CA2738786C - A version of fdg detectable by single-photon emission computed tomography - Google Patents
A version of fdg detectable by single-photon emission computed tomography Download PDFInfo
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- CA2738786C CA2738786C CA2738786A CA2738786A CA2738786C CA 2738786 C CA2738786 C CA 2738786C CA 2738786 A CA2738786 A CA 2738786A CA 2738786 A CA2738786 A CA 2738786A CA 2738786 C CA2738786 C CA 2738786C
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- acid
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- tomography
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- 238000002603 single-photon emission computed tomography Methods 0.000 title claims abstract description 14
- 229910052751 metal Inorganic materials 0.000 claims abstract description 95
- 239000002184 metal Substances 0.000 claims abstract description 95
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- 238000003384 imaging method Methods 0.000 claims abstract description 29
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- 238000000799 fluorescence microscopy Methods 0.000 claims abstract description 12
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- 238000004611 spectroscopical analysis Methods 0.000 claims abstract description 10
- 238000003325 tomography Methods 0.000 claims abstract description 10
- -1 hexose derivative compound Chemical class 0.000 claims description 95
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- 239000008103 glucose Substances 0.000 claims description 20
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- KRGPXXHMOXVMMM-UHFFFAOYSA-N nicotianamine Natural products OC(=O)C(N)CCNC(C(O)=O)CCN1CCC1C(O)=O KRGPXXHMOXVMMM-UHFFFAOYSA-N 0.000 claims description 4
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- ZSXHABVLNSQDFP-UHFFFAOYSA-N 2-(dihydroxyamino)-2-phenylacetic acid;ethane-1,2-diamine Chemical compound NCCN.ON(O)C(C(O)=O)C1=CC=CC=C1 ZSXHABVLNSQDFP-UHFFFAOYSA-N 0.000 claims description 3
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- 150000007942 carboxylates Chemical class 0.000 claims description 3
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- DNYWZCXLKNTFFI-UHFFFAOYSA-N uranium Chemical compound [U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U][U] DNYWZCXLKNTFFI-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 1
- NAWDYIZEMPQZHO-AHCXROLUSA-N ytterbium-169 Chemical compound [169Yb] NAWDYIZEMPQZHO-AHCXROLUSA-N 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19478208P | 2008-09-30 | 2008-09-30 | |
| US61/194,782 | 2008-09-30 | ||
| PCT/US2009/058379 WO2010039609A2 (en) | 2008-09-30 | 2009-09-25 | A version of fdg detectable by single-photon emission computed tomography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2738786A1 CA2738786A1 (en) | 2010-04-08 |
| CA2738786C true CA2738786C (en) | 2017-12-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2738786A Active CA2738786C (en) | 2008-09-30 | 2009-09-25 | A version of fdg detectable by single-photon emission computed tomography |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8858916B2 (enExample) |
| EP (1) | EP2341944B1 (enExample) |
| JP (1) | JP6013735B2 (enExample) |
| CA (1) | CA2738786C (enExample) |
| ES (1) | ES2743412T3 (enExample) |
| WO (1) | WO2010039609A2 (enExample) |
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| ES2743412T3 (es) | 2008-09-30 | 2020-02-19 | Curium Us Llc | Productos conjugados de hexosa y compuestos de coordinación de metales para la generación de imágenes |
| EP2721045B1 (en) * | 2011-06-20 | 2017-04-12 | Radiomedix Inc. | Compositions, methods of synthesis and use of carbohydrate targeted agents |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| EP3544964B1 (en) | 2016-11-28 | 2020-06-17 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| KR102296752B1 (ko) | 2017-01-12 | 2021-09-02 | 라디오메딕스 인크. | 방사성동위원소에 킬레이팅된 옥트레오티드 유도체를 이용한 소마토스타틴 수용체를 과발현하는 암 세포의 치료 |
| CN111542583B (zh) * | 2018-07-06 | 2023-06-23 | 中石化石油工程技术服务有限公司 | 取代的糖或糖苷及其在钻井液组合物中的应用 |
| PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
| KR102362962B1 (ko) * | 2020-06-12 | 2022-02-16 | (주)미래바이오팜 | 신규한 화합물 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
| WO2023106883A1 (ko) * | 2021-12-10 | 2023-06-15 | (주)에트노바테라퓨틱스 | 신규한 화합물, 이의 제조방법 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
| WO2023106616A1 (ko) * | 2021-12-10 | 2023-06-15 | (주)에트노바테라퓨틱스 | 신규한 화합물, 이의 제조방법 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
| CN114853827B (zh) * | 2022-06-02 | 2023-11-24 | 南京江原安迪科正电子研究发展有限公司 | 一种葡萄糖衍生配体化合物及其制备方法和应用 |
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| JPH0458156A (ja) | 1990-06-28 | 1992-02-25 | Bio Sensor Kenkyusho:Kk | インスリン生物活性の測定方法及びその測定用キット |
| US5326778A (en) * | 1992-03-03 | 1994-07-05 | Research Corporation Technologies, Inc. | Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy |
| AU5901501A (en) | 1999-10-19 | 2001-10-23 | Nicholas R. Abu-Absi | Measurement of nutrient uptake in cells and methods based thereon |
| KR100430061B1 (ko) * | 2000-03-21 | 2004-05-03 | 재단법인 아산사회복지재단 | 글루코스 유도체에 방사성 동위원소가 표지된 착화합물 및이를 생산하기 위한 조성물이 포함된 키트 |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| JP4751336B2 (ja) | 2003-12-11 | 2011-08-17 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 細胞増殖性疾患を治療する化合 |
| US20050170394A1 (en) | 2004-01-30 | 2005-08-04 | Xenoport, Inc. | GLUT1 transporters expressed in blood brain barrier cells |
| US20060003364A1 (en) | 2004-06-04 | 2006-01-05 | Xenoport, Inc. | GLUT1 transporters expressed in cancer cells |
| AU2005282160A1 (en) * | 2004-09-07 | 2006-03-16 | Triumf, Operating As A Joint Venture By The Governors Of The University Of Alberta, The University Of British Columbia, Carleton University, Simon Fraser University, The University Of Toronto And The University Of Victoria | Synthesis of radiolabeled sugar metal complexes |
| US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| ES2743412T3 (es) | 2008-09-30 | 2020-02-19 | Curium Us Llc | Productos conjugados de hexosa y compuestos de coordinación de metales para la generación de imágenes |
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2009
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- 2009-09-25 JP JP2011529259A patent/JP6013735B2/ja not_active Expired - Fee Related
- 2009-09-25 EP EP09736724.7A patent/EP2341944B1/en not_active Not-in-force
- 2009-09-25 CA CA2738786A patent/CA2738786C/en active Active
- 2009-09-25 WO PCT/US2009/058379 patent/WO2010039609A2/en not_active Ceased
- 2009-09-25 US US13/120,537 patent/US8858916B2/en active Active
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2014
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2738786A1 (en) | 2010-04-08 |
| US20140378677A1 (en) | 2014-12-25 |
| US8858916B2 (en) | 2014-10-14 |
| EP2341944A2 (en) | 2011-07-13 |
| US9217009B2 (en) | 2015-12-22 |
| ES2743412T3 (es) | 2020-02-19 |
| JP2012504131A (ja) | 2012-02-16 |
| JP6013735B2 (ja) | 2016-10-25 |
| WO2010039609A3 (en) | 2010-09-10 |
| EP2341944B1 (en) | 2019-06-26 |
| WO2010039609A2 (en) | 2010-04-08 |
| US20110177004A1 (en) | 2011-07-21 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20140826 |