ES2741141T3 - Colirio que comprende ácido hialurónico de sodio y carboximetilcelulosa - Google Patents
Colirio que comprende ácido hialurónico de sodio y carboximetilcelulosa Download PDFInfo
- Publication number
- ES2741141T3 ES2741141T3 ES14704747T ES14704747T ES2741141T3 ES 2741141 T3 ES2741141 T3 ES 2741141T3 ES 14704747 T ES14704747 T ES 14704747T ES 14704747 T ES14704747 T ES 14704747T ES 2741141 T3 ES2741141 T3 ES 2741141T3
- Authority
- ES
- Spain
- Prior art keywords
- eye
- cmc
- study
- formulation
- staining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002134 Carboxymethyl cellulose Polymers 0.000 title description 49
- 239000001768 carboxy methyl cellulose Substances 0.000 title description 48
- 235000010948 carboxy methyl cellulose Nutrition 0.000 title description 42
- 239000008112 carboxymethyl-cellulose Substances 0.000 title description 42
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title description 19
- 229920002674 hyaluronan Polymers 0.000 title description 19
- 229960003160 hyaluronic acid Drugs 0.000 title description 18
- 239000003889 eye drop Substances 0.000 title description 14
- 229940012356 eye drops Drugs 0.000 title description 13
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title description 2
- 239000011734 sodium Substances 0.000 title description 2
- 229910052708 sodium Inorganic materials 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 78
- 239000000607 artificial tear Substances 0.000 claims abstract 2
- 238000009472 formulation Methods 0.000 description 62
- 206010013774 Dry eye Diseases 0.000 description 33
- 238000010186 staining Methods 0.000 description 31
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 27
- 208000024891 symptom Diseases 0.000 description 15
- 230000008859 change Effects 0.000 description 14
- 208000033316 Acquired hemophilia A Diseases 0.000 description 13
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 13
- 230000006872 improvement Effects 0.000 description 13
- 238000011282 treatment Methods 0.000 description 10
- 210000004087 cornea Anatomy 0.000 description 9
- 210000002919 epithelial cell Anatomy 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 7
- 210000000744 eyelid Anatomy 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000009467 reduction Effects 0.000 description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 7
- 229940010747 sodium hyaluronate Drugs 0.000 description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 7
- 230000006003 cornification Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 5
- 229940001447 lactate Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 102000015728 Mucins Human genes 0.000 description 4
- 108010063954 Mucins Proteins 0.000 description 4
- 210000000795 conjunctiva Anatomy 0.000 description 4
- 239000006196 drop Substances 0.000 description 4
- 238000005243 fluidization Methods 0.000 description 4
- 210000002175 goblet cell Anatomy 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 102000043136 MAP kinase family Human genes 0.000 description 3
- 108091054455 MAP kinase family Proteins 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 230000004397 blinking Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000004299 exfoliation Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229940051875 mucins Drugs 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920002306 Glycocalyx Polymers 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 208000027993 eye symptom Diseases 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 210000004517 glycocalyx Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000001033 osmoprotective effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000004382 visual function Effects 0.000 description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 206010015946 Eye irritation Diseases 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 206010052143 Ocular discomfort Diseases 0.000 description 1
- 208000023715 Ocular surface disease Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000003090 exacerbative effect Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 229960001518 levocarnitine Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000065 osmolyte Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759710P | 2013-02-01 | 2013-02-01 | |
| US201361785857P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/014505 WO2014121232A1 (en) | 2013-02-01 | 2014-02-03 | Artificial tears comprising sodium hyaluronate and carboxymethylcellulose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2741141T3 true ES2741141T3 (es) | 2020-02-10 |
