample) |
| WO (1) | WO2010039609A2 (enExample) |
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| JP6013735B2 (ja) | 2008-09-30 | 2016-10-25 | マリンクロット ニュークリア メディシン エルエルシー | 画像目的のためのヘキソースおよび金属配位結合化合物の結合体 |
| PL2721045T3 (pl) * | 2011-06-20 | 2017-11-30 | Radiomedix Inc. | Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanych |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| PT3568205T (pt) | 2017-01-12 | 2023-10-26 | Radiomedix Inc | Tratamento de células de cancro que sobrexpressam recetores de somatostatina com a utilização de derivados de ocreótido quelado a radioisótopos |
| CN111542583B (zh) * | 2018-07-06 | 2023-06-23 | 中石化石油工程技术服务有限公司 | 取代的糖或糖苷及其在钻井液组合物中的应用 |
| US11944690B2 (en) | 2018-11-23 | 2024-04-02 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
| KR102362962B1 (ko) * | 2020-06-12 | 2022-02-16 | (주)미래바이오팜 | 신규한 화합물 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
| WO2023106883A1 (ko) * | 2021-12-10 | 2023-06-15 | (주)에트노바테라퓨틱스 | 신규한 화합물, 이의 제조방법 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
| WO2023106616A1 (ko) * | 2021-12-10 | 2023-06-15 | (주)에트노바테라퓨틱스 | 신규한 화합물, 이의 제조방법 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
| CN114853827B (zh) * | 2022-06-02 | 2023-11-24 | 南京江原安迪科正电子研究发展有限公司 | 一种葡萄糖衍生配体化合物及其制备方法和应用 |
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| JPH0458156A (ja) | 1990-06-28 | 1992-02-25 | Bio Sensor Kenkyusho:Kk | インスリン生物活性の測定方法及びその測定用キット |
| US5326778A (en) * | 1992-03-03 | 1994-07-05 | Research Corporation Technologies, Inc. | Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy |
| AU5901501A (en) | 1999-10-19 | 2001-10-23 | Nicholas R. Abu-Absi | Measurement of nutrient uptake in cells and methods based thereon |
| KR100430061B1 (ko) | 2000-03-21 | 2004-05-03 | 재단법인 아산사회복지재단 | 글루코스 유도체에 방사성 동위원소가 표지된 착화합물 및이를 생산하기 위한 조성물이 포함된 키트 |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| KR101218633B1 (ko) | 2003-12-11 | 2013-01-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 세포 증식 질환 치료용 화합물 |
| WO2005076011A2 (en) | 2004-01-30 | 2005-08-18 | Xenoport, Inc. | Use of glut1 transporter expressed in blood brain barrier cells for screening for pharmacologically active substances |
| US20060003364A1 (en) | 2004-06-04 | 2006-01-05 | Xenoport, Inc. | GLUT1 transporters expressed in cancer cells |
| JP2008512360A (ja) * | 2004-09-07 | 2008-04-24 | トライアンフ，オペレーティング アズ ア ジョイント ヴェンチャー バイ ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ，ザ ユニバーシティ オブ ブリティッシュ コロンビア，カールトン | 放射性同位体でラベル化された糖−金属錯体の合成方法 |
| US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| JP6013735B2 (ja) | 2008-09-30 | 2016-10-25 | マリンクロット ニュークリア メディシン エルエルシー | 画像目的のためのヘキソースおよび金属配位結合化合物の結合体 |
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2009
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- 2009-09-25 WO PCT/US2009/058379 patent/WO2010039609A2/en not_active Ceased
- 2009-09-25 CA CA2738786A patent/CA2738786C/en active Active
- 2009-09-25 ES ES09736724T patent/ES2743412T3/es active Active
- 2009-09-25 US US13/120,537 patent/US8858916B2/en active Active
- 2009-09-25 EP EP09736724.7A patent/EP2341944B1/en not_active Not-in-force
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2014
- 2014-09-05 US US14/478,154 patent/US9217009B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010039609A2 (en) | 2010-04-08 |
| WO2010039609A3 (en) | 2010-09-10 |
| EP2341944A2 (en) | 2011-07-13 |
| US20140378677A1 (en) | 2014-12-25 |
| US8858916B2 (en) | 2014-10-14 |
| US9217009B2 (en) | 2015-12-22 |
| JP6013735B2 (ja) | 2016-10-25 |
| CA2738786A1 (en) | 2010-04-08 |
| JP2012504131A (ja) | 2012-02-16 |
| US20110177004A1 (en) | 2011-07-21 |
| EP2341944B1 (en) | 2019-06-26 |
| CA2738786C (en) | 2017-12-19 |
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