Family
ID=50113045
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14704747T Active ES2741141T3 (es) | 2013-02-01 | 2014-02-03 | Colirio que comprende ácido hialurónico de sodio y carboximetilcelulosa |
| ES19151359T Active ES2841434T3 (es) | 2013-02-01 | 2014-02-03 | Lagrimas artificiales que comprenden hialuronato de sodio y carboximetilcelulosa |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19151359T Active ES2841434T3 (es) | 2013-02-01 | 2014-02-03 | Lagrimas artificiales que comprenden hialuronato de sodio y carboximetilcelulosa |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20140221309A1 (hu) |
| EP (2) | EP3517100B1 (hu) |
| JP (2) | JP6527468B2 (hu) |
| KR (1) | KR102227202B1 (hu) |
| CN (2) | CN111419794A (hu) |
| AU (2) | AU2014212025A1 (hu) |
| BR (1) | BR112015018414B1 (hu) |
| CA (1) | CA2898217C (hu) |
| CY (1) | CY1124054T1 (hu) |
| DK (2) | DK2950783T3 (hu) |
| ES (2) | ES2741141T3 (hu) |
| HK (1) | HK1218517A1 (hu) |
| HR (1) | HRP20191382T1 (hu) |
| HU (2) | HUE044555T2 (hu) |
| LT (1) | LT2950783T (hu) |
| MX (1) | MX367461B (hu) |
| PL (2) | PL3517100T3 (hu) |
| PT (2) | PT3517100T (hu) |
| RS (1) | RS59271B1 (hu) |
| RU (1) | RU2687275C2 (hu) |
| SA (1) | SA517381008B1 (hu) |
| SI (2) | SI3517100T1 (hu) |
| WO (1) | WO2014121232A1 (hu) |
| ZA (1) | ZA201505026B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613423B1 (en) | 2013-07-10 | 2022-10-26 | Matrix Biology Institute | Compositions of hyaluronan with high elasticity and uses thereof |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| US20170014339A1 (en) * | 2015-07-17 | 2017-01-19 | i.com medical GmbH | Tear Substitute, Fluid for Being Used as a Tear Substitute, and Method for Producing a Tear Substitute |
| PL3352766T3 (pl) | 2015-09-24 | 2021-08-02 | Matrix Biology Institute | Kompozycie z hialuronanem o dużej elastyczności i sposoby ich użycia |
| US20180338911A1 (en) * | 2015-10-28 | 2018-11-29 | David B. Welch | Eye Drops |
| ES2621877B1 (es) * | 2016-01-04 | 2018-05-04 | Agencia Pública Empresarial Sanitaria Hospital De Poniente | Solución para resección endoscópica |
| US10632202B2 (en) | 2016-03-04 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Preservative containing compositions |
| GB201618175D0 (en) * | 2016-10-27 | 2016-12-14 | Warneford Healthcare Ltd | Pharmaceutical compositions |
| EP3412276A3 (de) * | 2017-06-09 | 2019-07-17 | Omnivision GmbH | Zusammensetzung zur behandlung des trockenen auges |
| US20210353759A1 (en) * | 2018-09-20 | 2021-11-18 | The Hong Kong University Of Science And Technology | Eyedrop compositions |
| KR102051356B1 (ko) * | 2019-01-03 | 2019-12-03 | (주)휴온스 | 고농도의 히알루론산 또는 그의 염을 함유하는 점안 조성물 |
| WO2022189548A1 (en) * | 2021-03-10 | 2022-09-15 | Bausch + Lomb Ireland Limited | Contact lens treating solution |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US6271216B1 (en) * | 1989-07-24 | 2001-08-07 | Allergan | Stable solution of hyaluronate in a balanced salt medium |
| CA2371833C (en) * | 1999-02-19 | 2009-09-15 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel composition, process for its production and medical material containing it |
| JP2002539157A (ja) | 1999-03-15 | 2002-11-19 | トラスティーズ オブ ボストン ユニバーシティ | 血管新生阻害 |
| WO2001034549A1 (en) * | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders |
| EP1237588B1 (en) * | 1999-12-17 | 2004-12-01 | Genzyme Corporation | Surgical prosthesis |
| CN1485395A (zh) * | 2002-09-25 | 2004-03-31 | 宋海涛 | 一种环保型“冷热液” |
| US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
| JP2006052160A (ja) * | 2004-08-10 | 2006-02-23 | Rohto Pharmaceut Co Ltd | ドライアイ治療用眼科組成物 |
| JP2006143590A (ja) * | 2004-10-21 | 2006-06-08 | Rohto Pharmaceut Co Ltd | 粘膜適用組成物 |
| SG157374A1 (en) * | 2004-11-09 | 2009-12-29 | Abbott Medical Optics Inc | Ophthalmic solution |
| US8569367B2 (en) * | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| BRPI0714587A2 (pt) * | 2006-07-25 | 2013-05-07 | Osmotica Corp | suluÇço oftÁlmica aquosa e uso da nesna |
| WO2008073193A2 (en) * | 2006-11-06 | 2008-06-19 | Novartis Ag | Ocular devices and methods of making and using thereof |
| US8609634B2 (en) * | 2007-05-16 | 2013-12-17 | Mcneil-Ppc, Inc. | Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods |
| KR100827400B1 (ko) * | 2008-06-24 | 2008-05-06 | 김정춘 | 파이프 연결구를 갖는 수도계량기 및 그 제조방법 |
| KR100938500B1 (ko) * | 2008-06-24 | 2010-01-28 | 주식회사 디에이치피코리아 | 안과질환 예방 및 치료용 점안제 조성물 |
| US20100086512A1 (en) | 2008-10-02 | 2010-04-08 | Rolf Schaefer | Mucomimetic compositions and uses therefore |
| AU2009308017A1 (en) * | 2008-10-20 | 2010-04-29 | Allergan, Inc. | Ophthalmic compositions useful for improving visual acuity |
| KR20120112537A (ko) * | 2009-12-15 | 2012-10-11 | 포어사이트 바이오쎄라퓨틱스, 인코퍼레이티드 | 무자극성 안과용 포비돈-요오드 조성물 |
| CN101785852A (zh) * | 2010-01-21 | 2010-07-28 | 孙杰 | 一种真皮层微量介入美容抗衰除皱制剂与方法 |
| CN101884602A (zh) * | 2010-03-03 | 2010-11-17 | 孙杰 | 一种皮肤美容修复抗衰除皱的化妆品制剂 |
-
2014
- 2014-02-03 SI SI201431728T patent/SI3517100T1/sl unknown
- 2014-02-03 ES ES14704747T patent/ES2741141T3/es active Active
- 2014-02-03 JP JP2015556212A patent/JP6527468B2/ja active Active
- 2014-02-03 SI SI201431299T patent/SI2950783T1/sl unknown
- 2014-02-03 DK DK14704747.6T patent/DK2950783T3/da active
- 2014-02-03 CN CN202010439040.1A patent/CN111419794A/zh active Pending
- 2014-02-03 PL PL19151359T patent/PL3517100T3/pl unknown
- 2014-02-03 EP EP19151359.7A patent/EP3517100B1/en active Active
- 2014-02-03 CN CN201480007049.8A patent/CN104981234A/zh active Pending
- 2014-02-03 PT PT191513597T patent/PT3517100T/pt unknown
- 2014-02-03 US US14/171,076 patent/US20140221309A1/en not_active Abandoned
- 2014-02-03 MX MX2015009924A patent/MX367461B/es active IP Right Grant
- 2014-02-03 PT PT14704747T patent/PT2950783T/pt unknown
- 2014-02-03 PL PL14704747T patent/PL2950783T3/pl unknown
- 2014-02-03 CA CA2898217A patent/CA2898217C/en active Active
- 2014-02-03 LT LT14704747T patent/LT2950783T/lt unknown
- 2014-02-03 AU AU2014212025A patent/AU2014212025A1/en not_active Abandoned
- 2014-02-03 ES ES19151359T patent/ES2841434T3/es active Active
- 2014-02-03 BR BR112015018414-6A patent/BR112015018414B1/pt active IP Right Grant
- 2014-02-03 EP EP14704747.6A patent/EP2950783B1/en active Active
- 2014-02-03 HU HUE14704747 patent/HUE044555T2/hu unknown
- 2014-02-03 WO PCT/US2014/014505 patent/WO2014121232A1/en active Application Filing
- 2014-02-03 RU RU2015132974A patent/RU2687275C2/ru active
- 2014-02-03 HU HUE19151359A patent/HUE052793T2/hu unknown
- 2014-02-03 DK DK19151359.7T patent/DK3517100T3/da active
- 2014-02-03 RS RSP20190971 patent/RS59271B1/sr unknown
- 2014-02-03 KR KR1020157023645A patent/KR102227202B1/ko active IP Right Grant
-
2015
- 2015-07-13 ZA ZA2015/05026A patent/ZA201505026B/en unknown
- 2015-07-30 SA SA517381008A patent/SA517381008B1/ar unknown
-
2016
- 2016-04-27 US US15/140,291 patent/US20160235780A1/en not_active Abandoned
- 2016-06-08 HK HK16106565.4A patent/HK1218517A1/zh unknown
-
2018
- 2018-11-07 AU AU2018260857A patent/AU2018260857B2/en active Active
-
2019
- 2019-02-12 JP JP2019022506A patent/JP6876079B2/ja active Active
- 2019-07-31 HR HRP20191382 patent/HRP20191382T1/hr unknown
-
2020
- 2020-12-09 CY CY20201101166T patent/CY1124054T1/el unknown
-
2021
- 2021-08-11 US US17/399,504 patent/US20220096531A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2741141T3 (es) | Colirio que comprende ácido hialurónico de sodio y carboximetilcelulosa | |
| ES2819005T3 (es) | Composición oftálmica para el tratamiento de la enfermedad del ojo seco | |
| ES2244831T3 (es) | Composicion farmaceutica para aplicacion oftalmologica y rinologica. | |
| ES2332049T5 (es) | Composiciones de administración de sustancias terapéuticas en los ojos | |
| ES2871199T3 (es) | Composiciones de hialuronano de alta elasticidad y métodos de uso de las mismas | |
| ES2546263T3 (es) | Composición de reticulación mejorada administrada por iontoforesis, útil para el tratamiento de queratocono | |
| Bennett et al. | Material, immunological, and practical perspectives on eye drop formulation | |
| ES2304913T3 (es) | Composiciones farmacéuticas reepitelializantes que contienen goma de xantano. | |
| ES2896336T3 (es) | Suministro eficiente de lípidos a película lagrimal humana usando un sistema de emulsión sensible a sales | |
| KR102268002B1 (ko) | 효과 지속성 점안제 조성물 | |
| ES2407282T3 (es) | Medicamento de extracto de linaza para aplicación ocular | |
| Sahu et al. | Recent trends in nanocarrier based approach in the management of dry eye disease | |
| ES2754449T3 (es) | Acido carboxílico de pirrolidona (pca) para uso oftálmico | |
| ES2773537T3 (es) | Uso terapéutico de una solución oftálmica acuosa estéril | |
| JP2023038930A (ja) | 眼表面薬物滞留化剤およびこれを含む点眼剤、並びに、これらの剤を用いた眼表面薬物滞留方法および眼科疾患治療方法 | |
| Rajput et al. | THE USE OF IN-SITU HYDROGEL IN OCULAR DRUG DELIVERY | |
| WO2005115475A1 (ja) | 眼科用粘稠化剤 |